US994637A
(en)
|
1910-09-14 |
1911-06-06 |
Dexter Folder Co |
Paper-cutting machine.
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
CA1176659A
(en)
|
1981-09-14 |
1984-10-23 |
Gerhard Degischer |
Process for producing n-substituted-n-acetyl-2,6- dialkylanilines
|
US4588585A
(en)
|
1982-10-19 |
1986-05-13 |
Cetus Corporation |
Human recombinant cysteine depleted interferon-β muteins
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US5681718A
(en)
|
1986-03-14 |
1997-10-28 |
Celltech Limited |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
US5219837A
(en)
|
1990-06-21 |
1993-06-15 |
Trustees Of The University Of Pennsylvania |
Method of stimulating myelination of cells
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
ES2113940T3
(es)
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
IL101728A
(en)
|
1991-05-03 |
2007-08-19 |
Univ Yale |
Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
US20050112121A1
(en)
|
1992-04-30 |
2005-05-26 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
US5840299A
(en)
|
1994-01-25 |
1998-11-24 |
Athena Neurosciences, Inc. |
Humanized antibodies against leukocyte adhesion molecule VLA-4
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
PT861261E
(pt)
|
1995-06-28 |
2009-12-16 |
Imp Cancer Res Tech |
Sequências nucleotídicas e proteicas de genes delta de vertebrado e métodos nelas baseados
|
EP0859841B1
(en)
|
1995-08-18 |
2002-06-19 |
MorphoSys AG |
Protein/(poly)peptide libraries
|
US6706484B1
(en)
|
1995-08-18 |
2004-03-16 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
US5730977A
(en)
|
1995-08-21 |
1998-03-24 |
Mitsui Toatsu Chemicals, Inc. |
Anti-VEGF human monoclonal antibody
|
JPH09124697A
(ja)
|
1995-11-01 |
1997-05-13 |
Toagosei Co Ltd |
ペプチド及びモノクローナル抗体
|
WO1997019172A1
(fr)
|
1995-11-17 |
1997-05-29 |
Asahi Kasei Kogyo Kabushiki Kaisha |
Polypeptide suppresseur et de differenciation
|
US20020137890A1
(en)
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US6121045A
(en)
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
CA2285020A1
(en)
|
1997-04-04 |
1998-10-15 |
Millennium Biotherapeutics, Inc. |
Novel human delta3 compositions and therapeutic and diagnostic uses therefor
|
US20030180784A1
(en)
|
1997-04-04 |
2003-09-25 |
Millennium Pharmaceuticals, Inc. |
Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
|
US20060122373A1
(en)
|
1997-04-04 |
2006-06-08 |
Millennium Pharmaceuticals, Inc. |
Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
|
CA2286330C
(en)
|
1997-04-07 |
2008-06-10 |
Genentech, Inc. |
Anti-vegf antibodies
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
US7365166B2
(en)
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
ES2284205T3
(es)
|
1997-05-14 |
2007-11-01 |
Asahi Kasei Kabushiki Kaisha |
Nuevo inhibidor de diferenciacion.
