ATE397601T1 - Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors - Google Patents

Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors

Info

Publication number
ATE397601T1
ATE397601T1 AT05744719T AT05744719T ATE397601T1 AT E397601 T1 ATE397601 T1 AT E397601T1 AT 05744719 T AT05744719 T AT 05744719T AT 05744719 T AT05744719 T AT 05744719T AT E397601 T1 ATE397601 T1 AT E397601T1
Authority
AT
Austria
Prior art keywords
ethynylimidazole
pyrazoles
antagonists
pyridine
mglu5 receptor
Prior art date
Application number
AT05744719T
Other languages
English (en)
Inventor
Bernd Buettelmann
Simona Ceccarelli
Georg Jaeschke
Sabine Kolczewski
Richard Porter
Eric Vieira
Paul Spurr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34968402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE397601(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2004/005881 external-priority patent/WO2004108701A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE397601T1 publication Critical patent/ATE397601T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05744719T 2004-06-01 2005-05-23 Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors ATE397601T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2004/005881 WO2004108701A1 (en) 2003-06-05 2004-06-01 Imidazole derivatives as glutmate receptor antagonists
EP04021216 2004-09-07
PCT/EP2005/005559 WO2005118568A1 (en) 2004-06-01 2005-05-23 Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE397601T1 true ATE397601T1 (de) 2008-06-15

Family

ID=34968402

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05744719T ATE397601T1 (de) 2004-06-01 2005-05-23 Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors

Country Status (10)

Country Link
EP (1) EP1756086B1 (de)
CN (1) CN1960984B (de)
AT (1) ATE397601T1 (de)
AU (1) AU2005250101B2 (de)
CA (1) CA2568725C (de)
DE (1) DE602005007350D1 (de)
MX (1) MXPA06013603A (de)
PL (1) PL1756086T3 (de)
RS (1) RS50603B (de)
WO (1) WO2005118568A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006011574A1 (de) * 2006-03-10 2007-10-31 Grünenthal GmbH Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln
AU2007267183B2 (en) 2006-05-31 2011-10-20 F. Hoffmann-La Roche Ag Aryl-4-ethynyl-isoxazole derivatives
WO2008074697A1 (en) 2006-12-21 2008-06-26 F. Hoffmann-La Roche Ag Polymorphs of a mglur5 receptor antagonist
CN101965344B (zh) 2007-06-22 2013-03-06 弗·哈夫曼-拉罗切有限公司 异*唑-咪唑衍生物
WO2009024491A1 (en) * 2007-08-20 2009-02-26 F. Hoffmann-La Roche Ag Use of mglur5 antagonists for the treatment of gerd
KR101175859B1 (ko) 2007-12-04 2012-08-24 에프. 호프만-라 로슈 아게 이속사졸로-피라진 유도체
US7943619B2 (en) 2007-12-04 2011-05-17 Hoffmann-La Roche Inc. Isoxazolo-pyridazine derivatives
US7902201B2 (en) 2007-12-04 2011-03-08 Hoffmann-La Roche Inc. Isoxazolo-pyrazine derivatives
TW201033201A (en) 2009-02-19 2010-09-16 Hoffmann La Roche Isoxazole-isoxazole and isoxazole-isothiazole derivatives
US8389550B2 (en) 2009-02-25 2013-03-05 Hoffmann-La Roche Inc. Isoxazoles / O-pyridines with ethyl and ethenyl linker
US8222246B2 (en) 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
US8227461B2 (en) 2009-04-30 2012-07-24 Hoffmann-La Roche Inc. Isoxazoles
WO2010127968A1 (en) 2009-05-05 2010-11-11 F. Hoffmann-La Roche Ag Isoxazole-pyridazine derivatives
KR101354335B1 (ko) 2009-05-05 2014-02-19 에프. 호프만-라 로슈 아게 인지 장애의 치료에 사용되는 ｇａｂａ ａ 수용체 역 작용제로서의 아이속사졸-티아졸 유도체
CN102414205B (zh) 2009-05-05 2014-11-05 弗·哈夫曼-拉罗切有限公司 异噁唑-吡唑衍生物
MX2011011489A (es) 2009-05-05 2011-11-18 Hoffmann La Roche Derivados de isoxazol-piridina.
EP2427457B1 (de) 2009-05-07 2013-07-17 F.Hoffmann-La Roche Ag Isoxazolpyridinderivate als gaba-modulatoren
US8334287B2 (en) * 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US20120039999A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120040008A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
WO2012127393A1 (en) 2011-03-18 2012-09-27 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
US8785435B2 (en) 2011-10-20 2014-07-22 Hoffmann-La Roche Inc. Solid forms
WO2013163402A1 (en) * 2012-04-26 2013-10-31 Massachusetts Institute Of Technology Methods for treatment of 16p11.2 microdeletion syndrome
UA113223C2 (xx) * 2012-08-13 2016-12-26 Арилетинілпіримідини

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214303A1 (de) * 1999-08-31 2002-06-19 Merck & Co., Inc. Heterozyklische verbindungen und methode zu ihrer verwendung
AU2956702A (en) * 2000-12-04 2002-06-18 Hoffmann La Roche Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
US7091222B2 (en) * 2003-07-03 2006-08-15 Hoffmann-La Roche Inc. Imidazole derivatives
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives

Also Published As

Publication number Publication date
AU2005250101B2 (en) 2011-08-25
CN1960984A (zh) 2007-05-09
EP1756086B1 (de) 2008-06-04
RS50603B (sr) 2010-05-07
DE602005007350D1 (de) 2008-07-17
CA2568725C (en) 2012-11-27
AU2005250101A1 (en) 2005-12-15
CA2568725A1 (en) 2005-12-15
WO2005118568A1 (en) 2005-12-15
EP1756086A1 (de) 2007-02-28
MXPA06013603A (es) 2007-02-08
CN1960984B (zh) 2010-05-12
PL1756086T3 (pl) 2008-11-28

Similar Documents

Publication Publication Date Title
ATE397601T1 (de) Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors
DK1713475T3 (da) 1,3,5-trisubstituerede 4,5-dihydro-1H-pyrazol-derivater med CB1-antagonistisk aktivitet
MY143353A (en) Diazole derivatives
MY143565A (en) Novel fluorocglycoside derivatives of pyrazoles: medicaments containing these compounds, and the use thereof
NO20054082L (no) Pyrazol`1,5-A! 1,3,5! triazinderivater som kannabinoidreseptorligander
NO20055516L (no) Kannabinoidreceptorligander og anvendelser derav
NO20054905L (no) 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
MX2007011023A (es) 2-(4-oxo-4h-quinazolin-3-il) acetamidas y su uso como antagonistas de vasopresin v3.
ATE532781T1 (de) 5-(acylamino)indazol-derivate als kinase- inhibitoren
NO20054407L (no) Cannabinoid reseptor ligander og deres anvendelser
SG140591A1 (en) Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
NO20075624L (no) Nye histamin H3-reseptorligander og deres terapeutiske anvendelser
NO20064015L (no) Kondenserte derivater av pyrazol
DK1888063T3 (da) Antimykotiske midler
NO20070089L (no) DPP-IV inhibitorer
MX2009005358A (es) Derivados de 5-sulfanilmetil-pirazolo[1,5-a]pirimidin-7-ol como antagonistas de cxcr2.
TW200714603A (en) Acylaminobicyclic heteroaromatic compounds and uses thereof
NO20090779L (no) 5,6-bisaryl-2-pyridin-karboksamidderivater, fremstilling og anvendelse derav i terapeutika som uretosin II receptorantagonister
NO20071922L (no) Indazoler, benzisokazoler og benzinsotiazoler og anvendelse derav som ostrogene midler
MX2009006010A (es) Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2.
ATE467636T1 (de) Pyrazoloä3 , 4-düazepinderivate als histamin-h3- antagonisten
TW200609222A (en) Diazole derivatives
MX2010002352A (es) Piperazinil pirazinas y piridinas substituidas como antagonistas del receptor 5-ht7.
UA88910C2 (ru) Гетероциклические соединения для предотвращения или ослабления симптомов заболеваний, которые лечатся коноплей, и способы их получения

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1756086

Country of ref document: EP