FI942625A - Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina - Google Patents
Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina Download PDFInfo
- Publication number
- FI942625A FI942625A FI942625A FI942625A FI942625A FI 942625 A FI942625 A FI 942625A FI 942625 A FI942625 A FI 942625A FI 942625 A FI942625 A FI 942625A FI 942625 A FI942625 A FI 942625A
- Authority
- FI
- Finland
- Prior art keywords
- interleukin
- 1beta
- peptide
- inhibitors
- converting enzyme
- Prior art date
Links
- 102100035904 Caspase-1 Human genes 0.000 title 1
- 108090000426 Caspase-1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002576 ketones Chemical class 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 abstract 1
- 102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
- 108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- C07F9/4866—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the ester moiety containing a substituent or structure which is considered as characteristic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7321993A | 1993-06-04 | 1993-06-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI942625A0 FI942625A0 (fi) | 1994-06-03 |
| FI942625A true FI942625A (fi) | 1994-12-05 |
Family
ID=22112457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942625A FI942625A (fi) | 1993-06-04 | 1994-06-03 | Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0644197B1 (fi) |
| JP (1) | JPH0725887A (fi) |
| KR (1) | KR950000717A (fi) |
| AT (1) | ATE170868T1 (fi) |
| AU (1) | AU685447B2 (fi) |
| CA (1) | CA2125080A1 (fi) |
| CZ (1) | CZ137994A3 (fi) |
| DE (1) | DE69413167T2 (fi) |
| DK (1) | DK0644197T3 (fi) |
| ES (1) | ES2122145T3 (fi) |
| FI (1) | FI942625A (fi) |
| IL (1) | IL109901A (fi) |
| NO (1) | NO304983B1 (fi) |
| NZ (1) | NZ260675A (fi) |
| SK (1) | SK68694A3 (fi) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US6162828A (en) * | 1995-03-31 | 2000-12-19 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
| AU6458396A (en) * | 1995-07-17 | 1997-02-18 | Cephalon, Inc. | Phosphorous-containing cysteine and serine protease inhibitors |
| EP1389624A1 (en) * | 1995-07-17 | 2004-02-18 | Cephalon, Inc. | Phosphorous-containing cysteine and serine protease inhibitors |
| US5639732A (en) * | 1996-07-10 | 1997-06-17 | Cephalon, Inc. | Phosphorous-containing cysteine and serine protease inhibitors |
| US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| GB9702377D0 (en) * | 1996-02-23 | 1997-03-26 | Zeneca Ltd | Peptide derivatives |
| PL330348A1 (en) | 1996-06-07 | 1999-05-10 | Zeneca Ltd | Peptidic derivatives |
| GB9621836D0 (en) | 1996-10-19 | 1996-12-11 | Zeneca Ltd | Peptide compounds |
| GB9624562D0 (en) | 1996-11-27 | 1997-01-15 | Zeneca Ltd | Peptide derivatives |
| DE69925581T2 (de) | 1998-03-09 | 2006-04-27 | Vertex Pharmaceuticals Inc., Cambridge | 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms |
| KR100928878B1 (ko) | 1998-03-19 | 2009-11-30 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제의 억제제 |
| WO1999064434A1 (en) | 1998-06-11 | 1999-12-16 | Isis Pharmaceuticals, Inc. | Synthetic methods and intermediates for triester oligonucleotides |
| US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| US7157430B2 (en) | 1998-10-22 | 2007-01-02 | Idun Pharmaceuticals, Inc. | (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases |
| US6525024B1 (en) | 2000-04-17 | 2003-02-25 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| KR100448008B1 (ko) | 2002-07-20 | 2004-09-08 | 주식회사 효성 | 고강도 저수축 폴리에스테르 섬유 및 그 제조방법 |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| EP1778221A2 (en) | 2004-05-27 | 2007-05-02 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2111100C (en) * | 1991-08-30 | 2004-11-02 | Roy A. Black | Interleukin-1 beta protease and interleukin-1 beta protease inhibitors |
