RS50266B - Antipsihotični ciklični n-aralkil amini - Google Patents
Antipsihotični ciklični n-aralkil aminiInfo
- Publication number
- RS50266B RS50266B YU91101A YUP91101A RS50266B RS 50266 B RS50266 B RS 50266B YU 91101 A YU91101 A YU 91101A YU P91101 A YUP91101 A YU P91101A RS 50266 B RS50266 B RS 50266B
- Authority
- RS
- Serbia
- Prior art keywords
- group
- hydrogen
- atom
- phenyl
- chlorine
- Prior art date
Links
- 230000000561 anti-psychotic effect Effects 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- -1 bicyclo [3.2.1] octanyl Chemical group 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 229910052731 fluorine Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004342 dicyclopropylmethyl group Chemical group [H]C1([H])C([H])([H])C1([H])C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9908532A FR2795724B1 (fr) | 1999-07-02 | 1999-07-02 | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU91101A YU91101A (sh) | 2004-09-03 |
| RS50266B true RS50266B (sr) | 2009-07-15 |
Family
ID=9547628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU91101A RS50266B (sr) | 1999-07-02 | 2000-06-27 | Antipsihotični ciklični n-aralkil amini |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6908914B1 (cs) |
| EP (1) | EP1196403B1 (cs) |
| JP (1) | JP4931309B2 (cs) |
| KR (1) | KR100760446B1 (cs) |
| CN (1) | CN1156462C (cs) |
| AR (1) | AR029374A1 (cs) |
| AT (1) | ATE309231T1 (cs) |
| AU (1) | AU778299B2 (cs) |
| BG (1) | BG65209B1 (cs) |
| BR (1) | BR0012463B1 (cs) |
| CA (1) | CA2376691C (cs) |
| CO (1) | CO5021196A1 (cs) |
| CZ (1) | CZ300936B6 (cs) |
| DE (1) | DE60023898T2 (cs) |
| DK (1) | DK1196403T3 (cs) |
| EA (1) | EA004048B1 (cs) |
| ES (1) | ES2250160T3 (cs) |
| FR (1) | FR2795724B1 (cs) |
| HK (1) | HK1043122A1 (cs) |
| HR (1) | HRP20010949B1 (cs) |
| HU (1) | HU228983B1 (cs) |
| IL (2) | IL147069A0 (cs) |
| ME (1) | MEP25508A (cs) |
| MX (1) | MXPA01013207A (cs) |
| NO (1) | NO322230B1 (cs) |
| NZ (1) | NZ516342A (cs) |
| RS (1) | RS50266B (cs) |
| TW (1) | TWI285640B (cs) |
| UA (1) | UA71009C2 (cs) |
| WO (1) | WO2001002380A1 (cs) |
| ZA (1) | ZA200200018B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1420644B1 (de) * | 2001-08-23 | 2006-05-31 | Bayer CropScience S.A. | Substituierte propargylamine |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790971A (fr) * | 1971-11-09 | 1973-05-07 | Janssen Pharmaceutica Nv | Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen |
| JPS504086A (cs) * | 1973-01-18 | 1975-01-16 | ||
| GB1475314A (en) * | 1973-11-02 | 1977-06-01 | Cm Ind | Phenyl-propylamine derivatives |
| US4104383A (en) * | 1973-11-02 | 1978-08-01 | C M Industries | Derivatives of phenylpropenylamine |
| US4912222A (en) * | 1988-06-17 | 1990-03-27 | Fisons Corporation | Antihistamines related to cyproheptadine |
| EP0347123A3 (en) * | 1988-06-17 | 1991-07-03 | Fisons Corporation | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties |
| US4855462A (en) * | 1988-06-17 | 1989-08-08 | Pennwalt Corporation | Antihistamines |
| FR2663328B1 (fr) | 1990-06-14 | 1994-08-05 | Sanofi Sa | Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant. |
