KR900001683A - 피페리딘 유도체 - Google Patents
피페리딘 유도체 Download PDFInfo
- Publication number
- KR900001683A KR900001683A KR1019890009671A KR890009671A KR900001683A KR 900001683 A KR900001683 A KR 900001683A KR 1019890009671 A KR1019890009671 A KR 1019890009671A KR 890009671 A KR890009671 A KR 890009671A KR 900001683 A KR900001683 A KR 900001683A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- compound
- formula
- pharmaceutically acceptable
- group
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- -1 substituents hydrogen Chemical class 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- 208000000884 Airway Obstruction Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000003205 diastolic effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- (3R,S) - 또는 (3R) - 형태의 하기 일반식(I)의 화합물 또는 이의 약제학적으로 허용되는 염.상기식에서, R1은 하기 일반식의 그룹이고 ;[상기식에서, 각각의 Y는 동일하거나 상이할 수 있고, 치환체인 수소, 할로 및 C1-C4알킬중에서 선택되며 ; X는 -(CH2)2-, CH=CH-, CH2-S-, -CH2-O-, -S- 또는 -O- 이다.] R은 하기 일반식의 그룹이다.[상기식에서, R2및 R3는 각각 독립적으로 수소, C1-C4알킬, 하이드록시 - (C1-C4알킬), 하이드록시, C1-C4알콕시, 할로,트리플루오로메틸, 니트로, 시아노, 설파모일, -CO(C1-C4알킬), -OCO(C1-C4알킬), -CO2(C1-C4알킬), -(CH2)nCONR6R7, -(CH2)nOCONR6R7, NR8R9, 또는 -NHSO2NH2(여기에서, R6및 R7은 각각 독립적으로 H 또는 C1-C4알킬이고, n은 0,1 또는 2이며, R8및 R9는 각각 독립적으로 H 또는 C1-C4알킬이거나, 또는 R8이 수소이고 R9는 -SO2(C1-C4알킬), -CO(C1-C4알킬)또는 -CONH(C1-C4알킬)이다)이거나, 또는 R2및 R3가 함께는, 인접 탄소 원자에 결합될 경우, 일반식 -0(CH2)mO-의 그룹(여기에서, m은 1,2 또는 3이다), -O(CH2)2- 또는 -(CH2)3- 이고 ; R4는 H, C1-C4알킬 또는 -CONH2이며 ; R5는 H, C1-C4알킬 또는 C1-C4알콕시이다.]
- 제1항에 있어서, R이 하기 일반식의 그룹인 일반식(I)의 화합물.상기식에서, R2, R3, R4및 R5는 제1항에서 정의한 바와 같다.
- 제1항 또는 제2항에 있어서, R1이 하기 구조식의 그룹인 일반식(I)의 화합물.
- 제1항에 있어서, R이 하기 일반식(a),(b),(c) 또는 (d)의 그룹인 일반식(I) 의 화합물.상기식에서, R2및 R3는 각각 독립적으로 수소, C1-C2알킬, 하이드록시-(C1-C3알킬), 하이드록시, C1-C2알콕시, 할로, 설파모일, -CO(C1-C2알킬), -OCO(C1-C2알킬), -CONH2, -CONH(C1-C2알킬), -OCONH(C1-C2알킬), -NH2, -CH2NH2, -CH2NH(C1-C2알킬), -NHSO2(C1-C2알킬), -NHCO(C1-C2알킬), -CH2NHCO(C1-C2알킬), -CH2NHCONH (C1-C2알킬) 또는 -NHSO2NH2이거나, 또는 R2및 R3가 함께는 -O(CH2)mO-(여기에서, m은 1,2 또는 3이다), -O(CH2)2-, 또는 -(CH2)3-이고 ; R4는 H 또는 -CONH2이다.
- 제1항에 있어서, R1이인 일반식(I)의 화합물.
- 제1항에 있어서, R이인 일반식(I)의 화합물.
- 제1항에 있어서, 다음과 같은 (3R) - 배위를 갖는 일반식(I)의 화합물.
- (3R)-디페닐메톡시-1-(3,4-메틸렌디옥시펜에틸)-페페리딘 또는 이의 약제학적으로 허용되는 염.
- 제1항 또는 제2항에 있어서, 각각의 Y가 동일한 화합물.
