PT1414370E - Composições hemostáticas secas e processos para a sua preparação. - Google Patents
Composições hemostáticas secas e processos para a sua preparação. Download PDFInfo
- Publication number
- PT1414370E PT1414370E PT02744588T PT02744588T PT1414370E PT 1414370 E PT1414370 E PT 1414370E PT 02744588 T PT02744588 T PT 02744588T PT 02744588 T PT02744588 T PT 02744588T PT 1414370 E PT1414370 E PT 1414370E
- Authority
- PT
- Portugal
- Prior art keywords
- rehydration
- powder
- gelatin
- cross
- aid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims description 15
- 230000002439 hemostatic effect Effects 0.000 title description 7
- 239000000843 powder Substances 0.000 claims abstract description 80
- 229920000159 gelatin Polymers 0.000 claims abstract description 75
- 235000019322 gelatine Nutrition 0.000 claims abstract description 75
- 108010010803 Gelatin Proteins 0.000 claims abstract description 68
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 68
- 239000008273 gelatin Substances 0.000 claims abstract description 66
- 238000004132 cross linking Methods 0.000 claims abstract description 13
- 239000002202 Polyethylene glycol Substances 0.000 claims description 22
- 229920001223 polyethylene glycol Polymers 0.000 claims description 22
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 19
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 16
- 229920002307 Dextran Polymers 0.000 claims description 15
- 239000000017 hydrogel Substances 0.000 claims description 15
- 239000012065 filter cake Substances 0.000 claims description 14
- 108090000190 Thrombin Proteins 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 11
- 229960004072 thrombin Drugs 0.000 claims description 11
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 5
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 abstract description 10
- 238000006703 hydration reaction Methods 0.000 abstract description 5
- 239000000047 product Substances 0.000 description 28
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 102000008186 Collagen Human genes 0.000 description 8
- 108010035532 Collagen Proteins 0.000 description 8
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 239000001828 Gelatine Substances 0.000 description 7
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000010339 dilation Effects 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- 239000008187 granular material Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 210000001136 chorion Anatomy 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000565 sealant Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- -1 0.01% to 0.1% w / w Chemical compound 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- BXEFQPCKQSTMKA-UHFFFAOYSA-N OC(=O)C=[N+]=[N-] Chemical class OC(=O)C=[N+]=[N-] BXEFQPCKQSTMKA-UHFFFAOYSA-N 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 208000036064 Surgical Blood Loss Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 150000001541 aziridines Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical class C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical class OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 239000008237 rinsing water Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940068942 topical hemo-stat Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000007631 vascular surgery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/908,464 US7435425B2 (en) | 2001-07-17 | 2001-07-17 | Dry hemostatic compositions and methods for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1414370E true PT1414370E (pt) | 2007-05-31 |
Family
ID=25425842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT07005206T PT1803417E (pt) | 2001-07-17 | 2002-06-21 | Composições hemostáticas secas e processos para a sua preparação |
| PT02744588T PT1414370E (pt) | 2001-07-17 | 2002-06-21 | Composições hemostáticas secas e processos para a sua preparação. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT07005206T PT1803417E (pt) | 2001-07-17 | 2002-06-21 | Composições hemostáticas secas e processos para a sua preparação |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7435425B2 (enExample) |
| EP (2) | EP1414370B1 (enExample) |
| JP (1) | JP4316374B2 (enExample) |
| KR (1) | KR100904582B1 (enExample) |
| CN (2) | CN101284146B (enExample) |
| AT (2) | ATE415136T1 (enExample) |
| AU (1) | AU2002345846B2 (enExample) |
| BR (1) | BRPI0211258B8 (enExample) |
| CA (1) | CA2453592C (enExample) |
| DE (2) | DE60230079D1 (enExample) |
| DK (2) | DK1803417T3 (enExample) |
| ES (2) | ES2284883T3 (enExample) |
