PT1414370E - Composições hemostáticas secas e processos para a sua preparação. - Google Patents
Composições hemostáticas secas e processos para a sua preparação. Download PDFInfo
- Publication number
- PT1414370E PT1414370E PT02744588T PT02744588T PT1414370E PT 1414370 E PT1414370 E PT 1414370E PT 02744588 T PT02744588 T PT 02744588T PT 02744588 T PT02744588 T PT 02744588T PT 1414370 E PT1414370 E PT 1414370E
- Authority
- PT
- Portugal
- Prior art keywords
- rehydration
- powder
- gelatin
- cross
- aid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims description 15
- 230000002439 hemostatic effect Effects 0.000 title description 7
- 239000000843 powder Substances 0.000 claims abstract description 80
- 229920000159 gelatin Polymers 0.000 claims abstract description 75
- 235000019322 gelatine Nutrition 0.000 claims abstract description 75
- 108010010803 Gelatin Proteins 0.000 claims abstract description 68
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 68
- 239000008273 gelatin Substances 0.000 claims abstract description 66
- 238000004132 cross linking Methods 0.000 claims abstract description 13
- 239000002202 Polyethylene glycol Substances 0.000 claims description 22
- 229920001223 polyethylene glycol Polymers 0.000 claims description 22
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 19
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 16
- 229920002307 Dextran Polymers 0.000 claims description 15
- 239000000017 hydrogel Substances 0.000 claims description 15
- 239000012065 filter cake Substances 0.000 claims description 14
- 108090000190 Thrombin Proteins 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 11
- 229960004072 thrombin Drugs 0.000 claims description 11
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 5
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 abstract description 10
- 238000006703 hydration reaction Methods 0.000 abstract description 5
- 239000000047 product Substances 0.000 description 28
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 102000008186 Collagen Human genes 0.000 description 8
- 108010035532 Collagen Proteins 0.000 description 8
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 239000001828 Gelatine Substances 0.000 description 7
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000010339 dilation Effects 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- 239000008187 granular material Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 210000001136 chorion Anatomy 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000565 sealant Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000001488 sodium phosphate Substances 0.000 description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- -1 0.01% to 0.1% w / w Chemical compound 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- BXEFQPCKQSTMKA-UHFFFAOYSA-N OC(=O)C=[N+]=[N-] Chemical class OC(=O)C=[N+]=[N-] BXEFQPCKQSTMKA-UHFFFAOYSA-N 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 208000036064 Surgical Blood Loss Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 150000001541 aziridines Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical class C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 150000002463 imidates Chemical class 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical class OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 239000008237 rinsing water Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940068942 topical hemo-stat Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000007631 vascular surgery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0031—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/908,464 US7435425B2 (en) | 2001-07-17 | 2001-07-17 | Dry hemostatic compositions and methods for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1414370E true PT1414370E (pt) | 2007-05-31 |
