RS53384B - DERIVATIVES OF 1,3-DISUPSTITUTED IMIDAZOLIDIN-2-ON AS CYP 17 INHIBITORS - Google Patents
DERIVATIVES OF 1,3-DISUPSTITUTED IMIDAZOLIDIN-2-ON AS CYP 17 INHIBITORSInfo
- Publication number
- RS53384B RS53384B RS20140323A RSP20140323A RS53384B RS 53384 B RS53384 B RS 53384B RS 20140323 A RS20140323 A RS 20140323A RS P20140323 A RSP20140323 A RS P20140323A RS 53384 B RS53384 B RS 53384B
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- pyridin
- thiophen
- benzo
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1500CH2009 | 2009-06-26 | ||
| IN2181DE2009 | 2009-10-21 | ||
| PCT/EP2010/059029 WO2010149755A1 (en) | 2009-06-26 | 2010-06-24 | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS53384B true RS53384B (en) | 2014-10-31 |
Family
ID=42357251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20140323A RS53384B (en) | 2009-06-26 | 2010-06-24 | DERIVATIVES OF 1,3-DISUPSTITUTED IMIDAZOLIDIN-2-ON AS CYP 17 INHIBITORS |
Country Status (44)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ597107A (en) | 2009-06-25 | 2013-12-20 | Alkermes Pharma Ireland Ltd | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| MX345788B (es) | 2010-08-04 | 2017-02-15 | Pellficure Pharmaceuticals Inc * | Nuevo tratamiento del carcinoma de prostata. |
| US8946260B2 (en) | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| EP2663189B1 (en) | 2011-01-11 | 2018-07-04 | Novartis AG | Combination of bortezomib with afuresertib and use thereof in the treatment of cancer |
| EA023064B1 (ru) * | 2011-04-28 | 2016-04-29 | Новартис Аг | ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ |
| PL3318554T3 (pl) * | 2011-08-26 | 2022-01-17 | Meiji Seika Pharma Co., Ltd. | Sposób wytwarzania środka do zwalczania szkodników |
| EP2760870B1 (en) | 2011-09-27 | 2016-05-04 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds |
| CN102702223A (zh) * | 2012-05-28 | 2012-10-03 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-溴-4-氯噻吩并[3,2-c]吡啶的制备方法 |
| EP2858631A1 (en) | 2012-06-06 | 2015-04-15 | Novartis AG | Combination of a 17 -alpha -hydroxylase (c17, 20 - lyase) inhibitor and a specific pi-3k inhibitor for treating a tumor disease |
| WO2014158875A1 (en) | 2013-03-14 | 2014-10-02 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
| TW201534586A (zh) * | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| BR112015031155A2 (pt) | 2013-06-20 | 2017-07-25 | Bayer Cropscience Ag | derivados de sulfureto de arila e derivados de aril sulfóxido como acaricidas e inseticidas |
| AU2014330779A1 (en) * | 2013-10-01 | 2016-04-07 | Novartis Ag | Combination |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| AU2015229103C9 (en) | 2014-03-14 | 2020-11-26 | Immutep S.A.S | Antibody molecules to LAG-3 and uses thereof |
| AU2015314772B2 (en) | 2014-09-12 | 2020-02-27 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| US9783527B2 (en) * | 2014-09-16 | 2017-10-10 | Abbvie Inc. | Indazole ureas and method of use |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| MA40035A (fr) | 2014-10-14 | 2016-04-21 | Dana Farber Cancer Inst Inc | Molécules d'anticorps de pd-l1 et leurs utilisations |
| EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
| US10449211B2 (en) | 2015-03-10 | 2019-10-22 | Aduro Biotech, Inc. | Compositions and methods for activating “stimulator of interferon gene”—dependent signalling |
| BR112018000925A2 (pt) | 2015-07-17 | 2018-09-11 | Toyama Chemical Co., Ltd | composto heterocíclico contendo nitrogênio |
| EP3328418A1 (en) | 2015-07-29 | 2018-06-06 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| US20180207273A1 (en) | 2015-07-29 | 2018-07-26 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
| EP3964528A1 (en) | 2015-07-29 | 2022-03-09 | Novartis AG | Combination therapies comprising antibody molecules to lag-3 |
