DE69904448D1 - Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen - Google Patents

Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen

Info

Publication number
DE69904448D1
DE69904448D1 DE69904448T DE69904448T DE69904448D1 DE 69904448 D1 DE69904448 D1 DE 69904448D1 DE 69904448 T DE69904448 T DE 69904448T DE 69904448 T DE69904448 T DE 69904448T DE 69904448 D1 DE69904448 D1 DE 69904448D1
Authority
DE
Germany
Prior art keywords
hydrazones
hydrazines
vinylations
hydroxylamines
oximes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69904448T
Other languages
English (en)
Other versions
DE69904448T2 (de
Inventor
Stephen L Buchwald
Seble Wagaw
Oliver Geis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/030,936 external-priority patent/US6235936B1/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE69904448D1 publication Critical patent/DE69904448D1/de
Publication of DE69904448T2 publication Critical patent/DE69904448T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/02—Preparation of hydrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69904448T 1998-02-26 1999-02-26 Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen Expired - Lifetime DE69904448T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/030,936 US6235936B1 (en) 1998-02-26 1998-02-26 Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
US5555798A 1998-04-06 1998-04-06
PCT/US1999/004217 WO1999043643A2 (en) 1998-02-26 1999-02-26 Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes

Publications (2)

Publication Number Publication Date
DE69904448D1 true DE69904448D1 (de) 2003-01-23
DE69904448T2 DE69904448T2 (de) 2003-10-23

Family

ID=26706608

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69904448T Expired - Lifetime DE69904448T2 (de) 1998-02-26 1999-02-26 Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen

Country Status (6)

Country Link
EP (1) EP1058678B1 (de)
JP (1) JP4647780B2 (de)
AT (1) ATE229499T1 (de)
CA (1) CA2322194C (de)
DE (1) DE69904448T2 (de)
WO (1) WO1999043643A2 (de)

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US6677160B1 (en) 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
WO2001023330A2 (en) * 1999-09-29 2001-04-05 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
EP1130009A1 (de) * 2000-03-01 2001-09-05 Therascope AG Erzeugung und Screenen einer dynamischen kombinatorischen Verbindungsbibliothek
US6706895B1 (en) 2002-11-14 2004-03-16 Uniroyal Chemical Company, Inc. 4-methoxybiphenyl hydrazone derivatives
KR100676115B1 (ko) * 2003-07-25 2007-02-02 아사히 가세이 케미칼즈 가부시키가이샤 산화 촉매
FR2899897B1 (fr) 2006-04-13 2008-06-27 Oreal Composes monochromophoriques monocationiques particuliers de type hydrazone comprenant un motif 2-, 4-pyridinium ou 2-, 4-quinolinium, leur synthese, compositions tinctoriales les comprenant, procede de coloration de fibres keratiniques
ES2776889T3 (es) 2007-03-12 2020-08-03 Intra Cellular Therapies Inc Síntesis de gamma-carbolinas condensadas a heterociclo sustituido
JP5250029B2 (ja) * 2007-06-26 2013-07-31 サノフイ ２ｈ−インダゾールの遷移金属触媒合成
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
EP2593439B1 (de) 2010-07-16 2016-08-17 AbbVie Bahamas Ltd. Verfahren zur herstellung antiviraler verbindungen
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
CA2804827A1 (en) 2010-07-16 2012-01-19 Shashank Shekhar Phosphine ligands for catalytic reactions
RU2014145682A (ru) 2012-04-14 2016-06-10 Интра-Селлулар Терапиз, Инк Органические соединения
JP6166996B2 (ja) * 2013-09-27 2017-07-19 株式会社日本ファインケム ヒドラジノアリールカルボン酸類の製造方法
CN114366741A (zh) 2013-12-03 2022-04-19 细胞内治疗公司 新方法
DK3125893T3 (da) 2014-04-04 2023-11-20 Intra Cellular Therapies Inc Deutererede heterocyklus-fusionerede gamma-carboliner som antagonister af 5-ht2a-receptorer
WO2015154030A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2017132408A1 (en) 2016-01-26 2017-08-03 Intra-Cellular Therapies, Inc. Organic compounds
PT3407889T (pt) 2016-03-25 2021-07-14 Intra Cellular Therapies Inc Compostos orgânicos e a sua utilização no tratamento ou prevenção de distúrbios do sistema nervoso central
EP3436455A4 (de) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. Neuartige salze und kristalle
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
WO2017172811A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel co-crystals
CN110072518B (zh) 2016-10-12 2021-10-26 细胞内治疗公司 无定形固体分散体
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
IL268970B2 (en) 2017-03-24 2023-12-01 Intra Cellular Therapies Inc Oral preparations of heterocyclic gamma carboline derivatives fused for absorption through mucous membranes
AU2018307480B2 (en) 2017-07-26 2023-11-23 Intra-Cellular Therapies, Inc. Organic compounds
MX2020000968A (es) 2017-07-26 2020-09-28 Intra Cellular Therapies Inc Compuestos organicos.
CA3108558A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
WO2020047407A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods

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US3867452A (en) * 1970-12-30 1975-02-18 Merrill Wilcox 2-Nitrophenylhydrazines
US4374271A (en) * 1974-12-04 1983-02-15 United States Borax & Chemical Corporation Nitrophenylhydrazine compounds
CH654286A5 (de) * 1981-11-04 1986-02-14 Ciba Geigy Ag Verfahren zur pd-katalysierten arylierung von olefinen mit arylhalogeniden.
DE3447211A1 (de) * 1984-12-22 1986-06-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von substituierten phenylhydrazinen
DE3617977A1 (de) * 1985-12-05 1987-06-11 Bayer Ag 5-dichloracetamido-4-nitro-1-aryl-pyrazole
JP3059007B2 (ja) * 1992-09-29 2000-07-04 協和醗酵工業株式会社 １−（２−カルボキシフェニル）インダゾール誘導体の製造方法
JPH0827109A (ja) * 1994-07-14 1996-01-30 Kuraray Co Ltd β−（ベンジル）インドール−３−エタノールの製造方法
NZ325256A (en) * 1995-12-27 1999-11-29 Basf Ag Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof
JPH09227485A (ja) * 1996-02-16 1997-09-02 Fuji Photo Film Co Ltd ２−ヒドラジノナフタレン化合物の製造方法
GB9610813D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives
GB9610811D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of indole derivatives
DE69721775T2 (de) * 1996-07-01 2004-01-29 Du Pont Nickel-katalysierte addition von -nh- enthaltende verbindungen an vinyl und aryl halogeniden
AU6747098A (en) * 1997-04-11 1998-11-11 Otsuka Chemical Co. Ltd. Benzene derivatives, benzofuran derivatives, and processes for producing these
DE19728760C1 (de) * 1997-07-04 1998-10-29 Celanese Gmbh Verfahren zur Aminierung von Arylverbindungen in Gegenwart eines Palladium-Komplexkatalysators

Also Published As

Publication number Publication date
WO1999043643A3 (en) 1999-10-21
EP1058678A2 (de) 2000-12-13
JP4647780B2 (ja) 2011-03-09
WO1999043643A2 (en) 1999-09-02
DE69904448T2 (de) 2003-10-23
EP1058678B1 (de) 2002-12-11
JP2002504535A (ja) 2002-02-12
CA2322194A1 (en) 1999-09-02
ATE229499T1 (de) 2002-12-15
CA2322194C (en) 2011-04-26

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