Family
ID=25425842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02744588T PT1414370E (pt) | 2001-07-17 | 2002-06-21 | Composições hemostáticas secas e processos para a sua preparação. |
| PT07005206T PT1803417E (pt) | 2001-07-17 | 2002-06-21 | Composições hemostáticas secas e processos para a sua preparação |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT07005206T PT1803417E (pt) | 2001-07-17 | 2002-06-21 | Composições hemostáticas secas e processos para a sua preparação |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7435425B2 (enExample) |
| EP (2) | EP1414370B1 (enExample) |
| JP (1) | JP4316374B2 (enExample) |
| KR (1) | KR100904582B1 (enExample) |
| CN (2) | CN101284146B (enExample) |
| AT (2) | ATE415136T1 (enExample) |
| AU (1) | AU2002345846B2 (enExample) |
| BR (1) | BRPI0211258B8 (enExample) |
| CA (1) | CA2453592C (enExample) |
| DE (2) | DE60219319T2 (enExample) |
| DK (2) | DK1414370T3 (enExample) |
| ES (2) | ES2317600T3 (enExample) |
| MX (1) | MXPA04000514A (enExample) |
| PT (2) | PT1414370E (enExample) |
| WO (1) | WO2003007845A1 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
| US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
| US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
| BR0317237A (pt) | 2002-12-11 | 2005-11-01 | Ferrosan As | Dispositivo para amostragem ou coleta, kit, usos de um dispositivo e de um kit, e, métodos para diminuir a quantidade de um marcador em uma área de amostra, para amostrar de modo qualitativo ou quantitativo uma área quanto ao teor de um marcador e para cultivar microorganismos ou células de mamìferos coletados |
| US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
| US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| US20060019868A1 (en) * | 2004-01-30 | 2006-01-26 | Pendharkar Sanyog M | Hemostatic compositions and devices |
| US8440225B2 (en) * | 2003-08-07 | 2013-05-14 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| WO2005072700A2 (en) * | 2004-01-30 | 2005-08-11 | Ferrosan A/S | Haemostatic sprays and compositions |
| US7109163B2 (en) * | 2004-01-30 | 2006-09-19 | Ethicon, Inc. | Hemostatic compositions and devices |
| US8119160B2 (en) * | 2004-06-29 | 2012-02-21 | Ethicon, Inc. | Hemostatic compositions and devices |
| CN101001649B (zh) | 2004-07-09 | 2011-08-31 | 弗罗桑医疗设备公司 | 包括透明质酸的止血组合物及其制备方法 |
| FR2881651A1 (fr) * | 2005-02-09 | 2006-08-11 | Urodelia Sa | Nouveau produit pharmaceutique et procede de fabrication de ce produit pharmaceutique |
| EP2093256A3 (en) * | 2005-07-28 | 2009-10-14 | Carnegie Mellon University | Biocompatible polymers and methods of use |
| US8900575B2 (en) * | 2005-12-16 | 2014-12-02 | Oxthera Intellectual Property Ab | Compositions and methods for oxalate reduction |
| CA2651941C (en) | 2006-05-31 | 2015-02-17 | Baxter International Inc. | Method for directed cell in-growth and controlled tissue regeneration in spinal surgery |
| TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| AU2007334394B2 (en) | 2006-12-15 | 2013-06-06 | Lifebond Ltd. | Gelatin-transglutaminase hemostatic dressings and sealants |
| US8133484B2 (en) | 2006-12-15 | 2012-03-13 | Lifebond Ltd | Hemostatic materials and dressing |
| US20100143447A1 (en) * | 2006-12-19 | 2010-06-10 | Ferrosan A/S | Wound or tissue dressing comprising lactic acid bacteria |
| DE102007038125A1 (de) | 2007-08-03 | 2009-02-05 | Aesculap Ag | Kombination zum Verkleben von biologischen Geweben |
| WO2009056298A2 (en) | 2007-10-30 | 2009-05-07 | Baxter International Inc. | Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects |
| EP3338549A1 (en) * | 2007-11-20 | 2018-06-27 | Pioneer Surgical Orthobiologics, Inc. | Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles |
| RU2545810C2 (ru) | 2008-02-29 | 2015-04-10 | Ферросан Медикал Дивайсиз А/С | Устройство для ускорения остановки кровотечения и/или заживления ран |
| EP2265728A4 (en) * | 2008-04-03 | 2012-08-01 | Zymogenetics Inc | HEMOSTATIC MICROSPHERES |
| WO2009153750A2 (en) | 2008-06-18 | 2009-12-23 | Lifebond Ltd | Improved cross-linked compositions |
| US8110208B1 (en) | 2009-03-30 | 2012-02-07 | Biolife, L.L.C. | Hemostatic compositions for arresting blood flow from an open wound or surgical site |
| US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
| BRPI1015979A8 (pt) | 2009-06-16 | 2018-06-19 | Baxter Healthcare Sa | esponja porosa hemostática, e, método para fabricar uma esponja porosa hemostática |
| US20110081398A1 (en) * | 2009-10-01 | 2011-04-07 | Tyco Healthcare Group Lp | Multi-mechanism surgical compositions |
| US8968785B2 (en) * | 2009-10-02 | 2015-03-03 | Covidien Lp | Surgical compositions |
| US20110081701A1 (en) * | 2009-10-02 | 2011-04-07 | Timothy Sargeant | Surgical compositions |
| JP2013514093A (ja) | 2009-12-16 | 2013-04-25 | バクスター・インターナショナル・インコーポレイテッド | 止血スポンジ |
| ES2551388T3 (es) | 2009-12-22 | 2015-11-18 | Lifebond Ltd | Modificación de agentes de entrecruzamiento enzimáticos para controlar las propiedades de las matrices entrecruzadas |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| GB201008404D0 (en) * | 2010-05-20 | 2010-07-07 | Fujifilm Mfg Europe Bv | Hemostatic compositions |
| ES2676208T3 (es) | 2010-06-01 | 2018-07-17 | Baxter International Inc. | Proceso para la producción de composiciones hemostáticas secas y estables |
| CN103037845B (zh) | 2010-06-01 | 2015-11-25 | 巴克斯特国际公司 | 用于制备干燥、稳定的止血组合物的方法 |
| ES2682302T3 (es) | 2010-06-01 | 2018-09-19 | Baxter International Inc | Proceso para la producción de composiciones hemostáticas secas y estables |
| AU2011287215B2 (en) | 2010-08-05 | 2015-09-10 | Lifebond Ltd. | Dry composition wound dressings and adhesives |
| WO2012138453A1 (en) | 2011-04-03 | 2012-10-11 | The General Hospital Corporation | Efficient protein expression in vivo using modified rna (mod-rna) |
| US9149511B2 (en) * | 2011-06-30 | 2015-10-06 | Ethicon, Inc. | Procoagulant peptides and their derivatives and uses therefor |
| CN103998068B (zh) | 2011-10-11 | 2016-05-25 | 巴克斯特国际公司 | 止血组合物 |
| US20130096082A1 (en) | 2011-10-11 | 2013-04-18 | Baxter Healthcare S.A. | Hemostatic compositions |
| JP6195568B2 (ja) * | 2011-10-11 | 2017-09-13 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 止血組成物 |
| MX356185B (es) | 2011-10-11 | 2018-05-17 | Baxter Int | Composiciones hemostaticas. |
| KR101975624B1 (ko) | 2011-10-27 | 2019-05-07 | 백스터 인터내셔널 인코포레이티드 | 지혈 조성물 |
| WO2013060769A2 (en) | 2011-10-27 | 2013-05-02 | Baxter International Inc. | Hemostatic compositions |
| WO2013096650A2 (en) | 2011-12-23 | 2013-06-27 | Pioneer Surgical Technology | Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith |
| EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
| EP2977066A3 (en) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| EP3010419B1 (en) | 2013-06-21 | 2020-05-20 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
| JP6489485B2 (ja) * | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ／エス | 押し出し増強因子を含んでいる乾燥組成物 |
| US10814032B2 (en) | 2014-08-08 | 2020-10-27 | The Brigham And Women's Hospital, Inc. | Elastic biopolymer and use as a tissue adhesive |
| CN106999621B (zh) | 2014-10-13 | 2020-07-03 | 弗罗桑医疗设备公司 | 用于止血和伤口愈合的干组合物 |
| BR112017013565B1 (pt) | 2014-12-24 | 2021-12-28 | Ferrosan Medical Devices A/S | Seringa para retenção e mistura de primeira e segunda substâncias |
| WO2016149615A1 (en) | 2015-03-19 | 2016-09-22 | The Brigham And Women's Hospital, Inc. | Polypeptide compositions and methods of using the same |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| KR102641229B1 (ko) | 2015-09-01 | 2024-02-29 | 백스터 인터내셔널 인코포레이티드 | 지혈 물질 |
| ES3027197T3 (en) | 2016-02-08 | 2025-06-13 | Brigham & Womens Hospital Inc | Bioadhesive for corneal repair |
| CN105879109A (zh) * | 2016-03-31 | 2016-08-24 | 武汉华同信生物科技有限公司 | 一种医用胶粘剂及其制备方法 |
| KR20180027126A (ko) * | 2016-09-06 | 2018-03-14 | (주)한국비엠아이 | 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물 |
| US11679177B2 (en) | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
| EP3664872B1 (en) | 2017-11-03 | 2021-10-06 | Baxter International, Inc. | Polymeric compositions, delivery devices, and methods |
| KR20200093600A (ko) * | 2017-11-28 | 2020-08-05 | 백스터 인터내셔널 인코포레이티드 | 상처-치료용 흡수제 |
| US11583610B2 (en) | 2017-12-29 | 2023-02-21 | Baxter International Inc. | Spray-dried thrombin and methods of using and making spray-dried thrombin |
| AU2019266529B2 (en) | 2018-05-09 | 2024-05-23 | Ethicon Inc. | Method for preparing a haemostatic composition |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| WO2020051133A1 (en) | 2018-09-04 | 2020-03-12 | Massachusetts Eye And Ear Infirmary | Light activated adhesive scaffold |
| AU2020312628B2 (en) | 2019-07-12 | 2025-08-14 | Gatt Technologies B.V. | Biocompatible, flexible, haemostatic sheet |
| CA3146680A1 (en) | 2019-07-12 | 2021-01-21 | Gatt Technologies B.V. | Haemostatic powder |
| BR112022000513A2 (pt) | 2019-07-12 | 2022-03-03 | Gatt Tech B V | Método para preparar uma folha adesiva tecidual e folha adesiva tecidual |
| JPWO2021261080A1 (enExample) * | 2020-06-26 | 2021-12-30 | ||
| EP4274624B1 (en) | 2021-01-08 | 2024-09-25 | Cilag GmbH International | Bioresorbable sealing powder |
| CN113144277B (zh) * | 2021-04-13 | 2022-06-14 | 武汉理工大学 | 一种可注射流体明胶及其制备方法和应用 |
| CN113209357B (zh) * | 2021-05-14 | 2023-02-17 | 南方科技大学 | 复合止血粉 |
| WO2023042146A1 (en) * | 2021-09-16 | 2023-03-23 | Ethicon, Inc. | Kit for composition for tissue tract sealing |
| AU2022398334A1 (en) | 2021-11-29 | 2024-05-02 | Baxter Healthcare Sa | Improved hemostat reconstitution methods and devices |
| CN117298327B (zh) * | 2023-11-15 | 2024-10-01 | 北京帝康医药投资管理有限公司 | 一种止血微球颗粒及其制备方法和应用 |
Family Cites Families (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507244A (en) | 1947-04-14 | 1950-05-09 | Upjohn Co | Surgical gelatin dusting powder and process for preparing same |
| CH264752A (de) | 1947-06-03 | 1949-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Trägern für Arzneimittel. |
| US3089315A (en) | 1961-09-25 | 1963-05-14 | Gen Electric | Convertible self-contained cooling unit for air conditioning |
| SE420565B (sv) | 1974-06-06 | 1981-10-19 | Pharmacia Ab | Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel |
| US4013078A (en) * | 1974-11-25 | 1977-03-22 | Feild James Rodney | Intervertebral protector means |
| US4006220A (en) | 1975-06-04 | 1977-02-01 | Gottlieb Sheldon K | Compositions and methods useful for repairing depressed cutaneous scars |
| US4164559A (en) * | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
| DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| US4265233A (en) * | 1978-04-12 | 1981-05-05 | Unitika Ltd. | Material for wound healing |
| US4179400A (en) | 1978-05-09 | 1979-12-18 | W. R. Grace & Co. | Process for preparing catalytic solutions of sulfonium salts |
| AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| AT359653B (de) * | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| DE3036033A1 (de) | 1980-09-24 | 1982-05-06 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung |
| US4300494A (en) | 1979-09-26 | 1981-11-17 | Shell Oil Company | Thermal insulated intake ports |