|
AU8162898A
(en)
|
1997-06-18 |
1999-01-04 |
Trustees Of Columbia University In The City Of New York, The |
Angiogenic modulation by notch signal transduction
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
AU5099499A
(en)
|
1998-07-13 |
2000-02-01 |
Yale University |
Delta cleavage products and methods based thereon
|
WO2000006726A2
(en)
|
1998-07-27 |
2000-02-10 |
Amgen Inc. |
Delta-related polypeptides
|
WO2004009618A2
(en)
|
2002-07-18 |
2004-01-29 |
Crucell Holland B.V. |
Recombinant production of mixtures of antibodies
|
ATE269357T1
(de)
|
1999-04-28 |
2004-07-15 |
Univ Texas |
Zusammensetzungen und verfahren zur krebsbehandlung durch die selektive hemmung von vegf
|
WO2001002588A2
(en)
|
1999-07-02 |
2001-01-11 |
Morphosys Ag |
Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests
|
US6703221B1
(en)
|
1999-08-19 |
2004-03-09 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
CA2492049A1
(en)
|
1999-12-01 |
2001-06-07 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US20110131679A2
(en)
*
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
US20020028488A1
(en)
|
2000-06-19 |
2002-03-07 |
Sujay Singh |
Transgenic avian species for making human and chimeric antibodies
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
US6689744B2
(en)
|
2000-09-22 |
2004-02-10 |
Genentech, Inc. |
Notch receptor agonists and uses
|
ES2649037T3
(es)
|
2000-12-12 |
2018-01-09 |
Medimmune, Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
JP2004536877A
(ja)
|
2001-07-25 |
2004-12-09 |
ロランティス リミテッド |
免疫療法に用いるノッチシグナル伝達モジュレーター
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
WO2003012105A2
(en)
|
2001-08-01 |
2003-02-13 |
University Of Bristol |
Vegf isoform
|
WO2003041735A2
(en)
|
2001-11-14 |
2003-05-22 |
Lorantis Limited |
Composotion comprising inhibitors of the notch signalling pathway for the modulation of the immune system
|
EP1448599A2
(en)
|
2001-11-14 |
2004-08-25 |
Lorantis Limited |
Inhibitors of the notch signalling pathway for use in the treatment of cancer
|
US20050137130A1
(en)
|
2001-11-14 |
2005-06-23 |
Bodmer Mark W. |
Medical treatment
|
JP2005511754A
(ja)
|
2001-12-07 |
2005-04-28 |
リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
乳癌幹細胞の予測的同定および特徴づけ
|
US8034904B2
(en)
*
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
GB0216648D0
(en)
|
2002-07-18 |
2002-08-28 |
Lonza Biologics Plc |
Method of expressing recombinant protein in CHO cells
|
GB0218879D0
(en)
|
2002-08-14 |
2002-09-25 |
Lorantis Ltd |
Medical treatment
|
JP2006515177A
(ja)
|
2002-09-10 |
2006-05-25 |
ロランティス リミテッド |
Notchリガンドタンパク質を含む医薬組成物及び医学的処置
|
EP2085096A3
(en)
|
2002-09-11 |
2009-08-12 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
US7365168B2
(en)
|
2002-10-15 |
2008-04-29 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
CN1511850A
(zh)
|
2002-12-31 |
2004-07-14 |
王小宁 |
Mhc-肽抗体多聚体的制备方法
|
AU2004247095A1
(en)
|
2003-06-06 |
2004-12-23 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF inhibitors for tumor regression
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US20050079184A1
(en)
|
2003-08-08 |
2005-04-14 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
FR2859725B1
(fr)
|
2003-09-16 |
2006-03-10 |
Neovacs |
Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
WO2005054426A2
(en)
|
2003-12-05 |
2005-06-16 |
Angiogenetics Sweden Ab |
Angiogenesis affecting polypeptides, proteins, and compositions, and methods of use thereof
|
JP2007526455A
(ja)
|
2004-02-03 |
2007-09-13 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法
|
EP1725585A2
(en)
|
2004-03-10 |
2006-11-29 |
Lonza Ltd |
Method for producing antibodies
|
EP2583685A1
(en)
|
2004-06-10 |
2013-04-24 |
Regeneron Pharmaceuticals, Inc. |
Method of administering and using VEGF inhibitors for the treatment of human cancer
|
ES2421556T3
(es)
|
2004-06-15 |
2013-09-03 |
Hoffmann La Roche |
Utilización de hormonas cardíacas para diagnosticar el riesgo de sufrir complicaciones cardiovasculares como consecuencia de medicamentos cardiotóxicos
