MXPA05010736A - Nuevos carbamoil- y tiocarbamoil-fosfonatos y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos carbamoil- y tiocarbamoil-fosfonatos y composiciones farmaceuticas que los contienen.Info
- Publication number
- MXPA05010736A MXPA05010736A MXPA05010736A MXPA05010736A MXPA05010736A MX PA05010736 A MXPA05010736 A MX PA05010736A MX PA05010736 A MXPA05010736 A MX PA05010736A MX PA05010736 A MXPA05010736 A MX PA05010736A MX PA05010736 A MXPA05010736 A MX PA05010736A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical compositions
- compounds
- formula
- thiocarbamoyl
- phosphonates
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- ZHZVAPHAPQYEQU-UHFFFAOYSA-N carbamothioylphosphonic acid Chemical class NC(=S)P(O)(O)=O ZHZVAPHAPQYEQU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 amino, amidino Chemical group 0.000 abstract 2
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004437 phosphorous atom Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
- C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
- C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion proporciona un compuesto de la siguiente formula (I): R3NH-C(=X) -P(=O)OR1OR2 que incluye las sales, solvatos, hidratos y polimorfos farmaceuticamente aceptables de los compuestos de la formula I, asi como los isomeros geometricos y las formas opticamente activas de los compuestos de la formula I, y las sales, solvatos, hidratos y polimorfos farmaceuticamente aceptables de los isomeros y las formas, en donde R1 y R2 pueden ser los mismos o diferentes y son cada uno seleccionados de hidrogeno, aciloxialquilo y arilo o R1 y R2 pueden formar conjuntamente con los atomos de oxigeno y fosforo un anillo de dioxafosfacicloalcano; X es oxigeno o azufre; y R3 se seleccionad, cuando X es 0, de bicicloalquilo, cicloalquilalquilo y cicloalquilo sustituido con al menos uno de alquilo, amino, amidino y guanidino; y R3 se selecciona, cuando X es S, de bicicloqluilo, cicloalquilalquilo y cicloalquilo opcionalmente sustituido con al menos uno de alquilo, amino, amidino y guanidino; con la condicion de que cuando X sea oxigeno, R3 no sea ciclohexilmetilo, y cuando X sea azufre, R3 no sea ciclohexilo. La invencion proporciona ademas las composiciones farmaceuticas que comprenden los compuestos anteriores y su uso en medicina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46040803P | 2003-04-07 | 2003-04-07 | |
| PCT/IL2004/000302 WO2004089962A2 (en) | 2003-04-07 | 2004-04-01 | New carbamoyl-and thiocarbamoyl-phosphonates and pharmaceutical compositions comprising them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05010736A true MXPA05010736A (es) | 2005-12-15 |
Family
ID=33159769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05010736A MXPA05010736A (es) | 2003-04-07 | 2004-04-01 | Nuevos carbamoil- y tiocarbamoil-fosfonatos y composiciones farmaceuticas que los contienen. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7345033B2 (es) |
| EP (1) | EP1611143A2 (es) |
| JP (1) | JP2006522108A (es) |
| CN (1) | CN100378112C (es) |
| AU (1) | AU2004228478A1 (es) |
| CA (1) | CA2521384A1 (es) |
| MX (1) | MXPA05010736A (es) |
| WO (1) | WO2004089962A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2393495B1 (en) | 2009-02-09 | 2014-07-23 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Carbamoylphosphonates as inhibitors and uses thereof |
| DE102010062928B4 (de) | 2010-12-13 | 2023-09-07 | Robert Bosch Gmbh | Wischvorrichtung |
| EP2671575A1 (en) * | 2012-06-04 | 2013-12-11 | Universität Regensburg | Ras inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL132315A0 (en) * | 1999-10-11 | 2001-03-19 | Yissum Res Dev Co | Compositions comprising oxophosphonate-based metalloproteinase inhibitors |
-
2004
- 2004-04-01 CN CNB2004800091823A patent/CN100378112C/zh not_active Expired - Fee Related
- 2004-04-01 CA CA002521384A patent/CA2521384A1/en not_active Abandoned
- 2004-04-01 MX MXPA05010736A patent/MXPA05010736A/es unknown
- 2004-04-01 JP JP2006507598A patent/JP2006522108A/ja active Pending
- 2004-04-01 WO PCT/IL2004/000302 patent/WO2004089962A2/en active Application Filing
- 2004-04-01 EP EP04725138A patent/EP1611143A2/en not_active Withdrawn
- 2004-04-01 AU AU2004228478A patent/AU2004228478A1/en not_active Abandoned
-
2005
- 2005-10-06 US US11/244,405 patent/US7345033B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7345033B2 (en) | 2008-03-18 |
| WO2004089962A2 (en) | 2004-10-21 |
| CN1768069A (zh) | 2006-05-03 |
| EP1611143A2 (en) | 2006-01-04 |
| US20060111328A1 (en) | 2006-05-25 |
| CN100378112C (zh) | 2008-04-02 |
| WO2004089962A3 (en) | 2005-07-21 |
| JP2006522108A (ja) | 2006-09-28 |
| CA2521384A1 (en) | 2004-10-21 |
| AU2004228478A1 (en) | 2004-10-21 |
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