| US4292972A (en) | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
| US4443332A (en) * | 1980-07-14 | 1984-04-17 | Oros Company | Cross flow solid-to-solid heat transfer apparatus |
| DE3105624A1 (de) * | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| DE3360633D1 (en) * | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
| US4482386A (en) | 1982-03-26 | 1984-11-13 | Warner-Lambert Company | Method of conditioning a water swellable hydrocolloid |
| US4543332A (en) | 1982-03-29 | 1985-09-24 | Miles Laboratories, Inc. | Method for the preparation of spherical microorganism cell aggregates |
| US4540410A (en) | 1982-11-16 | 1985-09-10 | Serono Pharmaceutical Partners | Lyophilized compositions, preparation and use thereof |
| DE3466702D1 (en) | 1983-07-14 | 1987-11-12 | Hitachi Chemical Co Ltd | Gelatin spherical gels and production thereof |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4515637A (en) * | 1983-11-16 | 1985-05-07 | Seton Company | Collagen-thrombin compositions |
| AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
| US4600574A (en) * | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
| US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
| JPS6144825A (ja) * | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
| GB8422950D0 (en) * | 1984-09-11 | 1984-10-17 | Warne K J | Hydrogel |
| JPS61122222A (ja) * | 1984-11-19 | 1986-06-10 | Koken:Kk | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
| US5178883A (en) * | 1984-11-29 | 1993-01-12 | Regents Of The University Of Minnesota | Method for promoting hair growth |
| US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
| US4600533A (en) | 1984-12-24 | 1986-07-15 | Collagen Corporation | Collagen membranes for medical use |
| US5007916A (en) * | 1985-08-22 | 1991-04-16 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
| IE59361B1 (en) * | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
| IL78826A (en) * | 1986-05-19 | 1991-05-12 | Yissum Res Dev Co | Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom |
| US5300494A (en) * | 1986-06-06 | 1994-04-05 | Union Carbide Chemicals & Plastics Technology Corporation | Delivery systems for quaternary and related compounds |
| US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
| US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
| US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
| CA1305069C (en) | 1987-03-11 | 1992-07-14 | John Cornell | Wound dressings in sheet or gelled paste form |
| US4885161A (en) | 1987-03-11 | 1989-12-05 | Medi-Tech International Corporation | Wound dressings in gelled paste form |
| US5080893A (en) * | 1988-05-31 | 1992-01-14 | University Of Florida | Method for preventing surgical adhesions using a dilute solution of polymer |
| US5017229A (en) * | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US5140016A (en) * | 1988-05-31 | 1992-08-18 | University Of Florida | Method and composition for preventing surgical adhesions using a dilute solution of polymer |
| US5350573A (en) * | 1988-05-31 | 1994-09-27 | University Of Florida Research Foundation, Inc. | Method and composition for preventing surgical adhesions |
| US5447966A (en) * | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
| US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
| US5041292A (en) * | 1988-08-31 | 1991-08-20 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
| US5126141A (en) * | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
| US5135751A (en) * | 1988-11-16 | 1992-08-04 | Mediventures Incorporated | Composition for reducing postsurgical adhesions |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5614587A (en) * | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
