RO116194B1 - Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica - Google Patents

Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica Download PDF

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Publication number
RO116194B1
RO116194B1 RO98-01093A RO9801093A RO116194B1 RO 116194 B1 RO116194 B1 RO 116194B1 RO 9801093 A RO9801093 A RO 9801093A RO 116194 B1 RO116194 B1 RO 116194B1
Authority
RO
Romania
Prior art keywords
carbon atoms
radical
atoms
hydrogen atom
alkyl
Prior art date
Application number
RO98-01093A
Other languages
English (en)
Romanian (ro)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of RO116194B1 publication Critical patent/RO116194B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RO98-01093A 1995-12-22 1996-12-19 Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica RO116194B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
RO116194B1 true RO116194B1 (ro) 2000-11-30

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
RO98-01093A RO116194B1 (ro) 1995-12-22 1996-12-19 Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica

Country Status (40)

Country Link
US (1) US5728849A (cg-RX-API-DMAC7.html)
EP (1) EP0876362B1 (cg-RX-API-DMAC7.html)
JP (1) JP3953106B2 (cg-RX-API-DMAC7.html)
KR (1) KR100500351B1 (cg-RX-API-DMAC7.html)
CN (1) CN1103766C (cg-RX-API-DMAC7.html)
AR (1) AR005197A1 (cg-RX-API-DMAC7.html)
AT (1) ATE250593T1 (cg-RX-API-DMAC7.html)
AU (1) AU712597B2 (cg-RX-API-DMAC7.html)
BG (1) BG63204B1 (cg-RX-API-DMAC7.html)
BR (1) BR9612135A (cg-RX-API-DMAC7.html)
CA (1) CA2238884C (cg-RX-API-DMAC7.html)
CO (1) CO4520184A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ294972B6 (cg-RX-API-DMAC7.html)
DE (1) DE69630145T2 (cg-RX-API-DMAC7.html)
DK (1) DK0876362T3 (cg-RX-API-DMAC7.html)
DZ (1) DZ2149A1 (cg-RX-API-DMAC7.html)
EA (1) EA001533B1 (cg-RX-API-DMAC7.html)
ES (1) ES2202490T3 (cg-RX-API-DMAC7.html)
FR (1) FR2742751B1 (cg-RX-API-DMAC7.html)
HU (1) HU225032B1 (cg-RX-API-DMAC7.html)
IL (1) IL124994A (cg-RX-API-DMAC7.html)
IN (4) IN186768B (cg-RX-API-DMAC7.html)
MA (1) MA26412A1 (cg-RX-API-DMAC7.html)
MX (1) MX9804688A (cg-RX-API-DMAC7.html)
MY (1) MY113934A (cg-RX-API-DMAC7.html)
NO (1) NO317358B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ324337A (cg-RX-API-DMAC7.html)
OA (1) OA10700A (cg-RX-API-DMAC7.html)
PE (1) PE25198A1 (cg-RX-API-DMAC7.html)
PL (1) PL189311B1 (cg-RX-API-DMAC7.html)
PT (1) PT876362E (cg-RX-API-DMAC7.html)
RO (1) RO116194B1 (cg-RX-API-DMAC7.html)
SK (1) SK282835B6 (cg-RX-API-DMAC7.html)
TN (1) TNSN96169A1 (cg-RX-API-DMAC7.html)
TR (1) TR199801179T2 (cg-RX-API-DMAC7.html)
TW (1) TW371659B (cg-RX-API-DMAC7.html)
UA (1) UA48205C2 (cg-RX-API-DMAC7.html)
UY (1) UY24386A1 (cg-RX-API-DMAC7.html)
WO (1) WO1997023473A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA9610737B (cg-RX-API-DMAC7.html)

