PT2897956T - Piridinonas bicíclicas inovadoras - Google Patents

Piridinonas bicíclicas inovadoras

Info

Publication number
PT2897956T
PT2897956T PT137920856T PT13792085T PT2897956T PT 2897956 T PT2897956 T PT 2897956T PT 137920856 T PT137920856 T PT 137920856T PT 13792085 T PT13792085 T PT 13792085T PT 2897956 T PT2897956 T PT 2897956T
Authority
PT
Portugal
Prior art keywords
novel bicyclic
pyridinones
bicyclic pyridinones
novel
bicyclic
Prior art date
Application number
PT137920856T
Other languages
English (en)
Portuguese (pt)
Inventor
William Am Ende Christopher
Eric Green Michael
Scott Johnson Douglas
Wayne Kauffman Gregory
John O'donnell Christopher
Chaturbhai Patel Nandini
Youngjin Pettersson Martin
Friederike Stepan Antonia
Michael Stiff Cory
Subramanyam Chakrapani
Phong Tran Tuan
Robert Verhoest Patrick
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT2897956T publication Critical patent/PT2897956T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epidemiology (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT137920856T 2012-09-21 2013-09-06 Piridinonas bicíclicas inovadoras PT2897956T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261703969P 2012-09-21 2012-09-21

Publications (1)

Publication Number Publication Date
PT2897956T true PT2897956T (pt) 2017-01-13

Family

ID=49585452

Family Applications (1)

Application Number Title Priority Date Filing Date
PT137920856T PT2897956T (pt) 2012-09-21 2013-09-06 Piridinonas bicíclicas inovadoras

Country Status (46)