| US4891359A (en) * | 1988-12-08 | 1990-01-02 | Johnson & Johnson Patient Care, Inc. | Hemostatic collagen paste composition |
| DE3903672C1 (enExample) * | 1989-02-08 | 1990-02-01 | Lohmann Gmbh & Co Kg | |
| CA2051638A1 (en) | 1989-08-10 | 1991-02-11 | John Richard Hull | Medical dispensing system for tissue adhesive components |
| US5196185A (en) | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
| US5061274A (en) | 1989-12-04 | 1991-10-29 | Kensey Nash Corporation | Plug device for sealing openings and method of use |
| US5219328A (en) * | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
| US5134229A (en) * | 1990-01-12 | 1992-07-28 | Johnson & Johnson Medical, Inc. | Process for preparing a neutralized oxidized cellulose product and its method of use |
| JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
| US5306501A (en) * | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
| US5595735A (en) * | 1990-05-23 | 1997-01-21 | Johnson & Johnson Medical, Inc. | Hemostatic thrombin paste composition |
| US5209776A (en) * | 1990-07-27 | 1993-05-11 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
| US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
| US5108421A (en) | 1990-10-01 | 1992-04-28 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
| US5192300A (en) * | 1990-10-01 | 1993-03-09 | Quinton Instrument Company | Insertion assembly and method of inserting a vessel plug into the body of a patient |
| NO302481B1 (no) * | 1990-10-16 | 1998-03-09 | Takeda Chemical Industries Ltd | Polymer for et preparat med forlenget frigjöring, samt preparat med forlenget frigjöring |
| US5129882A (en) * | 1990-12-27 | 1992-07-14 | Novoste Corporation | Wound clotting device and method of using same |
| US5690675A (en) | 1991-02-13 | 1997-11-25 | Fusion Medical Technologies, Inc. | Methods for sealing of staples and other fasteners in tissue |
| JPH06500802A (ja) * | 1991-06-14 | 1994-01-27 | アムジエン・インコーポレーテツド | コラーゲンフィルムによるタンパクのドラッグ・デリバリー |
| AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
| JP3267972B2 (ja) * | 1992-02-28 | 2002-03-25 | コラーゲン コーポレイション | 高濃度均質化コラーゲン組成物 |
| US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
| EP0627899B1 (en) | 1992-02-28 | 2001-11-07 | Cohesion Technologies, Inc. | Injectable ceramic compositions and methods for their preparation and use |
| US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
| JPH07506991A (ja) * | 1992-04-23 | 1995-08-03 | シメッド ライフ システムズ インコーポレイテッド | 血管穿刺を密封するための装置及び方法 |
| IL105529A0 (en) * | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
| AU4406793A (en) * | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
| US5385606A (en) * | 1992-07-06 | 1995-01-31 | Kowanko; Nicholas | Adhesive composition and method |
| US5413571A (en) * | 1992-07-16 | 1995-05-09 | Sherwood Medical Company | Device for sealing hemostatic incisions |
| US5428022A (en) * | 1992-07-29 | 1995-06-27 | Collagen Corporation | Composition of low type III content human placental collagen |
| US5514379A (en) * | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
| DE4227681C2 (de) | 1992-08-21 | 1995-05-18 | Becker & Co Naturinwerk | Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung |
| ATE206602T1 (de) * | 1992-11-12 | 2001-10-15 | Neville Alleyne | Einrichtung zum schutz des herzens |
| US5667839A (en) * | 1993-01-28 | 1997-09-16 | Collagen Corporation | Human recombinant collagen in the milk of transgenic animals |
| DE69427908T2 (de) | 1993-05-31 | 2001-11-22 | Kaken Pharmaceutical Co., Ltd. | Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält |
| FR2715309B1 (fr) * | 1994-01-24 | 1996-08-02 | Imedex | Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé. |
| US5674275A (en) | 1994-04-06 | 1997-10-07 | Graphic Controls Corporation | Polyacrylate and polymethacrylate ester based hydrogel adhesives |
| US5531759A (en) * | 1994-04-29 | 1996-07-02 | Kensey Nash Corporation | System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating |
| DE69530553T2 (de) * | 1994-05-13 | 2004-03-25 | KURARAY CO., LTD, Kurashiki | Medizinisches polymergel |
| GB9415739D0 (en) | 1994-07-30 | 1994-09-21 | Scimat Ltd | Gel wound dressing |
| US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5931165A (en) * | 1994-09-06 | 1999-08-03 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
| US20030039695A1 (en) | 2001-08-10 | 2003-02-27 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Collagen carrier of therapeutic genetic material, and method |
| US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
| US5580923A (en) | 1995-03-14 | 1996-12-03 | Collagen Corporation | Anti-adhesion films and compositions for medical use |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
| PT876165E (pt) * | 1995-12-18 | 2006-10-31 | Angiotech Biomaterials Corp | Composicoes de polimeros reticulados e processos para a sua utilizacao |
| US5748318A (en) * | 1996-01-23 | 1998-05-05 | Brown University Research Foundation | Optical stress generator and detector |
| EP0891193B1 (en) | 1996-04-04 | 2003-08-20 | Baxter Aktiengesellschaft | Hemostatic sponge based on collagen |
| US5902832A (en) * | 1996-08-20 | 1999-05-11 | Menlo Care, Inc. | Method of synthesizing swollen hydrogel for sphincter augmentation |
| US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US7435425B2 (en) | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US6706690B2 (en) * | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US7871637B2 (en) * | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
| US7320962B2 (en) * | 1996-08-27 | 2008-01-22 | Baxter International Inc. | Hemoactive compositions and methods for their manufacture and use |
| CN1157355A (zh) * | 1996-10-21 | 1997-08-20 | 山西省化学纤维研究所 | 止血纤维组成及其气体牵伸法纺丝工艺 |
| AU736784B2 (en) * | 1997-06-03 | 2001-08-02 | Celltran Limited | New medicaments based on polymers composed of methacrylamide-modified gelatin |
| US5908054A (en) | 1997-06-16 | 1999-06-01 | Fusion Medical Technologies, Inc. | Fluid dispersion and delivery assembly and method |
| DE69831964T2 (de) | 1997-09-16 | 2006-07-27 | Integra Lifesciences Corp. | Zusammensetzung zur förderung des wachstums von duralem oder meningealem gewebe enthaltend kollagen |
| US5997895A (en) | 1997-09-16 | 1999-12-07 | Integra Lifesciences Corporation | Dural/meningeal repair product using collagen matrix |
| US6179872B1 (en) * | 1998-03-17 | 2001-01-30 | Tissue Engineering | Biopolymer matt for use in tissue repair and reconstruction |
| US6227394B1 (en) * | 1998-06-09 | 2001-05-08 | Asahi Glass Company Ltd. | Glass bulb for a cathode ray tube and a method for producing a cathode ray tube |
| US6110484A (en) * | 1998-11-24 | 2000-08-29 | Cohesion Technologies, Inc. | Collagen-polymer matrices with differential biodegradability |
| US6328229B1 (en) | 1998-12-18 | 2001-12-11 | Cohesion Technologies, Inc. | Low volume mixing spray head for mixing and dispensing of two reactive fluid components |
| US6312725B1 (en) | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| US6312474B1 (en) | 1999-09-15 | 2001-11-06 | Bio-Vascular, Inc. | Resorbable implant materials |
| US6221109B1 (en) | 1999-09-15 | 2001-04-24 | Ed. Geistlich Söhne AG fur Chemische Industrie | Method of protecting spinal area |
| CN1114728C (zh) * | 2000-04-21 | 2003-07-16 | 中国石油化工集团公司 | 止血纤维及其制造方法 |
| CA2777791A1 (en) | 2000-09-18 | 2002-03-21 | Organogenesis Inc. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
| EE05587B1 (et) | 2001-01-25 | 2012-10-15 | Nycomed Pharma As | Meetod kollageenksna valmistamiseks |