| MX (1) | MXPA04000514A (enExample) |
| PT (2) | PT1803417E (enExample) |
| WO (1) | WO2003007845A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
| US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
| US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
| US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
| US7955288B2 (en) | 2002-12-11 | 2011-06-07 | Ferrosan Medical Devices A/S | Gelatine-based materials as swabs |
| US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
| US8440225B2 (en) * | 2003-08-07 | 2013-05-14 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| US20060019868A1 (en) * | 2004-01-30 | 2006-01-26 | Pendharkar Sanyog M | Hemostatic compositions and devices |
| US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| WO2005072700A2 (en) * | 2004-01-30 | 2005-08-11 | Ferrosan A/S | Haemostatic sprays and compositions |
| US7109163B2 (en) * | 2004-01-30 | 2006-09-19 | Ethicon, Inc. | Hemostatic compositions and devices |
| US8119160B2 (en) * | 2004-06-29 | 2012-02-21 | Ethicon, Inc. | Hemostatic compositions and devices |
| WO2006005340A1 (en) | 2004-07-09 | 2006-01-19 | Ferrosan A/S | Haemostatic composition comprising hyaluronic acid |
| FR2881651A1 (fr) * | 2005-02-09 | 2006-08-11 | Urodelia Sa | Nouveau produit pharmaceutique et procede de fabrication de ce produit pharmaceutique |
| WO2007126411A2 (en) * | 2005-07-28 | 2007-11-08 | Carnegie Mellon University | Biocompatible polymers and methods of use |
| ES2362897T3 (es) * | 2005-12-16 | 2011-07-14 | Oxthera, Inc. | Composiciones y métodos para reducción del oxalato. |
| ES2575933T3 (es) | 2006-05-31 | 2016-07-04 | Baxter International Inc. | Colágeno para su uso en la prevención de la formación de fibrosis epidural después de cirugía espinal |
| TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| CN103933606B (zh) | 2006-12-15 | 2016-08-24 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
| US8133484B2 (en) | 2006-12-15 | 2012-03-13 | Lifebond Ltd | Hemostatic materials and dressing |
| RU2009127718A (ru) * | 2006-12-19 | 2011-01-27 | Ферросан А/С (Dk) | Раневой или тканевой перевязочный материал, содержащий молочнокислые бактерии |
| DE102007038125A1 (de) | 2007-08-03 | 2009-02-05 | Aesculap Ag | Kombination zum Verkleben von biologischen Geweben |
| AR069109A1 (es) | 2007-10-30 | 2009-12-30 | Baxter Int | Uso de una biomatriz de colageno biofuncional regenerativa para tratar defectos viscerales o parietales |
| US20090130756A1 (en) * | 2007-11-20 | 2009-05-21 | Pioneer Surgical Orthobiologics,Inc. | Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles |
| US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| CA2716010C (en) * | 2008-04-03 | 2019-10-01 | Zymogenetics, Inc. | Hemostatic microspheres |
| US8367388B2 (en) | 2008-06-18 | 2013-02-05 | Lifebond Ltd. | Cross-linked compositions |
| US8110208B1 (en) | 2009-03-30 | 2012-02-07 | Biolife, L.L.C. | Hemostatic compositions for arresting blood flow from an open wound or surgical site |
| US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
| CN102802683B (zh) | 2009-06-16 | 2015-11-25 | 巴克斯特国际公司 | 止血海绵 |
| US20110081398A1 (en) * | 2009-10-01 | 2011-04-07 | Tyco Healthcare Group Lp | Multi-mechanism surgical compositions |
| US8968785B2 (en) * | 2009-10-02 | 2015-03-03 | Covidien Lp | Surgical compositions |
| US20110081701A1 (en) * | 2009-10-02 | 2011-04-07 | Timothy Sargeant | Surgical compositions |
| CA2784432C (en) | 2009-12-16 | 2019-01-15 | Baxter Healthcare S.A. | Hemostatic sponge |
| AU2010334412B2 (en) | 2009-12-22 | 2016-02-04 | Lifebond Ltd | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| GB201008404D0 (en) * | 2010-05-20 | 2010-07-07 | Fujifilm Mfg Europe Bv | Hemostatic compositions |
| US8940335B2 (en) * | 2010-06-01 | 2015-01-27 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
| KR101865427B1 (ko) | 2010-06-01 | 2018-06-07 | 백스터 인터내셔널 인코포레이티드 | 건성의 안정된 지혈 조성물의 제조 방법 |
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2001
- 2001-07-17 US US09/908,464 patent/US7435425B2/en not_active Expired - Lifetime
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2002
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- 2002-06-21 DK DK07005206T patent/DK1803417T3/da active
- 2002-06-21 WO PCT/US2002/020022 patent/WO2003007845A1/en not_active Ceased
- 2002-06-21 PT PT07005206T patent/PT1803417E/pt unknown
- 2002-06-21 BR BRPI0211258A patent/BRPI0211258B8/pt not_active IP Right Cessation
- 2002-06-21 EP EP02744588A patent/EP1414370B1/en not_active Expired - Lifetime
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