Country Link
US (3) US8916564B2 (cg-RX-API-DMAC10.html)
EP (1) EP2897956B1 (cg-RX-API-DMAC10.html)
JP (1) JP5844018B2 (cg-RX-API-DMAC10.html)
KR (1) KR101725696B1 (cg-RX-API-DMAC10.html)
CN (1) CN104662021B (cg-RX-API-DMAC10.html)
AP (1) AP2015008277A0 (cg-RX-API-DMAC10.html)
AR (1) AR092628A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013319845B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015006436A2 (cg-RX-API-DMAC10.html)
CA (1) CA2882386C (cg-RX-API-DMAC10.html)
CL (1) CL2015000717A1 (cg-RX-API-DMAC10.html)
CR (1) CR20150053A (cg-RX-API-DMAC10.html)
CU (1) CU20150021A7 (cg-RX-API-DMAC10.html)
CY (1) CY1118662T1 (cg-RX-API-DMAC10.html)
DK (1) DK2897956T3 (cg-RX-API-DMAC10.html)
DO (1) DOP2015000069A (cg-RX-API-DMAC10.html)
EA (1) EA026668B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP15015594A (cg-RX-API-DMAC10.html)
ES (1) ES2609987T3 (cg-RX-API-DMAC10.html)
GE (1) GEP201706659B (cg-RX-API-DMAC10.html)
GT (1) GT201500069A (cg-RX-API-DMAC10.html)
HR (1) HRP20161558T1 (cg-RX-API-DMAC10.html)
HU (1) HUE031248T2 (cg-RX-API-DMAC10.html)
IL (1) IL237163A (cg-RX-API-DMAC10.html)
IN (1) IN2015DN01119A (cg-RX-API-DMAC10.html)
LT (1) LT2897956T (cg-RX-API-DMAC10.html)
MA (1) MA37886B1 (cg-RX-API-DMAC10.html)
MD (1) MD4583B1 (cg-RX-API-DMAC10.html)
ME (1) ME02571B (cg-RX-API-DMAC10.html)
MX (1) MX360599B (cg-RX-API-DMAC10.html)
MY (1) MY181891A (cg-RX-API-DMAC10.html)
NI (1) NI201500038A (cg-RX-API-DMAC10.html)
NZ (1) NZ704863A (cg-RX-API-DMAC10.html)
PE (1) PE20150686A1 (cg-RX-API-DMAC10.html)
PH (1) PH12015500376B1 (cg-RX-API-DMAC10.html)
PL (1) PL2897956T3 (cg-RX-API-DMAC10.html)
PT (1) PT2897956T (cg-RX-API-DMAC10.html)
RS (1) RS55426B1 (cg-RX-API-DMAC10.html)
SG (1) SG11201501074WA (cg-RX-API-DMAC10.html)
SI (1) SI2897956T1 (cg-RX-API-DMAC10.html)
TN (1) TN2015000084A1 (cg-RX-API-DMAC10.html)
TW (1) TWI500616B (cg-RX-API-DMAC10.html)
UA (1) UA110688C2 (cg-RX-API-DMAC10.html)
UY (1) UY35039A (cg-RX-API-DMAC10.html)
WO (1) WO2014045156A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201501195B (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
ES2608356T3 (es) 2012-12-20 2017-04-10 Janssen Pharmaceutica Nv Novedosos derivados tricíclicos de 3,4-dihidro-2H-pirido[1,2-a]pirazin-1,6-diona como moduladores de la secretasa gamma
EP2945944B1 (en) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
ES2742078T3 (es) * 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
DK3126361T3 (da) * 2014-04-01 2020-01-02 Pfizer Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer
TN2017000342A1 (en) * 2015-02-03 2019-01-16 Pfizer Novel cyclopropabenzofuranyl pyridopyrazinediones
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
WO2017216279A1 (en) 2016-06-16 2017-12-21 F. Hoffmann-La Roche Ag Heteroaryl estrogen receptor modulators and uses thereof
JP6904612B2 (ja) 2016-12-16 2021-07-21 パイプライン セラピューティクス, インコーポレイテッド 蝸牛シナプス障害を処置する方法
TW202034900A (zh) 2018-10-02 2020-10-01 美商頻率醫療公司 有關耳用治療劑之醫藥組成物及方法
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
US20220175776A1 (en) 2019-04-08 2022-06-09 Frequency Therapeutics, Inc. Combination of chir99021 and valproic acid for treating hearing loss
UA130303C2 (uk) 2019-12-06 2026-01-14 Вертекс Фармасьютикалз Інкорпорейтед Заміщені тетрагідрофурани як модулятори натрієвих каналів
CN113402490B (zh) * 2021-03-29 2023-01-03 白银京宇新药业有限公司 一种1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-酮的制备方法
MX2023014378A (es) 2021-06-04 2023-12-15 Vertex Pharma N-(hidroxialquil(hetero)aril)tetrahidrofurano carboxamidas como moduladores de canales de sodio.
CN114034792B (zh) * 2021-11-09 2024-06-25 山东新华制药股份有限公司 检测氯酮含量的液相色谱分析方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419789A (en) 1972-08-02 1975-12-31 Pfizer 2-trifluoromethyl-4-quinolinols