- 제1항 내지 제9항중 어느 한 항에서 청구된 일반식(I)의 화합물 또는 이의 약제학적으로 허용되는 염을 약제학적으로 허용되는 희석제 또는 담체와 함께 함유하는 약제학적 조성물.
- 약제로서 사용하기 위한 각각 제1항 내지 제9항중 어느 한 항 및 제10항에서 청구된 일반식(I)의 화합물 또는 이의 약제학적으로 허용되는 염 또는 조성물.
- 평활근의 변화된 운동성 및 /또는 긴장력과 관련된 질환(예 : 신경성 장증후군, 게실 질환, 요실금, 오에소파게알(Oesophageal) 이완불능증 및 만성 기도 폐쇄질환(의 치료용 약제를 제조하기 위한, 각각 제1항 내지 제9항중 어느 한 항 및 제10항에서 청구된 일반식(I)의 화합물 또는 이의 약제학적으로 허용되는 염 또는 조성물의 용도.
- (3R,S) - 또는 (3R) - 형태으 하기 일반식(IV) 또는 (VI)의 화합물.상기식에서, R 및 R1은 제1항 내지 제6항중 어느 한 항에서 정의한 바와 같다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8816365.4 | 1988-07-08 | ||
| GB888816365A GB8816365D0 (en) | 1988-07-08 | 1988-07-08 | Therapeutic agents |
| GB8816365.4 | 1988-07-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR900001683A true KR900001683A (ko) | 1990-02-27 |
| KR930002728B1 KR930002728B1 (ko) | 1993-04-09 |
Family
ID=10640168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019890009671A KR930002728B1 (ko) | 1988-07-08 | 1989-07-07 | 피페리딘 유도체 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5089505A (ko) |
| EP (1) | EP0350309B1 (ko) |
| JP (2) | JPH0739388B2 (ko) |
| KR (1) | KR930002728B1 (ko) |
| CN (1) | CN1022914C (ko) |
| AT (1) | ATE82262T1 (ko) |
| AU (1) | AU602453B2 (ko) |
| CA (1) | CA1336833C (ko) |
| DD (1) | DD284011A5 (ko) |
| DE (1) | DE68903437T2 (ko) |
| DK (1) | DK337589A (ko) |
| EG (1) | EG18853A (ko) |
| ES (1) | ES2052917T3 (ko) |
| FI (1) | FI94241C (ko) |
| GB (1) | GB8816365D0 (ko) |
| GR (1) | GR3006595T3 (ko) |
| HU (1) | HUT50771A (ko) |
| IE (1) | IE63438B1 (ko) |
| IL (1) | IL90792A0 (ko) |
| MX (1) | MX16728A (ko) |
| MY (1) | MY106976A (ko) |
| NO (1) | NO892828L (ko) |
| NZ (1) | NZ229865A (ko) |
| PL (2) | PL161887B1 (ko) |
| PT (1) | PT91081B (ko) |
| RU (2) | RU1838307C (ko) |
| YU (1) | YU135389A (ko) |
| ZA (1) | ZA895175B (ko) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231104A (en) * | 1988-07-08 | 1993-07-27 | Pfizer Inc. | 1-arylethyl-3-substituted piperidines |
| GB9000301D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Piperidine & pyrrolidine derivatives |
| GB9208230D0 (en) * | 1992-04-14 | 1992-05-27 | Pfizer Ltd | Treatment of delayed gastric emptying |
| US5340826A (en) * | 1993-02-04 | 1994-08-23 | Pfizer Inc. | Pharmaceutical agents for treatment of urinary incontinence |
| GB9400600D0 (en) * | 1994-01-14 | 1994-03-09 | Pfizer Ltd | Treatment of motion seckness |
| US6525069B1 (en) | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| WO2000035449A1 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6331541B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| IL142768A0 (en) * | 1998-12-18 | 2002-03-10 | Du Pont Pharm Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6492400B1 (en) | 1998-12-18 | 2002-12-10 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6897234B2 (en) | 1999-12-17 | 2005-05-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| BR0111878A (pt) | 2000-06-30 | 2005-05-24 | Bristol Myers Squibb Co | N-ureido-(heterociclo-alquil)-piperidinas como moduladores da atividade de receptores de quimiocinas |
| JP2004509103A (ja) * | 2000-09-11 | 2004-03-25 | セプレイコー インコーポレイテッド | モノアミン受容体及び輸送体のリガンドならびにその使用方法 |
| US6508872B2 (en) * | 2001-02-26 | 2003-01-21 | Hewlett-Packard Company | Lightfast additive molecule for inkjet ink |
