CY1111946T1 - To (1s, 5s) -3-(5,6-διχλωρο-3-πυριδινυλο)-3, 6-διαζαδικυ-κλο[3.2.0]επτανιο ειναι ενας αποτελεσματiκος αναλγητικος παραγοντας - Google Patents
To (1s, 5s) -3-(5,6-διχλωρο-3-πυριδινυλο)-3, 6-διαζαδικυ-κλο[3.2.0]επτανιο ειναι ενας αποτελεσματiκος αναλγητικος παραγονταςInfo
- Publication number
- CY1111946T1 CY1111946T1 CY20111100032T CY111100032T CY1111946T1 CY 1111946 T1 CY1111946 T1 CY 1111946T1 CY 20111100032 T CY20111100032 T CY 20111100032T CY 111100032 T CY111100032 T CY 111100032T CY 1111946 T1 CY1111946 T1 CY 1111946T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyridinyl
- dichloro
- heptane
- diazodicyclo
- analgesic agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η παρούσα εφεύρεση αποκαλύπτει το (1S,5S) -3- (5,6-διχλωρο-3-πυριδινυλο) -3, 6-διαζαδικύκλο[3.2.0]επτάνιο και τη χρήση του στην αντιμετώπιση του πόνου και άλλων διαταραχών που συνδέονται με το νικοτινικό υποδοχέα της ακετυλοχολίνης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/445,555 US20040242641A1 (en) | 2003-05-27 | 2003-05-27 | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
EP04752844A EP1626973B1 (en) | 2003-05-27 | 2004-05-20 | (1s,5s)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111946T1 true CY1111946T1 (el) | 2015-11-04 |
Family
ID=33450880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100032T CY1111946T1 (el) | 2003-05-27 | 2011-01-11 | To (1s, 5s) -3-(5,6-διχλωρο-3-πυριδινυλο)-3, 6-διαζαδικυ-κλο[3.2.0]επτανιο ειναι ενας αποτελεσματiκος αναλγητικος παραγοντας |
Country Status (22)
Country | Link |
---|---|
US (1) | US20040242641A1 (el) |
EP (1) | EP1626973B1 (el) |
JP (1) | JP4716999B2 (el) |
KR (2) | KR20060015738A (el) |
CN (1) | CN1826344B (el) |
AT (1) | ATE485296T1 (el) |
AU (1) | AU2004243270B2 (el) |
BR (1) | BRPI0410808A (el) |
CA (1) | CA2526530C (el) |
CY (1) | CY1111946T1 (el) |
DE (1) | DE602004029671D1 (el) |
DK (1) | DK1626973T3 (el) |
ES (1) | ES2352199T3 (el) |
HK (1) | HK1092135A1 (el) |
MX (1) | MXPA05012738A (el) |
NZ (2) | NZ588123A (el) |
PL (1) | PL1626973T3 (el) |
PT (1) | PT1626973E (el) |
SI (1) | SI1626973T1 (el) |
TW (1) | TWI332502B (el) |
WO (1) | WO2004106342A1 (el) |
ZA (1) | ZA200509601B (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1603585A2 (en) * | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
US20050261348A1 (en) * | 2004-05-21 | 2005-11-24 | Buckley Michael J | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
US7354937B2 (en) * | 2004-05-21 | 2008-04-08 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane |
US7351833B2 (en) * | 2004-07-23 | 2008-04-01 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate |
WO2008028903A2 (en) | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
US8222278B2 (en) * | 2008-06-03 | 2012-07-17 | Abbott Laboratories | Treatment of attention-deficit/hyperactivity disorder |
JP5848251B2 (ja) | 2009-10-23 | 2016-01-27 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
JP5759470B2 (ja) | 2009-10-23 | 2015-08-05 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての二置換オクタヒドロピロロ[3,4−c]ピロール |
EP2491034B1 (en) * | 2009-10-23 | 2013-12-18 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as orexin receptor modulators |
WO2011090669A1 (en) * | 2010-01-20 | 2011-07-28 | Abbott Laboratories | Methods for treating pain |
WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