WO1992000075A1 (en) 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
DE69315920T2 (de) 1992-09-04 1998-06-10 Takeda Chemical Industries Ltd Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
EP0683234B2 (en) 1993-01-25 2007-06-06 Takeda Chemical Industries, Ltd. Antibody against beta-amyloid or their derivative and use thereof
ATE242243T1 (de) 1995-03-24 2003-06-15 Takeda Chemical Industries Ltd Zyklische verbindungen, ihre herstellung und ihre verwendung als tachykininrezeptorantagonisten
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
PT994728E (pt) 1997-04-09 2008-11-11 Intellect Neurosciences Inc Anticorpos recombinantes específicos contra terminações beta-amilóide, codificação por adn e métodos de utilização destes
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
DE69903715T2 (de) 1998-03-03 2003-08-14 Ppg Industries Ohio, Inc. Imprägnierte glasspinnfäden und diese enthaltende produkte
US20020132817A1 (en) 1998-03-19 2002-09-19 Hideaki Natsugari Heterocyclic compounds, their production and use
CA2352612A1 (en) 1998-11-27 2000-06-08 Hideo Fukui Pharmaceuticals
KR100767146B1 (ko) 2000-02-24 2007-10-15 워싱톤 유니버시티 Aβ 펩티드를 격리시키는 인간화 항체
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
AU2002239764B2 (en) 2000-11-03 2007-06-21 Proteotech, Inc. Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants
JP2005503789A (ja) 2001-08-17 2005-02-10 イーライ・リリー・アンド・カンパニー 抗Aβ抗体
US20030195205A1 (en) 2001-11-02 2003-10-16 Pfizer Inc. PDE9 inhibitors for treating cardiovascular disorders
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
US7517532B2 (en) 2002-09-11 2009-04-14 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
BR0315158A (pt) 2002-10-09 2005-08-16 Pfizer Prod Inc Compostos de pirazol para o tratamento de distúrbios neurodegenarativos
JP2006519762A (ja) 2002-10-09 2006-08-31 ライナット ニューロサイエンス コーポレイション アミロイドβペプチド及びその組成物に対する抗体を使用して、アルツハイマー病を治療する方法
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EP1638935A1 (en) 2003-06-19 2006-03-29 Pfizer Products Inc. Nk1 antagonist
WO2005020991A1 (en) 2003-08-21 2005-03-10 Pfizer Products, Inc. Compounds for the treatment of neurodegenerative disorders
EP1666061A1 (en) 2003-09-09 2006-06-07 Takeda Pharmaceutical Company Limited Use of antibody
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
JP2007519734A (ja) 2004-01-28 2007-07-19 メルク エンド カムパニー インコーポレーテッド アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
JP2007519707A (ja) 2004-02-02 2007-07-19 ファイザー・プロダクツ・インク ヒスタミン−3受容体モジュレーター
JP2007528394A (ja) 2004-03-09 2007-10-11 メルク エンド カムパニー インコーポレーテッド Hivインテグラーゼ阻害薬
US7342118B2 (en) 2004-03-23 2008-03-11 Pfizer Inc Imidazole compounds for the treatment of neurodegenerative disorders
ATE411030T1 (de) 2004-04-14 2008-10-15 Gilead Sciences Inc Phosphonatanaloga von hiv- integrasehemmerverbindungen
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
MX2007000998A (es) 2004-07-30 2007-07-11 Rinat Neuroscience Corp Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
FR2877015B1 (fr) 2004-10-21 2007-10-26 Commissariat Energie Atomique Revetement nanostructure et procede de revetement.
GB0423356D0 (en) 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
WO2006069081A2 (en) 2004-12-22 2006-06-29 Washington University In St. Louis USE OF ANTI-Aβ ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY
PE20061323A1 (es) 2005-04-29 2007-02-09 Rinat Neuroscience Corp Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
AU2006244424B2 (en) 2005-05-10 2011-09-22 Merck Sharp & Dohme Corp. HIV integrase inhibitors
WO2006120552A2 (en) 2005-05-12 2006-11-16 Pfizer Inc. ANHYDROUS CRYSTALLINE FORMS OF N-[1-(2-ETHOXYETHYL)-5-(N-ETHYL-N-METHYLAMINO)-7-(4-METHYLPYRIDIN-2-yl-AMINO)-1H-PYRAZOLO[4,3-d]PYRIMIDINE-3-CARBONYL]METHANESULFONAMIDE
WO2006126082A2 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
WO2006126081A2 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors
WO2006126083A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
US7812040B2 (en) 2005-06-22 2010-10-12 Pfizer Inc. Histamine-3 receptor antagonists
US20070060534A1 (en) 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
JP2009514846A (ja) 2005-11-04 2009-04-09 ファイザー・リミテッド テトラヒドロナフチリジン誘導体
JP2009516703A (ja) 2005-11-18 2009-04-23 グラクソ グループ リミテッド 新規中間体およびその使用
WO2007061923A2 (en) 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
AU2006317457B2 (en) 2005-11-24 2011-09-08 Eisai R & D Management Co., Ltd. Morpholine type cinnamide compound
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
WO2007063385A2 (en) 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
WO2007069053A1 (en) 2005-12-14 2007-06-21 Pfizer Products Inc. Benzimidazole antagonists of the h-3 receptor
US8067621B2 (en) * 2006-01-20 2011-11-29 Schering Corporation Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
WO2007088462A1 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Spirochromane antagonists of the h-3 receptor
WO2007088450A2 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
JP2009539762A (ja) 2006-03-13 2009-11-19 ファイザー・プロダクツ・インク H3受容体のテトラリン拮抗薬
HRP20110539T1 (hr) 2006-04-21 2011-08-31 Pfizer Products Inc. PIRIDINO[3,4-b]PIRAZINONI
EP2021327B1 (en) 2006-05-15 2012-04-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US20090306054A1 (en) 2006-05-16 2009-12-10 Gilead Sciences ,Inc. Integrase inhibitors
US20100105904A1 (en) 2006-05-19 2010-04-29 Teiji Kimura Urea type cinnamide derivative
WO2007138431A2 (en) 2006-05-30 2007-12-06 Pfizer Products Inc. Azabicyclic ether histamine-3 antagonists
NZ577951A (en) 2007-01-22 2012-02-24 Pfizer Prod Inc Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
JP2010518064A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Adおよび関連状態の治療のためのピペラジン誘導体
US8252803B2 (en) 2007-02-12 2012-08-28 Merck Sharp & Dohme Corp. Piperidine derivatives
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
WO2008137102A2 (en) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Methods of modulating amyloid beta and compounds useful therefor
CN101809019A (zh) 2007-05-07 2010-08-18 先灵公司 γ分泌酶调节剂
MX2009012163A (es) 2007-05-11 2009-12-01 Hoffmann La Roche Hetarilanilinas como moduladores para beta-amiloide.
TW200908968A (en) 2007-05-29 2009-03-01 Sgx Pharmaceuticals Inc Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
CA2689930A1 (en) 2007-06-01 2008-12-18 Schering Corporation Gamma secretase modulators
CN101809016A (zh) 2007-06-01 2010-08-18 先灵公司 γ-分泌酶调节剂
WO2008156580A1 (en) 2007-06-13 2008-12-24 Merck & Co., Inc. Triazole derivatives for treating alzheimer's disease and related conditions
CN101772493A (zh) 2007-06-29 2010-07-07 先灵公司 γ分泌酶调节剂
JP2010535762A (ja) 2007-08-06 2010-11-25 シェーリング コーポレイション ガンマセクレターゼモジュレーター
JP5433418B2 (ja) 2007-08-31 2014-03-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 多環式化合物
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
WO2009032277A1 (en) 2007-09-06 2009-03-12 Schering Corporation Gamma secretase modulators
MX2010003397A (es) 2007-09-28 2010-04-09 Schering Corp Moduladores de la gamma secretasa.
GB0720444D0 (en) 2007-10-18 2007-11-28 Glaxo Group Ltd Novel compounds
CA2704698A1 (en) 2007-11-05 2009-05-14 Schering Corporation Gamma secretase modulators
JP2011506336A (ja) * 2007-12-06 2011-03-03 シェーリング コーポレイション γ−セクレターゼ調節剤
US20100298372A1 (en) 2007-12-11 2010-11-25 Schering Corporation Gamma secretase modulators
CA2708300A1 (en) 2007-12-11 2009-06-18 Schering Corporation Gamma secretase modulators
CN101896461A (zh) 2007-12-13 2010-11-24 安姆根有限公司 γ分泌酶调节剂
WO2009087127A1 (en) 2008-01-11 2009-07-16 F. Hoffmann-La Roche Ag Modulators for amyloid beta
ES2428716T3 (es) 2008-02-22 2013-11-11 F. Hoffmann-La Roche Ag Moduladores de beta-amiloide
US20110027264A1 (en) 2008-02-29 2011-02-03 Xianhai Huang Gamma secretase modulators for the treatment of alzheimer's disease
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
EP2300427A1 (en) 2008-05-05 2011-03-30 Amgen Inc. Urea compounds as gamma secretase modulators
FR2933700B1 (fr) * 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
EP2312945A4 (en) 2008-08-13 2012-05-09 Merck Sharp & Dohme PURE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
US8685972B2 (en) 2008-08-13 2014-04-01 Merck Sharp & Dohme Corp. Pyrimidine derivatives for treatment of alzheimer's disease
WO2010025197A1 (en) 2008-08-27 2010-03-04 Eisai R&D Management Co., Ltd. Process for preparing certain cinnamide compounds
WO2010040661A1 (en) 2008-10-09 2010-04-15 F. Hoffmann-La Roche Ag Modulators for amyloid beta
CA2742317A1 (en) 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
MX2011004680A (es) 2008-11-06 2011-05-25 Astrazeneca Ab Moduladores de beta amiloide.
EP2356124A1 (en) 2008-11-06 2011-08-17 Schering Corporation Gamma secretase modulators
KR101293421B1 (ko) 2008-11-10 2013-08-05 에프. 호프만-라 로슈 아게 헤테로사이클릭 감마 분비효소 조절제
EP2379075A4 (en) 2008-12-16 2012-05-30 Merck Sharp & Dohme TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
WO2010071741A1 (en) 2008-12-16 2010-06-24 Merck Sharp & Dohme Corp. Triazole derivatives for treatment of alzheimer's disease
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
EP2379566A2 (en) 2008-12-22 2011-10-26 Schering Corporation Gamma secretase modulators
TW201034666A (en) 2008-12-22 2010-10-01 Schering Corp Gamma secretase modulators
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
WO2010089292A1 (en) 2009-02-06 2010-08-12 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
US8703954B2 (en) 2009-02-26 2014-04-22 Eisai R&D Management Co., Ltd. Salt of tetrahydrotriazolopyridine derivative and crystal thereof
JP2012121809A (ja) 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
CA2751534A1 (en) 2009-03-03 2010-09-10 Pfizer Inc. Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators
NZ597597A (en) 2009-08-07 2014-01-31 Dow Agrosciences Llc Pesticidal compositions containing heteroaryl-n-aryl carbamate compounds
WO2011048525A1 (en) * 2009-10-20 2011-04-28 Pfizer Inc. Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
SG10201502073PA (en) * 2009-12-22 2015-05-28 Vertex Pharma Isoindolinone inhibitors of phosphatidylinositol 3-kinase
JP5767393B2 (ja) 2011-03-31 2015-08-19 ファイザー・インク 新規二環式ピリジノン
EA027242B1 (ru) 2012-05-16 2017-07-31 Янссен Фармасьютикалз, Инк. ЗАМЕЩЕННЫЕ 3,4-ДИГИДРО-2H-ПИРИДО[1,2-a]ПИРАЗИН-1,6-ДИОНОВЫЕ ПРОИЗВОДНЫЕ, ПРИМЕНИМЫЕ ДЛЯ ЛЕЧЕНИЯ (В ТОМ ЧИСЛЕ) БОЛЕЗНИ АЛЬЦГЕЙМЕРА
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
ES2608356T3 (es) 2012-12-20 2017-04-10 Janssen Pharmaceutica Nv Novedosos derivados tricíclicos de 3,4-dihidro-2H-pirido[1,2-a]pirazin-1,6-diona como moduladores de la secretasa gamma
EP2945944B1 (en) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
ES2742078T3 (es) 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
EP3119347B1 (en) 2014-03-21 2023-06-07 Align Technology, Inc. Segmented orthodontic appliance with elastics
DK3126361T3 (da) 2014-04-01 2020-01-02 Pfizer Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer

Also Published As

Publication number Publication date
JP2015529238A (ja) 2015-10-05
IN2015DN01119A (cg-RX-API-DMAC10.html) 2015-06-26
EP2897956B1 (en) 2016-11-09
CL2015000717A1 (es) 2015-06-19
ZA201501195B (en) 2016-01-27
HK1206013A1 (zh) 2015-12-31
AP2015008277A0 (en) 2015-02-28
AR092628A1 (es) 2015-04-29
GEP201706659B (en) 2017-04-25
TWI500616B (zh) 2015-09-21
AU2013319845A1 (en) 2015-02-26
CA2882386C (en) 2017-11-28
CN104662021A (zh) 2015-05-27
JP5844018B2 (ja) 2016-01-13
AU2013319845B2 (en) 2017-09-14
PH12015500376A1 (en) 2015-04-20
TN2015000084A1 (fr) 2016-06-29
PE20150686A1 (es) 2015-05-23
MD20150023A2 (ro) 2015-07-31
MA37886B1 (fr) 2016-09-30
EA201590319A1 (ru) 2015-09-30
IL237163A (en) 2016-12-29
HUE031248T2 (en) 2017-06-28
CY1118662T1 (el) 2017-07-12
RS55426B1 (sr) 2017-04-28
PH12015500376B1 (en) 2015-04-20
UA110688C2 (uk) 2016-01-25
LT2897956T (lt) 2017-01-10
IL237163A0 (en) 2015-04-30
KR20150044948A (ko) 2015-04-27
EA026668B1 (ru) 2017-05-31
US9193726B2 (en) 2015-11-24
SI2897956T1 (sl) 2017-02-28
US20140088111A1 (en) 2014-03-27
DK2897956T3 (en) 2017-01-16
CR20150053A (es) 2015-03-25
GT201500069A (es) 2016-03-01
EP2897956A1 (en) 2015-07-29
US20160024088A1 (en) 2016-01-28
ME02571B (me) 2017-06-20
ECSP15015594A (es) 2017-08-31
US9751877B2 (en) 2017-09-05
ES2609987T3 (es) 2017-04-25
KR101725696B1 (ko) 2017-04-10
MX2015003637A (es) 2015-06-05
DOP2015000069A (es) 2015-05-15
NZ704863A (en) 2017-03-31
CU20150021A7 (es) 2015-08-27
MY181891A (en) 2021-01-12
HRP20161558T1 (hr) 2016-12-30
TW201425311A (zh) 2014-07-01
UY35039A (es) 2014-04-30
MX360599B (es) 2018-11-08
WO2014045156A1 (en) 2014-03-27
NI201500038A (es) 2015-06-05
PL2897956T3 (pl) 2017-05-31
US20150072990A1 (en) 2015-03-12
SG11201501074WA (en) 2015-05-28
BR112015006436A2 (pt) 2017-07-04
MA37886A1 (fr) 2016-02-29
MD4583B1 (ro) 2018-07-31
CN104662021B (zh) 2016-08-24
CA2882386A1 (en) 2014-03-27
US8916564B2 (en) 2014-12-23

Similar Documents

Publication Publication Date Title
IL254716B (en) Zinc-lysine conjugate
ZA201501195B (en) Novel bicyclic pyridinones
ZA201500345B (en) New bicyclic derivatives
ZA201407694B (en) Substituted pyrrolidine-2-carboxamides
GB201301173D0 (en) Object production
SG11201404344XA (en) Substituted pyrrolidine-2-carboxamides
GB2498643B (en) Distributed switch
IL237636A0 (en) new uses
EP2934541A4 (en) NORIBOGAINE SUBSTITUTE
EP2903012A4 (en) SWITCH
EP2924703A4 (en) LIGHT SWITCH
EP2927925A4 (en) SWITCH
GB201201720D0 (en) Novel combinations
EP2897145A4 (en) SWITCH
GB201222528D0 (en) Novel uses
GB201222391D0 (en) Novel Uses
GB201207154D0 (en) Novel form
PH32012000844S1 (en) Switch
PH32012000481S1 (en) Switch
PH32012000480S1 (en) Switch
PH32012000482S1 (en) Switch
PH32012000479S1 (en) Switch
GB201212393D0 (en) Novel combination
GB201204381D0 (en) Novel process
GB201219337D0 (en) Garrods movement