ES2162277T3 - Sustratos e inhibidores de enzimas proteoliticos. - Google Patents
Sustratos e inhibidores de enzimas proteoliticos.Info
- Publication number
- ES2162277T3 ES2162277T3 ES97918252T ES97918252T ES2162277T3 ES 2162277 T3 ES2162277 T3 ES 2162277T3 ES 97918252 T ES97918252 T ES 97918252T ES 97918252 T ES97918252 T ES 97918252T ES 2162277 T3 ES2162277 T3 ES 2162277T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- substrates
- proteases
- proteolytic enzymes
- enzymes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE AL CAMPO DE COMPUESTOS QUE SON SUBSTRATOS E INHIBIDORES DE ENZIMAS PROTEOLITICAS Y A UN APARATO Y A METODOS PARA LA IDENTIFICACION DE LOS SUBSTRATOS E INHIBIDORES DE ENZIMAS PROTEOLITICAS. HEMOS DESARROLLADO UN METODO COMBINATORIO PARA LA IDENTIFICACION RAPIDA DE SERIES DE UNION CON EL QUE SE ACELERA EN GRAN MEDIDA LA SINTESIS DE INHIBIDORES DE UNA VARIEDAD DE ENZIMAS PROTEOLITICAS TALES COMO PROTEASAS DE ASPARTILO, PROTEASAS DE SERINA, PROTEASAS DE METALO Y PROTEASAS DE CISTEINILO.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9608457.9A GB9608457D0 (en) | 1996-04-24 | 1996-04-24 | Inhibitors of proteolytic enzymes |
GBGB9616115.3A GB9616115D0 (en) | 1996-07-31 | 1996-07-31 | Substrate and inhibitors of proteolytic enzymes |
GBGB9624584.0A GB9624584D0 (en) | 1996-11-27 | 1996-11-27 | Substances and inhibitors of proteolytic enzymes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2162277T3 true ES2162277T3 (es) | 2001-12-16 |
Family
ID=27268257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97918252T Expired - Lifetime ES2162277T3 (es) | 1996-04-24 | 1997-04-24 | Sustratos e inhibidores de enzimas proteoliticos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US6528275B1 (es) |
EP (2) | EP0906333B1 (es) |
JP (2) | JP2000512979A (es) |
AT (1) | ATE203545T1 (es) |
AU (2) | AU728263B2 (es) |
CA (2) | CA2252408A1 (es) |
DE (1) | DE69705838T2 (es) |
DK (1) | DK0906333T3 (es) |
ES (1) | ES2162277T3 (es) |
WO (2) | WO1997040065A2 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6149869A (en) * | 1996-10-23 | 2000-11-21 | Glaxo Wellcome Inc. | Chemical synthesizers |
US6042789A (en) * | 1996-10-23 | 2000-03-28 | Glaxo Group Limited | System for parallel synthesis of organic compounds |
US6617114B1 (en) | 1996-10-31 | 2003-09-09 | Karo Bio Ab | Identification of drug complementary combinatorial libraries |
EP0937253A1 (en) * | 1996-10-31 | 1999-08-25 | Novalon Pharmaceutical Corporation | Identification of drugs using complementary combinatorial libraries |
US6054325A (en) * | 1996-12-02 | 2000-04-25 | Glaxo Wellcom Inc. | Method and apparatus for transferring and combining distinct chemical compositions with reagents |
US6083761A (en) * | 1996-12-02 | 2000-07-04 | Glaxo Wellcome Inc. | Method and apparatus for transferring and combining reagents |
GB9722818D0 (en) * | 1997-10-30 | 1997-12-24 | Peptide Therapeutics Ltd | A method for mapping the active sites bound by enzymes that covalently modify substrate molecules |
WO1999026902A1 (en) * | 1997-11-26 | 1999-06-03 | Peptide Therapeutics Limited | A solid-phase technology for the preparation of combinatorial libraries through amide-bond anchoring |
US6083682A (en) * | 1997-12-19 | 2000-07-04 | Glaxo Group Limited | System and method for solid-phase parallel synthesis of a combinatorial collection of compounds |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6569636B2 (en) | 1998-05-29 | 2003-05-27 | Hawaii Biotechnology Group, Inc. | Assay for modulators of metallo-enzyme activity |
DE19925402C2 (de) * | 1999-06-02 | 2001-12-20 | Molecular Machines & Ind Gmbh | Screening von Target-Ligand-Wechselwirkungen |
CA2398583A1 (en) | 2000-02-11 | 2001-08-16 | Cellomics, Inc. | Peptide biosensors for anthrax protease |
JP2002250730A (ja) * | 2001-02-27 | 2002-09-06 | Shinwa Kako Kk | 分子センサー及びその製造方法 |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
CN1703395A (zh) * | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物以及调节凝血的方法 |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
US7459472B2 (en) * | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US8015064B2 (en) * | 2005-04-20 | 2011-09-06 | At&T Intellectual Property I, Lp | System and method of providing advertisements to cellular devices |