| US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
| ES2258255T3 (es) | 2003-06-05 | 2006-08-16 | Baxter International Inc. | Composiciones destinadas a la reparacion y la regeneracion de la duramadre humana. |
| WO2005046516A2 (en) * | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and anti-scarring agents |
| US20080091277A1 (en) * | 2004-08-13 | 2008-04-17 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
| EP1907482B1 (en) | 2005-05-04 | 2011-06-08 | SupraPolix B.V. | Hydrogen bonded hydrogels |
| WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
| CA2651941C (en) | 2006-05-31 | 2015-02-17 | Baxter International Inc. | Method for directed cell in-growth and controlled tissue regeneration in spinal surgery |
| TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| WO2009056298A2 (en) * | 2007-10-30 | 2009-05-07 | Baxter International Inc. | Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects |
| US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
| BRPI1015979A8 (pt) | 2009-06-16 | 2018-06-19 | Baxter Healthcare Sa | esponja porosa hemostática, e, método para fabricar uma esponja porosa hemostática |
-
2001
- 2001-07-17 US US09/908,464 patent/US7435425B2/en not_active Expired - Lifetime
-
2002
- 2002-06-21 AU AU2002345846A patent/AU2002345846B2/en not_active Expired
- 2002-06-21 ES ES07005206T patent/ES2317600T3/es not_active Expired - Lifetime
- 2002-06-21 WO PCT/US2002/020022 patent/WO2003007845A1/en not_active Ceased
- 2002-06-21 ES ES02744588T patent/ES2284883T3/es not_active Expired - Lifetime
- 2002-06-21 BR BRPI0211258A patent/BRPI0211258B8/pt not_active IP Right Cessation
- 2002-06-21 EP EP02744588A patent/EP1414370B1/en not_active Expired - Lifetime
- 2002-06-21 AT AT07005206T patent/ATE415136T1/de active
- 2002-06-21 DE DE60219319T patent/DE60219319T2/de not_active Expired - Lifetime
- 2002-06-21 DK DK02744588T patent/DK1414370T3/da active
- 2002-06-21 AT AT02744588T patent/ATE358455T1/de active
- 2002-06-21 JP JP2003513454A patent/JP4316374B2/ja not_active Expired - Fee Related
- 2002-06-21 EP EP07005206A patent/EP1803417B1/en not_active Expired - Lifetime
- 2002-06-21 CN CN2008101081388A patent/CN101284146B/zh not_active Expired - Lifetime
- 2002-06-21 CN CNB028182073A patent/CN100402096C/zh not_active Expired - Lifetime
- 2002-06-21 MX MXPA04000514A patent/MXPA04000514A/es active IP Right Grant
- 2002-06-21 PT PT02744588T patent/PT1414370E/pt unknown
- 2002-06-21 DK DK07005206T patent/DK1803417T3/da active
- 2002-06-21 DE DE60230079T patent/DE60230079D1/de not_active Expired - Lifetime
- 2002-06-21 CA CA002453592A patent/CA2453592C/en not_active Expired - Lifetime
- 2002-06-21 PT PT07005206T patent/PT1803417E/pt unknown
- 2002-06-21 KR KR1020047000565A patent/KR100904582B1/ko not_active Expired - Lifetime
-
2007
- 2007-06-21 US US11/766,516 patent/US7547446B2/en not_active Expired - Lifetime
-
2008
- 2008-07-21 US US12/176,945 patent/US8383141B2/en not_active Expired - Fee Related
-
2009
- 2009-05-19 US US12/468,316 patent/US8092820B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1414370E (pt) | Composições hemostáticas secas e processos para a sua preparação. | |
| US7871637B2 (en) | Dry hemostatic compositions and methods for their preparation | |
| AU2002345846A1 (en) | Dry hemostatic compositions and methods for their preparation | |
| JP6195569B2 (ja) | 止血組成物 | |
| JP6195568B2 (ja) | 止血組成物 | |
| KR20140074993A (ko) | 지혈 조성물 | |
| JP7436052B2 (ja) | 架橋化ヒアルロン酸誘導体マトリックスが含まれている止血組成物 | |
| HK1103342B (en) | Dry hemostatic compositions and methods for their preparation | |
| HK1060277B (en) | Dry hemostatic compositions and methods for their preparation | |
| KR20210053275A (ko) | 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물 |