JP2009509988A5 - - Google Patents
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- JP2009509988A5 JP2009509988A5 JP2008532647A JP2008532647A JP2009509988A5 JP 2009509988 A5 JP2009509988 A5 JP 2009509988A5 JP 2008532647 A JP2008532647 A JP 2008532647A JP 2008532647 A JP2008532647 A JP 2008532647A JP 2009509988 A5 JP2009509988 A5 JP 2009509988A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- formula
- aryl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000002947 alkylene group Chemical group 0.000 claims 50
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 229910052731 fluorine Inorganic materials 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 6
- 238000011282 treatment Methods 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- -1 4-F- phenyl Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229940127003 anti-diabetic drug Drugs 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000004129 fatty acid metabolism Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 description 3
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 2
- 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 description 1
- 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
- 125000004419 alkynylene group Chemical group 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05021277 | 2005-09-29 | ||
| PCT/EP2006/009303 WO2007039177A2 (en) | 2005-09-29 | 2006-09-26 | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009509988A JP2009509988A (ja) | 2009-03-12 |
| JP2009509988A5 true JP2009509988A5 (https=) | 2009-11-05 |
Family
ID=35788653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008532647A Abandoned JP2009509988A (ja) | 2005-09-29 | 2006-09-26 | フェニル−及びピリジニル−１，２，４−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7709481B2 (https=) |
| EP (1) | EP1931337B1 (https=) |
| JP (1) | JP2009509988A (https=) |
| KR (1) | KR20080048504A (https=) |
| CN (1) | CN101272784A (https=) |
| AR (1) | AR056095A1 (https=) |
| AU (1) | AU2006299091A1 (https=) |
| BR (1) | BRPI0617207A2 (https=) |
| CA (1) | CA2624102A1 (https=) |
| CR (1) | CR9785A (https=) |
| DO (1) | DOP2006000203A (https=) |
| EC (1) | ECSP088322A (https=) |
| IL (1) | IL190231A0 (https=) |
| MA (1) | MA29805B1 (https=) |
| NO (1) | NO20081369L (https=) |
| NZ (1) | NZ566877A (https=) |
| PE (1) | PE20070620A1 (https=) |
| RU (1) | RU2008112198A (https=) |
| TN (1) | TNSN08148A1 (https=) |
| TW (1) | TW200806658A (https=) |
| UY (1) | UY29831A1 (https=) |
| WO (1) | WO2007039177A2 (https=) |
| ZA (1) | ZA200801629B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| AU2008279447A1 (en) | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
| AU2009231906A1 (en) * | 2008-03-31 | 2009-10-08 | Metabolex, Inc. | Oxymethylene aryl compounds and uses thereof |
| BRPI0920767B1 (pt) * | 2008-10-01 | 2018-07-17 | Bayer Intellectual Property Gmbh | tiazóis substituídos por heterociclila como agentes protetores de cultura, seus usos e seus processos de preparação, composições e seu processo de preparação, e método para combate a fungos nocivos fitopatogênicos |
| BRPI0923366A2 (pt) | 2008-12-11 | 2019-09-24 | Bayer Cropscience Ag | éteres e hodrazonas de oxima de tiazolila como agentes protetors de culturas. |
| EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
| NZ596467A (en) * | 2009-06-05 | 2014-01-31 | Pfizer | L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators |
| JP5909185B2 (ja) | 2009-10-01 | 2016-04-26 | シマベイ セラピューティクス， インコーポレーテッド | 置換テトラゾール−１−イルフェノキシメチルチアゾール−２−イルピペリジニルピリミジン塩 |
| NZ599099A (en) | 2009-10-08 | 2013-05-31 | Sanofi Sa | Phenyloxadiazole derivatives as pgds inhibitors |
| JP5960683B2 (ja) | 2010-04-28 | 2016-08-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺真菌剤としてのケトヘテロアリールピペリジンおよび−ピペラジン誘導体 |
| JP5847813B2 (ja) | 2010-06-23 | 2016-01-27 | シマベイ セラピューティクス， インコーポレーテッド | ５−エチル−２−｛４−［４−（４−テトラゾル−１−イル−フェノキシメチル）−チアゾール−２−イル］−ピペリジン−１−イル｝−ピリミジンの組成物 |
| EP2532233A1 (en) | 2011-06-07 | 2012-12-12 | Bayer CropScience AG | Active compound combinations |
| SI2841437T1 (sl) | 2012-04-26 | 2017-09-29 | Bristol-Myers Squibb Company | Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov |
| EP2855489B1 (en) | 2012-04-26 | 2017-01-04 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| SG11201406759YA (en) | 2012-04-26 | 2014-11-27 | Bristol Myers Squibb Co | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| AU2017305392A1 (en) | 2016-08-03 | 2019-02-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
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| KR20070007104A (ko) | 2004-02-18 | 2007-01-12 | 아스트라제네카 아베 | 화합물 |
| BRPI0507746A (pt) | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, composição farmacêutica, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
| SI1751131T1 (sl) | 2004-03-10 | 2009-04-30 | Janssen Pharmaceutica Nv | MTP inhibirajoči aril piperidini ali piperazini substituirani s 5-členskimi heterocikli |
| US7687502B2 (en) | 2004-03-23 | 2010-03-30 | Banyu Pharmaceutical Co., Ltd. | Substituted quinazoline or pyridopyrimidine derivative |
| RU2375358C2 (ru) * | 2004-04-01 | 2009-12-10 | Авентис Фармасьютикалз, Инк. | 1,3,4-оксадиазол-2-оны в качестве модуляторов ppar-дельта и их применение |
| BRPI0508180A (pt) | 2004-04-01 | 2007-08-07 | Aventis Pharma Inc | 1,3,4-oxadiazol-2-onas como moduladores de ppar delta e seu uso deste |
| DE602004004631D1 (de) | 2004-04-01 | 2007-03-22 | Sanofi Aventis Deutschland | Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika |
| EP1736467A4 (en) | 2004-04-06 | 2009-07-01 | Dainippon Sumitomo Pharma Co | NEW SULFONIC ACID AMID DERIVATIVE |
| MXPA06012008A (es) | 2004-04-21 | 2007-01-25 | Prosidion Ltd | Compuestos de amida tri(ciclo) sustituidos. |
| CA2565211A1 (en) | 2004-04-29 | 2005-11-24 | Abbott Laboratories | Amino-tetrazoles analogues and methods of use |
| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| US20080026987A1 (en) | 2004-06-17 | 2008-01-31 | Novo Nordisk A/S | Use of Liver-Selective Glucokinase Activators |
| GB0418046D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
| DE102004039533B4 (de) | 2004-08-14 | 2006-09-28 | Sanofi-Aventis Deutschland Gmbh | Essigsäurederivate mit Cyclohexylmethoxy-Substituenten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE102004039509B4 (de) | 2004-08-14 | 2006-09-21 | Sanofi-Aventis Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102004039532B4 (de) | 2004-08-14 | 2006-09-21 | Sanofi-Aventis Deutschland Gmbh | Cyclohexyl-methyloxy substituierte Essigsäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| EP1794159B1 (en) | 2004-09-11 | 2012-08-01 | Sanofi-Aventis Deutschland GmbH | 7-azaindoles and their use as ppar agonists |
| DE102005033100B3 (de) | 2005-07-15 | 2007-01-25 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung |
| DE102005033099A1 (de) | 2005-07-15 | 2007-01-18 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung |
-
2006
- 2006-09-26 CA CA002624102A patent/CA2624102A1/en not_active Abandoned
- 2006-09-26 JP JP2008532647A patent/JP2009509988A/ja not_active Abandoned
- 2006-09-26 EP EP06792251.8A patent/EP1931337B1/en active Active
- 2006-09-26 KR KR1020087007393A patent/KR20080048504A/ko not_active Withdrawn
- 2006-09-26 WO PCT/EP2006/009303 patent/WO2007039177A2/en not_active Ceased
- 2006-09-26 AU AU2006299091A patent/AU2006299091A1/en not_active Abandoned
- 2006-09-26 RU RU2008112198/04A patent/RU2008112198A/ru not_active Application Discontinuation
- 2006-09-26 BR BRPI0617207-5A patent/BRPI0617207A2/pt not_active IP Right Cessation
- 2006-09-26 NZ NZ566877A patent/NZ566877A/en not_active IP Right Cessation
- 2006-09-26 CN CNA2006800359361A patent/CN101272784A/zh active Pending
- 2006-09-27 TW TW095135658A patent/TW200806658A/zh unknown
- 2006-09-27 DO DO2006000203A patent/DOP2006000203A/es unknown
- 2006-09-27 AR ARP060104223A patent/AR056095A1/es not_active Application Discontinuation
- 2006-09-27 PE PE2006001170A patent/PE20070620A1/es not_active Application Discontinuation
- 2006-09-29 UY UY29831A patent/UY29831A1/es not_active Application Discontinuation
-
2008
- 2008-02-19 ZA ZA200801629A patent/ZA200801629B/xx unknown
- 2008-02-29 CR CR9785A patent/CR9785A/es not_active Application Discontinuation
- 2008-03-14 NO NO20081369A patent/NO20081369L/no not_active Application Discontinuation
- 2008-03-17 IL IL190231A patent/IL190231A0/en unknown
- 2008-03-24 MA MA30781A patent/MA29805B1/fr unknown
- 2008-03-26 US US12/055,780 patent/US7709481B2/en not_active Expired - Fee Related
- 2008-03-27 EC EC2008008322A patent/ECSP088322A/es unknown
- 2008-03-28 TN TNP2008000148A patent/TNSN08148A1/en unknown
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