RU2004120784A - Замещенные 2-аминоциклоалканкарбоксамиды и их применение в качестве ингибиторов цистеиновой протеазы - Google Patents
Замещенные 2-аминоциклоалканкарбоксамиды и их применение в качестве ингибиторов цистеиновой протеазы Download PDFInfo
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- RU2004120784A RU2004120784A RU2004120784/04A RU2004120784A RU2004120784A RU 2004120784 A RU2004120784 A RU 2004120784A RU 2004120784/04 A RU2004120784/04 A RU 2004120784/04A RU 2004120784 A RU2004120784 A RU 2004120784A RU 2004120784 A RU2004120784 A RU 2004120784A
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- 0 CCCC(C(C)CC1(C)C(C)C1)C(N(*)C(C)(*)*)=O Chemical compound CCCC(C(C)CC1(C)C(C)C1)C(N(*)C(C)(*)*)=O 0.000 description 1
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/81—Amides; Imides
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
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- Rheumatology (AREA)
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- Virology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
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- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
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- Pulmonology (AREA)
- Molecular Biology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33675001P | 2001-12-04 | 2001-12-04 | |
| US60/336,750 | 2001-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004120784A true RU2004120784A (ru) | 2005-08-10 |
Family
ID=23317485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004120784/04A RU2004120784A (ru) | 2001-12-04 | 2002-11-25 | Замещенные 2-аминоциклоалканкарбоксамиды и их применение в качестве ингибиторов цистеиновой протеазы |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6747053B2 (https=) |
| EP (1) | EP1453801B1 (https=) |
| JP (1) | JP2005517640A (https=) |
| KR (1) | KR20050044660A (https=) |
| CN (1) | CN1315806C (https=) |
| AR (1) | AR037683A1 (https=) |
| AT (1) | ATE357432T1 (https=) |
| AU (1) | AU2002352126A1 (https=) |
| BR (1) | BR0214642A (https=) |
| CA (1) | CA2467435A1 (https=) |
| DE (1) | DE60219068T2 (https=) |
| ES (1) | ES2282497T3 (https=) |
| GT (1) | GT200200253A (https=) |
| HU (1) | HUP0402344A2 (https=) |
| IL (1) | IL161992A0 (https=) |
| MX (1) | MXPA04005263A (https=) |
| NO (1) | NO20042719L (https=) |
| PA (1) | PA8559701A1 (https=) |
| PE (1) | PE20030723A1 (https=) |
| PL (1) | PL370766A1 (https=) |
| RU (1) | RU2004120784A (https=) |
| TW (1) | TW200303861A (https=) |
| UY (1) | UY27561A1 (https=) |
| WO (1) | WO2003048123A1 (https=) |
| ZA (1) | ZA200404343B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2676328C2 (ru) * | 2014-02-14 | 2018-12-28 | Тоа Эйо Лтд. | Циклическое углеводородное соединение |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000042213A1 (en) * | 1999-01-13 | 2000-07-20 | The Research Foundation Of State University Of New York | A novel method for designing protein kinase inhibitors |
| US7005445B2 (en) * | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| DK1474425T3 (da) * | 2002-01-07 | 2006-09-25 | Eisai Co Ltd | Deazapuriner og anvendelser deraf |
| SE0203712D0 (sv) | 2002-12-13 | 2002-12-13 | Astrazeneca Ab | Novel compounds |
| GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
