UY33702A - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents
Inmunoglobulinas con dominio variable dual y usos de las mismasInfo
- Publication number
- UY33702A UY33702A UY0001033702A UY33702A UY33702A UY 33702 A UY33702 A UY 33702A UY 0001033702 A UY0001033702 A UY 0001033702A UY 33702 A UY33702 A UY 33702A UY 33702 A UY33702 A UY 33702A
- Authority
- UY
- Uruguay
- Prior art keywords
- immunoglobulins
- same
- variable domain
- dual variable
- dual
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 229940072221 immunoglobulins Drugs 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07—ORGANIC CHEMISTRY
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract
Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para elaborarlas y sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.
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CN105820245B (zh) * | 2015-01-06 | 2018-03-13 | 珠海亿胜生物制药有限公司 | 抗vegf抗体 |
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CN102076355B (zh) * | 2008-04-29 | 2014-05-07 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
KR20110016958A (ko) * | 2008-06-03 | 2011-02-18 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
CA2728909A1 (en) * | 2008-07-08 | 2010-01-14 | Abbott Laboratories | Prostaglandin e2 binding proteins and uses thereof |
CN102149825B (zh) * | 2008-07-08 | 2015-07-22 | Abbvie公司 | 前列腺素e2双重可变结构域免疫球蛋白及其用途 |
UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
TW201211252A (en) * | 2010-08-26 | 2012-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
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CL2013001210A1 (es) | 2013-11-08 |
CA2816803A1 (en) | 2012-05-10 |
JP2014500712A (ja) | 2014-01-16 |
IL226083A0 (en) | 2013-06-27 |
CN103492583A (zh) | 2014-01-01 |
KR20130118892A (ko) | 2013-10-30 |
EP2635694A2 (en) | 2013-09-11 |
AR083672A1 (es) | 2013-03-13 |
WO2012061374A3 (en) | 2012-11-01 |
BR112013010857A2 (pt) | 2016-09-13 |
MX2013004979A (es) | 2013-07-30 |
EP2635694A4 (en) | 2015-11-11 |
TW201241180A (en) | 2012-10-16 |
CO6801630A2 (es) | 2013-11-29 |
SG191712A1 (en) | 2013-08-30 |
WO2012061374A2 (en) | 2012-05-10 |
RU2013125479A (ru) | 2014-12-10 |
AU2011323521A1 (en) | 2013-06-20 |
US20120258108A1 (en) | 2012-10-11 |
ECSP13012648A (es) | 2013-07-31 |
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