DE69013511T4 - Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. - Google Patents

Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Info

Publication number
DE69013511T4
DE69013511T4 DE69013511T DE69013511T DE69013511T4 DE 69013511 T4 DE69013511 T4 DE 69013511T4 DE 69013511 T DE69013511 T DE 69013511T DE 69013511 T DE69013511 T DE 69013511T DE 69013511 T4 DE69013511 T4 DE 69013511T4
Authority
DE
Germany
Prior art keywords
grouping
represent
hydrogen atom
production
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69013511T
Other languages
English (en)
Other versions
DE69013511D1 (de
DE69013511T2 (de
Inventor
Bernard Roques
Marie-Claude Fournie-Zaluski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of DE69013511T2 publication Critical patent/DE69013511T2/de
Application granted granted Critical
Publication of DE69013511T4 publication Critical patent/DE69013511T4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
DE69013511T 1989-08-24 1990-08-23 Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. Expired - Lifetime DE69013511T4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8911224A FR2651229B1 (fr) 1989-08-24 1989-08-24 Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.
PCT/FR1990/000627 WO1991002718A1 (fr) 1989-08-24 1990-08-23 Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
DE69013511T2 DE69013511T2 (de) 1995-04-20
DE69013511T4 true DE69013511T4 (de) 1995-10-12

Family

ID=9384904

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69013511A Expired - Fee Related DE69013511D1 (de) 1989-08-24 1990-08-23 Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69013511T Expired - Lifetime DE69013511T4 (de) 1989-08-24 1990-08-23 Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69013511A Expired - Fee Related DE69013511D1 (de) 1989-08-24 1990-08-23 Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Country Status (10)

Country Link
US (1) US5491169A (de)
EP (1) EP0487620B1 (de)
JP (1) JP2948658B2 (de)
AT (1) ATE113033T1 (de)
CA (1) CA2064592A1 (de)
DE (2) DE69013511D1 (de)
DK (1) DK0487620T3 (de)
ES (1) ES2062552T3 (de)
FR (1) FR2651229B1 (de)
WO (1) WO1991002718A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6447772B1 (en) 1999-10-01 2002-09-10 Klaire Laboratories, Inc. Compositions and methods relating to reduction of symptoms of autism
US6251391B1 (en) * 1999-10-01 2001-06-26 Klaire Laboratories, Inc. Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons
ES2369256T3 (es) * 2000-06-26 2011-11-28 Helen Of Troy Limited Sistema de lámpara recargable.
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
US20070092501A1 (en) * 2005-04-26 2007-04-26 Prothera, Inc. Compositions and methods relating to reduction of symptoms of autism
US8247609B2 (en) 2005-10-25 2012-08-21 Pharamleads Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors
PL1940818T3 (pl) * 2005-10-25 2012-01-31 Pharmaleads Pochodne aminokwasów zawierające grupę disulfanylową jako mieszane inhibitory neprylizyny i aminopeptydazy n
FR2931151A1 (fr) 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
DK2435409T3 (da) 2009-05-28 2014-10-27 Novartis Ag Substituerede aminopropionsyrederivater som neprilysininhibitorer
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
BR112015019307A8 (pt) 2013-02-14 2018-01-30 Novartis Ag derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica
JP6295277B2 (ja) 2013-02-14 2018-03-14 ノバルティス アーゲー Ｎｅｐ（中性エンドペプチダーゼ）阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体
TWI712582B (zh) * 2015-10-14 2020-12-11 法商領先藥物公司 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法
FR3098217B1 (fr) 2019-07-05 2023-04-21 Pharmaleads N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57142962A (en) * 1981-02-28 1982-09-03 Santen Pharmaceut Co Ltd Cyclodextrin clathrate compound of sulfur-containing compound
EP0254032A3 (de) * 1986-06-20 1990-09-05 Schering Corporation Hemmer der neutralen Metallendopeptidase zur Behandlung von Hypertension

Also Published As

Publication number Publication date
DE69013511D1 (de) 1994-11-24
DE69013511T2 (de) 1995-04-20
EP0487620B1 (de) 1994-10-19
DK0487620T3 (da) 1995-05-01
CA2064592A1 (fr) 1991-02-25
FR2651229A1 (fr) 1991-03-01
EP0487620A1 (de) 1992-06-03
JP2948658B2 (ja) 1999-09-13
FR2651229B1 (fr) 1991-12-13
WO1991002718A1 (fr) 1991-03-07
ES2062552T3 (es) 1994-12-16
US5491169A (en) 1996-02-13
ATE113033T1 (de) 1994-11-15
JPH05502016A (ja) 1993-04-15

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