KR102559922B1 (ko) | 2016-03-10 | 2023-07-25 | 얀센 파마슈티카 엔.브이. | 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
EP1147112B1 (en) * | 1999-01-29 | 2003-10-29 | Abbott Laboratories | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
CN1348449A (zh) * | 1999-04-26 | 2002-05-08 | 神经研究公司 | 杂芳基二氮杂环烷烃及其制备方法和应用 |
HU225894B1 (en) * | 1999-05-21 | 2007-12-28 | Abbott Lab | Heterocyclic substituted aminoazacycles useful as central nervous system agents |
MY137020A (en) | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
-
2003
- 2003-05-27 US US10/445,555 patent/US20040242641A1/en not_active Abandoned
-
2004
- 2004-05-20 KR KR1020057022595A patent/KR20060015738A/ko active IP Right Grant
- 2004-05-20 DK DK04752844.3T patent/DK1626973T3/da active
- 2004-05-20 AT AT04752844T patent/ATE485296T1/de active
- 2004-05-20 NZ NZ588123A patent/NZ588123A/en not_active IP Right Cessation
- 2004-05-20 SI SI200431546T patent/SI1626973T1/sl unknown
- 2004-05-20 BR BRPI0410808-6A patent/BRPI0410808A/pt not_active IP Right Cessation
- 2004-05-20 PT PT04752844T patent/PT1626973E/pt unknown
- 2004-05-20 WO PCT/US2004/015905 patent/WO2004106342A1/en active Application Filing
- 2004-05-20 PL PL04752844T patent/PL1626973T3/pl unknown
- 2004-05-20 NZ NZ543615A patent/NZ543615A/xx not_active IP Right Cessation
- 2004-05-20 JP JP2006533261A patent/JP4716999B2/ja not_active Expired - Fee Related
- 2004-05-20 MX MXPA05012738A patent/MXPA05012738A/es active IP Right Grant
- 2004-05-20 CA CA2526530A patent/CA2526530C/en not_active Expired - Fee Related
- 2004-05-20 DE DE602004029671T patent/DE602004029671D1/de not_active Expired - Lifetime
- 2004-05-20 AU AU2004243270A patent/AU2004243270B2/en not_active Ceased
- 2004-05-20 CN CN2004800213271A patent/CN1826344B/zh not_active Expired - Fee Related
- 2004-05-20 KR KR1020127001475A patent/KR101238281B1/ko not_active IP Right Cessation
- 2004-05-20 ES ES04752844T patent/ES2352199T3/es not_active Expired - Lifetime
- 2004-05-20 EP EP04752844A patent/EP1626973B1/en not_active Expired - Lifetime
- 2004-05-26 TW TW093114944A patent/TWI332502B/zh not_active IP Right Cessation
-
2005
- 2005-11-28 ZA ZA200509601A patent/ZA200509601B/en unknown
-
2006
- 2006-08-07 HK HK06108741.9A patent/HK1092135A1/xx not_active IP Right Cessation
-
2011
- 2011-01-11 CY CY20111100032T patent/CY1111946T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ588123A (en) | 2012-04-27 |
JP2007500220A (ja) | 2007-01-11 |
ATE485296T1 (de) | 2010-11-15 |
ZA200509601B (en) | 2006-10-25 |
CA2526530A1 (en) | 2004-12-09 |
AU2004243270A1 (en) | 2004-12-09 |
BRPI0410808A (pt) | 2006-06-27 |
KR20060015738A (ko) | 2006-02-20 |
CN1826344B (zh) | 2013-03-06 |
AU2004243270B2 (en) | 2009-12-17 |
DK1626973T3 (da) | 2011-01-10 |
KR101238281B1 (ko) | 2013-03-04 |
SI1626973T1 (sl) | 2011-01-31 |
DE602004029671D1 (de) | 2010-12-02 |
CA2526530C (en) | 2013-01-08 |
US20040242641A1 (en) | 2004-12-02 |
JP4716999B2 (ja) | 2011-07-06 |
TWI332502B (en) | 2010-11-01 |
KR20120014235A (ko) | 2012-02-16 |
EP1626973B1 (en) | 2010-10-20 |
HK1092135A1 (en) | 2007-02-02 |
ES2352199T3 (es) | 2011-02-16 |
WO2004106342A1 (en) | 2004-12-09 |
NZ543615A (en) | 2009-04-30 |
MXPA05012738A (es) | 2006-02-22 |
TW200510420A (en) | 2005-03-16 |
PL1626973T3 (pl) | 2011-04-29 |
EP1626973A1 (en) | 2006-02-22 |
CN1826344A (zh) | 2006-08-30 |
PT1626973E (pt) | 2010-12-31 |
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