ATE113033T1 - Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. - Google Patents
Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.Info
- Publication number
- ATE113033T1 ATE113033T1 AT90913213T AT90913213T ATE113033T1 AT E113033 T1 ATE113033 T1 AT E113033T1 AT 90913213 T AT90913213 T AT 90913213T AT 90913213 T AT90913213 T AT 90913213T AT E113033 T1 ATE113033 T1 AT E113033T1
- Authority
- AT
- Austria
- Prior art keywords
- grouping
- represent
- hydrogen atom
- processes
- production
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8911224A FR2651229B1 (fr) | 1989-08-24 | 1989-08-24 | Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE113033T1 true ATE113033T1 (de) | 1994-11-15 |
Family
ID=9384904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90913213T ATE113033T1 (de) | 1989-08-24 | 1990-08-23 | Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5491169A (de) |
| EP (1) | EP0487620B1 (de) |
| JP (1) | JP2948658B2 (de) |
| AT (1) | ATE113033T1 (de) |
| CA (1) | CA2064592A1 (de) |
| DE (2) | DE69013511T4 (de) |
| DK (1) | DK0487620T3 (de) |
| ES (1) | ES2062552T3 (de) |
| FR (1) | FR2651229B1 (de) |
| WO (1) | WO1991002718A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2755135B1 (fr) * | 1996-10-25 | 2002-12-27 | Inst Nat Sante Rech Med | Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent |
| US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| US6251391B1 (en) * | 1999-10-01 | 2001-06-26 | Klaire Laboratories, Inc. | Compositions containing dipepitidyl peptidase IV and tyrosinase or phenylalaninase for reducing opioid-related symptons |
| US6447772B1 (en) | 1999-10-01 | 2002-09-10 | Klaire Laboratories, Inc. | Compositions and methods relating to reduction of symptoms of autism |
| ES2369256T3 (es) * | 2000-06-26 | 2011-11-28 | Helen Of Troy Limited | Sistema de lámpara recargable. |
| FR2823212B1 (fr) * | 2001-04-10 | 2005-12-02 | Inst Nat Sante Rech Med | Inhibiteurs de la toxine botulique de type b |
| US20070092501A1 (en) * | 2005-04-26 | 2007-04-26 | Prothera, Inc. | Compositions and methods relating to reduction of symptoms of autism |
| US8247609B2 (en) | 2005-10-25 | 2012-08-21 | Pharamleads | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors |
| WO2007048787A1 (fr) * | 2005-10-25 | 2007-05-03 | Pharmaleads | Derives d'amino-acides contenant un groupement disulfanyle comme inhibiteurs mixtes de la neprilysine et de l 'aminopeptidase n |
| FR2931151A1 (fr) | 2008-05-13 | 2009-11-20 | Pharmaleads Soc Par Actions Si | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
| FR2934267B1 (fr) | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
| SG176010A1 (en) | 2009-05-28 | 2011-12-29 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
| KR101442897B1 (ko) | 2009-05-28 | 2014-09-23 | 노파르티스 아게 | 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체 |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| FR2997081B1 (fr) | 2012-10-23 | 2015-11-27 | Pharmaleads | Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine |
| BR112015019307A8 (pt) | 2013-02-14 | 2018-01-30 | Novartis Ag | derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica |
| NZ710574A (en) | 2013-02-14 | 2017-11-24 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
| TWI712582B (zh) * | 2015-10-14 | 2020-12-11 | 法商領先藥物公司 | 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法 |
| FR3098217B1 (fr) | 2019-07-05 | 2023-04-21 | Pharmaleads | N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57142962A (en) * | 1981-02-28 | 1982-09-03 | Santen Pharmaceut Co Ltd | Cyclodextrin clathrate compound of sulfur-containing compound |
| EP0254032A3 (de) * | 1986-06-20 | 1990-09-05 | Schering Corporation | Hemmer der neutralen Metallendopeptidase zur Behandlung von Hypertension |
-
1989
- 1989-08-24 FR FR8911224A patent/FR2651229B1/fr not_active Expired - Fee Related
-
1990
- 1990-08-23 ES ES90913213T patent/ES2062552T3/es not_active Expired - Lifetime
- 1990-08-23 DE DE69013511T patent/DE69013511T4/de not_active Expired - Lifetime
- 1990-08-23 DE DE69013511A patent/DE69013511D1/de not_active Expired - Fee Related
- 1990-08-23 CA CA002064592A patent/CA2064592A1/fr not_active Abandoned
- 1990-08-23 WO PCT/FR1990/000627 patent/WO1991002718A1/fr active IP Right Grant
- 1990-08-23 EP EP90913213A patent/EP0487620B1/de not_active Expired - Lifetime
- 1990-08-23 AT AT90913213T patent/ATE113033T1/de not_active IP Right Cessation
- 1990-08-23 JP JP2512398A patent/JP2948658B2/ja not_active Expired - Lifetime
- 1990-08-23 DK DK90913213.6T patent/DK0487620T3/da active
-
1994
- 1994-09-26 US US08/312,117 patent/US5491169A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0487620B1 (de) | 1994-10-19 |
| EP0487620A1 (de) | 1992-06-03 |
| FR2651229A1 (fr) | 1991-03-01 |
| US5491169A (en) | 1996-02-13 |
| DE69013511T2 (de) | 1995-04-20 |
| JPH05502016A (ja) | 1993-04-15 |
| CA2064592A1 (fr) | 1991-02-25 |
| DE69013511T4 (de) | 1995-10-12 |
| JP2948658B2 (ja) | 1999-09-13 |
| DE69013511D1 (de) | 1994-11-24 |
| FR2651229B1 (fr) | 1991-12-13 |
| WO1991002718A1 (fr) | 1991-03-07 |
| ES2062552T3 (es) | 1994-12-16 |
| DK0487620T3 (da) | 1995-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |