DK0644197T3 - Peptidphosphinyloxymethylketoner som inhibitorer af interleukin-1beta-konverterende enzymer - Google Patents

Peptidphosphinyloxymethylketoner som inhibitorer af interleukin-1beta-konverterende enzymer

Info

Publication number
DK0644197T3
DK0644197T3 DK94201570T DK94201570T DK0644197T3 DK 0644197 T3 DK0644197 T3 DK 0644197T3 DK 94201570 T DK94201570 T DK 94201570T DK 94201570 T DK94201570 T DK 94201570T DK 0644197 T3 DK0644197 T3 DK 0644197T3
Authority
DK
Denmark
Prior art keywords
interleukin
peptide
inhibitors
converting enzymes
phosphinyloxymethyl
Prior art date
Application number
DK94201570T
Other languages
English (en)
Inventor
Rolamd E Dolle
Jasbir Singh
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK0644197T3 publication Critical patent/DK0644197T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32Esters thereof
    • C07F9/3258Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/48Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
    • C07F9/4866Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof the ester moiety containing a substituent or structure which is considered as characteristic
DK94201570T 1993-06-04 1994-06-02 Peptidphosphinyloxymethylketoner som inhibitorer af interleukin-1beta-konverterende enzymer DK0644197T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7321993A 1993-06-04 1993-06-04

Publications (1)

Publication Number Publication Date
DK0644197T3 true DK0644197T3 (da) 1999-06-07

Family

ID=22112457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94201570T DK0644197T3 (da) 1993-06-04 1994-06-02 Peptidphosphinyloxymethylketoner som inhibitorer af interleukin-1beta-konverterende enzymer

Country Status (15)

Country Link
EP (1) EP0644197B1 (da)
JP (1) JPH0725887A (da)
KR (1) KR950000717A (da)
AT (1) ATE170868T1 (da)
AU (1) AU685447B2 (da)
CA (1) CA2125080A1 (da)
CZ (1) CZ137994A3 (da)
DE (1) DE69413167T2 (da)
DK (1) DK0644197T3 (da)
ES (1) ES2122145T3 (da)
FI (1) FI942625A (da)
IL (1) IL109901A (da)
NO (1) NO304983B1 (da)
NZ (1) NZ260675A (da)
SK (1) SK68694A3 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
EP0820464A2 (en) * 1995-03-31 1998-01-28 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5639732A (en) * 1996-07-10 1997-06-17 Cephalon, Inc. Phosphorous-containing cysteine and serine protease inhibitors
DK0871454T3 (da) * 1995-07-17 2004-03-22 Cephalon Inc Phosphorholdige inhibitorer af cystein- og serinprotease
EP1389624A1 (en) * 1995-07-17 2004-02-18 Cephalon, Inc. Phosphorous-containing cysteine and serine protease inhibitors
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
ATE283278T1 (de) 1996-06-07 2004-12-15 Astrazeneca Ab Peptid derivate
GB9621836D0 (en) * 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
EP1062210B1 (en) 1998-03-09 2005-06-01 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
ES2315010T3 (es) 1998-03-19 2009-03-16 Vertex Pharmaceuticals Incorporated Inhibidores de caspasas.
AU4434299A (en) 1998-06-11 1999-12-30 Isis Pharmaceuticals, Inc. Synthetic methods and intermediates for triester oligonucleotides
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
KR100448008B1 (ko) 2002-07-20 2004-09-08 주식회사 효성 고강도 저수축 폴리에스테르 섬유 및 그 제조방법
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
EP1778221A2 (en) 2004-05-27 2007-05-02 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2759895B2 (ja) * 1991-08-30 1998-05-28 サノフィ インターロイキン1βプロテアーゼをコードするDNA配列単離体
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
FI942625A0 (fi) 1994-06-03
EP0644197A1 (en) 1995-03-22
AU685447B2 (en) 1998-01-22
IL109901A0 (en) 1994-10-07
NZ260675A (en) 1996-04-26
IL109901A (en) 1999-06-20
DE69413167D1 (de) 1998-10-15
SK68694A3 (en) 1995-02-08
NO942065D0 (no) 1994-06-03
AU6451494A (en) 1994-12-08
KR950000717A (ko) 1995-01-03
JPH0725887A (ja) 1995-01-27
DE69413167T2 (de) 1999-05-06
CZ137994A3 (en) 1995-06-14
NO304983B1 (no) 1999-03-15
EP0644197B1 (en) 1998-09-09
FI942625A (fi) 1994-12-05
CA2125080A1 (en) 1994-12-05
ATE170868T1 (de) 1998-09-15
ES2122145T3 (es) 1998-12-16
NO942065L (no) 1994-12-05

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