| BR112018008867A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e seus usos |
| AU2016369537B2 (en) | 2015-12-17 | 2024-03-14 | Novartis Ag | Antibody molecules to PD-1 and uses thereof |
| EP3464321B1 (en) * | 2016-06-06 | 2023-01-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Proteasome inhibitors |
| CA3026564A1 (en) * | 2016-06-06 | 2017-12-14 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Proteasome inhibitors |
| WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| EP3528799A1 (en) | 2016-10-24 | 2019-08-28 | Pellficure Pharmaceuticals, Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
| KR102271111B1 (ko) | 2016-12-27 | 2021-06-29 | 후지필름 가부시키가이샤 | 항종양제 및 브로모도메인 저해제 |
| CN108264509B (zh) * | 2016-12-30 | 2021-05-04 | 复旦大学 | 取代的苯并噻吩并[2，3-c]四氢吡啶衍生物及其制备方法和用途 |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES |
| CN111278816B (zh) * | 2017-09-04 | 2024-03-15 | C4医药公司 | 二氢喹啉酮 |
| EP3761983A1 (en) | 2018-03-05 | 2021-01-13 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| BR112020019111A2 (pt) | 2018-03-22 | 2021-01-12 | Aurigene Discovery Technologies Limited | Derivados de imidazolidin-2-ona substituída como inibidores de prmt5 |
| UY38247A (es) | 2018-05-30 | 2019-12-31 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| KR20220047589A (ko) | 2019-08-08 | 2022-04-18 | 래크나 리미티드 | 암 치료 방법 |
| JP2022548881A (ja) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | Ｅｎｔｐｄ２抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法 |
| TW202321210A (zh) * | 2021-07-22 | 2023-06-01 | 瑞士商諾華公司 | 用於治療冠狀病毒相關疾病之化合物及組成物 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL39283A (en) * | 1971-05-03 | 1976-01-30 | Ciba Geigy Ag | Substituted 2-oxo or thioxo-3-(5-nitro-imidazol-2-yl)-tetrahydroimidazoles and their manufacture |
| CH590266A5 (es) * | 1972-10-04 | 1977-07-29 | Ciba Geigy Ag | |
| DE2701794A1 (de) * | 1976-01-21 | 1977-07-28 | Ciba Geigy Ag | Oxigenierte n-aryl-diazacyclen |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| ATE28864T1 (de) | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| ZA882717B (en) | 1987-04-22 | 1988-10-17 | Merrell Dow Pharmaceuticals Inc. | 17beta-(cyclopropylamino)-androst-5-eb-3beta-ol and related compounds useful as c17-20 lyase inhibitors |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| US4966898A (en) | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5395855A (en) | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
| AU659632B2 (en) | 1991-03-01 | 1995-05-25 | Electrostatic Technology, Inc. | Powder coating method for producing circuit board laminae and the like |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| US5457102A (en) | 1994-07-07 | 1995-10-10 | Janssen Pharmaceutica, N.V. | Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives |
| ATE186913T1 (de) | 1992-03-31 | 1999-12-15 | Btg Int Ltd | 17-substituierte steroide, verwendbar bei behandlung von krebs |
| TW225528B (es) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| HU225646B1 (en) | 1992-10-28 | 2007-05-29 | Genentech Inc | Hvegf receptors as vascular endothelial cell growth factor antagonists |
| US5270329A (en) * | 1992-12-10 | 1993-12-14 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB9310635D0 (en) | 1993-05-21 | 1993-07-07 | Glaxo Group Ltd | Chemical compounds |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| JP3916092B2 (ja) * | 1993-09-17 | 2007-05-16 | 杏林製薬株式会社 | イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬 |
| ATE176481T1 (de) | 1993-09-30 | 1999-02-15 | Btg Int Ltd | Synthese von 17-(3-pyridyl) steroiden |
| CN1131944A (zh) | 1993-09-30 | 1996-09-25 | 山之内制药株式会社 | 唑类衍生物和它的药物组合物 |
| WO1996014090A1 (en) | 1994-11-07 | 1996-05-17 | Janssen Pharmaceutica N.V. | Compositions comprising carbazoles and cyclodextrins |
| JPH08176111A (ja) * | 1994-12-20 | 1996-07-09 | Kyorin Pharmaceut Co Ltd | Ｎ，ｎ′−ジ置換エチレンジアミン誘導体及びそれらを用いたｎ，ｎ′−ジ置換イミダゾリジノン誘導体の製造方法 |
| ES2332984T3 (es) | 1995-03-30 | 2010-02-16 | Pfizer Products Inc. | Derivados de quinazolinas. |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| AU6015796A (en) | 1995-06-14 | 1997-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Fused imidazole derivatives and medicinal composition thereof |
| CZ1598A3 (cs) | 1995-07-06 | 1998-04-15 | Novartis Ag | Pyrrolopyrimidiny a způsoby jejich přípravy |
| AU1592697A (en) | 1995-08-22 | 1997-03-19 | Du Pont Merck Pharmaceutical Company, The | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| CZ295468B6 (cs) | 1996-04-12 | 2005-08-17 | Warner-Lambert Company | Polycyklické sloučeniny |
| EP0901489A1 (en) * | 1996-05-20 | 1999-03-17 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0907642B1 (en) | 1996-06-24 | 2005-11-02 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| NZ334821A (en) | 1996-08-30 | 2000-12-22 | Novartis Ag | Method for producing epothilones |
| WO1998010121A1 (en) | 1996-09-06 | 1998-03-12 | Obducat Ab | Method for anisotropic etching of structures in conducting materials |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| EP0954315A2 (en) | 1996-09-13 | 1999-11-10 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| CZ303422B6 (cs) | 1996-11-18 | 2012-09-05 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilon C, zpusob jeho výroby a jeho použití jako cytostatik a prostredku pro ochranu rostlin |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| HUP0004037A3 (en) | 1997-10-02 | 2002-03-28 | Daiichi Seiyaku Co | Novel dihydronaphthalene compounds and process for producing the same |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| MXPA00008365A (es) | 1998-02-25 | 2002-11-07 | Sloan Kettering Inst Cancer | Sintesis de epotilonas, intermediarios y analogos de las mismas. |
| AU3534699A (en) | 1998-04-23 | 1999-11-08 | Takeda Chemical Industries Ltd. | Naphthalene derivatives, their production and use |
| CA2339961C (en) | 1998-08-11 | 2009-01-20 | Novartis Ag | Isoquinoline derivatives with angiogenesis inhibiting activity |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| US6303342B1 (en) | 1998-11-20 | 2001-10-16 | Kason Biosciences, Inc. | Recombinant methods and materials for producing epothilones C and D |
| ATE300957T1 (de) | 1998-12-22 | 2005-08-15 | Genentech Inc | Antagonisten von vaskular-endothelialen zellwachstumsfaktoren und ihre anwendung |
| ATE329596T1 (de) | 1999-03-30 | 2006-07-15 | Novartis Pharma Gmbh | Phthalazinderivate zur behandlung von entzündlicher erkrankungen |
| AU3294701A (en) | 2000-01-28 | 2001-08-07 | Bristol-Myers Squibb Company | Tetrahydropyrimidone inhibitors of fatty acid binding protein and method |
| JP2002302488A (ja) * | 2000-03-30 | 2002-10-18 | Takeda Chem Ind Ltd | 置換１，３−チアゾール化合物、その製造法および用途 |
| NO312876B1 (no) * | 2000-07-21 | 2002-07-15 | Balans Man As | Regulerbar stol |
| WO2002020493A2 (en) | 2000-09-06 | 2002-03-14 | Chugai Seiyaku Kabushiki Kaisha | A traceless solid-phase synthesis of 2-imidazolones |
| AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| US20040198773A1 (en) | 2001-09-26 | 2004-10-07 | Barry Hart | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
| GB0200283D0 (en) | 2002-01-08 | 2002-02-20 | Smithkline Beecham Plc | Compounds |
| WO2004009558A2 (en) * | 2002-07-24 | 2004-01-29 | Ptc Therapeutics, Inc. | Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations |
| AU2003263404A1 (en) | 2002-09-18 | 2004-04-08 | Pfizer Products Inc. | Novel imidazole compounds as transforming growth factor (tgf) inhibitors |
