DK1385825T3 - Substituerede 2-pyridincyclohexan-1,4-diaminderivater - Google Patents
Substituerede 2-pyridincyclohexan-1,4-diaminderivaterInfo
- Publication number
- DK1385825T3 DK1385825T3 DK02750900T DK02750900T DK1385825T3 DK 1385825 T3 DK1385825 T3 DK 1385825T3 DK 02750900 T DK02750900 T DK 02750900T DK 02750900 T DK02750900 T DK 02750900T DK 1385825 T3 DK1385825 T3 DK 1385825T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- diamine derivatives
- pyridine cyclohexane
- cyclohexane
- pyridine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123163A DE10123163A1 (de) | 2001-05-09 | 2001-05-09 | Substituierte Cyclohexan-1,4-diaminderivate |
| PCT/EP2002/005078 WO2002090330A1 (de) | 2001-05-09 | 2002-05-08 | Substituierte 2-pyridin-cyclohexan-1,4-diaminderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1385825T3 true DK1385825T3 (da) | 2007-11-05 |
Family
ID=7684562
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02738038T DK1392641T3 (da) | 2001-05-09 | 2002-05-08 | Substituerede cyclohexan-1,4-diaminderivater |
| DK02750900T DK1385825T3 (da) | 2001-05-09 | 2002-05-08 | Substituerede 2-pyridincyclohexan-1,4-diaminderivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02738038T DK1392641T3 (da) | 2001-05-09 | 2002-05-08 | Substituerede cyclohexan-1,4-diaminderivater |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20040229872A1 (da) |
| EP (3) | EP1385825B1 (da) |
| JP (3) | JP2004528374A (da) |
| KR (2) | KR20040002943A (da) |
| CN (2) | CN1307158C (da) |
| AR (1) | AR035883A1 (da) |
| AT (2) | ATE359260T1 (da) |
| AU (3) | AU2002312883B2 (da) |
| BR (2) | BR0209580A (da) |
| CA (3) | CA2446463C (da) |
| CO (2) | CO5700725A2 (da) |
| CY (2) | CY1106468T1 (da) |
| CZ (2) | CZ20033005A3 (da) |
| DE (3) | DE10123163A1 (da) |
| DK (2) | DK1392641T3 (da) |
| EC (2) | ECSP034831A (da) |
| ES (2) | ES2291486T3 (da) |
| HK (2) | HK1062911A1 (da) |
| HU (3) | HU228253B1 (da) |
| IL (4) | IL158782A0 (da) |
| MX (3) | MXPA03010134A (da) |
| NO (2) | NO326784B1 (da) |
| NZ (2) | NZ529334A (da) |
| PE (1) | PE20021094A1 (da) |
| PL (3) | PL220595B1 (da) |
| PT (2) | PT1385825E (da) |
| RU (2) | RU2321579C2 (da) |
| SI (2) | SI1392641T1 (da) |
| SK (2) | SK287319B6 (da) |
| WO (3) | WO2002090317A1 (da) |
| ZA (2) | ZA200309521B (da) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| ATE457299T1 (de) | 2002-11-12 | 2010-02-15 | Gruenenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ |
| AU2003295605A1 (en) * | 2002-11-19 | 2004-06-15 | Achillion Pharmaceuticals, Inc. | Substituted aryl thioureas and releated compounds; inhibitors of viral replication |
| US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
| DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023501A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
| DE102004023506A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023522A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| DE102005061428A1 (de) * | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006035787A1 (de) | 2006-07-28 | 2008-03-13 | Tesa Ag | Verfahren zum Stanzen von bei Raumtemperatur nicht tackigen hitzeaktivierbaren Klebmassen |
| US20080194557A1 (en) * | 2007-01-18 | 2008-08-14 | Joseph Barbosa | Methods and compositions for the treatment of pain, inflammation and cancer |
| EP2166841A4 (en) * | 2007-06-15 | 2014-05-07 | Mission Pharma Co | METHODS AND COMPOSITIONS FOR INHIBITING DOME FACTOR AND ADENYLYLCYCLASE |
| US20090215725A1 (en) * | 2008-02-26 | 2009-08-27 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| CL2009000731A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Gmbh | Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea. |
| SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
| DK2257526T3 (da) | 2008-03-27 | 2012-02-06 | Gruenenthal Gmbh | Spiro(5,5)undecan-derivater |
| ES2621407T3 (es) * | 2008-03-27 | 2017-07-04 | Grünenthal GmbH | Ciclohexildiaminas sustituidas |
| CA2718209A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | (hetero)aryl cyclohexane derivatives |
| CN102046595B (zh) * | 2008-03-27 | 2014-03-05 | 格吕伦塔尔有限公司 | 取代的4-氨基环己烷衍生物 |
| UA99540C2 (ru) | 2008-07-21 | 2012-08-27 | Пердью Фарма Л.П. | Замещенные мостиковым хиноксалином пиперидиновые соединения и их применение |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| US8859555B2 (en) | 2009-09-25 | 2014-10-14 | Oryzon Genomics S.A. | Lysine Specific Demethylase-1 inhibitors and their use |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| WO2011106106A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
| WO2011106574A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
| CA2796726C (en) | 2010-04-19 | 2021-02-16 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US9006449B2 (en) | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| RS57331B1 (sr) | 2010-07-29 | 2018-08-31 | Oryzon Genomics Sa | Inhibitori demetilaze za lsd1 zasnovani na arilciklopropilaminu i njihova medicinska upotreba |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712315B1 (en) | 2011-02-08 | 2021-11-24 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| US9469597B2 (en) | 2011-10-20 | 2016-10-18 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| CN104203914B (zh) | 2011-10-20 | 2017-07-11 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
| TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物 |
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| US4065573A (en) * | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
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| WO1997006803A1 (en) | 1995-08-21 | 1997-02-27 | Eli Lilly And Company | 2-acylaminopropanamides as growth hormone secretagogues |
| US6194437B1 (en) | 1996-08-22 | 2001-02-27 | Warner-Lambert Company | Non-peptide bombesin receptor antagonists |
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| GB0012240D0 (en) * | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| US20020028799A1 (en) | 2000-07-06 | 2002-03-07 | Naylor Alasdair Mark | Treatment of male sexual dysfunction |
| US6991916B2 (en) | 2000-07-14 | 2006-01-31 | Pfizer Inc. | Compounds for the treatment of sexual dysfunction |
| KR100526091B1 (ko) * | 2000-10-06 | 2005-11-08 | 다나베 세이야꾸 가부시키가이샤 | 지방족 질소 함유 오원환 화합물 |
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| JP2004517068A (ja) | 2000-11-16 | 2004-06-10 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
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| JP2004522710A (ja) | 2000-11-17 | 2004-07-29 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 性機能障害の治療 |
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