| EP0591426A4 (en) * | 1991-06-27 | 1996-08-21 | Univ Virginia Commonwealth | Sigma receptor ligands and the use thereof |
| JP3199405B2 (ja) * | 1991-08-30 | 2001-08-20 | 生化学工業株式会社 | 肝細胞球状集塊化剤及び球状集塊化肝細胞の製造方法 |
| US5486517A (en) * | 1994-05-10 | 1996-01-23 | Warner-Lambert Company | Benzimidazoles and imidazopyridines as central nervous system agents |
| FR2751645B1 (fr) | 1996-07-29 | 1998-12-24 | Sanofi Sa | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
| TR199902283T2 (xx) * | 1997-03-18 | 1999-12-21 | Smithkline Beecham P.L.C. | �kame edilmi� izokuinolin t�revleri ve bunlar�n antikonvulsant olarak kullan�m�. |
-
1999
- 1999-07-02 FR FR9908532A patent/FR2795724B1/fr not_active Expired - Fee Related
-
2000
- 2000-06-27 AU AU59924/00A patent/AU778299B2/en not_active Ceased
- 2000-06-27 TW TW089112618A patent/TWI285640B/zh not_active IP Right Cessation
- 2000-06-27 RS YU91101A patent/RS50266B/sr unknown
- 2000-06-27 DK DK00946022T patent/DK1196403T3/da active
- 2000-06-27 ME MEP-255/08A patent/MEP25508A/xx unknown
- 2000-06-27 HK HK02104681.4A patent/HK1043122A1/zh unknown
- 2000-06-27 US US10/019,205 patent/US6908914B1/en not_active Expired - Lifetime
- 2000-06-27 EA EA200101209A patent/EA004048B1/ru not_active IP Right Cessation
- 2000-06-27 BR BRPI0012463-0A patent/BR0012463B1/pt not_active IP Right Cessation
- 2000-06-27 ES ES00946022T patent/ES2250160T3/es not_active Expired - Lifetime
- 2000-06-27 HU HU0202200A patent/HU228983B1/hu not_active IP Right Cessation
- 2000-06-27 CA CA002376691A patent/CA2376691C/en not_active Expired - Fee Related
- 2000-06-27 HR HR20010949A patent/HRP20010949B1/xx not_active IP Right Cessation
- 2000-06-27 NZ NZ516342A patent/NZ516342A/en not_active IP Right Cessation
- 2000-06-27 WO PCT/FR2000/001790 patent/WO2001002380A1/fr active IP Right Grant
- 2000-06-27 IL IL14706900A patent/IL147069A0/xx active IP Right Grant
- 2000-06-27 AT AT00946022T patent/ATE309231T1/de active
- 2000-06-27 CN CNB008111413A patent/CN1156462C/zh not_active Expired - Fee Related
- 2000-06-27 JP JP2001507818A patent/JP4931309B2/ja not_active Expired - Fee Related
- 2000-06-27 UA UA2001128823A patent/UA71009C2/uk unknown
- 2000-06-27 EP EP00946022A patent/EP1196403B1/fr not_active Expired - Lifetime
- 2000-06-27 MX MXPA01013207A patent/MXPA01013207A/es active IP Right Grant
- 2000-06-27 KR KR1020017016966A patent/KR100760446B1/ko not_active Expired - Fee Related
- 2000-06-27 DE DE60023898T patent/DE60023898T2/de not_active Expired - Lifetime
- 2000-06-27 CZ CZ20014697A patent/CZ300936B6/cs not_active IP Right Cessation
- 2000-06-28 CO CO00048530A patent/CO5021196A1/es unknown
- 2000-06-30 AR ARP000103334A patent/AR029374A1/es active IP Right Grant
-
2001
- 2001-12-12 IL IL147069A patent/IL147069A/en not_active IP Right Cessation
- 2001-12-20 BG BG106255A patent/BG65209B1/bg unknown
- 2001-12-27 NO NO20016392A patent/NO322230B1/no not_active IP Right Cessation
-
2002
- 2002-01-02 ZA ZA200200018A patent/ZA200200018B/en unknown
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