| GB0418900D0 (en) | 2004-08-24 | 2004-09-29 | Btg Int Ltd | Novel salt forms |
| US20080070867A1 (en) * | 2005-01-19 | 2008-03-20 | Metabasis Therapeutics, Inc. | 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases |
| US7875599B2 (en) | 2005-03-02 | 2011-01-25 | University Of Maryland | C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity |
| JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
| AU2007227274A1 (en) | 2006-03-21 | 2007-09-27 | Epix Delaware, Inc. | S1P receptor modulating compounds |
| CN101528309A (zh) | 2006-08-25 | 2009-09-09 | 库伽尔生物科技公司 | 包括给予维生素d化合物和另外的治疗剂的治疗癌症的方法 |
| US20110039893A1 (en) * | 2006-10-11 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Gsk-3beta inhibitor |
| US20100035918A1 (en) | 2007-01-30 | 2010-02-11 | Biogen Idec Ma Inc | Imidazolone Compounds and Methods of Making and Using the Same |
| WO2008154382A1 (en) | 2007-06-06 | 2008-12-18 | University Of Maryland, Baltimore | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
| CN101084881B (zh) | 2007-06-23 | 2012-08-29 | 淮北辉克药业有限公司 | 靶向速释泡腾制剂及其制备方法 |
| WO2009078992A1 (en) * | 2007-12-17 | 2009-06-25 | Amgen Inc. | Linear tricyclic compounds as p38 kinase inhibitors |
| ES2390004T3 (es) * | 2008-01-30 | 2012-11-05 | Cephalon, Inc. | Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de la histamina 3(H3) |
| CN102099340A (zh) * | 2008-05-19 | 2011-06-15 | 先灵公司 | 作为因子ixa抑制剂的杂环化合物 |
| EP2297133B1 (en) | 2008-06-25 | 2017-09-13 | Forum Pharmaceuticals Inc. | 1, 2 disubstituted heterocyclic compounds |
| PE20110136A1 (es) | 2008-06-27 | 2011-03-17 | Novartis Ag | Compuestos organicos |
| JP2012505898A (ja) | 2008-10-16 | 2012-03-08 | シェーリング コーポレイション | ピロリジン、ピペリジンおよびピペラジン誘導体ならびにそれらの使用方法 |
| US8431699B2 (en) * | 2009-02-27 | 2013-04-30 | Vertichem Corporation | Method for manufacture of 2-oxoimidazolidines |
| KR20120056267A (ko) | 2009-08-07 | 2012-06-01 | 토카이 파마슈티컬, 아이엔씨. | 전립선 암의 치료 |
| CA2780365A1 (en) | 2009-11-13 | 2011-05-19 | Tokai Pharmaceuticals, Inc. | Mammalian metabolites of steroids |
| US20110178065A1 (en) | 2010-01-15 | 2011-07-21 | Biomarin Pharmaceutical Inc. | Novel cyp17 inhibitors |
| GB201002563D0 (en) | 2010-02-15 | 2010-03-31 | Cambridge Entpr Ltd | Compounds |
-
2010
- 2010-06-24 AR ARP100102237A patent/AR078228A1/es unknown
- 2010-06-24 MY MYPI2011005620A patent/MY155570A/en unknown
- 2010-06-24 ES ES10730132.7T patent/ES2475945T3/es active Active
- 2010-06-24 PE PE2011002130A patent/PE20121048A1/es not_active Application Discontinuation
- 2010-06-24 KR KR1020127001913A patent/KR101360725B1/ko active IP Right Grant
- 2010-06-24 MX MX2011013771A patent/MX2011013771A/es active IP Right Grant
- 2010-06-24 EA EA201200049A patent/EA021011B1/ru not_active IP Right Cessation
- 2010-06-24 JP JP2012516752A patent/JP5456891B2/ja active Active
- 2010-06-24 PT PT107301327T patent/PT2445903E/pt unknown
- 2010-06-24 UA UAA201115301A patent/UA105794C2/uk unknown
- 2010-06-24 SG SG2011084407A patent/SG176105A1/en unknown
- 2010-06-24 DK DK10730132.7T patent/DK2445903T3/da active
- 2010-06-24 CA CA2765983A patent/CA2765983C/en active Active
- 2010-06-24 AU AU2010264698A patent/AU2010264698C1/en active Active
- 2010-06-24 ME MEP-2014-65A patent/ME01886B/me unknown
- 2010-06-24 CN CN201080028351.3A patent/CN102803250B/zh active Active
- 2010-06-24 EP EP10730132.7A patent/EP2445903B1/en active Active
- 2010-06-24 NZ NZ596488A patent/NZ596488A/xx not_active IP Right Cessation
- 2010-06-24 WO PCT/EP2010/059029 patent/WO2010149755A1/en active Application Filing
- 2010-06-24 SI SI201030633T patent/SI2445903T1/sl unknown
- 2010-06-24 PL PL10730132T patent/PL2445903T3/pl unknown
- 2010-06-24 BR BRPI1015568A patent/BRPI1015568B8/pt active IP Right Grant
- 2010-06-24 MA MA34559A patent/MA33451B1/fr unknown
