MXPA03010195A - Derivados de ciclohexan-1,4-diamina sustituidos con actividad antiarreica y analgesica periferica. - Google Patents
Derivados de ciclohexan-1,4-diamina sustituidos con actividad antiarreica y analgesica periferica.Info
- Publication number
- MXPA03010195A MXPA03010195A MXPA03010195A MXPA03010195A MXPA03010195A MX PA03010195 A MXPA03010195 A MX PA03010195A MX PA03010195 A MXPA03010195 A MX PA03010195A MX PA03010195 A MXPA03010195 A MX PA03010195A MX PA03010195 A MXPA03010195 A MX PA03010195A
- Authority
- MX
- Mexico
- Prior art keywords
- constipating
- diamine derivatives
- analgesic properties
- pains
- peripheral analgesic
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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Abstract
La presente invencion se refiere al uso de derivados de 1,4-diamina sustituidos para la preparacion de medicamentos para el tratamiento de diarrea o "enfermedades de irritacion intestinal" o para el uso como agentes de inmunoterapia o como analgesico periferico, particularmente para el tratamiento de dolor de quemaduras, dolores perifericos quirurgicos, inflamaciones de tejido blando o enfermedades inflamatorias de las articulaciones, particularmente reumatismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10123163A DE10123163A1 (de) | 2001-05-09 | 2001-05-09 | Substituierte Cyclohexan-1,4-diaminderivate |
PCT/EP2002/005122 WO2002089783A1 (de) | 2001-05-09 | 2002-05-09 | Substituierte cyclohexan-1,4-diaminderivate mit antidiarrhoeischer und peripher analgetischer wirksamkeit |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010195A true MXPA03010195A (es) | 2004-03-10 |
Family
ID=7684562
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010134A MXPA03010134A (es) | 2001-05-09 | 2002-05-08 | Derivados de ciclohexan-1-4-diamina sustituidos. |
MXPA03010201A MXPA03010201A (es) | 2001-05-09 | 2002-05-08 | Derivados de 2-piridin-ciclohexan-1,4-diamina sustituidos. |
MXPA03010195A MXPA03010195A (es) | 2001-05-09 | 2002-05-09 | Derivados de ciclohexan-1,4-diamina sustituidos con actividad antiarreica y analgesica periferica. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010134A MXPA03010134A (es) | 2001-05-09 | 2002-05-08 | Derivados de ciclohexan-1-4-diamina sustituidos. |
MXPA03010201A MXPA03010201A (es) | 2001-05-09 | 2002-05-08 | Derivados de 2-piridin-ciclohexan-1,4-diamina sustituidos. |
Country Status (31)
Country | Link |
---|---|
US (3) | US20040229872A1 (es) |
EP (3) | EP1385825B1 (es) |
JP (3) | JP2004528374A (es) |
KR (2) | KR100895778B1 (es) |
CN (2) | CN1307158C (es) |
AR (1) | AR035883A1 (es) |
AT (2) | ATE370120T1 (es) |
AU (3) | AU2002341195B2 (es) |
BR (2) | BR0209579A (es) |
CA (3) | CA2446461C (es) |
CO (2) | CO5540300A2 (es) |
CY (2) | CY1106468T1 (es) |
CZ (2) | CZ20032995A3 (es) |
DE (3) | DE10123163A1 (es) |
DK (2) | DK1392641T3 (es) |
EC (2) | ECSP034830A (es) |
ES (2) | ES2291486T3 (es) |
HK (2) | HK1062911A1 (es) |
HU (3) | HU228253B1 (es) |
IL (4) | IL158784A0 (es) |
MX (3) | MXPA03010134A (es) |
NO (2) | NO326784B1 (es) |
NZ (2) | NZ529147A (es) |
PE (1) | PE20021094A1 (es) |
PL (3) | PL220595B1 (es) |
PT (2) | PT1385825E (es) |
RU (2) | RU2321579C2 (es) |
SI (2) | SI1385825T1 (es) |
SK (2) | SK287319B6 (es) |
WO (3) | WO2002090330A1 (es) |
ZA (2) | ZA200309521B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
ATE457299T1 (de) | 2002-11-12 | 2010-02-15 | Gruenenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ |
JP4206382B2 (ja) | 2002-11-19 | 2009-01-07 | アキリオン ファーマシューティカルズ,インコーポレーテッド | 置換されたアリールチオウレアおよび関連化合物;ウイルス複製のインヒビター |
US7378409B2 (en) | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
DE102004023501A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023507A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023522A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
DE102005061428A1 (de) * | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
DE102006035787A1 (de) | 2006-07-28 | 2008-03-13 | Tesa Ag | Verfahren zum Stanzen von bei Raumtemperatur nicht tackigen hitzeaktivierbaren Klebmassen |
US20080194557A1 (en) * | 2007-01-18 | 2008-08-14 | Joseph Barbosa | Methods and compositions for the treatment of pain, inflammation and cancer |
EP2166841A4 (en) * | 2007-06-15 | 2014-05-07 | Mission Pharma Co | METHODS AND COMPOSITIONS FOR INHIBITING DOME FACTOR AND ADENYLYLCYCLASE |
US20090215725A1 (en) * | 2008-02-26 | 2009-08-27 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
ATE525379T1 (de) | 2008-03-27 | 2011-10-15 | Gruenenthal Gmbh | Substituierte spirocyclische cyclohexan-derivate |
WO2009118163A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | (hetero-)aryl-cyclohexan-derivate |
CA2719739A1 (en) | 2008-03-27 | 2009-10-01 | Sven Frormann | Hydroxymethylcyclohexylamines |
MX2010010339A (es) | 2008-03-27 | 2010-10-07 | Gruenenthal Gmbh | Ciclohexildiaminas sustituidas. |
CA2719735A1 (en) * | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
SI2257526T1 (sl) | 2008-03-27 | 2012-01-31 | Gruenenthal Chemie | Spiro(5.5)undekanski derivati |
RS52590B2 (sr) | 2008-07-21 | 2018-05-31 | Purdue Pharma Lp | Jedinjenja tipa supstituisanog hinoksalina sa premošćenim piperidinom i njihova upotreba |
WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
MX338041B (es) | 2009-09-25 | 2016-03-30 | Oryzon Genomics Sa | Inhibidores de demetilasa-1 especificos de lisina y su uso. |
WO2011042217A1 (en) | 2009-10-09 | 2011-04-14 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
WO2011106574A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
WO2011106106A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
KR101794020B1 (ko) | 2010-04-19 | 2017-11-06 | 오리존 지노믹스 에스.에이. | 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도 |
WO2012013727A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
LT2598482T (lt) | 2010-07-29 | 2018-07-10 | Oryzon Genomics, S.A. | Demetilazės lsd1 inhibitoriai arilciklopropilamino pagrindu ir jų medicininis panaudojimas |
US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
EP2712315B1 (en) | 2011-02-08 | 2021-11-24 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
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EP3495349B1 (en) | 2011-10-20 | 2023-06-28 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
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