ATE229499T1 - Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen - Google Patents

Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen

Info

Publication number
ATE229499T1
ATE229499T1 AT99908515T AT99908515T ATE229499T1 AT E229499 T1 ATE229499 T1 AT E229499T1 AT 99908515 T AT99908515 T AT 99908515T AT 99908515 T AT99908515 T AT 99908515T AT E229499 T1 ATE229499 T1 AT E229499T1
Authority
AT
Austria
Prior art keywords
hydrazones
hydrazines
vinylations
hydroxylamines
oximes
Prior art date
Application number
AT99908515T
Other languages
English (en)
Inventor
Stephen L Buchwald
Seble Wagaw
Oliver Geis
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/030,936 external-priority patent/US6235936B1/en
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE229499T1 publication Critical patent/ATE229499T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/02—Preparation of hydrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT99908515T 1998-02-26 1999-02-26 Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen ATE229499T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/030,936 US6235936B1 (en) 1998-02-26 1998-02-26 Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
US5555798A 1998-04-06 1998-04-06
PCT/US1999/004217 WO1999043643A2 (en) 1998-02-26 1999-02-26 Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes

Publications (1)

Publication Number Publication Date
ATE229499T1 true ATE229499T1 (de) 2002-12-15

Family

ID=26706608

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99908515T ATE229499T1 (de) 1998-02-26 1999-02-26 Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen

Country Status (6)

Country Link
EP (1) EP1058678B1 (de)
JP (1) JP4647780B2 (de)
AT (1) ATE229499T1 (de)
CA (1) CA2322194C (de)
DE (1) DE69904448T2 (de)
WO (1) WO1999043643A2 (de)

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US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
EP1130009A1 (de) * 2000-03-01 2001-09-05 Therascope AG Erzeugung und Screenen einer dynamischen kombinatorischen Verbindungsbibliothek
US6706895B1 (en) 2002-11-14 2004-03-16 Uniroyal Chemical Company, Inc. 4-methoxybiphenyl hydrazone derivatives
US20060229471A1 (en) * 2003-07-25 2006-10-12 Asahi Kasei Chemicals Corporation Oxidation catalyst
FR2899897B1 (fr) 2006-04-13 2008-06-27 Oreal Composes monochromophoriques monocationiques particuliers de type hydrazone comprenant un motif 2-, 4-pyridinium ou 2-, 4-quinolinium, leur synthese, compositions tinctoriales les comprenant, procede de coloration de fibres keratiniques
JP5567349B2 (ja) 2007-03-12 2014-08-06 イントラ−セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ−カルボリンの合成
MX2009014203A (es) * 2007-06-26 2010-01-28 Sanofi Aventis Una sintesis de 2h-indazoles catalizada por un metal de transicion.
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
AU2011278927B2 (en) 2010-07-16 2015-05-21 Abbvie Ireland Unlimited Company Process for preparing antiviral compounds
NZ605471A (en) 2010-07-16 2015-02-27 Abbvie Bahamas Ltd Phosphine ligands for catalytic reactions
ES2727815T3 (es) 2012-04-14 2019-10-18 Intra Cellular Therapies Inc Tratamiento del TEPT y de trastornos del control de impulsos
JP6166996B2 (ja) * 2013-09-27 2017-07-19 株式会社日本ファインケム ヒドラジノアリールカルボン酸類の製造方法
KR102495941B1 (ko) 2013-12-03 2023-02-06 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
BR112016023162B1 (pt) 2014-04-04 2022-11-29 Intra-Cellular Therapies, Inc Compostos orgânicos gama-carbolinas, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento ou na profilaxia de transtornos de sistema nervoso central
MX2016013046A (es) 2014-04-04 2017-02-15 Intra-Cellular Therapies Inc Compuestos organicos.
BR112018015283B1 (pt) 2016-01-26 2023-09-26 Intra-Cellular Therapies, Inc Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central
EP3888656A1 (de) 2016-03-25 2021-10-06 Intra-Cellular Therapies, Inc. Deuterierte heterozyklische gamma-carboline verbindungen und deren verwendung zur behandlumg oder prophylaxe einer störung des zentralen nervensystems.
EP3436455A4 (de) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. Neuartige salze und kristalle
WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
EP3436016B1 (de) 2016-03-28 2022-04-27 Intra-Cellular Therapies, Inc. Neuartige co-kristalle
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
CA3054841A1 (en) 2017-03-24 2018-09-27 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2019023063A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
MX2020000968A (es) 2017-07-26 2020-09-28 Intra Cellular Therapies Inc Compuestos organicos.
EP3843738A4 (de) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. Neuartige verfahren
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods

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Also Published As

Publication number Publication date
EP1058678B1 (de) 2002-12-11
WO1999043643A2 (en) 1999-09-02
DE69904448D1 (de) 2003-01-23
DE69904448T2 (de) 2003-10-23
JP2002504535A (ja) 2002-02-12
WO1999043643A3 (en) 1999-10-21
CA2322194A1 (en) 1999-09-02
JP4647780B2 (ja) 2011-03-09
CA2322194C (en) 2011-04-26
EP1058678A2 (de) 2000-12-13

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