PT2972360T - Intensificação sinérgica da entrega de ácidos nucleicos via formulações combinadas - Google Patents
Intensificação sinérgica da entrega de ácidos nucleicos via formulações combinadasInfo
- Publication number
- PT2972360T PT2972360T PT147216477T PT14721647T PT2972360T PT 2972360 T PT2972360 T PT 2972360T PT 147216477 T PT147216477 T PT 147216477T PT 14721647 T PT14721647 T PT 14721647T PT 2972360 T PT2972360 T PT 2972360T
- Authority
- PT
- Portugal
- Prior art keywords
- delivery
- nucleic acids
- acids via
- synergistic enhancement
- blended formulations
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361789375P | 2013-03-15 | 2013-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2972360T true PT2972360T (pt) | 2018-05-25 |
Family
ID=50639976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT147216477T PT2972360T (pt) | 2013-03-15 | 2014-03-14 | Intensificação sinérgica da entrega de ácidos nucleicos via formulações combinadas |
Country Status (13)
Country | Link |
---|---|
US (3) | US10130649B2 (pt) |
EP (4) | EP3757570B1 (pt) |
CY (1) | CY1120507T1 (pt) |
DK (2) | DK2972360T3 (pt) |
ES (3) | ES2795249T3 (pt) |
HR (1) | HRP20180749T1 (pt) |
HU (1) | HUE039189T2 (pt) |
LT (1) | LT2972360T (pt) |
NO (1) | NO3014045T3 (pt) |
PT (1) | PT2972360T (pt) |
RS (1) | RS57316B1 (pt) |
SI (1) | SI2972360T1 (pt) |
WO (1) | WO2014144196A1 (pt) |
Families Citing this family (112)
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US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
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- 2014-03-14 SI SI201430708T patent/SI2972360T1/en unknown
- 2014-03-14 ES ES20169318T patent/ES2967701T3/es active Active
- 2014-03-14 EP EP14721647.7A patent/EP2972360B1/en active Active
- 2014-03-14 LT LTEP14721647.7T patent/LT2972360T/lt unknown
- 2014-03-14 DK DK18160237.6T patent/DK3388834T3/da active
- 2014-03-14 EP EP23202696.3A patent/EP4332576A3/en active Pending
- 2014-06-26 NO NO14816715A patent/NO3014045T3/no unknown
-
2018
- 2018-05-14 HR HRP20180749TT patent/HRP20180749T1/hr unknown
- 2018-05-23 CY CY20181100543T patent/CY1120507T1/el unknown
- 2018-10-10 US US16/157,050 patent/US10646504B2/en active Active
-
2020
- 2020-03-31 US US16/836,513 patent/US20200390797A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CY1120507T1 (el) | 2019-07-10 |
HRP20180749T1 (hr) | 2018-08-10 |
US10130649B2 (en) | 2018-11-20 |
EP4332576A2 (en) | 2024-03-06 |
NO3014045T3 (pt) | 2018-08-04 |
DK2972360T3 (en) | 2018-05-22 |
SI2972360T1 (en) | 2018-08-31 |
US10646504B2 (en) | 2020-05-12 |
EP3757570C0 (en) | 2023-10-11 |
EP3757570A1 (en) | 2020-12-30 |
US20200390797A1 (en) | 2020-12-17 |
EP2972360A1 (en) | 2016-01-20 |
EP3757570B1 (en) | 2023-10-11 |
EP3388834A1 (en) | 2018-10-17 |
HUE039189T2 (hu) | 2018-12-28 |
EP2972360B1 (en) | 2018-03-07 |
ES2795249T3 (es) | 2020-11-23 |
RS57316B1 (sr) | 2018-08-31 |
ES2967701T3 (es) | 2024-05-03 |
LT2972360T (lt) | 2018-09-10 |
US20190216843A1 (en) | 2019-07-18 |
ES2670529T3 (es) | 2018-05-30 |
EP3388834B1 (en) | 2020-04-15 |
WO2014144196A1 (en) | 2014-09-18 |
US20160151409A1 (en) | 2016-06-02 |
DK3388834T3 (da) | 2020-05-04 |
EP4332576A3 (en) | 2024-04-24 |
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