NZ324337A - Taxoids, preparation thereof and pharmaceutical compositions containing same - Google Patents

Taxoids, preparation thereof and pharmaceutical compositions containing same

Info

Publication number
NZ324337A
NZ324337A NZ324337A NZ32433796A NZ324337A NZ 324337 A NZ324337 A NZ 324337A NZ 324337 A NZ324337 A NZ 324337A NZ 32433796 A NZ32433796 A NZ 32433796A NZ 324337 A NZ324337 A NZ 324337A
Authority
NZ
New Zealand
Prior art keywords
radical
hydrogen atom
together form
formula
optionally substituted
Prior art date
Application number
NZ324337A
Other languages
English (en)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NZ324337A publication Critical patent/NZ324337A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ324337A 1995-12-22 1996-12-19 Taxoids, preparation thereof and pharmaceutical compositions containing same NZ324337A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
NZ324337A true NZ324337A (en) 2000-03-27

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ324337A NZ324337A (en) 1995-12-22 1996-12-19 Taxoids, preparation thereof and pharmaceutical compositions containing same

Country Status (40)

Country Link
US (1) US5728849A (instruction)
EP (1) EP0876362B1 (instruction)
JP (1) JP3953106B2 (instruction)
KR (1) KR100500351B1 (instruction)
CN (1) CN1103766C (instruction)
AR (1) AR005197A1 (instruction)
AT (1) ATE250593T1 (instruction)
AU (1) AU712597B2 (instruction)
BG (1) BG63204B1 (instruction)
BR (1) BR9612135A (instruction)
CA (1) CA2238884C (instruction)
CO (1) CO4520184A1 (instruction)
CZ (1) CZ294972B6 (instruction)
DE (1) DE69630145T2 (instruction)
DK (1) DK0876362T3 (instruction)
DZ (1) DZ2149A1 (instruction)
EA (1) EA001533B1 (instruction)
ES (1) ES2202490T3 (instruction)
FR (1) FR2742751B1 (instruction)
HU (1) HU225032B1 (instruction)
IL (1) IL124994A (instruction)
IN (4) IN186768B (instruction)
MA (1) MA26412A1 (instruction)
MX (1) MX9804688A (instruction)
MY (1) MY113934A (instruction)
NO (1) NO317358B1 (instruction)
NZ (1) NZ324337A (instruction)
OA (1) OA10700A (instruction)
PE (1) PE25198A1 (instruction)
PL (1) PL189311B1 (instruction)
PT (1) PT876362E (instruction)
RO (1) RO116194B1 (instruction)
SK (1) SK282835B6 (instruction)
TN (1) TNSN96169A1 (instruction)
TR (1) TR199801179T2 (instruction)
TW (1) TW371659B (instruction)
UA (1) UA48205C2 (instruction)
UY (1) UY24386A1 (instruction)
WO (1) WO1997023473A1 (instruction)
ZA (1) ZA9610737B (instruction)

Families Citing this family (41)

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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
GEP20043239B (en) 2000-02-02 2004-05-25 Florida State Univ Research Foundation Us C10 Carbonate Substituted Taxanes as Antitumor Agents
PT1368349E (pt) * 2001-02-24 2007-04-30 Boehringer Ingelheim Pharma Derivados de xantina, sua preparação e sua utilização como medicamento
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN101437823B (zh) 2006-05-04 2014-12-10 勃林格殷格翰国际有限公司 多晶型
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
NZ600126A (en) * 2007-08-17 2013-12-20 Boehringer Ingelheim Int Purine derivatives for use in the treatment of fap-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
CA2735562C (en) * 2008-08-15 2017-10-17 Boehringer Ingelheim International Gmbh Dpp-4 inhibitors for wound healing
JP2012502081A (ja) 2008-09-10 2012-01-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連症状の治療のための組み合わせ治療
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ592924A (en) 2008-12-23 2014-05-30 Boehringer Ingelheim Int Salt forms of a xanthine derivative
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
CA2782179C (en) 2009-11-27 2020-06-23 Boehringer Ingelheim International Gmbh Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
KR101927068B1 (ko) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
KR102018038B1 (ko) 2010-06-24 2019-09-05 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
PL3517539T3 (pl) 2011-07-15 2023-04-24 Boehringer Ingelheim International Gmbh Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
NZ747331A (en) 2016-06-10 2025-06-27 Boehringer Ingelheim Int Combinations of linagliptin and metformin
KR102459469B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
DE69325454T2 (de) * 1992-04-17 2000-01-20 Abbott Laboratories, Abbott Park Taxol-derivate
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.

Also Published As

Publication number Publication date
SK85398A3 (en) 1998-11-04
ES2202490T3 (es) 2004-04-01
IN188680B (instruction) 2002-10-26
RO116194B1 (ro) 2000-11-30
HK1017895A1 (en) 1999-12-03
HUP9904046A3 (en) 2001-08-28
NO317358B1 (no) 2004-10-18
CZ294972B6 (cs) 2005-04-13
DZ2149A1 (fr) 2002-10-23
CA2238884A1 (fr) 1997-07-03
KR100500351B1 (ko) 2005-12-21
BR9612135A (pt) 1999-07-13
JP2000502671A (ja) 2000-03-07
AU1180997A (en) 1997-07-17
BG63204B1 (bg) 2001-06-29
MX9804688A (es) 1998-10-31
ATE250593T1 (de) 2003-10-15
FR2742751A1 (fr) 1997-06-27
NO982580D0 (no) 1998-06-05
CN1103766C (zh) 2003-03-26
PE25198A1 (es) 1998-05-10
UY24386A1 (es) 2001-08-27
TW371659B (en) 1999-10-11
EP0876362B1 (fr) 2003-09-24
TNSN96169A1 (fr) 2005-03-15
UA48205C2 (uk) 2002-08-15
JP3953106B2 (ja) 2007-08-08
PT876362E (pt) 2004-02-27
DK0876362T3 (da) 2004-02-02
OA10700A (fr) 2002-11-27
CZ196198A3 (cs) 1998-09-16
TR199801179T2 (xx) 1998-10-21
BG102569A (en) 1999-04-30
DE69630145T2 (de) 2004-07-15
CO4520184A1 (es) 1997-10-15
PL189311B1 (pl) 2005-07-29
IN188469B (instruction) 2002-09-28
HUP9904046A1 (hu) 2001-04-28
AU712597B2 (en) 1999-11-11
WO1997023473A1 (fr) 1997-07-03
CN1205697A (zh) 1999-01-20
EA001533B1 (ru) 2001-04-23
IN188470B (instruction) 2002-09-28
HU225032B1 (en) 2006-05-29
SK282835B6 (sk) 2002-12-03
MY113934A (en) 2002-06-29
ZA9610737B (en) 1997-06-27
EP0876362A1 (fr) 1998-11-11
FR2742751B1 (fr) 1998-01-30
IN186768B (instruction) 2001-11-03
EA199800588A1 (ru) 1998-12-24
AR005197A1 (es) 1999-04-14
KR19990076680A (ko) 1999-10-15
IL124994A (en) 2000-12-06
DE69630145D1 (de) 2003-10-30
IL124994A0 (en) 1999-01-26
NO982580L (no) 1998-06-05
CA2238884C (fr) 2007-02-06
US5728849A (en) 1998-03-17
MA26412A1 (fr) 2004-12-20
PL327405A1 (en) 1998-12-07

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