RS49998B - Derivati benzena, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže - Google Patents

Derivati benzena, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Info

Publication number
RS49998B
RS49998B YUP-871/01A YUP87101A RS49998B RS 49998 B RS49998 B RS 49998B YU P87101 A YUP87101 A YU P87101A RS 49998 B RS49998 B RS 49998B
Authority
RS
Serbia
Prior art keywords
group
hydrogen
chlorine
atom
preparation
Prior art date
Application number
YUP-871/01A
Other languages
English (en)
Inventor
Robert Boigegrain
Bernard Bourrie
Martine Bourrie
Pierre Casellas
Jean Marc Herbert
Pierre Lair
Dino Nisato
Raymond Paul
Jean Claude Vernieres
Original Assignee
Sanofi-Aventis,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis, filed Critical Sanofi-Aventis,
Publication of YU87101A publication Critical patent/YU87101A/sh
Publication of RS49998B publication Critical patent/RS49998B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)

Abstract

Jedinjenja formule I: u kojoj A predstavlja grupu koja se bira od sledećih: - -C == C-, -CH=CH-, -CH2-CH2-; - n je jednako 1 ili 2; - X predstavlja atom vodonika, hlora ili fluora ili metil ili metoksi grupu; - Y predstavlja atom vodonika ili atom hlora ili fluora; - R1 predstavlja cikloheksil grupu, monosupstituisanu, disupstituisanu, trisupstituisanu ili tetrasupstituisanu sa meti I grupom; fenil grupu, monosupstituisanu ili disupstituisanu atomom fluora ili hlora ili sa metoksi grupom; cikloheptil, tere-butil, diciklopropilmetil, biciklo[3 .2.1 ]oktanil, 4tetrahidropiranil, 4-tetrahidrotiopiranil ili 1- ili 2 - adamantil ili adamantan- 2-ol grupu; ili R1 predstavlja fenil grupu i očekuje se da u ovom slučaju X i Y nisu vodonik; - R2 predstavlja atom vodonika ili (C1-C4)alkil grupu kojaje po izboru supstituisana sa trifluorometil grupom; - R3 predstavlja (C5-C7 )cikloalkil; i adicione soli ovih jedinjenjanja sa farmaceutski prihvatljivim kiselinama i njihovi solvati i hidrati .Prijava ima 14 zahteva.
YUP-871/01A 1999-06-11 2000-06-08 Derivati benzena, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže RS49998B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907396A FR2794742B1 (fr) 1999-06-11 1999-06-11 Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
YU87101A YU87101A (sh) 2004-07-15
RS49998B true RS49998B (sr) 2008-09-29

Family

ID=9546664

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-871/01A RS49998B (sr) 1999-06-11 2000-06-08 Derivati benzena, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Country Status (33)

Country Link
US (1) US6482986B1 (sr)
EP (1) EP1192122B1 (sr)
JP (1) JP4711579B2 (sr)
KR (1) KR100668581B1 (sr)
CN (1) CN1210250C (sr)
AR (1) AR033793A1 (sr)
AT (1) ATE252542T1 (sr)
AU (1) AU768420B2 (sr)
BR (1) BR0011738A (sr)
CA (1) CA2374631C (sr)
CO (1) CO5180554A1 (sr)
CZ (1) CZ299659B6 (sr)
DE (1) DE60006113T2 (sr)
DK (1) DK1192122T3 (sr)
ES (1) ES2208345T3 (sr)
FR (1) FR2794742B1 (sr)
HK (1) HK1042891B (sr)
HU (1) HU228683B1 (sr)
IL (1) IL146545A0 (sr)
MX (1) MXPA01012783A (sr)
NO (1) NO327778B1 (sr)
NZ (1) NZ515529A (sr)
PL (1) PL196491B1 (sr)
PT (1) PT1192122E (sr)
RS (1) RS49998B (sr)
RU (1) RU2248964C2 (sr)
SI (1) SI1192122T1 (sr)
SK (1) SK286390B6 (sr)
TW (1) TWI279398B (sr)
UA (1) UA71959C2 (sr)
UY (1) UY26199A1 (sr)
WO (1) WO2000076953A1 (sr)
ZA (1) ZA200109486B (sr)

