MX9805948A - Substratos e inhibidores para proteasa de cisteina ich-1. - Google Patents

Substratos e inhibidores para proteasa de cisteina ich-1.

Info

Publication number
MX9805948A
MX9805948A MX9805948A MX9805948A MX9805948A MX 9805948 A MX9805948 A MX 9805948A MX 9805948 A MX9805948 A MX 9805948A MX 9805948 A MX9805948 A MX 9805948A MX 9805948 A MX9805948 A MX 9805948A
Authority
MX
Mexico
Prior art keywords
inhibitors
ich
substrates
cysteine protease
compounds
Prior art date
Application number
MX9805948A
Other languages
English (en)
Inventor
Robert V Talanian
Tariq Ghayur
John C Hodges
Original Assignee
Basf Ag
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Warner Lambert Co filed Critical Basf Ag
Publication of MX9805948A publication Critical patent/MX9805948A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se dan a conocer los substratos e inhibidores para la proteasa de cisteina Ich-1. Estos compuestos se diseñan basándose en un substrato mínimo optimo para Ich-1 e incluyen inhibidores reversibles, inhibidores irreversibles, inhibidores reversibles selectivamente, substratos cromogénicos, substratos fluorogénicos y substratos/inhibidores irradiados. Se proporcionan asimismo las composiciones farmacéuticas que comprenden los compuestos de la invencion. Se dan también a conocer los métodos para inhibir la actividad proteolítica de Ich-1, los métodos para detectar la presencia de Ich-1 y los métodos para aislar Ich-1, usando los compuestos de la invencion.
MX9805948A 1996-01-29 1998-07-23 Substratos e inhibidores para proteasa de cisteina ich-1. MX9805948A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59294396A 1996-01-29 1996-01-29
US08/665,643 US6288037B1 (en) 1996-01-29 1996-06-18 Substrates and inhibitors for cysteine protease ICH-1

Publications (1)

Publication Number Publication Date
MX9805948A true MX9805948A (es) 1998-11-29

Family

ID=27081579

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805948A MX9805948A (es) 1996-01-29 1998-07-23 Substratos e inhibidores para proteasa de cisteina ich-1.

Country Status (7)

Country Link
US (1) US6288037B1 (es)
EP (1) EP0880542A2 (es)
JP (1) JP2000504331A (es)
AU (1) AU725569B2 (es)
CA (1) CA2243497A1 (es)
MX (1) MX9805948A (es)
WO (1) WO1997027220A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048703A (en) * 1996-11-15 2000-04-11 Cephalon, Inc. Methods for detecting cell apoptosis
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
WO2005105829A2 (en) * 2004-04-30 2005-11-10 Theraptosis S.A. Caspase-2 inhibitors and their biological applications
EP1817328A2 (en) 2004-11-24 2007-08-15 Theraptosis S.A. New peptides useful as dual caspase-2/-6 inhibitors and their biological applications
BRPI0808046A2 (pt) * 2007-02-28 2014-07-08 Sanofi Aventis Sondas de imageamento
WO2011094426A1 (en) 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
WO2011153464A2 (en) * 2010-06-03 2011-12-08 New York University In situ oriented immobilization of proteins on a support
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
CN104536010B (zh) * 2014-12-24 2017-04-12 电子科技大学 基于led光源的3d成像光雷达系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416013A (en) 1990-04-04 1995-05-16 Sterling Winthrop Inc. Interleukin 1β protease and interleukin 1β protease inhibitors
AU7775991A (en) 1990-04-04 1991-10-30 Immunex Corporation Interleukin 1beta protease
CA2071674C (en) 1991-06-21 2003-08-19 Kevin T. Chapman Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme
ES2213138T3 (es) 1991-08-30 2004-08-16 Vertex Pharmaceuticals Incorporated Proteasa de la interleuquina 1-beta e inhibidores de la proteasa de la interleuquina 1-beta.
EP0547699A1 (en) 1991-12-19 1993-06-23 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
WO1993014777A1 (en) 1992-01-31 1993-08-05 Merck & Co., Inc. PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
CA2129976C (en) 1992-02-21 2002-09-17 Kevin T. Chapman Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme
JPH08500242A (ja) 1992-06-24 1996-01-16 メルク エンド カンパニー インコーポレーテッド インターロイキン１β前駆体の転換酵素をコードするＤＮＡ
US6083735A (en) 1993-06-24 2000-07-04 The General Hospital Corporation Programmed cell death genes and proteins
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases
AU7250494A (en) 1994-06-23 1996-01-19 Human Genome Sciences, Inc. Interleukin-1 beta converting enzyme like apoptosis protease-1 and 2

Also Published As

Publication number Publication date
WO1997027220A3 (en) 1997-09-25
EP0880542A2 (en) 1998-12-02
AU725569B2 (en) 2000-10-12
JP2000504331A (ja) 2000-04-11
CA2243497A1 (en) 1997-07-31
AU2114197A (en) 1997-08-20
WO1997027220A2 (en) 1997-07-31
US6288037B1 (en) 2001-09-11

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Legal Events

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GB Transfer or rights

Owner name: ABBOTT GMBH & CO. KG

FA Abandonment or withdrawal