| GB9123326D0 (en) * | 1991-11-04 | 1991-12-18 | Sandoz Ltd | Improvements in or relating to organic compounds |
-
1994
- 1994-06-02 AT AT94201570T patent/ATE170868T1/de not_active IP Right Cessation
- 1994-06-02 DK DK94201570T patent/DK0644197T3/da active
- 1994-06-02 JP JP6120910A patent/JPH0725887A/ja active Pending
- 1994-06-02 DE DE69413167T patent/DE69413167T2/de not_active Expired - Lifetime
- 1994-06-02 ES ES94201570T patent/ES2122145T3/es not_active Expired - Lifetime
- 1994-06-02 EP EP94201570A patent/EP0644197B1/en not_active Expired - Lifetime
- 1994-06-03 FI FI942625A patent/FI942625A/fi unknown
- 1994-06-03 NO NO942065A patent/NO304983B1/no not_active IP Right Cessation
- 1994-06-03 NZ NZ260675A patent/NZ260675A/en unknown
- 1994-06-03 CA CA002125080A patent/CA2125080A1/en not_active Abandoned
- 1994-06-03 KR KR1019940012530A patent/KR950000717A/ko not_active Application Discontinuation
- 1994-06-03 AU AU64514/94A patent/AU685447B2/en not_active Ceased
- 1994-06-05 IL IL10990194A patent/IL109901A/xx not_active IP Right Cessation
- 1994-06-06 SK SK686-94A patent/SK68694A3/sk unknown
- 1994-06-06 CZ CZ941379A patent/CZ137994A3/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO942065D0 (no) | 1994-06-03 |
| FI942625A0 (fi) | 1994-06-03 |
| CA2125080A1 (en) | 1994-12-05 |
| EP0644197A1 (en) | 1995-03-22 |
| AU6451494A (en) | 1994-12-08 |
| CZ137994A3 (en) | 1995-06-14 |
| ES2122145T3 (es) | 1998-12-16 |
| KR950000717A (ko) | 1995-01-03 |
| AU685447B2 (en) | 1998-01-22 |
| NZ260675A (en) | 1996-04-26 |
| IL109901A (en) | 1999-06-20 |
| SK68694A3 (en) | 1995-02-08 |
| NO942065L (no) | 1994-12-05 |
| EP0644197B1 (en) | 1998-09-09 |
| IL109901A0 (en) | 1994-10-07 |
| DE69413167T2 (de) | 1999-05-06 |
| DE69413167D1 (de) | 1998-10-15 |
| JPH0725887A (ja) | 1995-01-27 |
| DK0644197T3 (da) | 1999-06-07 |
| NO304983B1 (no) | 1999-03-15 |
| ATE170868T1 (de) | 1998-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI942625A (fi) | Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina | |
| NO942064L (no) | yminhibitorer | |
| DE69536064D1 (de) | Bizyklischer Lactaminhibitor des Interleukin-1-beta-konvertierenden Enzyms | |
| FI942423A0 (fi) | Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina | |
| BG104780A (en) | Inhibitors of phospholipase enzymes | |
| DK0966465T3 (da) | Inhibitorer af IMPDH-enzymer | |
| TR199801168T2 (xx) | �nterleukin-1 beta d�n��t�r�c� enzim inhibit�rleri. | |
| DK0572166T3 (da) | Hidtil ukendte 7beta-substitueret-4-aza-5beta-androstan-3-oner som 5beta-reduktaseinhibitorer | |
| MX9703564A (es) | Inhibidores de proteasa multicatalitica. | |
| NO990855D0 (no) | Substituerte sykliske amin-metallprotease-inhibitorer | |
| NO970410L (no) | Azaasparaginsyreanaloger som inhibitorer av interleukin-1 <beta> omdannende enzym | |
| DK0623592T3 (da) | Peptidanaloge som irreversible interleukin-1beta-proteaseinhibitorer | |
| MX9207449A (es) | Inhibidores de la enzima proteolitica derivada de sacarina. | |
| DK39093D0 (da) | Enzym | |
| TR199802136T2 (xx) | �MPDH enzimi inhibit�rleri olarak �re t�revleri. | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| FI915093A0 (fi) | Sackarinderivat anvaendbara som inhibitorer foer proteolytiskt enzym och deras framstaellning. | |
| ATE153670T1 (de) | Peptidboronsäurederivate mit protease inhibierenden aktivität | |
| MX9605196A (es) | Halometilamidas como inhibidores de la proteasa il-1b. | |
| NO20003828L (no) | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepin-3-hydroksamsyrer som matriks-metalloproteinase inhibitorer | |
| NO943765L (no) | Aryloksybenzen-herbicidmidler | |
| ATE28186T1 (de) | Alpha-allenyl-alpha-amino carbonsaeuren. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: VERTEX PHARMACEUTICALS INCORPORATED |
|
| GB | Transfer or assigment of application |
Owner name: VERTEX PHARMACEUTICALS INCORPORATED |