PT1406894E - Derivados de oxima de piperazina com actividade antagonistica do receptor nk-1 - Google Patents

Derivados de oxima de piperazina com actividade antagonistica do receptor nk-1

Info

Publication number
PT1406894E
PT1406894E PT02784838T PT02784838T PT1406894E PT 1406894 E PT1406894 E PT 1406894E PT 02784838 T PT02784838 T PT 02784838T PT 02784838 T PT02784838 T PT 02784838T PT 1406894 E PT1406894 E PT 1406894E
Authority
PT
Portugal
Prior art keywords
sub
compounds
alkyl
phenyl
substituted
Prior art date
Application number
PT02784838T
Other languages
English (en)
Inventor
Gustaaf J M Van Scharrenburg
Jan H Van Maarseveen
Martinus Th M Tulp
Andrew C Mccreary
Bakker Wouter I Iwema
Hein K A C Coolen
Arnoldus H J Herremans
Den Hoogenband Van Adrianus
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of PT1406894E publication Critical patent/PT1406894E/pt

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
PT02784838T 2001-07-09 2002-07-03 Derivados de oxima de piperazina com actividade antagonistica do receptor nk-1 PT1406894E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202631 2001-07-09
PCT/EP2002/007472 WO2003006459A1 (en) 2001-07-09 2002-07-03 Piperazine oxime derivatives having nk-1 receptor antagonistic activity

Publications (1)

Publication Number Publication Date
PT1406894E true PT1406894E (pt) 2005-05-31

Family

ID=8180620

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02784838T PT1406894E (pt) 2001-07-09 2002-07-03 Derivados de oxima de piperazina com actividade antagonistica do receptor nk-1

Country Status (26)

Country Link
US (1) US7094779B2 (pt)
EP (1) EP1406894B1 (pt)
JP (1) JP3765543B2 (pt)
KR (1) KR100900889B1 (pt)
CN (1) CN1223591C (pt)
AR (1) AR034722A1 (pt)
AT (1) ATE285407T1 (pt)
AU (1) AU2002333229B2 (pt)
BR (1) BR0210080A (pt)
CA (1) CA2446726A1 (pt)
DE (1) DE60202371T2 (pt)
DK (1) DK1406894T3 (pt)
ES (1) ES2230521T3 (pt)
HK (1) HK1067364A1 (pt)
HR (1) HRP20030912A2 (pt)
HU (1) HUP0401093A3 (pt)
IL (2) IL158728A0 (pt)
MX (1) MXPA04000230A (pt)
NO (1) NO20040065L (pt)
PL (1) PL366841A1 (pt)
PT (1) PT1406894E (pt)
RU (1) RU2273639C2 (pt)
SI (1) SI1406894T1 (pt)
UA (1) UA75425C2 (pt)
WO (1) WO2003006459A1 (pt)
ZA (1) ZA200308782B (pt)

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US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
KR100616099B1 (ko) * 2004-09-20 2006-08-28 한국과학기술연구원 Ｔ-타입 칼슘채널 길항제로 유효한 신규 피페라지닐알킬이소옥사졸 유도체
MX2007014377A (es) 2005-05-17 2008-02-06 Plexxikon Inc Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
BRPI0611863B1 (pt) 2005-06-22 2021-11-23 Plexxikon, Inc Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100168197A1 (en) * 2007-02-28 2010-07-01 Naresh Kumar Muscarinic receptor antagonists
EP2170830B1 (en) 2007-07-17 2014-10-15 Plexxikon, Inc. 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS
MY172424A (en) 2009-04-03 2019-11-25 Hoffmann La Roche Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
BR112012012156A2 (pt) 2009-11-06 2015-09-08 Plexxikon Inc compostos e métodos para modulação de cinase, e indicações para esta
TR201816421T4 (tr) 2011-02-07 2018-11-21 Plexxikon Inc Kinaz modülasyonu için bileşikler ve metotlar ve bunların endikasyonları.
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN104958297A (zh) * 2015-06-03 2015-10-07 周玉梅 一种用于麻醉镇静催眠的药物组合物及其应用
CN110615774B (zh) * 2019-09-19 2022-11-11 安徽中医药大学 具有抗炎活性的苄基哌嗪类化合物、制法及医药用途
JP2022090346A (ja) 2020-12-07 2022-06-17 三星電子株式会社 共重合体、ならびに当該共重合体を用いるエレクトロルミネッセンス素子材料およびエレクトロルミネッセンス素子

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AU2002333229B2 (en) 2006-11-30
KR20040013134A (ko) 2004-02-11
RU2003136264A (ru) 2005-04-20
WO2003006459A1 (en) 2003-01-23
CN1223591C (zh) 2005-10-19
JP3765543B2 (ja) 2006-04-12
HRP20030912A2 (en) 2005-08-31
ES2230521T3 (es) 2005-05-01
BR0210080A (pt) 2004-06-22
KR100900889B1 (ko) 2009-06-03
ATE285407T1 (de) 2005-01-15
CA2446726A1 (en) 2003-01-23
DE60202371D1 (de) 2005-01-27
EP1406894A1 (en) 2004-04-14
PL366841A1 (en) 2005-02-07
HK1067364A1 (en) 2005-04-08
NO20040065L (no) 2004-03-09
CN1520409A (zh) 2004-08-11
JP2004536851A (ja) 2004-12-09
US7094779B2 (en) 2006-08-22
IL158728A0 (en) 2004-05-12
AR034722A1 (es) 2004-03-17
HUP0401093A2 (hu) 2004-08-30
RU2273639C2 (ru) 2006-04-10
SI1406894T1 (en) 2005-06-30
MXPA04000230A (es) 2004-05-04
ZA200308782B (en) 2005-02-11
EP1406894B1 (en) 2004-12-22
IL158728A (en) 2009-09-22
HUP0401093A3 (en) 2004-10-28
DE60202371T2 (de) 2005-04-14
DK1406894T3 (da) 2005-03-14
UA75425C2 (en) 2006-04-17
US20040176389A1 (en) 2004-09-09

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