- 2010-06-24 RS RS20140323A patent/RS53384B/en unknown
- 2010-06-24 UY UY0001032730A patent/UY32730A/es not_active Application Discontinuation
- 2010-06-24 JO JO2010210A patent/JO2892B1/en active
- 2010-06-24 GE GEAP201012550A patent/GEP20156250B/en unknown
- 2010-06-25 TW TW099120966A patent/TWI492942B/zh not_active IP Right Cessation
- 2010-06-28 US US12/824,845 patent/US8263635B2/en not_active Ceased
-
2011
- 2011-11-15 ZA ZA2011/08373A patent/ZA201108373B/en unknown
- 2011-11-29 TN TNP2011000611A patent/TN2011000611A1/en unknown
- 2011-12-01 IL IL216741A patent/IL216741A/en not_active IP Right Cessation
- 2011-12-19 CU CU2011000235A patent/CU24039B1/es active IP Right Grant
- 2011-12-20 CR CR20110684A patent/CR20110684A/es unknown
- 2011-12-21 DO DO2011000399A patent/DOP2011000399A/es unknown
- 2011-12-21 NI NI201100223A patent/NI201100223A/es unknown
- 2011-12-22 CO CO11177195A patent/CO6480927A2/es active IP Right Grant
- 2011-12-22 CL CL2011003266A patent/CL2011003266A1/es unknown
- 2011-12-22 HN HN2011003371A patent/HN2011003371A/es unknown
-
2012
- 2012-01-26 EC EC2012011625A patent/ECSP12011625A/es unknown
- 2012-06-12 HK HK12105692.6A patent/HK1164876A1/xx not_active IP Right Cessation
-
2013
- 2013-06-28 US US13/929,901 patent/USRE45173E1/en active Active
-
2014
- 2014-04-21 US US14/257,433 patent/US20140228394A1/en not_active Abandoned
- 2014-06-24 HR HRP20140593AT patent/HRP20140593T1/hr unknown
- 2014-06-26 CY CY20141100465T patent/CY1115426T1/el unknown
- 2014-07-10 SM SM201400091T patent/SMT201400091B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS53384B (en) | DERIVATIVES OF 1,3-DISUPSTITUTED IMIDAZOLIDIN-2-ON AS CYP 17 INHIBITORS | |
| RS54506B1 (en) | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | |
| RU2014114466A (ru) | ИНДАЗОЛ-3-КАРБОКСАМИДЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ WNT/β-КАТЕНИНА | |
| SMT201500165B (it) | Composti di n-(1h-indazol-4-il) imidazo[1,2a] piridina-3-carbossammide sostituiti come inibitori di tirosin-chinasi di recettore di tipo III | |
| RS52605B (en) | Benzoic Acids (1-Phenyl-2-pyridin-4-yl) -ETHYL ESTERS AS PHOSPHODIESTERASE INHIBITORS | |
| RS54492B1 (en) | KINASE INHIBITOR REGULATING THE SIGNAL PATH OF APOPTOSIS | |
| RS53830B1 (en) | INDASOLS SUBSTITUTED BY OXAZOLE AS PI3-KINASE INHIBITORS | |
| RS54702B1 (en) | PYRAZOLOCHINOLINE DERIVATIVES AS PDE9 INHIBITORS | |
| AR088669A1 (es) | Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos | |
| RS54369B1 (en) | NEW QUINOLINE COMPOUNDS SUBSTITUTED AS S-NITROSOGLUTATHION REDUCTASE INHIBITORS | |
| NZ607638A (en) | Novel compounds and compositions for the inhibition of nampt | |
| RS53641B1 (en) | PYRAZOLOPYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | |
| RS53357B (en) | ISOINDOLINE-1,3-DION DEUTERUM DERIVATIVES AS PDE4 AND TNF-ALPHA INHIBITORS | |
| RS54339B1 (en) | NEW ANTIMALARIAN AGENTS | |
| JP2015537015A5 (es) | ||
| RS53226B (en) | NEW DERIVATIVES FENILIMIDAZOLA KAO INHIBITORS Enzyme PDE10A | |
| RS54786B1 (sr) | Nova jedinjenja koja moduliraju fxr (nr1h4) | |
| MEP8009A (en) | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors | |
| RS53385B (en) | DERIVATIVES OF HINAZOLIN-4 (3H) -ONE USED AS PI3 KINASE INHIBITOR | |
| EA201590023A1 (ru) | Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса | |
| RS54773B1 (sr) | Pirano [3,2-d][1,3] tiazol kao inhibitor glukozidaze | |
| NO20092770L (no) | Nye aminopyrimidinderivater som PLK1-inhibitorer | |
| NO20051051L (no) | Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme i terapeutiske midler | |
| RS54415B1 (en) | BENZAMIDE SUBSTITUTED DERIVATIVES | |
| AR107798A1 (es) | Compuestos derivados de piridazin y sus composiciones farmacéuticas para el tratamiento de la fibrosis |