RS60604A - Derivati karboksamidina i njihova upotreba u tretiranju vaskularnih oboljenja - Google Patents
Derivati karboksamidina i njihova upotreba u tretiranju vaskularnih oboljenjaInfo
- Publication number
- RS60604A RS60604A YU60604A YUP60604A RS60604A RS 60604 A RS60604 A RS 60604A YU 60604 A YU60604 A YU 60604A YU P60604 A YUP60604 A YU P60604A RS 60604 A RS60604 A RS 60604A
- Authority
- RS
- Serbia
- Prior art keywords
- nitrogen
- heterocyclic ring
- hydroxy
- optionally substituted
- atom
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0200109A HUP0200109D0 (en) | 2002-01-11 | 2002-01-11 | Compounds having pharmaceutical activity |
| HU0204362A HUP0204362D0 (en) | 2002-12-17 | 2002-12-17 | Compounds having pharmaceutical activity |
| PCT/HU2003/000003 WO2003057664A1 (en) | 2002-01-11 | 2003-01-10 | Carboxamidine derivatives and their use in the treatment of vascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS60604A true RS60604A (sr) | 2006-12-15 |
Family
ID=90001534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU60604A RS60604A (sr) | 2002-01-11 | 2003-01-10 | Derivati karboksamidina i njihova upotreba u tretiranju vaskularnih oboljenja |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7384936B2 (enExample) |
| EP (1) | EP1492763A1 (enExample) |
| JP (1) | JP2005514418A (enExample) |
| KR (1) | KR20040089102A (enExample) |
| CN (1) | CN1615296A (enExample) |
| AU (1) | AU2003202104B8 (enExample) |
| BR (1) | BR0306778A (enExample) |
| CA (1) | CA2471752A1 (enExample) |
| HR (1) | HRP20040558A2 (enExample) |
| IL (1) | IL162941A0 (enExample) |
| MX (1) | MXPA04006716A (enExample) |
| NO (1) | NO20043029L (enExample) |
| NZ (1) | NZ533795A (enExample) |
| PL (1) | PL371251A1 (enExample) |
| RS (1) | RS60604A (enExample) |
| RU (1) | RU2320330C2 (enExample) |
| WO (1) | WO2003057664A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057664A1 (en) * | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| JP5616336B2 (ja) | 2008-06-26 | 2014-10-29 | オルファザイム エーピーエスＯｒｐｈａｚｙｍｅ Ａｐｓ | 酵素活性の調節因子としてのＨｓｐ７０の使用 |
| US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| DK2892540T3 (en) * | 2012-09-06 | 2018-11-19 | Mcpharma Biotech Inc | TREATMENT OF DIARRES AND DRAWN DIARRES WITH RESISTANT POTATO STARCH |
| US10709700B2 (en) | 2014-09-15 | 2020-07-14 | Orphazyme A/S | Arimoclomol formulation |
| CN109069298B (zh) | 2016-04-01 | 2021-08-10 | 3M创新有限公司 | 听力保护装置及形成其的方法 |
| WO2017178029A1 (en) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Heat shock proteins and cholesterol homeostasis |
| ES2831764T3 (es) | 2016-04-29 | 2021-06-09 | Orphazyme As | Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa |
| EP4247792A1 (en) | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177578B (en) | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| DE2651083A1 (de) | 1976-11-09 | 1978-05-18 | Hoechst Ag | Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung |
| IT1110460B (it) | 1977-03-02 | 1985-12-23 | Ciba Geigy Ag | Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego |
| US4187220A (en) | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| EP0369944A1 (de) | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Substituierte Oxadiaminobutane |
| HUT54347A (en) | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| GB9017351D0 (en) | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| EP0495750A3 (en) | 1991-01-14 | 1992-09-16 | Ciba-Geigy Ag | Heterocyclic hydroxylamine |
| US5334600A (en) | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
| BR9407933A (pt) * | 1993-11-01 | 1996-11-26 | Japat Ltd | Antagonistas de receptores de endotelina |
| CN1079789C (zh) * | 1994-05-06 | 2002-02-27 | 拜奥列克斯研究发展公司 | 新的羟肟酸衍生物,包含它们的药物组合物及其制法 |
| HU218480B (hu) | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| HU220971B1 (hu) | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HUP9702365A3 (en) * | 1997-04-22 | 1999-09-28 | Biorex Kutato Fejlesztoe Kft | Application of hydroxilamin-derivatives, as well as process and composition for increase of weather extreme resistent by cultivated plants |
| HU226617B1 (en) | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| WO2003057664A1 (en) * | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
-
2003
- 2003-01-10 WO PCT/HU2003/000003 patent/WO2003057664A1/en not_active Ceased
- 2003-01-10 CN CNA03802151XA patent/CN1615296A/zh active Pending
- 2003-01-10 AU AU2003202104A patent/AU2003202104B8/en not_active Ceased
- 2003-01-10 PL PL03371251A patent/PL371251A1/xx unknown
- 2003-01-10 IL IL16294103A patent/IL162941A0/xx unknown
- 2003-01-10 KR KR10-2004-7010650A patent/KR20040089102A/ko not_active Ceased
- 2003-01-10 CA CA002471752A patent/CA2471752A1/en not_active Abandoned
- 2003-01-10 US US10/501,029 patent/US7384936B2/en not_active Expired - Fee Related
- 2003-01-10 EP EP03700962A patent/EP1492763A1/en not_active Withdrawn
- 2003-01-10 BR BR0306778-5A patent/BR0306778A/pt not_active IP Right Cessation
- 2003-01-10 RS YU60604A patent/RS60604A/sr unknown
- 2003-01-10 JP JP2003557981A patent/JP2005514418A/ja active Pending
- 2003-01-10 RU RU2004124378/15A patent/RU2320330C2/ru not_active IP Right Cessation
- 2003-01-10 HR HR20040558A patent/HRP20040558A2/hr not_active Application Discontinuation
- 2003-01-10 NZ NZ533795A patent/NZ533795A/xx not_active IP Right Cessation
- 2003-01-10 MX MXPA04006716A patent/MXPA04006716A/es active IP Right Grant
-
2004
- 2004-07-12 US US10/889,966 patent/US7361655B2/en not_active Expired - Fee Related
- 2004-07-13 NO NO20043029A patent/NO20043029L/no not_active Application Discontinuation
-
2007
- 2007-10-30 US US11/981,376 patent/US7691849B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/981,422 patent/US7550457B2/en not_active Expired - Fee Related
-
2009
- 2009-06-18 US US12/487,151 patent/US20090253690A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20043029L (no) | 2004-10-11 |
| RU2320330C2 (ru) | 2008-03-27 |
| IL162941A0 (en) | 2005-11-20 |
| HRP20040558A2 (en) | 2004-10-31 |
| MXPA04006716A (es) | 2004-11-10 |
| BR0306778A (pt) | 2004-12-28 |
| US20080058323A1 (en) | 2008-03-06 |
| KR20040089102A (ko) | 2004-10-20 |
| EP1492763A1 (en) | 2005-01-05 |
| US7361655B2 (en) | 2008-04-22 |
| AU2003202104B8 (en) | 2008-10-02 |
| RU2004124378A (ru) | 2005-04-20 |
| US20090075993A1 (en) | 2009-03-19 |
| JP2005514418A (ja) | 2005-05-19 |
| CA2471752A1 (en) | 2003-07-17 |
| US20090253690A1 (en) | 2009-10-08 |
| WO2003057664A1 (en) | 2003-07-17 |
| US7550457B2 (en) | 2009-06-23 |
| US7384936B2 (en) | 2008-06-10 |
| AU2003202104A1 (en) | 2003-07-24 |
| NZ533795A (en) | 2006-03-31 |
| US7691849B2 (en) | 2010-04-06 |
| US20050043295A1 (en) | 2005-02-24 |
| AU2003202104B2 (en) | 2008-09-18 |
| PL371251A1 (en) | 2005-06-13 |
| CN1615296A (zh) | 2005-05-11 |
| US20060058294A1 (en) | 2006-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7691849B2 (en) | Carboxamidine derivatives and their use in the treatment of vascular diseases | |
| DE69934238T2 (de) | Azabicyclo-verbindungen welche die inhibition der zell adhesion modulieren | |
| US3261859A (en) | Basically substituted phenyl acetonitrile compounds | |
| UA89514C2 (uk) | Похідні феніламідів 4-(бензил)-піперазин-1-карбонових кислот та споріднені сполуки як модулятори гідролази амідів жирних кислот для лікування тривоги, болю та інших станів | |
| JPS5877867A (ja) | ピリダジンのアミノ誘導体、その製造法およびそれを有効成分とする中枢神経系賦活剤 | |
| JP2015502402A (ja) | ６−アミノピリジン−３−オール誘導体またはその薬剤学的に許容可能な塩、及びそれを有効成分として含有する血管新生による疾患の予防または治療用薬学組成物 | |
| JPS6230780A (ja) | １，７−ナフチリジン誘導体及びこれを含有する薬剤 | |
| BRPI0110184B1 (pt) | derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes | |
| KR100661774B1 (ko) | 광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도 | |
| JPS63502179A (ja) | 新規なアリ−ル誘導体類 | |
| US4340541A (en) | 4-(2-Benzoyloxy-3-tert.-butylaminopropoxy-2-methyl indole | |
| JP3158638B2 (ja) | 新規アミノフェノール誘導体及びその医薬用途 | |
| US4868190A (en) | N-pyridinyl-9H-carbazol-9-amines | |
| US4434176A (en) | Use of 4-(2-benzoyloxy-3-tert-butylaminopropoxy)-2-methyl-indole for inducing beta-adrenoceptor blocade | |
| NO793578L (no) | Analogifremgangsmaate for fremstilling av fysiologisk aktive trifenylalkenderivater | |
| JPS62155253A (ja) | グアニジノ安息香酸エステル誘導体 | |
| PT90212B (pt) | Processo aperfeicoado para a preparacao de derivados de 3-fenoloxi-3-fenil-propanaminas | |
| EA018024B1 (ru) | Фенантреноновые соединения, композиции и способы | |
| ZA200404996B (en) | Carboxamidine derivatives and their use in the treatment of vascular diseases | |
| UA77731C2 (en) | Carboxaniidine derivatives and use thereof in the treatment of vascular diseases | |
| US11787819B2 (en) | Crystalline salt of a multi-tyrosine kinase inhibitor, method of preparation, and use thereof | |
| DE2753391A1 (de) | Benzisothiazolone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate | |
| TW414794B (en) | Substituted 4H-pyrans for use in treating CNS disorders, the preparation processes and the pharmaceutical compositions thereof | |
| JPH02202857A (ja) | アミノアルコキシベンゼン誘導体 | |
| JPS6183175A (ja) | ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤 |