MXPA04000230A - Derivados novedosos de piperazina oxima que tienen actividad antagonista beuroquinina-1. - Google Patents

Derivados novedosos de piperazina oxima que tienen actividad antagonista beuroquinina-1.

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Publication number
MXPA04000230A
MXPA04000230A MXPA04000230A MXPA04000230A MXPA04000230A MX PA04000230 A MXPA04000230 A MX PA04000230A MX PA04000230 A MXPA04000230 A MX PA04000230A MX PA04000230 A MXPA04000230 A MX PA04000230A MX PA04000230 A MXPA04000230 A MX PA04000230A
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compounds
alkyl
phenyl
substituted
group
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MXPA04000230A
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H Van Maarseveen Jan
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Solvay Pharm Bv
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Publication of MXPA04000230A publication Critical patent/MXPA04000230A/es

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Abstract

La presente invencion se refiere a un grupo de derivados novedosos de piperazina oxima que tienen actividad antagonistica NK-1 interesante; (ver formula) la invencion se refiere a los compuestos de la formula general (l), en donde: - X representa fenilo o piridilo sustituido con 1 o 2 sustituyentes a partir del grupo de CH3, CF3, OCH3, halogeno, ciano y 5-CF3-tetrazol-1-ilo; -Y representa 2- o 3-indolilo, fenilo, 7-aza-indol-3-ilo o 3-indazolilo, 2-naftilo, 3- benzo[b]tiofenilo, 2-benzofuranilo, dichos grupos pueden estar sustituidos con uno o mas halogenos o alquilos (1-3C); - n tiene el valor 0-3; - m tiene el valor 0-2; - R1 representa NH2, NH-alquilo (1-3C), dialquilo (1- 3C)N, morfolino o morfolino sustituido con uno o mas grupos metilo y/o metoximetilo, tiomorfolino, 1,1-dioxotiomorfolino, 2-, 3- o 4-piridilo o 4-CH3- piperazinilo; - R2 es hidrogeno, alquilo (1-4C) o fenilo, o R2 junto con (CH2)m en donde m es 1, y los atomos intermediarios de carbono, nitrogeno y oxigeno forman un grupo isoxazolilo o 4,5-dihidroisoxazolilo; - R3 y R4 independientemente representan hidrogeno o metilo, o R3 y R4 juntos son oxigeno; la invencion tambien se refiere a un metodo para la preparacion de los compuestos novedosos, y a las composiciones farmaceuticas que comprenden los compuestos con la formula (1) como un ingrediente activo y al uso de estos compuestos para el tratamiento de trastornos en los cuales estan implicados los receptores de neuroquinina-1 .
MXPA04000230A 2001-07-09 2002-07-03 Derivados novedosos de piperazina oxima que tienen actividad antagonista beuroquinina-1. MXPA04000230A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202631 2001-07-09
PCT/EP2002/007472 WO2003006459A1 (en) 2001-07-09 2002-07-03 Piperazine oxime derivatives having nk-1 receptor antagonistic activity

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MXPA04000230A true MXPA04000230A (es) 2004-05-04

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US (1) US7094779B2 (es)
EP (1) EP1406894B1 (es)
JP (1) JP3765543B2 (es)
KR (1) KR100900889B1 (es)
CN (1) CN1223591C (es)
AR (1) AR034722A1 (es)
AT (1) ATE285407T1 (es)
AU (1) AU2002333229B2 (es)
BR (1) BR0210080A (es)
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HK (1) HK1067364A1 (es)
HR (1) HRP20030912A2 (es)
HU (1) HUP0401093A3 (es)
IL (2) IL158728A0 (es)
MX (1) MXPA04000230A (es)
NO (1) NO20040065L (es)
PL (1) PL366841A1 (es)
PT (1) PT1406894E (es)
RU (1) RU2273639C2 (es)
SI (1) SI1406894T1 (es)
UA (1) UA75425C2 (es)
WO (1) WO2003006459A1 (es)
ZA (1) ZA200308782B (es)

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