DE60202371D1 - Piperazinoximderivate mit nk-1-rezeptorantagonistischer wirkung - Google Patents

Piperazinoximderivate mit nk-1-rezeptorantagonistischer wirkung

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Publication number
DE60202371D1
DE60202371D1 DE60202371T DE60202371T DE60202371D1 DE 60202371 D1 DE60202371 D1 DE 60202371D1 DE 60202371 T DE60202371 T DE 60202371T DE 60202371 T DE60202371 T DE 60202371T DE 60202371 D1 DE60202371 D1 DE 60202371D1
Authority
DE
Germany
Prior art keywords
oxide derivatives
antagonistic effect
receptor antagonistic
piperazine oxide
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60202371T
Other languages
English (en)
Other versions
DE60202371T2 (de
Inventor
Maarseveen H Van
Scharrenburg J Van
Th Tulp
C Mccreary
Bakker I Iwema
K Coolen
H Herremans
Den Hoogenband Adrianus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Healthcare Products BV
Original Assignee
Solvay Pharmaceuticals BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals BV filed Critical Solvay Pharmaceuticals BV
Publication of DE60202371D1 publication Critical patent/DE60202371D1/de
Application granted granted Critical
Publication of DE60202371T2 publication Critical patent/DE60202371T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60202371T 2001-07-09 2002-07-03 Piperazinoximderivate mit nk-1-rezeptorantagonistischer wirkung Expired - Fee Related DE60202371T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01202631 2001-07-09
EP01202631 2001-07-09
PCT/EP2002/007472 WO2003006459A1 (en) 2001-07-09 2002-07-03 Piperazine oxime derivatives having nk-1 receptor antagonistic activity

Publications (2)

Publication Number Publication Date
DE60202371D1 true DE60202371D1 (de) 2005-01-27
DE60202371T2 DE60202371T2 (de) 2005-04-14

Family

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DE60202371T Expired - Fee Related DE60202371T2 (de) 2001-07-09 2002-07-03 Piperazinoximderivate mit nk-1-rezeptorantagonistischer wirkung

Country Status (26)

Country Link
US (1) US7094779B2 (de)
EP (1) EP1406894B1 (de)
JP (1) JP3765543B2 (de)
KR (1) KR100900889B1 (de)
CN (1) CN1223591C (de)
AR (1) AR034722A1 (de)
AT (1) ATE285407T1 (de)
AU (1) AU2002333229B2 (de)
BR (1) BR0210080A (de)
CA (1) CA2446726A1 (de)
DE (1) DE60202371T2 (de)
DK (1) DK1406894T3 (de)
ES (1) ES2230521T3 (de)
HK (1) HK1067364A1 (de)
HR (1) HRP20030912A2 (de)
HU (1) HUP0401093A3 (de)
IL (2) IL158728A0 (de)
MX (1) MXPA04000230A (de)
NO (1) NO20040065L (de)
PL (1) PL366841A1 (de)
PT (1) PT1406894E (de)
RU (1) RU2273639C2 (de)
SI (1) SI1406894T1 (de)
UA (1) UA75425C2 (de)
WO (1) WO2003006459A1 (de)
ZA (1) ZA200308782B (de)

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WO2005062795A2 (en) 2003-12-19 2005-07-14 Plexxikon, Inc. Compounds and methods for development of ret modulators
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
KR100616099B1 (ko) * 2004-09-20 2006-08-28 한국과학기술연구원 Ｔ-타입 칼슘채널 길항제로 유효한 신규 피페라지닐알킬이소옥사졸 유도체
AU2006272951A1 (en) 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
EP1893612B1 (de) 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo[2,3-b]pyridinderivate als proteinkinaseinhibitoren
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100168197A1 (en) * 2007-02-28 2010-07-01 Naresh Kumar Muscarinic receptor antagonists
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
SG173178A1 (en) 2009-04-03 2011-09-29 Hoffmann La Roche Propane- i-sulfonic acid {3- [5- (4 -chloro-phenyl) -1h-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
EA028821B9 (ru) 2011-02-07 2018-10-31 Плексксикон, Инк. Соединения и способы для модуляции киназ, а также показания к их применению
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN104958297A (zh) * 2015-06-03 2015-10-07 周玉梅 一种用于麻醉镇静催眠的药物组合物及其应用
CN110615774B (zh) * 2019-09-19 2022-11-11 安徽中医药大学 具有抗炎活性的苄基哌嗪类化合物、制法及医药用途
JP2022090346A (ja) 2020-12-07 2022-06-17 三星電子株式会社 共重合体、ならびに当該共重合体を用いるエレクトロルミネッセンス素子材料およびエレクトロルミネッセンス素子

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JP3765543B2 (ja) 2006-04-12
ATE285407T1 (de) 2005-01-15
EP1406894B1 (de) 2004-12-22
HK1067364A1 (en) 2005-04-08
RU2273639C2 (ru) 2006-04-10
DK1406894T3 (da) 2005-03-14
US7094779B2 (en) 2006-08-22
IL158728A0 (en) 2004-05-12
CA2446726A1 (en) 2003-01-23
AR034722A1 (es) 2004-03-17
SI1406894T1 (en) 2005-06-30
BR0210080A (pt) 2004-06-22
HUP0401093A2 (hu) 2004-08-30
NO20040065L (no) 2004-03-09
KR20040013134A (ko) 2004-02-11
HRP20030912A2 (en) 2005-08-31
DE60202371T2 (de) 2005-04-14
PL366841A1 (en) 2005-02-07
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PT1406894E (pt) 2005-05-31
IL158728A (en) 2009-09-22
JP2004536851A (ja) 2004-12-09
US20040176389A1 (en) 2004-09-09
UA75425C2 (en) 2006-04-17
CN1520409A (zh) 2004-08-11
WO2003006459A1 (en) 2003-01-23
KR100900889B1 (ko) 2009-06-03
EP1406894A1 (de) 2004-04-14
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MXPA04000230A (es) 2004-05-04
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