|
EP1755645A2
(en)
|
2004-06-18 |
2007-02-28 |
Regeneron Pharmaceuticals, Inc. |
Vegf inhibitors for the treatment of malignant pleural effusion
|
EP1615036B1
(en)
|
2004-07-07 |
2007-09-19 |
F.Hoffmann-La Roche Ag |
Multimarker panel for diabetes type 1 and 2
|
KR20070072510A
(ko)
|
2004-08-30 |
2007-07-04 |
론자 바이올로직스 피엘씨 |
항체 정제를 위한 친화도- 및 이온 교환- 크로마토그래피
|
AU2005282700A1
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
US20080254031A1
(en)
|
2004-09-09 |
2008-10-16 |
Exonhit Therapeutics Sa |
Tumor Specific Genes and Variant Rnas and Uses Thereof as Targets for Cancer Therapy and Diagnosis
|
US8911726B2
(en)
|
2004-09-22 |
2014-12-16 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human Igg4 antibodies
|
US20060134121A1
(en)
|
2004-10-29 |
2006-06-22 |
Gavin Thurston |
DII4 antagonists, assays, and therapeutic methods thereof
|
US8048418B2
(en)
|
2004-10-29 |
2011-11-01 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists
|
RU2392961C2
(ru)
|
2004-11-10 |
2010-06-27 |
Хубрехт Лабораториум |
Лечение аденомы и/или аденокарциномы кишечника с помощью ингибирования активации пути notch
|
EP1812064A4
(en)
|
2004-11-19 |
2009-07-08 |
Cornell Res Foundation Inc |
USE OF ENDOTHELIAL VASCULAR GROWTH FACTOR RECEPTOR CELLS IN THE TREATMENT AND MONITORING OF CANCER AND IN THE SCREENING OF CHEMOTHERAPEUTIC AGENTS
|
CA2595794A1
(en)
|
2005-01-24 |
2006-07-27 |
F. Hoffmann-La Roche Ag |
The use of cardiac hormones for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs
|
US7432107B2
(en)
|
2005-01-24 |
2008-10-07 |
Roche Diagnostics Operations, Inc. |
Cardiac hormones for assessing cardiovascular risk
|
EP1853298A2
(en)
|
2005-02-11 |
2007-11-14 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
US9296816B2
(en)
|
2005-04-15 |
2016-03-29 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
CA2607147C
(en)
|
2005-05-09 |
2018-07-17 |
Ono Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
US20070054360A1
(en)
|
2005-05-12 |
2007-03-08 |
Zeren Gao |
Compositions and methods for modulating immune responses
|
JP2008545753A
(ja)
|
2005-06-02 |
2008-12-18 |
ギャラクシー バイオテック, エルエルシー |
抗体で脳腫瘍を処置する方法
|
US7531172B2
(en)
|
2005-08-12 |
2009-05-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating diseases with a VEGF antagonist
|
US7774903B2
(en)
|
2005-08-16 |
2010-08-17 |
Lummus Corporation |
Roller gin apparatus, method and system
|
US7906116B2
(en)
|
2005-09-01 |
2011-03-15 |
Parkash Gill |
Methods for using and identifying modulators of Delta-like 4
|
EP1928486A2
(en)
|
2005-09-01 |
2008-06-11 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
TW200732350A
(en)
|
2005-10-21 |
2007-09-01 |
Amgen Inc |
Methods for generating monovalent IgG
|
US7723112B2
(en)
|
2005-10-31 |
2010-05-25 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
AU2006326417B2
(en)
|
2005-12-16 |
2012-05-24 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic methods for inhibiting tumor growth with Dll4 antagonists
|
CA2642685A1
(en)
|
2006-02-17 |
2007-08-30 |
Gilead Colorado, Inc. |
Antihypertensive therapy
|
WO2007103114A2
(en)
|
2006-03-07 |
2007-09-13 |
The Brigham & Women's Hospital, Inc. |
Notch inhibition in the treatment or prevention of atherosclerosis
|
US7354582B2
(en)
|
2006-03-10 |
2008-04-08 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF antagonists for the treatment of malignant gliomas
|
PT1999154E
(pt)
|
2006-03-24 |
2013-01-24 |
Merck Patent Gmbh |
Domínios proteicos heterodiméricos modificados
|
RU2008152435A
(ru)
|
2006-06-06 |
2010-07-20 |
Дженентек, Инк. (Us) |
Композиции и способы регулирования развития сосудов
|
AU2007319672B2
(en)
|
2006-06-06 |
2011-06-30 |
Genentech, Inc. |
Anti-DLL4 antibodies and methods using same
|
PL2032166T3
(pl)
|
2006-06-13 |
2013-09-30 |
Oncomed Pharm Inc |
Kompozycje i sposoby diagnozowania i leczenia nowotworów
|
JP2009541275A
(ja)
|
2006-06-22 |
2009-11-26 |
ノボ・ノルデイスク・エー/エス |
二重特異性抗体の生産
|
NZ574794A
(en)
|
2006-08-07 |
2011-06-30 |
Regeneron Pharma |
Use of delta-like ligand 4 (DLL4) antagonists for treating eye vascular and ischemic injury
|
WO2008027236A2
(en)
|
2006-08-30 |
2008-03-06 |
Genentech, Inc. |
Multispecific antibodies
|
JP5535633B2
(ja)
|
2006-09-29 |
2014-07-02 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
癌の診断および処置のための組成物および方法
|
CN101583624B
(zh)
*
|
2006-09-29 |
2012-11-21 |
昂考梅德药品有限公司 |
用于诊断和治疗癌症的组合物及其用途
|
WO2008133706A2
(en)
|
2006-10-20 |
2008-11-06 |
Schering Corporation |
Fully human anti-vegf antibodies and methods of using
|
WO2008070350A2
(en)
|
2006-10-27 |
2008-06-12 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions related to wrapping of dehydrons
|
WO2008070042A2
(en)
|
2006-12-04 |
2008-06-12 |
Medimmune, Inc. |
High potency recombinant antibodies, methods for producing them and use in cancer therapy
|
KR101320198B1
(ko)
|
2006-12-11 |
2013-10-30 |
제넨테크, 인크. |
신생물의 치료를 위한 조성물 및 방법
|
NO347649B1
(no)
|
2006-12-14 |
2024-02-12 |
Regeneron Pharma |
Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
|
PL2101807T3
(pl)
|
2006-12-19 |
2016-11-30 |
|
Antagoniści specyficzni względem VEGF dla terapii adiuwantem i neoadiuwantem i leczenie wczesnych stadiów guzów
|
EP2120996A2
(en)
|
2006-12-20 |
2009-11-25 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
JP2010517944A
(ja)
|
2007-01-26 |
2010-05-27 |
バイオインヴェント インターナショナル アーベー |
Dll4シグナリング阻害薬およびその使用
|
WO2008137318A1
(en)
|
2007-05-04 |
2008-11-13 |
Ironwood Pharmaceuticals, Inc. |
Compositions and methods for treating disorders associated with salt or fluid retention
|
GB0709333D0
(en)
|
2007-05-15 |
2007-06-20 |
Smart Targeting Ltd |
Binding protein
|
CN101918579A
(zh)
|
2007-10-22 |
2010-12-15 |
先灵公司 |
完全人抗-vegf抗体和使用方法
|
AU2008315414A1
(en)
|
2007-10-25 |
2009-04-30 |
Philogene, Inc. |
Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (VEGF)
|
TWI468417B
(zh)
|
2007-11-30 |
2015-01-11 |
Genentech Inc |
抗-vegf抗體
|
WO2009075565A1
(en)
|
2007-12-12 |
2009-06-18 |
Erasmus University Medical Center Rotterdam |
Methods for controlling vasculogenesis
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
MX350962B
(es)
|
2008-01-07 |
2017-09-27 |
Amgen Inc |
Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion.
|
JP5624476B2
(ja)
|
2008-01-18 |
2014-11-12 |
バイオ−ラッド ラボラトリーズ インコーポレーティッド |
アパタイトクロマトグラフィーによるリン酸化生体分子および非リン酸化生体分子の向上した精製法
|
WO2009124931A2
(en)
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Amino acid sequences directed against the notch pathways and uses thereof
|
KR101855381B1
(ko)
|
2008-04-09 |
2018-05-09 |
제넨테크, 인크. |
면역 관련 질병의 치료를 위한 신규한 조성물 및 방법
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
KR20110014607A
(ko)
*
|
2008-04-29 |
2011-02-11 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
PL2307459T3
(pl)
|
2008-07-08 |
2015-05-29 |
Oncomed Pharm Inc |
Czynniki wiążące receptor Notch1 i sposoby ich stosowania
|
JP2011528798A
(ja)
|
2008-07-23 |
2011-11-24 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗血管形成療法のモニター
|
JP5606438B2
(ja)
|
2008-07-23 |
2014-10-15 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗血管新生療法を受容可能な被験体の同定
|
US8192738B2
(en)
|
2008-09-19 |
2012-06-05 |
Medimmune, Llc |
Targeted antibodies directed to DLL4
|
WO2010054007A1
(en)
|
2008-11-07 |
2010-05-14 |
Fabrus Llc |
Combinatorial antibody libraries and uses thereof
|
TWI471139B
(zh)
*
|
2008-12-12 |
2015-02-01 |
Boehringer Ingelheim Int |
抗-igf抗體
|
JP2012524083A
(ja)
|
2009-04-20 |
2012-10-11 |
ジェネンテック, インコーポレイテッド |
アジュバント癌治療
|
WO2010124009A2
(en)
|
2009-04-21 |
2010-10-28 |
Schering Corporation |
Fully human anti-vegf antibodies and methods of using
|
CA2759233C
(en)
*
|
2009-04-27 |
2019-07-16 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
TWI513465B
(zh)
|
2009-06-25 |
2015-12-21 |
Regeneron Pharma |
以dll4拮抗劑與化學治療劑治療癌症之方法
|
MX2011013455A
(es)
|
2009-07-08 |
2012-02-13 |
Amgen Inc |
Diseño de moleculas de fc de anticuerpo estables y libres de agregacion a traves del diseño de la interfase del dominio de ch3.