BRPI0615980A2 (pt) * | 2005-07-26 | 2011-05-31 | Council Scient Ind Res | método de identificação de genes que aumentam a toleráncia ao stress na levedura para melhorar a eficiência da levedura |
DK2364366T3 (da) | 2008-11-05 | 2014-03-31 | Morphosys Ag | Affoldningsmetode |
JP5798487B2 (ja) * | 2008-11-20 | 2015-10-21 | ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー | Fretに基づく病原体の迅速診断 |
EP2189536A1 (en) * | 2008-11-20 | 2010-05-26 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Rapid FRET based anthrax diagnosis |
EP3608317A1 (en) * | 2012-01-12 | 2020-02-12 | Yale University | Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
AU2016349781A1 (en) | 2015-11-02 | 2018-05-10 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0428000A1 (en) | 1989-11-03 | 1991-05-22 | Abbott Laboratories | Fluorogenic substrates for the detection of proteolytic enzyme activity |
US5011910A (en) * | 1989-12-28 | 1991-04-30 | Washington University | Reagent and method for determining activity of retroviral protease |
US5164300A (en) | 1989-12-28 | 1992-11-17 | Washington University | Method for determining activity of retroviral protease |
DK93990D0 (da) | 1990-04-17 | 1990-04-17 | Carlsberg As | Fluorogene peptider og deres anvendelse ved bestemmelse af enzymatisk aktivitet |
HU9201687D0 (en) | 1992-05-21 | 1992-08-28 | Arpad Furka | Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides |
US5585275A (en) * | 1992-09-02 | 1996-12-17 | Arris Pharmaceutical Corporation | Pilot apparatus for peptide synthesis and screening |
WO1995016918A1 (en) | 1993-12-15 | 1995-06-22 | Combichem, Inc. | Combinatorial libraries and methods for their use |
US5506115A (en) | 1994-04-29 | 1996-04-09 | G. D. Searle & Co. | Reagent and method for determining activity of herpes protease |
US5738996A (en) * | 1994-06-15 | 1998-04-14 | Pence, Inc. | Combinational library composition and method |
DE69725901T2 (de) * | 1996-01-04 | 2004-09-09 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Methode zur bestimmung von proteolytischen enzymen unter benutzung von fluoreszenzgelöschten substraten |
US7135288B2 (en) * | 2002-09-27 | 2006-11-14 | Ut-Battelle, Llc | Combinatorial synthesis of ceramic materials |
-
1997
- 1997-04-24 CA CA002252408A patent/CA2252408A1/en not_active Abandoned
- 1997-04-24 US US09/171,680 patent/US6528275B1/en not_active Expired - Fee Related
- 1997-04-24 ES ES97918252T patent/ES2162277T3/es not_active Expired - Lifetime
- 1997-04-24 WO PCT/GB1997/001157 patent/WO1997040065A2/en active IP Right Grant
- 1997-04-24 DE DE69705838T patent/DE69705838T2/de not_active Expired - Fee Related
- 1997-04-24 AU AU26450/97A patent/AU728263B2/en not_active Ceased
- 1997-04-24 JP JP09539622A patent/JP2000512979A/ja not_active Abandoned
- 1997-04-24 JP JP53786497A patent/JP4215822B2/ja not_active Expired - Fee Related
- 1997-04-24 EP EP97918252A patent/EP0906333B1/en not_active Expired - Lifetime
- 1997-04-24 EP EP97918253A patent/EP0906334A1/en not_active Withdrawn
- 1997-04-24 AU AU26449/97A patent/AU706855B2/en not_active Ceased
- 1997-04-24 CA CA002252508A patent/CA2252508A1/en not_active Abandoned
- 1997-04-24 WO PCT/GB1997/001158 patent/WO1997042216A1/en not_active Application Discontinuation
- 1997-04-24 DK DK97918252T patent/DK0906333T3/da active
- 1997-04-24 AT AT97918252T patent/ATE203545T1/de not_active IP Right Cessation
-
2002
- 2002-09-30 US US10/259,420 patent/US20030092067A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU728263B2 (en) | 2001-01-04 |
AU2645097A (en) | 1997-11-26 |
WO1997042216A1 (en) | 1997-11-13 |
US20030092067A1 (en) | 2003-05-15 |
WO1997040065A3 (en) | 1997-12-04 |
EP0906333A2 (en) | 1999-04-07 |
DK0906333T3 (da) | 2001-11-12 |
JP2001501170A (ja) | 2001-01-30 |
AU2644997A (en) | 1997-11-12 |
US6528275B1 (en) | 2003-03-04 |
CA2252508A1 (en) | 1997-10-30 |
JP2000512979A (ja) | 2000-10-03 |
EP0906333B1 (en) | 2001-07-25 |
JP4215822B2 (ja) | 2009-01-28 |
DE69705838T2 (de) | 2002-04-11 |
WO1997040065A2 (en) | 1997-10-30 |
DE69705838D1 (de) | 2001-08-30 |
ATE203545T1 (de) | 2001-08-15 |
AU706855B2 (en) | 1999-06-24 |
EP0906334A1 (en) | 1999-04-07 |
CA2252408A1 (en) | 1997-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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