ATE250593T1 - Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen - Google Patents
Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungenInfo
- Publication number
- ATE250593T1 ATE250593T1 AT96942433T AT96942433T ATE250593T1 AT E250593 T1 ATE250593 T1 AT E250593T1 AT 96942433 T AT96942433 T AT 96942433T AT 96942433 T AT96942433 T AT 96942433T AT E250593 T1 ATE250593 T1 AT E250593T1
- Authority
- AT
- Austria
- Prior art keywords
- taxal
- derivatives
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9515379A FR2742751B1 (fr) | 1995-12-22 | 1995-12-22 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR1996/002031 WO1997023473A1 (fr) | 1995-12-22 | 1996-12-19 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250593T1 true ATE250593T1 (de) | 2003-10-15 |
Family
ID=9485871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96942433T ATE250593T1 (de) | 1995-12-22 | 1996-12-19 | Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen |
Country Status (40)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
| CZ20013405A3 (cs) | 2000-02-02 | 2002-03-13 | Florida State University Research Foundation, Inc. | C10 karbonátem substituované taxany jako protinádorová činidla |
| DK1757606T3 (da) * | 2001-02-24 | 2009-09-07 | Boehringer Ingelheim Pharma | Anvendelse af xanthinderivater som l gemidler samt fremgangsm de til deres fremstilling |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| CA2526278A1 (en) * | 2003-05-20 | 2004-12-02 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising a liposomal platinum complex |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| EP1669358A1 (en) * | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| JP5323684B2 (ja) * | 2006-05-04 | 2013-10-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 多形体 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| AU2008290582B2 (en) * | 2007-08-17 | 2014-08-14 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| EP2326326B1 (en) * | 2008-08-15 | 2019-10-09 | Boehringer Ingelheim International GmbH | Dpp-4 inhibitors for use for the treatment of wound healing in diabetic patients |
| JP2012502081A (ja) | 2008-09-10 | 2012-01-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連症状の治療のための組み合わせ治療 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| TWI508965B (zh) | 2008-12-23 | 2015-11-21 | Boehringer Ingelheim Int | 有機化合物的鹽形式 |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| KR20190071840A (ko) | 2009-11-27 | 2019-06-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| MX366325B (es) | 2010-05-05 | 2019-07-05 | Boehringer Ingelheim Int | Terapia de combinacion. |
| CA2803504C (en) | 2010-06-24 | 2022-08-30 | Boehringer Ingelheim International Gmbh | A combination for diabetes therapy comprising linagliptin and a long-acting insulin |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| KR101985384B1 (ko) | 2011-07-15 | 2019-06-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 치환된 퀴나졸린, 이의 제조 및 약제학적 조성물에서의 이의 용도 |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| JP6218811B2 (ja) | 2012-05-14 | 2017-10-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| FR3010839B1 (fr) * | 2013-09-17 | 2017-04-21 | Schneider Electric Ind Sas | Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique |
| PT3122757T (pt) | 2014-02-28 | 2023-11-03 | Hangzhou Dac Biotech Co Ltd | Ligantes carregados e as suas utilizações em conjugação |
| ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
| WO2015151081A2 (en) | 2015-07-12 | 2015-10-08 | Suzhou M-Conj Biotech Co., Ltd | Bridge linkers for conjugation of a cell-binding molecule |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| BR112018072401A2 (pt) | 2016-06-10 | 2019-02-19 | Boehringer Ingelheim International Gmbh | combinações de linagliptina e metformina |
| WO2018086139A1 (en) | 2016-11-14 | 2018-05-17 | Hangzhou Dac Biotech Co., Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 抗体の特異的共役 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017724C1 (ru) * | 1990-07-12 | 1994-08-15 | Дзе Юниверсити оф Канзас | Способ получения производных таксола |
| US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
| FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
| RU2059631C1 (ru) * | 1991-11-29 | 1996-05-10 | Дзе Юниверсити оф Канзас | Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью |
| ES2134847T3 (es) * | 1992-04-17 | 1999-10-16 | Abbott Lab | Derivados de taxol. |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1995
- 1995-12-22 FR FR9515379A patent/FR2742751B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-04 PE PE1996000871A patent/PE25198A1/es not_active Application Discontinuation
- 1996-12-18 MA MA24431A patent/MA26412A1/fr unknown
- 1996-12-19 AT AT96942433T patent/ATE250593T1/de active
- 1996-12-19 CA CA002238884A patent/CA2238884C/fr not_active Expired - Fee Related
- 1996-12-19 BR BR9612135A patent/BR9612135A/pt not_active IP Right Cessation
- 1996-12-19 DE DE69630145T patent/DE69630145T2/de not_active Expired - Lifetime
- 1996-12-19 JP JP52336197A patent/JP3953106B2/ja not_active Expired - Fee Related
- 1996-12-19 AU AU11809/97A patent/AU712597B2/en not_active Ceased
- 1996-12-19 PT PT96942433T patent/PT876362E/pt unknown
- 1996-12-19 TW TW085115683A patent/TW371659B/zh not_active IP Right Cessation
- 1996-12-19 PL PL96327405A patent/PL189311B1/pl not_active IP Right Cessation
- 1996-12-19 ES ES96942433T patent/ES2202490T3/es not_active Expired - Lifetime
- 1996-12-19 IL IL12499496A patent/IL124994A/xx not_active IP Right Cessation
- 1996-12-19 EA EA199800588A patent/EA001533B1/ru not_active IP Right Cessation
- 1996-12-19 RO RO98-01093A patent/RO116194B1/ro unknown
- 1996-12-19 WO PCT/FR1996/002031 patent/WO1997023473A1/fr not_active Ceased
- 1996-12-19 HU HU9904046A patent/HU225032B1/hu not_active IP Right Cessation
- 1996-12-19 NZ NZ324337A patent/NZ324337A/xx not_active IP Right Cessation
- 1996-12-19 EP EP96942433A patent/EP0876362B1/fr not_active Expired - Lifetime
- 1996-12-19 SK SK853-98A patent/SK282835B6/sk not_active IP Right Cessation
- 1996-12-19 CZ CZ19981961A patent/CZ294972B6/cs not_active IP Right Cessation
- 1996-12-19 TR TR1998/01179T patent/TR199801179T2/xx unknown
- 1996-12-19 ZA ZA9610737A patent/ZA9610737B/xx unknown
- 1996-12-19 CN CN96199168A patent/CN1103766C/zh not_active Expired - Fee Related
- 1996-12-19 UA UA98063216A patent/UA48205C2/uk unknown
- 1996-12-19 KR KR10-1998-0704792A patent/KR100500351B1/ko not_active Expired - Fee Related
- 1996-12-19 DK DK96942433T patent/DK0876362T3/da active
- 1996-12-20 US US08/771,751 patent/US5728849A/en not_active Expired - Lifetime
- 1996-12-20 AR ARP960105851A patent/AR005197A1/es active IP Right Grant
- 1996-12-20 MY MYPI96005421A patent/MY113934A/en unknown
- 1996-12-20 IN IN2893DE1996 patent/IN186768B/en unknown
- 1996-12-20 CO CO96067023A patent/CO4520184A1/es unknown
- 1996-12-20 TN TNTNSN96169A patent/TNSN96169A1/fr unknown
- 1996-12-21 DZ DZ960194A patent/DZ2149A1/fr active
-
1998
- 1998-06-05 NO NO19982580A patent/NO317358B1/no not_active IP Right Cessation
- 1998-06-11 MX MX9804688A patent/MX9804688A/es not_active IP Right Cessation
- 1998-06-19 OA OA9800087A patent/OA10700A/fr unknown
- 1998-06-22 BG BG102569A patent/BG63204B1/bg unknown
-
2000
- 2000-04-10 IN IN419DE2000 patent/IN188680B/en unknown
- 2000-04-10 IN IN421DE2000 patent/IN188470B/en unknown
- 2000-04-10 IN IN420DE2000 patent/IN188469B/en unknown
- 2000-12-02 UY UY24386A patent/UY24386A1/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE250593T1 (de) | Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen | |
| DE69606028D1 (de) | Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzung | |
| DE60142890D1 (de) | 3-aminoazetidinderivate enthaltende pharmazeutische zusammensetzungen, diese derivate und deren herstellung | |
| DE69131813D1 (de) | Amido-3-Pyrazol-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen | |
| DE69928260D1 (de) | Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen | |
| FI934274A7 (fi) | N-sulfonyyli-2-oksi-indolijohdannaiset, niiden valmistus ja niitä sisä ltävät farmaseuttiset koostumukset | |
| DE69618587D1 (de) | Chinazoline und pharmazeutische zusammensetzungen | |
| EE9500064A (et) | Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid | |
| DE69616323D1 (de) | Aromatische verbindungen und diese enthaltende pharmazeutische zusammenstellungen | |
| DE59712959D1 (de) | Orale pharmazeutische zubereitung enthaltend ibandronat | |
| ATE297935T1 (de) | 2-(iminomethyl)aminophenyl-derivate, deren herstellung, verwendung als medikamente und diese enthaltende pharmazeutische zubereitungen | |
| FI953898A7 (fi) | Glysiiniamidijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita | |
| DE69608680D1 (de) | Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen | |
| DE69618210D1 (de) | Aromatische verbindungen und diese enthaltende pharmazeutische zusammenstellungen | |
| ATE222897T1 (de) | Substituierte thiazolidinedione derivate, ihre herstellung und pharmazeutische zusammensetzungen,die sie enthalten | |
| HUP9901096A3 (en) | Indole derivatives, preparation and use thereof, pharmaceutical composition containing these compounds | |
| FI952550A7 (fi) | Uudet N-pyridyylikarboksamidit ja johdannaiset, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset | |
| EE9900112A (et) | 2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid | |
| DE59814412D1 (de) | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate | |
| EE04493B1 (et) | Tsüklopenteeni derivaadid, neid sisaldav farmatseutiline kompositsioon ning ühendite kasutamine ravimina inimestel esinevate motiliini retseptoriga seotud häirete raviks | |
| ATE195940T1 (de) | Taxol derivate,deren herstellung und diese enthaltende pharmazeutische zusammenstellungen | |
| FI943645A7 (fi) | Uusia bakkatiini-III ja 10-deasetyylibakkatiini-III-johdannaisia, niid en valmistus ja niitä sisältäviä farmaseuttisia koostumuksia | |
| EE9800069A (et) | Bensotiasolooni derivaadid, protsessid ja kasutatud vaheühendid nende saamiseks ning neid sisaldavad ravimkoostised | |
| HUP9900865A3 (en) | Anti-viral benzimidazole derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds | |
| ATE204266T1 (de) | Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0876362 Country of ref document: EP |