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DE10110750A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
CN101184732B (zh) * 2005-03-28 2012-05-16 株式会社半导体能源研究所 蒽衍生物、发光元件用材料、发光元件、发光装置和电子器件
FR2887454B1 (fr) * 2005-06-28 2009-06-05 Sanofi Aventis Sa Combinaisons antitumorales contenant des derives du taxane et des sigma ligands
GB0514501D0 (en) * 2005-07-14 2005-08-24 Cambridge Lab Ireland Ltd Pharmaceutical compounds
GB0516168D0 (en) * 2005-08-05 2005-09-14 Cambridge Lab Ireland Ltd Pharmaceutical compounds
US7731377B2 (en) * 2006-03-21 2010-06-08 Semiconductor Energy Laboratory Co., Ltd. Backlight device and display device
CN101506163B (zh) * 2006-08-30 2012-05-02 株式会社半导体能源研究所 合成蒽衍生物的方法和蒽衍生物、发光元件、发光装置、电子装置
GR1005865B (el) * 2007-01-17 2008-04-07 Anavex Life Sciences Corp. Νεοι συνδετες των σιγμα υποδοχεων με αντι-αποπτωτικες και/η προ-αποπτωτικες ιδιοτητες επι των κυτταρικων βιοχημικων μηχανισμων, με νευρο-προστατευτικη, αντικαρκινικη, αντι-μεταστατικη και αντι- αντι-(χρονιο)φλεγμονικη δραση.
US7723722B2 (en) 2007-03-23 2010-05-25 Semiconductor Energy Laboratory Co., Ltd. Organic compound, anthracene derivative, and light-emitting element, light-emitting device, and electronic device using anthracene derivative
FR2915994B1 (fr) * 2007-05-11 2009-07-03 Galderma Res & Dev Procede de synthese de l'acide (z)-3-[2-butoxy-3'-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl] -2-methoxy-acrylique.
US20080286445A1 (en) * 2007-05-17 2008-11-20 Semiconductor Energy Laboratory Co., Ltd. Composition, and method of fabricating light-emitting element
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
WO2010005066A1 (en) * 2008-07-08 2010-01-14 Semiconductor Energy Laboratory Co., Ltd. Carbazole derivative, light-emitting element material, light-emitting element, and light-emitting device
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
ATE517088T1 (de) * 2008-09-19 2011-08-15 Semiconductor Energy Lab Carbazolderivat und herstellungsverfahren dafür
US8349898B2 (en) 2008-11-18 2013-01-08 Wisconsin Alumni Research Foundation Sigma-1 receptor ligands and methods of use
GR1006794B (el) * 2009-02-26 2010-06-04 Αλεξανδρος Βαμβακιδης Προσδετες των σιγμα υποδοχεων, αντι-αποπτωτικες και προ-αποπτωτικες ιδιοτητες επι των κυτταρικων μηχανισμων, και με πρωτοτυπη κυτταρο-προστατευτικη αλλα και αντικαρκινικη δραση
JP6492432B2 (ja) * 2013-07-09 2019-04-03 東ソー株式会社 アダマンチル基を有する環状アジン化合物、その製造方法、及びそれを構成成分とする有機電界発光素子
KR20170101128A (ko) 2016-02-26 2017-09-05 가부시키가이샤 한도오따이 에네루기 켄큐쇼 유기 화합물, 발광 소자, 발광 장치, 전자 기기, 및 조명 장치
EP3490556A4 (en) 2016-07-27 2020-04-15 Case Western Reserve University CONNECTIONS AND METHOD FOR PROMOTING MYELINIZATION
WO2019126759A1 (en) * 2017-12-22 2019-06-27 Convelo Therapeutics, Inc. Compounds and methods of promoting myelination
WO2019126702A1 (en) 2017-12-22 2019-06-27 Case Western Reserve University Compounds for promoting myelination
CA3229664A1 (en) * 2021-08-23 2023-03-02 William A. DONALDSON Synthesis and evaluation of novel (4-hydroxyphenyl) substituted carbocycles as potent and selective estrogen receptor beta agonists

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US4104383A (en) * 1973-11-02 1978-08-01 C M Industries Derivatives of phenylpropenylamine
FR2641276B1 (fr) 1988-12-30 1991-07-12 Sanofi Sa Derives du benzene, leur preparation et les compositions pharmaceutiques en contenant
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
ZA909902B (en) * 1989-12-21 1991-10-30 Himont Inc Graft copolymers of polyolefins and a method of producing same
FR2663328B1 (fr) 1990-06-14 1994-08-05 Sanofi Sa Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant.
PT100639A (pt) * 1991-06-27 1993-09-30 Univ Virginia Commonwealth Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina
US5449639A (en) 1994-10-24 1995-09-12 Taiwan Semiconductor Manufacturing Company Ltd. Disposable metal anti-reflection coating process used together with metal dry/wet etch
FR2751645B1 (fr) 1996-07-29 1998-12-24 Sanofi Sa Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales

Also Published As

Publication number Publication date
WO2000076953A1 (fr) 2000-12-21
DK1192122T3 (da) 2004-03-01
UA71959C2 (en) 2005-01-17
NO20016038L (no) 2002-02-11
ES2208345T3 (es) 2004-06-16
JP2003502306A (ja) 2003-01-21
KR20020009632A (ko) 2002-02-01
NO20016038D0 (no) 2001-12-10
EP1192122A1 (fr) 2002-04-03
AR033793A1 (es) 2004-01-07
BR0011738A (pt) 2002-03-05
CN1210250C (zh) 2005-07-13
NZ515529A (en) 2004-01-30
SI1192122T1 (en) 2004-04-30
KR100668581B1 (ko) 2007-01-17
ZA200109486B (en) 2002-11-18
AU5539600A (en) 2001-01-02
CZ20014443A3 (cs) 2002-05-15
DE60006113T2 (de) 2004-07-15
RU2248964C2 (ru) 2005-03-27
US6482986B1 (en) 2002-11-19
YU87101A (sh) 2004-07-15
TWI279398B (en) 2007-04-21
SK286390B6 (sk) 2008-09-05
PL352742A1 (en) 2003-09-08
DE60006113D1 (de) 2003-11-27
CN1355782A (zh) 2002-06-26
JP4711579B2 (ja) 2011-06-29
PL196491B1 (pl) 2008-01-31
HK1042891A1 (en) 2002-08-30
EP1192122B1 (fr) 2003-10-22
NO327778B1 (no) 2009-09-21
MXPA01012783A (es) 2002-09-18
CO5180554A1 (es) 2002-07-30
UY26199A1 (es) 2001-01-31
CA2374631A1 (en) 2000-12-21
SK18062001A3 (sk) 2002-05-09
CA2374631C (en) 2010-10-19
HUP0201953A2 (hu) 2002-12-28
PT1192122E (pt) 2004-03-31
FR2794742A1 (fr) 2000-12-15
HU228683B1 (en) 2013-05-28
AU768420B2 (en) 2003-12-11
CZ299659B6 (cs) 2008-10-08
ATE252542T1 (de) 2003-11-15
FR2794742B1 (fr) 2005-06-03
HUP0201953A3 (en) 2006-03-28
IL146545A0 (en) 2002-07-25
HK1042891B (zh) 2004-04-08

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