| WO2006007664A1 (en) * | 2004-07-22 | 2006-01-26 | Genomics Research Partners Pty Ltd | Agents and methods for diagnosing osteoarthritis |
| WO2007002481A2 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| EP1749822B1 (en) * | 2005-08-05 | 2008-10-15 | Hybrigenics S.A. | Novel cysteine protease inhibitors and their therapeutic applications |
| RU2424234C2 (ru) * | 2005-08-05 | 2011-07-20 | Ибриженикс Са | Новые ингибиторы цистеиновых протеаз и их терапевтическое применение |
| WO2007041775A1 (en) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
| WO2007081530A2 (en) * | 2006-01-03 | 2007-07-19 | Med Institute, Inc. | Endoluminal medical device for local delivery of cathepsin inhibitors |
| JP4012239B2 (ja) * | 2006-01-11 | 2007-11-21 | 生化学工業株式会社 | オキサゾロン誘導体 |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| WO2009001129A1 (en) | 2007-06-26 | 2008-12-31 | Astrazeneca Ab | 1-cyanocyclopropyl-derivatives as cathepsin k inhibitors |
| CN101591327B (zh) * | 2008-05-26 | 2012-07-25 | 华东理工大学 | 苯烷酰胺类化合物及其用途 |
| MY169319A (en) * | 2011-07-26 | 2019-03-21 | Sanofi Sa | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals |
| ES2660210T3 (es) | 2012-09-07 | 2018-03-21 | Novartis Ag | Derivados de indolcarboxamida y usos de los mismos |
| NO2699580T3 (https=) | 2014-01-24 | 2018-02-24 | ||
| EP3661500B1 (en) | 2017-07-31 | 2026-01-07 | Novartis AG | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| HUE070049T2 (hu) | 2018-03-01 | 2025-05-28 | Astrazeneca Ab | (2S)-{(1S)-1-ciano-2-[4-(3-metil-2-oxo-2,3-dihidro-1,3-benzoxazol-5-il)fenil]etil} -1,4-oxazepán-2-karboxamidot tartalmazó gyógyászati készítmények |
| WO2020018547A1 (en) | 2018-07-17 | 2020-01-23 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis |
| CN115996923B (zh) | 2020-08-26 | 2025-07-18 | 海思科医药集团股份有限公司 | 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途 |
| KR20230117738A (ko) | 2020-12-04 | 2023-08-09 | 레이스톤 바이오파마 컴퍼니 리미티드 | 카텝신 c의 소분자 억제제 및 이의 의약적 용도 |
| EP4538271A4 (en) | 2022-06-07 | 2025-10-08 | Reistone Biopharma Company Ltd | POLYMORPH OF BENZO[C]CHROMANE COMPOUND, ITS PREPARATION METHOD AND ITS USE |
| TW202404961A (zh) | 2022-06-07 | 2024-02-01 | 大陸商瑞石生物醫藥有限公司 | 苯并[c]色滿化合物的可藥用鹽、其多晶型及用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177576B (en) | 1975-06-02 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 2-amino-cyclohexane carboxylic acid,its amides and similar compounds |
| DE4417163A1 (de) | 1994-05-17 | 1995-11-23 | Hoechst Schering Agrevo Gmbh | Heterocyclylamino- und Heterocyclyloxy-cycloalkyl-Derivate, ihre Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| IT1283467B1 (it) | 1996-07-19 | 1998-04-21 | Menarini Farma Ind | Derivati di cicloalcani 1,2 sostituiti come inibitori della trombina, procedimento per la loro preparazione e loro impiego in formulazioni |
| SK6572000A3 (en) | 1997-11-05 | 2000-10-09 | Novartis Ag | Dipeptide nitriles, process for the preparation thereof, their use as medicaments and pharmaceutical composition comprising them |
| ES2270898T3 (es) * | 1999-12-24 | 2007-04-16 | F. Hoffmann-La Roche Ag | Derivados de nitrilo como inhibidores de catepsina k. |
| DE60132975T2 (de) | 2000-01-06 | 2009-02-26 | Merck Frosst Canada Inc., Kirkland | Neue substanzen und verbindungen als protease-inhibitoren |