|
KR20120089659A
(ko)
|
2009-08-29 |
2012-08-13 |
아보트 러보러터리즈 |
치료용 dll4 결합 단백질
|
WO2011028811A2
(en)
|
2009-09-01 |
2011-03-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
US20110172398A1
(en)
|
2009-10-02 |
2011-07-14 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules for anti-angiogenesis therapy
|
US20110195494A1
(en)
|
2009-10-02 |
2011-08-11 |
Boehringer Ingelheim International Gmbh |
Dll4-binging molecules
|
PT2488204E
(pt)
*
|
2009-10-16 |
2016-06-09 |
Oncomed Pharm Inc |
Combinação terapêutica e utilização de anticorpos antagonistas de dll4 e agentes anti-hipertensivos
|
CN102686609A
(zh)
|
2009-10-23 |
2012-09-19 |
加文医学研究所 |
修饰的可变域分子及其生产和使用方法
|
EP2493497A4
(en)
|
2009-11-01 |
2013-07-24 |
Brigham & Womens Hospital |
INHIBITION OF NOTCH FOR THE TREATMENT AND PREVENTION OF OBESITY AND METABOLIC SYNDROME
|
EP2506875A4
(en)
*
|
2009-12-01 |
2013-11-27 |
Oncomed Pharm Inc |
METHOD FOR THE TREATMENT OF TUMORS WITH K-RAS MUTATIONS
|
JO3183B1
(ar)
|
2010-01-29 |
2018-03-08 |
Regeneron Pharma |
طرق لمعالجة أمراض المناعة الذاتية مضادات dll4
|
CN102844442B
(zh)
|
2010-02-12 |
2016-09-07 |
昂考梅德药品有限公司 |
用于鉴定和分离表达多肽的细胞的方法
|
AU2011221229B2
(en)
|
2010-02-23 |
2015-06-18 |
F. Hoffmann-La Roche Ag |
Anti-angiogenesis therapy for the treatment of ovarian cancer
|
MX348312B
(es)
|
2010-03-02 |
2017-06-06 |
Abbvie Inc |
Proteínas terapéuticas de enlace dll4.
|
UY33702A
(es)
|
2010-11-02 |
2012-05-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
US20130323265A1
(en)
|
2010-11-15 |
2013-12-05 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating cancer with dll4 antagonists
|
WO2012092539A2
(en)
|
2010-12-31 |
2012-07-05 |
Takeda Pharmaceutical Company Limited |
Antibodies to dll4 and uses thereof
|
TWI530489B
(zh)
|
2011-03-22 |
2016-04-21 |
必治妥美雅史谷比公司 |
雙(氟烷基)-1,4-苯二氮呯酮化合物
|
JP2014523421A
(ja)
|
2011-06-17 |
2014-09-11 |
ハリス,エイドリアン,エル. |
抗dll4抗体を使用して腫瘍治療における放射線に対する反応を増大させる方法
|
LT2758073T
(lt)
|
2011-09-23 |
2019-01-10 |
Oncomed Pharmaceuticals, Inc. |
Vegf/dll4 surišantys agentai ir jų panaudojimas
|
EP2855522A1
(en)
|
2012-02-03 |
2015-04-08 |
MedImmune Limited |
Process for reducing antibody aggregate levels and antibodies produced thereby
|
KR102082363B1
(ko)
|
2012-03-13 |
2020-02-27 |
에프. 호프만-라 로슈 아게 |
난소암의 치료를 위한 조합 치료
|
CA2873402C
(en)
|
2012-05-15 |
2023-10-24 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
AR092325A1
(es)
|
2012-05-31 |
2015-04-15 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-dll4 y kit
|
CN104603151A
(zh)
|
2012-05-31 |
2015-05-06 |
索伦托治疗有限公司 |
与dll-4结合的抗原结合蛋白
|
KR101535341B1
(ko)
|
2012-07-02 |
2015-07-13 |
한화케미칼 주식회사 |
Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도
|
LT3495387T
(lt)
|
2012-07-13 |
2021-11-25 |
Roche Glycart Ag |
Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti
|
AU2013322564A1
(en)
|
2012-09-28 |
2015-03-12 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical combinations comprising dual Angiopoietin-2 / Dll4 binders and anti-VEGF agents
|
WO2014062659A2
(en)
|
2012-10-15 |
2014-04-24 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating ocular diseases
|
US20140227252A1
(en)
|
2012-10-31 |
2014-08-14 |
Oncomed Pharmaceuticals , Inc. |
Methods and Monitoring of Treatment with a DLL4 Antagonist
|
RU2636043C2
(ru)
|
2012-11-01 |
2017-11-17 |
Эббви Инк. |
Анти-vegf/dll4-иммуноглобулины с двойными вариабельными доменами и их применения
|
TW201438736A
(zh)
|
2012-11-14 |
2014-10-16 |
Regeneron Pharma |
以dll4拮抗劑治療卵巢癌之方法
|
US20140154255A1
(en)
|
2012-11-30 |
2014-06-05 |
Abbvie Biotherapeutics Inc. |
Anti-vegf antibodies and their uses
|
JP6283411B2
(ja)
|
2013-07-09 |
2018-02-21 |
エービーエルバイオ |
Dll4とvegfに特異的に結合する新規二重標的タンパク質とこれの用途
|
PT3021869T
(pt)
|
2013-07-16 |
2020-09-10 |
Hoffmann La Roche |
Métodos de tratamento do cancro com antagonistas da ligação ao eixo pd-1 e inibidores do tigit
|
WO2015130751A1
(en)
|
2014-02-26 |
2015-09-03 |
Medimmune, Llc |
Methods of treatment with dll4 antagonists
|
EP3125937A4
(en)
|
2014-04-04 |
2017-11-01 |
Oncomed Pharmaceuticals, Inc. |
Treatment of gastric cancer
|
KR20170029490A
(ko)
|
2014-07-11 |
2017-03-15 |
제넨테크, 인크. |
노치 경로 억제
|
EP3169363A4
(en)
|
2014-07-16 |
2018-02-21 |
F. Hoffmann-La Roche AG |
Methods of treating cancer using tigit inhibitors and anti-cancer agents
|
TWI790593B
(zh)
|
2014-08-19 |
2023-01-21 |
美商默沙東有限責任公司 |
抗tigit抗體
|
MX2017005258A
(es)
|
2014-10-31 |
2017-07-26 |
Oncomed Pharm Inc |
Terapia combinada para tratamiento de enfermedad.
|
EP4249066A3
(en)
|
2014-12-23 |
2023-11-22 |
Bristol-Myers Squibb Company |
Antibodies to tigit
|
CN109071644B
(zh)
|
2015-09-23 |
2023-09-19 |
昂考梅德药品有限公司 |
治疗癌症的方法和组合物
|
TWI747841B
(zh)
|
2015-09-25 |
2021-12-01 |
美商建南德克公司 |
抗tigit抗體及使用方法
|
AU2019380595A1
(en)
|
2018-11-15 |
2021-06-03 |
Oncomed Pharmaceuticals, Inc. |
Methods and monitoring of treatment with VEGF/DLL4 binding agent
|