MX9702742A - Nuevos taxoides, su preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Nuevos taxoides, su preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- MX9702742A MX9702742A MX9702742A MX9702742A MX9702742A MX 9702742 A MX9702742 A MX 9702742A MX 9702742 A MX9702742 A MX 9702742A MX 9702742 A MX9702742 A MX 9702742A MX 9702742 A MX9702742 A MX 9702742A
- Authority
- MX
- Mexico
- Prior art keywords
- radical
- alkynyl
- alkenyl
- cycloalkyl
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
Se describen los nuevos taxoides de la formula general (I), (II): su preparacion y las composiciones farmacéuticas que los composiciones farmacéuticas que los contienen, En la formula general(I): Ra representa hidrogeno, hidroxilo, alcoxi, aciloxi, alcoxiacetoxi y Rb representa hidrogeno o bien Ra y Rb forman conjuntamente con el átomo de carbono al cual están unidos, un grupo funcional cetona Z representa un átomo de hidrogeno o un radical de formula general (II) en la cual R1 representa un radical benzoilo eventualmente substituido, tenoilo o furoilo o un radical R2-O-CO- en el cual R2 representa un radical alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, bicicloalquilo, fenilo eventualmente substituido o heterociclilo, R3 representa un radical alquilo, alquenilo, alquinilo, cicloalquilo, fenilo, naftilo o heterocíclico aromático. R4 representa un radical alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, bicicloalquilo, arilo, o heterociclilo, y R5 representa un radical alquilo, alquenilo, alquinilo, cicloalquilo o cicloalquenilo eventualmente substituido. Los nuevos productos de la formula general (I) en la cual Z representa un radical de la formula general (II) presentan propiedades antitumorales y antileucémicas notables.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR94/12795 | 1994-10-26 | ||
| FR9412795 | 1994-10-26 | ||
| FR9412795A FR2726272B1 (fr) | 1994-10-26 | 1994-10-26 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR1995/001393 WO1996013494A1 (fr) | 1994-10-26 | 1995-10-23 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9702742A true MX9702742A (es) | 1997-09-30 |
| MXPA97002742A MXPA97002742A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996013494A1 (fr) | 1996-05-09 |
| RU2153496C2 (ru) | 2000-07-27 |
| BG62697B1 (bg) | 2000-05-31 |
| GR3029838T3 (en) | 1999-07-30 |
| BG101442A (en) | 1998-03-31 |
| ZA958997B (en) | 1996-05-15 |
| NO971765D0 (no) | 1997-04-17 |
| NO971765L (no) | 1997-04-17 |
| AU704719B2 (en) | 1999-04-29 |
| DK0788492T3 (da) | 1999-10-11 |
| DE69508781T2 (de) | 1999-09-02 |
| DE69508781D1 (de) | 1999-05-06 |
| EP0788492A1 (fr) | 1997-08-13 |
| US5840931A (en) | 1998-11-24 |
| SK281556B6 (sk) | 2001-05-10 |
| ES2131864T3 (es) | 1999-08-01 |
| ATE178326T1 (de) | 1999-04-15 |
| FR2726272B1 (fr) | 1996-12-06 |
| FR2726272A1 (fr) | 1996-05-03 |
| CZ125797A3 (en) | 1997-08-13 |
| HUT77930A (hu) | 1998-11-30 |
| RO115876B1 (ro) | 2000-07-28 |
| AU3809195A (en) | 1996-05-23 |
| KR970707113A (ko) | 1997-12-01 |
| CN1166170A (zh) | 1997-11-26 |
| CZ287649B6 (en) | 2001-01-17 |
| NZ294880A (en) | 1999-02-25 |
| PL319834A1 (en) | 1997-09-01 |
| SK51997A3 (en) | 1997-10-08 |
| CA2202682A1 (fr) | 1996-05-09 |
| OA10417A (fr) | 2001-12-05 |
| JPH10508015A (ja) | 1998-08-04 |
| BR9510235A (pt) | 1997-11-04 |
| EP0788492B1 (fr) | 1999-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |