MX2010002352A - Piperazinil pirazinas y piridinas substituidas como antagonistas del receptor 5-ht7. - Google Patents

Piperazinil pirazinas y piridinas substituidas como antagonistas del receptor 5-ht7.

Info

Publication number
MX2010002352A
MX2010002352A MX2010002352A MX2010002352A MX2010002352A MX 2010002352 A MX2010002352 A MX 2010002352A MX 2010002352 A MX2010002352 A MX 2010002352A MX 2010002352 A MX2010002352 A MX 2010002352A MX 2010002352 A MX2010002352 A MX 2010002352A
Authority
MX
Mexico
Prior art keywords
pyridines
receptor antagonists
optionally substituted
substituted piperazinyl
pyrazines
Prior art date
Application number
MX2010002352A
Other languages
English (en)
Inventor
Michael Philip Cohen
Michael Wade Tidwell
Sandra Ann Filla
Sarah Lynn Hellman
Sean Patrick Hollinshead
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2010002352A publication Critical patent/MX2010002352A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención proporciona compuestos antagonistas del receptor 5-HT7 selectivo de la Fórmula (I) y su uso en el tratamiento de migraña, en donde A es C(H)= o N; m es 0, 1, ó 2; R1 es opcionalmente fenilo substituido, pirazol-4-ilo opcionalmente substituido; imidazolilo opcionalmente substituido, piridilo opcionalmente substituido, o tienilo; R2 es hidrógeno o metilo; y R3 y R4 son como se define aquí.
MX2010002352A 2007-08-28 2008-08-19 Piperazinil pirazinas y piridinas substituidas como antagonistas del receptor 5-ht7. MX2010002352A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96834407P 2007-08-28 2007-08-28
US4875208P 2008-04-29 2008-04-29
PCT/US2008/073543 WO2009029439A1 (en) 2007-08-28 2008-08-19 Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists

Publications (1)

Publication Number Publication Date
MX2010002352A true MX2010002352A (es) 2010-08-04

Family

ID=39873874

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002352A MX2010002352A (es) 2007-08-28 2008-08-19 Piperazinil pirazinas y piridinas substituidas como antagonistas del receptor 5-ht7.

Country Status (21)

Country Link
US (1) US8048884B2 (es)
EP (1) EP2188268B1 (es)
JP (1) JP5290293B2 (es)
KR (1) KR101148616B1 (es)
CN (1) CN101790522B (es)
AR (1) AR068111A1 (es)
AT (1) ATE520673T1 (es)
AU (1) AU2008293715B2 (es)
BR (1) BRPI0816468A2 (es)
CA (1) CA2694911C (es)
CY (1) CY1111848T1 (es)
DK (1) DK2188268T3 (es)
EA (1) EA017809B1 (es)
HR (1) HRP20110624T1 (es)
MX (1) MX2010002352A (es)
PE (1) PE20090629A1 (es)
PL (1) PL2188268T3 (es)
PT (1) PT2188268E (es)
SI (1) SI2188268T1 (es)
TW (1) TW200914020A (es)
WO (1) WO2009029439A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI118473B (fi) 2006-02-17 2007-11-30 Outotec Oyj Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista
CA2699674C (en) * 2007-10-12 2013-07-16 Eli Lilly And Company 5-ht7 receptor antagonists
BR112012026530B1 (pt) 2010-04-16 2018-03-20 Bayer Intellectual Property Gmbh Compostos heterocíclicos como pesticidas, composição os compreendendo e suas utilizações, bem como método para controle de pragas de pragas
CA2849385A1 (en) 2011-10-11 2013-04-18 Ucb Pharma, S.A. 2-oxo-piperidinyl derivatives
FR2995605B1 (fr) 2012-09-18 2014-09-19 Sanofi Sa Derives de macrolides, leur preparation et leur application therapeutique.
US10351535B2 (en) * 2013-12-20 2019-07-16 Esteve Pharmaceuticals, S.A. Piperazine derivatives having multimodal activity against pain
US11505529B2 (en) 2017-03-03 2022-11-22 National Taiwan University 8-phenyl-isoquinolines and pharmaceutical composition thereof used in the treatment of irritable bowel syndrome
KR102014335B1 (ko) * 2017-12-01 2019-08-26 한국과학기술연구원 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1149195C (zh) * 1999-02-10 2004-05-12 伊莱利利公司 5－ht1f激动剂
US20030008880A1 (en) * 2001-05-02 2003-01-09 Pfizer Inc. 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
US7153858B2 (en) * 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
CA2514656A1 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists

Also Published As

Publication number Publication date
SI2188268T1 (sl) 2011-11-30
JP2010537994A (ja) 2010-12-09
EA017809B1 (ru) 2013-03-29
JP5290293B2 (ja) 2013-09-18
AU2008293715B2 (en) 2013-09-19
CN101790522B (zh) 2012-06-27
CY1111848T1 (el) 2015-10-07
BRPI0816468A2 (pt) 2015-03-24
CN101790522A (zh) 2010-07-28
CA2694911C (en) 2013-05-07
EP2188268B1 (en) 2011-08-17
EA201070321A1 (ru) 2010-08-30
US8048884B2 (en) 2011-11-01
CA2694911A1 (en) 2009-03-05
KR101148616B1 (ko) 2012-05-21
TW200914020A (en) 2009-04-01
ATE520673T1 (de) 2011-09-15
HRP20110624T1 (hr) 2011-09-30
WO2009029439A1 (en) 2009-03-05
US20100075976A1 (en) 2010-03-25
KR20100038117A (ko) 2010-04-12
EP2188268A1 (en) 2010-05-26
AR068111A1 (es) 2009-11-04
DK2188268T3 (da) 2011-10-03
PE20090629A1 (es) 2009-05-16
PT2188268E (pt) 2011-10-03
PL2188268T3 (pl) 2011-12-30
AU2008293715A1 (en) 2009-03-05

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