| US20090005309A1 (en) * | 2007-05-18 | 2009-01-01 | Auspex Pharmaceuticals, Inc. | Substituted piperidines |
| JP5841529B2 (ja) * | 2010-05-27 | 2016-01-13 | あすか製薬株式会社 | 複素環化合物及びｈ１受容体拮抗剤 |
| CN107129453B (zh) * | 2016-02-26 | 2019-10-11 | 中国科学院大连化学物理研究所 | 化合物、毒蕈碱m受体拮抗剂、组合物及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA541598A (en) * | 1957-05-28 | Levy Joseph | N-substituted-4-benzhydryl etherpiperidines and method for obtaining the same | |
| GB688345A (en) * | 1951-02-19 | 1953-03-04 | Greenwood And Hughes Ltd | Improvements in sanitary liquid traps |
| US2745837A (en) * | 1954-01-21 | 1956-05-15 | Schering Corp | Benzhydryl ethers of alkyl piperidinols |
| GB780027A (en) * | 1955-01-20 | 1957-07-31 | Schering Corp | 3-piperidyl ethers and thioethers |
| US2974146A (en) * | 1956-02-24 | 1961-03-07 | Lakeside Lab Inc | 3-piperidyl benzhydryl ethers |
| NL237664A (ko) * | 1959-04-01 |
-
1988
- 1988-07-08 GB GB888816365A patent/GB8816365D0/en active Pending
-
1989
- 1989-06-29 IL IL90792A patent/IL90792A0/xx not_active IP Right Cessation
- 1989-07-05 MY MYPI89000908A patent/MY106976A/en unknown
- 1989-07-06 US US07/376,263 patent/US5089505A/en not_active Expired - Fee Related
- 1989-07-06 EG EG32789A patent/EG18853A/xx active
- 1989-07-06 EP EP89306881A patent/EP0350309B1/en not_active Expired - Lifetime
- 1989-07-06 AT AT89306881T patent/ATE82262T1/de not_active IP Right Cessation
- 1989-07-06 ES ES89306881T patent/ES2052917T3/es not_active Expired - Lifetime
- 1989-07-06 DE DE8989306881T patent/DE68903437T2/de not_active Expired - Fee Related
- 1989-07-06 DD DD89330509A patent/DD284011A5/de not_active IP Right Cessation
- 1989-07-06 PT PT91081A patent/PT91081B/pt not_active IP Right Cessation
- 1989-07-06 CA CA000604882A patent/CA1336833C/en not_active Expired - Fee Related
- 1989-07-06 YU YU01353/89A patent/YU135389A/xx unknown
- 1989-07-07 PL PL89280474A patent/PL161887B1/pl unknown
- 1989-07-07 NO NO89892828A patent/NO892828L/no unknown
- 1989-07-07 ZA ZA895175A patent/ZA895175B/xx unknown
- 1989-07-07 PL PL89283209A patent/PL162318B1/pl unknown
- 1989-07-07 FI FI893326A patent/FI94241C/fi not_active IP Right Cessation
- 1989-07-07 KR KR1019890009671A patent/KR930002728B1/ko not_active IP Right Cessation
- 1989-07-07 MX MX1672889A patent/MX16728A/es unknown
- 1989-07-07 IE IE220289A patent/IE63438B1/en not_active IP Right Cessation
- 1989-07-07 HU HU893449A patent/HUT50771A/hu unknown
- 1989-07-07 AU AU37971/89A patent/AU602453B2/en not_active Ceased
- 1989-07-07 DK DK337589A patent/DK337589A/da not_active Application Discontinuation
- 1989-07-07 NZ NZ229865A patent/NZ229865A/en unknown
- 1989-07-07 RU SU894614534A patent/RU1838307C/ru active
- 1989-07-08 CN CN89104933A patent/CN1022914C/zh not_active Expired - Fee Related
- 1989-07-10 JP JP1177854A patent/JPH0739388B2/ja not_active Expired - Fee Related
-
1990
- 1990-09-17 RU SU904831151A patent/RU1836364C/ru active
-
1992
- 1992-12-21 GR GR920403003T patent/GR3006595T3/el unknown
-
1994
- 1994-07-26 JP JP6173882A patent/JPH07157469A/ja active Pending
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| KR900001683A (ko) | 피페리딘 유도체 | |
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