| US6462076B2 (en) * | 2000-06-14 | 2002-10-08 | Hoffmann-La Roche Inc. | Beta-amino acid nitrile derivatives as cathepsin K inhibitors |
| WO2003041649A2 (en) | 2001-11-13 | 2003-05-22 | Merck Frosst Canada & Co. | Cyanoalkylamino derivatives as protease inhibitors |
-
2002
- 2002-11-25 HU HU0402344A patent/HUP0402344A2/hu unknown
- 2002-11-25 PL PL02370766A patent/PL370766A1/xx not_active Application Discontinuation
- 2002-11-25 BR BR0214642-8A patent/BR0214642A/pt not_active IP Right Cessation
- 2002-11-25 RU RU2004120784/04A patent/RU2004120784A/ru not_active Application Discontinuation
- 2002-11-25 WO PCT/EP2002/013221 patent/WO2003048123A1/en not_active Ceased
- 2002-11-25 IL IL16199202A patent/IL161992A0/xx unknown
- 2002-11-25 ES ES02787799T patent/ES2282497T3/es not_active Expired - Lifetime
- 2002-11-25 CA CA002467435A patent/CA2467435A1/en not_active Abandoned
- 2002-11-25 DE DE60219068T patent/DE60219068T2/de not_active Expired - Fee Related
- 2002-11-25 KR KR1020047008481A patent/KR20050044660A/ko not_active Ceased
- 2002-11-25 EP EP02787799A patent/EP1453801B1/en not_active Expired - Lifetime
- 2002-11-25 CN CNB02824060XA patent/CN1315806C/zh not_active Expired - Fee Related
- 2002-11-25 MX MXPA04005263A patent/MXPA04005263A/es unknown
- 2002-11-25 AT AT02787799T patent/ATE357432T1/de not_active IP Right Cessation
- 2002-11-25 AU AU2002352126A patent/AU2002352126A1/en not_active Abandoned
- 2002-11-25 JP JP2003549315A patent/JP2005517640A/ja active Pending
- 2002-11-29 PA PA20028559701A patent/PA8559701A1/es unknown
- 2002-11-29 PE PE2002001152A patent/PE20030723A1/es not_active Application Discontinuation
- 2002-11-29 TW TW091134784A patent/TW200303861A/zh unknown
- 2002-12-02 AR ARP020104642A patent/AR037683A1/es unknown
- 2002-12-03 GT GT200200253A patent/GT200200253A/es unknown
- 2002-12-03 UY UY27561A patent/UY27561A1/es not_active Application Discontinuation
- 2002-12-03 US US10/308,963 patent/US6747053B2/en not_active Expired - Fee Related
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2004
- 2004-06-02 ZA ZA200404343A patent/ZA200404343B/en unknown
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2676328C2 (ru) * | 2014-02-14 | 2018-12-28 | Тоа Эйо Лтд. | Циклическое углеводородное соединение |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60219068T2 (de) | 2007-12-13 |
| WO2003048123A1 (en) | 2003-06-12 |
| PA8559701A1 (es) | 2003-07-28 |
| MXPA04005263A (es) | 2004-10-11 |
| IL161992A0 (en) | 2005-11-20 |
| AR037683A1 (es) | 2004-12-01 |
| ATE357432T1 (de) | 2007-04-15 |
| EP1453801A1 (en) | 2004-09-08 |
| CN1639119A (zh) | 2005-07-13 |
| CN1315806C (zh) | 2007-05-16 |
| GT200200253A (es) | 2003-07-03 |
| BR0214642A (pt) | 2004-11-03 |
| NO20042719L (no) | 2004-06-28 |
| US6747053B2 (en) | 2004-06-08 |
| ES2282497T3 (es) | 2007-10-16 |
| TW200303861A (en) | 2003-09-16 |
| US20030212097A1 (en) | 2003-11-13 |
| ZA200404343B (en) | 2006-07-26 |
| JP2005517640A (ja) | 2005-06-16 |
| EP1453801B1 (en) | 2007-03-21 |
| DE60219068D1 (de) | 2007-05-03 |
| AU2002352126A1 (en) | 2003-06-17 |
| PE20030723A1 (es) | 2003-08-29 |
| UY27561A1 (es) | 2003-06-30 |
| KR20050044660A (ko) | 2005-05-12 |
| PL370766A1 (en) | 2005-05-30 |
| HUP0402344A2 (hu) | 2005-02-28 |
| CA2467435A1 (en) | 2003-06-12 |
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