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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
AU2008290582B2 (en) * 2007-08-17 2014-08-14 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
EP2326326B1 (en) * 2008-08-15 2019-10-09 Boehringer Ingelheim International GmbH Dpp-4 inhibitors for use for the treatment of wound healing in diabetic patients
JP2012502081A (ja) 2008-09-10 2012-01-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連症状の治療のための組み合わせ治療
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
TWI508965B (zh) 2008-12-23 2015-11-21 Boehringer Ingelheim Int 有機化合物的鹽形式
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KR20190071840A (ko) 2009-11-27 2019-06-24 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
MX366325B (es) 2010-05-05 2019-07-05 Boehringer Ingelheim Int Terapia de combinacion.
CA2803504C (en) 2010-06-24 2022-08-30 Boehringer Ingelheim International Gmbh A combination for diabetes therapy comprising linagliptin and a long-acting insulin
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
KR101985384B1 (ko) 2011-07-15 2019-06-03 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도
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JP6218811B2 (ja) 2012-05-14 2017-10-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
BR112018072401A2 (pt) 2016-06-10 2019-02-19 Boehringer Ingelheim International Gmbh combinações de linagliptina e metformina
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JP2024541058A (ja) 2021-11-03 2024-11-06 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． 抗体の特異的共役

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Also Published As

Publication number Publication date
AU1180997A (en) 1997-07-17
EP0876362A1 (fr) 1998-11-11
IN188469B (cg-RX-API-DMAC7.html) 2002-09-28
IN186768B (cg-RX-API-DMAC7.html) 2001-11-03
NZ324337A (en) 2000-03-27
UY24386A1 (es) 2001-08-27
DE69630145D1 (de) 2003-10-30
OA10700A (fr) 2002-11-27
PL189311B1 (pl) 2005-07-29
CO4520184A1 (es) 1997-10-15
IL124994A0 (en) 1999-01-26
HUP9904046A1 (hu) 2001-04-28
CZ294972B6 (cs) 2005-04-13
TW371659B (en) 1999-10-11
EA199800588A1 (ru) 1998-12-24
TR199801179T2 (xx) 1998-10-21
HUP9904046A3 (en) 2001-08-28
AU712597B2 (en) 1999-11-11
CA2238884A1 (fr) 1997-07-03
IL124994A (en) 2000-12-06
NO982580L (no) 1998-06-05
IN188470B (cg-RX-API-DMAC7.html) 2002-09-28
JP3953106B2 (ja) 2007-08-08
SK282835B6 (sk) 2002-12-03
BR9612135A (pt) 1999-07-13
DZ2149A1 (fr) 2002-10-23
EA001533B1 (ru) 2001-04-23
US5728849A (en) 1998-03-17
KR100500351B1 (ko) 2005-12-21
ZA9610737B (en) 1997-06-27
MX9804688A (es) 1998-10-31
ATE250593T1 (de) 2003-10-15
UA48205C2 (uk) 2002-08-15
CZ196198A3 (cs) 1998-09-16
PL327405A1 (en) 1998-12-07
IN188680B (cg-RX-API-DMAC7.html) 2002-10-26
BG63204B1 (bg) 2001-06-29
AR005197A1 (es) 1999-04-14
KR19990076680A (ko) 1999-10-15
DE69630145T2 (de) 2004-07-15
FR2742751B1 (fr) 1998-01-30
CA2238884C (fr) 2007-02-06
CN1205697A (zh) 1999-01-20
ES2202490T3 (es) 2004-04-01
NO317358B1 (no) 2004-10-18
PT876362E (pt) 2004-02-27
HK1017895A1 (en) 1999-12-03
EP0876362B1 (fr) 2003-09-24
MA26412A1 (fr) 2004-12-20
DK0876362T3 (da) 2004-02-02
TNSN96169A1 (fr) 2005-03-15
PE25198A1 (es) 1998-05-10
MY113934A (en) 2002-06-29
FR2742751A1 (fr) 1997-06-27
BG102569A (en) 1999-04-30
HU225032B1 (en) 2006-05-29
SK85398A3 (en) 1998-11-04
WO1997023473A1 (fr) 1997-07-03
CN1103766C (zh) 2003-03-26
JP2000502671A (ja) 2000-03-07
NO982580D0 (no) 1998-06-05

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