JP2015514135A5 - - Google Patents
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- JP2015514135A5 JP2015514135A5 JP2015505973A JP2015505973A JP2015514135A5 JP 2015514135 A5 JP2015514135 A5 JP 2015514135A5 JP 2015505973 A JP2015505973 A JP 2015505973A JP 2015505973 A JP2015505973 A JP 2015505973A JP 2015514135 A5 JP2015514135 A5 JP 2015514135A5
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- Prior art keywords
- dementia
- pharmaceutical composition
- disease
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 206010012289 Dementia Diseases 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 208000035475 disorder Diseases 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 150000003839 salts Chemical group 0.000 claims 7
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 4
- 239000000651 prodrug Chemical group 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 229960003530 donepezil Drugs 0.000 claims 3
- 208000027061 mild cognitive impairment Diseases 0.000 claims 3
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000006264 Korsakoff syndrome Diseases 0.000 claims 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims 2
- 201000002832 Lewy body dementia Diseases 0.000 claims 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 208000024777 Prion disease Diseases 0.000 claims 2
- 201000004810 Vascular dementia Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 210000004227 basal ganglia Anatomy 0.000 claims 2
- 230000003542 behavioural effect Effects 0.000 claims 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 230000036651 mood Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 1
- 206010001488 Aggression Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010048327 Supranuclear palsy Diseases 0.000 claims 1
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000016571 aggressive behavior Effects 0.000 claims 1
- 208000012761 aggressive behavior Diseases 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940120402 donepezil and memantine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 238000004880 explosion Methods 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 208000021090 palsy Diseases 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 235000003441 saturated fatty acids Nutrition 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624293P | 2012-04-14 | 2012-04-14 | |
| US201261624291P | 2012-04-14 | 2012-04-14 | |
| US201261624292P | 2012-04-14 | 2012-04-14 | |
| US61/624,291 | 2012-04-14 | ||
| US61/624,292 | 2012-04-14 | ||
| US61/624,293 | 2012-04-14 | ||
| US201261671723P | 2012-07-14 | 2012-07-14 | |
| US201261671713P | 2012-07-14 | 2012-07-14 | |
| US61/671,723 | 2012-07-14 | ||
| US61/671,713 | 2012-07-14 | ||
| PCT/US2013/036515 WO2013155506A1 (en) | 2012-04-14 | 2013-04-14 | Novel compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018107717A Division JP2018168161A (ja) | 2012-04-14 | 2018-06-05 | 新規組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514135A JP2015514135A (ja) | 2015-05-18 |
| JP2015514135A5 true JP2015514135A5 (https=) | 2016-06-09 |
Family
ID=49328233
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505972A Active JP6242855B2 (ja) | 2012-04-14 | 2013-04-14 | 有機化合物 |
| JP2015505973A Withdrawn JP2015514135A (ja) | 2012-04-14 | 2013-04-14 | 新規組成物および方法 |
| JP2015505971A Active JP6334511B2 (ja) | 2012-04-14 | 2013-04-14 | 新規方法 |
| JP2018107717A Withdrawn JP2018168161A (ja) | 2012-04-14 | 2018-06-05 | 新規組成物および方法 |
| JP2021035948A Pending JP2021098724A (ja) | 2012-04-14 | 2021-03-08 | 新規組成物および方法 |
| JP2023136052A Pending JP2023159345A (ja) | 2012-04-14 | 2023-08-24 | 新規組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505972A Active JP6242855B2 (ja) | 2012-04-14 | 2013-04-14 | 有機化合物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505971A Active JP6334511B2 (ja) | 2012-04-14 | 2013-04-14 | 新規方法 |
| JP2018107717A Withdrawn JP2018168161A (ja) | 2012-04-14 | 2018-06-05 | 新規組成物および方法 |
| JP2021035948A Pending JP2021098724A (ja) | 2012-04-14 | 2021-03-08 | 新規組成物および方法 |
| JP2023136052A Pending JP2023159345A (ja) | 2012-04-14 | 2023-08-24 | 新規組成物および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US9428506B2 (https=) |
| EP (4) | EP3791879A1 (https=) |
| JP (6) | JP6242855B2 (https=) |
| KR (1) | KR20140146192A (https=) |
| CN (1) | CN104519886B (https=) |
| AU (1) | AU2013245702A1 (https=) |
| CA (1) | CA2870303A1 (https=) |
| ES (1) | ES2727815T3 (https=) |
| IN (1) | IN2014DN08562A (https=) |
| MX (1) | MX2014012374A (https=) |
| RU (1) | RU2014145682A (https=) |
| WO (3) | WO2013155504A1 (https=) |
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| JP5611846B2 (ja) | 2008-03-12 | 2014-10-22 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 置換ヘテロ環縮合ガンマ−カルボリン類固体 |
| CN105168219B (zh) * | 2008-05-27 | 2018-11-20 | 细胞内治疗公司 | 用于睡眠障碍和其他疾病的方法和组合物 |
| EP2560676B8 (en) | 2010-04-22 | 2016-10-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
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| WO2014144231A1 (en) | 2013-03-15 | 2014-09-18 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| HUE053159T2 (hu) | 2013-03-15 | 2021-06-28 | Intra Cellular Therapies Inc | Szerves vegyületek |
| IL305990B2 (en) | 2013-12-03 | 2025-12-01 | Intra Cellular Therapies Inc | Long-acting injectable composition comprising polymeric microspheres of heterocycle fused gamma-carboline compounds or a pharmaceutical composition for sustained or delayed release comprising the compounds and their use in the treatment of bipolar disorder i and/or bipolar ii disorder |
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