RO116194B1 - Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica - Google Patents

Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica Download PDF

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Publication number
RO116194B1
RO116194B1 RO98-01093A RO9801093A RO116194B1 RO 116194 B1 RO116194 B1 RO 116194B1 RO 9801093 A RO9801093 A RO 9801093A RO 116194 B1 RO116194 B1 RO 116194B1
Authority
RO
Romania
Prior art keywords
carbon atoms
radical
atoms
hydrogen atom
alkyl
Prior art date
Application number
RO98-01093A
Other languages
English (en)
Romanian (ro)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of RO116194B1 publication Critical patent/RO116194B1/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RO98-01093A 1995-12-22 1996-12-19 Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica RO116194B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
RO116194B1 true RO116194B1 (ro) 2000-11-30

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
RO98-01093A RO116194B1 (ro) 1995-12-22 1996-12-19 Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica

Country Status (40)

Country Link
US (1) US5728849A (instruction)
EP (1) EP0876362B1 (instruction)
JP (1) JP3953106B2 (instruction)
KR (1) KR100500351B1 (instruction)
CN (1) CN1103766C (instruction)
AR (1) AR005197A1 (instruction)
AT (1) ATE250593T1 (instruction)
AU (1) AU712597B2 (instruction)
BG (1) BG63204B1 (instruction)
BR (1) BR9612135A (instruction)
CA (1) CA2238884C (instruction)
CO (1) CO4520184A1 (instruction)
CZ (1) CZ294972B6 (instruction)
DE (1) DE69630145T2 (instruction)
DK (1) DK0876362T3 (instruction)
DZ (1) DZ2149A1 (instruction)
EA (1) EA001533B1 (instruction)
ES (1) ES2202490T3 (instruction)
FR (1) FR2742751B1 (instruction)
HU (1) HU225032B1 (instruction)
IL (1) IL124994A (instruction)
IN (4) IN186768B (instruction)
MA (1) MA26412A1 (instruction)
MX (1) MX9804688A (instruction)
MY (1) MY113934A (instruction)
NO (1) NO317358B1 (instruction)
NZ (1) NZ324337A (instruction)
OA (1) OA10700A (instruction)
PE (1) PE25198A1 (instruction)
PL (1) PL189311B1 (instruction)
PT (1) PT876362E (instruction)
RO (1) RO116194B1 (instruction)
SK (1) SK282835B6 (instruction)
TN (1) TNSN96169A1 (instruction)
TR (1) TR199801179T2 (instruction)
TW (1) TW371659B (instruction)
UA (1) UA48205C2 (instruction)
UY (1) UY24386A1 (instruction)
WO (1) WO1997023473A1 (instruction)
ZA (1) ZA9610737B (instruction)

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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
MXPA01009902A (es) 2000-02-02 2003-07-28 Univ Florida State Res Found Taxanos sustituidos con carbonato en c10 como agentes antitumor.
RS55023B1 (sr) * 2001-02-24 2016-11-30 Boehringer Ingelheim Pharma Derivati ksantina, njihovo dobijanje i njihova primena kao lekova
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
EP1663153A4 (en) * 2003-05-20 2011-01-05 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH A LIPOSOMAL PLATINUM COMPLEX
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
KR101610005B1 (ko) * 2007-08-17 2016-04-08 베링거 인겔하임 인터내셔날 게엠베하 Ｆａｂ 관련 질환의 치료에 사용하기 위한 푸린 유도체
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
AU2009281122C1 (en) * 2008-08-15 2016-04-21 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
EP2344195A2 (en) 2008-09-10 2011-07-20 Boehringer Ingelheim International GmbH Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ592924A (en) 2008-12-23 2014-05-30 Boehringer Ingelheim Int Salt forms of a xanthine derivative
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR20240090632A (ko) 2009-11-27 2024-06-21 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
US9186392B2 (en) 2010-05-05 2015-11-17 Boehringer Ingelheim International Gmbh Combination therapy
EP3725325B1 (en) 2010-06-24 2023-05-31 Boehringer Ingelheim International GmbH Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN103781788B (zh) 2011-07-15 2016-08-17 勃林格殷格翰国际有限公司 经取代的喹唑啉、其制备及其在药物组合物中的用途
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
CA2938919C (en) 2014-02-28 2020-12-29 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
CN108449940B (zh) 2015-07-12 2021-06-08 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR102391564B1 (ko) 2016-06-10 2022-04-29 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴 및 메트포르민의 병용물
CA3042442C (en) 2016-11-14 2024-01-02 Hangzhou Dac Biotech Co., Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
US5352806A (en) * 1992-04-17 1994-10-04 Abbott Laboratories Taxol derivatives
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
MY113934A (en) 2002-06-29
UA48205C2 (uk) 2002-08-15
HU225032B1 (en) 2006-05-29
CA2238884A1 (fr) 1997-07-03
CO4520184A1 (es) 1997-10-15
BG63204B1 (bg) 2001-06-29
JP2000502671A (ja) 2000-03-07
BR9612135A (pt) 1999-07-13
PE25198A1 (es) 1998-05-10
NZ324337A (en) 2000-03-27
OA10700A (fr) 2002-11-27
CA2238884C (fr) 2007-02-06
NO982580D0 (no) 1998-06-05
IN188470B (instruction) 2002-09-28
AU1180997A (en) 1997-07-17
AU712597B2 (en) 1999-11-11
PT876362E (pt) 2004-02-27
ES2202490T3 (es) 2004-04-01
SK85398A3 (en) 1998-11-04
IN188469B (instruction) 2002-09-28
HUP9904046A3 (en) 2001-08-28
TNSN96169A1 (fr) 2005-03-15
EA199800588A1 (ru) 1998-12-24
ZA9610737B (en) 1997-06-27
NO317358B1 (no) 2004-10-18
SK282835B6 (sk) 2002-12-03
FR2742751B1 (fr) 1998-01-30
BG102569A (en) 1999-04-30
TR199801179T2 (xx) 1998-10-21
AR005197A1 (es) 1999-04-14
IL124994A (en) 2000-12-06
CZ196198A3 (cs) 1998-09-16
DE69630145T2 (de) 2004-07-15
HUP9904046A1 (hu) 2001-04-28
IN188680B (instruction) 2002-10-26
JP3953106B2 (ja) 2007-08-08
DK0876362T3 (da) 2004-02-02
HK1017895A1 (en) 1999-12-03
PL327405A1 (en) 1998-12-07
FR2742751A1 (fr) 1997-06-27
US5728849A (en) 1998-03-17
CZ294972B6 (cs) 2005-04-13
EP0876362B1 (fr) 2003-09-24
MX9804688A (es) 1998-10-31
NO982580L (no) 1998-06-05
KR100500351B1 (ko) 2005-12-21
IN186768B (instruction) 2001-11-03
DZ2149A1 (fr) 2002-10-23
ATE250593T1 (de) 2003-10-15
CN1205697A (zh) 1999-01-20
MA26412A1 (fr) 2004-12-20
EA001533B1 (ru) 2001-04-23
PL189311B1 (pl) 2005-07-29
CN1103766C (zh) 2003-03-26
WO1997023473A1 (fr) 1997-07-03
IL124994A0 (en) 1999-01-26
KR19990076680A (ko) 1999-10-15
TW371659B (en) 1999-10-11
UY24386A1 (es) 2001-08-27
DE69630145D1 (de) 2003-10-30
EP0876362A1 (fr) 1998-11-11

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