RU2008112198A - Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств - Google Patents
Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств Download PDFInfo
- Publication number
- RU2008112198A RU2008112198A RU2008112198/04A RU2008112198A RU2008112198A RU 2008112198 A RU2008112198 A RU 2008112198A RU 2008112198/04 A RU2008112198/04 A RU 2008112198/04A RU 2008112198 A RU2008112198 A RU 2008112198A RU 2008112198 A RU2008112198 A RU 2008112198A
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- Russia
- Prior art keywords
- alkylene
- alkyl
- compounds
- formula
- mono
- Prior art date
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- 238000000034 method Methods 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 title claims 2
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 35
- 125000002947 alkylene group Chemical group 0.000 claims abstract 28
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 23
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 21
- 125000000217 alkyl group Chemical group 0.000 claims abstract 20
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims abstract 19
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 19
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 18
- 125000003118 aryl group Chemical group 0.000 claims abstract 17
- 229910052736 halogen Inorganic materials 0.000 claims abstract 17
- 150000002367 halogens Chemical class 0.000 claims abstract 17
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 16
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 12
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims abstract 12
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 5
- 125000004450 alkenylene group Chemical group 0.000 claims abstract 5
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 5
- 125000005842 heteroatom Chemical group 0.000 claims abstract 5
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 4
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims abstract 2
- 229910052794 bromium Inorganic materials 0.000 claims abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 230000002265 prevention Effects 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 6
- 239000008177 pharmaceutical agent Substances 0.000 claims 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- -1 CF2CH2CH3 Chemical group 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000003210 demyelinating effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 230000004129 fatty acid metabolism Effects 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Immunology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05021277 | 2005-09-29 | ||
| EP05021277.8 | 2005-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008112198A true RU2008112198A (ru) | 2009-10-10 |
Family
ID=35788653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008112198/04A RU2008112198A (ru) | 2005-09-29 | 2006-09-26 | Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7709481B2 (https=) |
| EP (1) | EP1931337B1 (https=) |
| JP (1) | JP2009509988A (https=) |
| KR (1) | KR20080048504A (https=) |
| CN (1) | CN101272784A (https=) |
| AR (1) | AR056095A1 (https=) |
| AU (1) | AU2006299091A1 (https=) |
| BR (1) | BRPI0617207A2 (https=) |
| CA (1) | CA2624102A1 (https=) |
| CR (1) | CR9785A (https=) |
| DO (1) | DOP2006000203A (https=) |
| EC (1) | ECSP088322A (https=) |
| IL (1) | IL190231A0 (https=) |
| MA (1) | MA29805B1 (https=) |
| NO (1) | NO20081369L (https=) |
| NZ (1) | NZ566877A (https=) |
| PE (1) | PE20070620A1 (https=) |
| RU (1) | RU2008112198A (https=) |
| TN (1) | TNSN08148A1 (https=) |
| TW (1) | TW200806658A (https=) |
| UY (1) | UY29831A1 (https=) |
| WO (1) | WO2007039177A2 (https=) |
| ZA (1) | ZA200801629B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| AU2008279447A1 (en) | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
| BRPI0909469A2 (pt) * | 2008-03-31 | 2015-12-29 | Metabolex Inc | compostos de oximetileno de arila e usos dos mesmos |
| EP2334669B1 (de) * | 2008-10-01 | 2015-12-23 | Bayer Intellectual Property GmbH | Heterocyclyl substituierte thiazole als pflanzenschutzmittel |
| CN102292334A (zh) | 2008-12-11 | 2011-12-21 | 拜尔农作物科学股份公司 | 噻唑基肟醚和腙植物保护剂 |
| EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
| NZ596467A (en) * | 2009-06-05 | 2014-01-31 | Pfizer | L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators |
| US8410127B2 (en) | 2009-10-01 | 2013-04-02 | Metabolex, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| CN107875155A (zh) | 2009-10-08 | 2018-04-06 | 赛诺菲 | 苯基噁二唑衍生物在制备治疗变应性或炎性疾病的药物中的用途 |
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2006
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- 2006-09-26 EP EP06792251.8A patent/EP1931337B1/en active Active
- 2006-09-26 NZ NZ566877A patent/NZ566877A/en not_active IP Right Cessation
- 2006-09-26 RU RU2008112198/04A patent/RU2008112198A/ru not_active Application Discontinuation
- 2006-09-26 KR KR1020087007393A patent/KR20080048504A/ko not_active Withdrawn
- 2006-09-26 CN CNA2006800359361A patent/CN101272784A/zh active Pending
- 2006-09-26 AU AU2006299091A patent/AU2006299091A1/en not_active Abandoned
- 2006-09-26 CA CA002624102A patent/CA2624102A1/en not_active Abandoned
- 2006-09-26 BR BRPI0617207-5A patent/BRPI0617207A2/pt not_active IP Right Cessation
- 2006-09-26 WO PCT/EP2006/009303 patent/WO2007039177A2/en not_active Ceased
- 2006-09-27 AR ARP060104223A patent/AR056095A1/es not_active Application Discontinuation
- 2006-09-27 TW TW095135658A patent/TW200806658A/zh unknown
- 2006-09-27 DO DO2006000203A patent/DOP2006000203A/es unknown
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- 2006-09-29 UY UY29831A patent/UY29831A1/es not_active Application Discontinuation
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- 2008-03-27 EC EC2008008322A patent/ECSP088322A/es unknown
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| DOP2006000203A (es) | 2007-06-30 |
| EP1931337B1 (en) | 2013-10-23 |
| CR9785A (es) | 2008-05-21 |
| AU2006299091A1 (en) | 2007-04-12 |
| CN101272784A (zh) | 2008-09-24 |
| NO20081369L (no) | 2008-05-28 |
| EP1931337A2 (en) | 2008-06-18 |
| TNSN08148A1 (en) | 2009-07-14 |
| PE20070620A1 (es) | 2007-07-10 |
| CA2624102A1 (en) | 2007-04-12 |
| NZ566877A (en) | 2010-05-28 |
| WO2007039177A3 (en) | 2007-09-07 |
| JP2009509988A (ja) | 2009-03-12 |
| ECSP088322A (es) | 2008-04-28 |
| ZA200801629B (en) | 2009-03-25 |
| TW200806658A (en) | 2008-02-01 |
| US7709481B2 (en) | 2010-05-04 |
| MA29805B1 (fr) | 2008-09-01 |
| US20080261979A1 (en) | 2008-10-23 |
| BRPI0617207A2 (pt) | 2011-07-19 |
| WO2007039177B1 (en) | 2007-11-01 |
| AR056095A1 (es) | 2007-09-19 |
| UY29831A1 (es) | 2007-04-30 |
| KR20080048504A (ko) | 2008-06-02 |
| WO2007039177A2 (en) | 2007-04-12 |
| IL190231A0 (en) | 2008-11-03 |
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