EA201070321A1 - Замещённые пиперазинил-пиразины и пиридины в качестве антагонистов рецепторов 5-нт - Google Patents

Замещённые пиперазинил-пиразины и пиридины в качестве антагонистов рецепторов 5-нт

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Publication number
EA201070321A1
EA201070321A1 EA201070321A EA201070321A EA201070321A1 EA 201070321 A1 EA201070321 A1 EA 201070321A1 EA 201070321 A EA201070321 A EA 201070321A EA 201070321 A EA201070321 A EA 201070321A EA 201070321 A1 EA201070321 A1 EA 201070321A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
pyrazines
pyridines
receptors
optionally
Prior art date
Application number
EA201070321A
Other languages
English (en)
Other versions
EA017809B1 (ru
Inventor
Майкл Филип Коэн
Сандра Энн Филла
Сара Линн Хеллман
Шон Патрик Холлиншед
Майкл Вэйд Тидуэлл
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201070321A1 publication Critical patent/EA201070321A1/ru
Publication of EA017809B1 publication Critical patent/EA017809B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Согласно настоящему изобретению предложены соединения, представляющие собой селективные антагонисты рецепторов 5-НТ, имеющие формулу I, и применение указанных соединений при лечении мигренигде А представляет собой -С(Н)= или -N=, m равно 0, 1 или 2; Rпредставляет собой необязательно содержащий заместители фенил; необязательно содержащий заместители пиразол-4-ил; необязательно содержащий заместители имидазолил, необязательно содержащий заместители пиридил или ткенил; Rпредставляет собой водород или метил; а Rи Rимеют значения, определенные в настоящем описании.
EA201070321A 2007-08-28 2008-08-19 Замещённые пиперазинилпиразины и пиридины в качестве антагонистов рецепторов 5-нт EA017809B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96834407P 2007-08-28 2007-08-28
US4875208P 2008-04-29 2008-04-29
PCT/US2008/073543 WO2009029439A1 (en) 2007-08-28 2008-08-19 Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists

Publications (2)

Publication Number Publication Date
EA201070321A1 true EA201070321A1 (ru) 2010-08-30
EA017809B1 EA017809B1 (ru) 2013-03-29

Family

ID=39873874

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070321A EA017809B1 (ru) 2007-08-28 2008-08-19 Замещённые пиперазинилпиразины и пиридины в качестве антагонистов рецепторов 5-нт

Country Status (21)

Country Link
US (1) US8048884B2 (ru)
EP (1) EP2188268B1 (ru)
JP (1) JP5290293B2 (ru)
KR (1) KR101148616B1 (ru)
CN (1) CN101790522B (ru)
AR (1) AR068111A1 (ru)
AT (1) ATE520673T1 (ru)
AU (1) AU2008293715B2 (ru)
BR (1) BRPI0816468A2 (ru)
CA (1) CA2694911C (ru)
CY (1) CY1111848T1 (ru)
DK (1) DK2188268T3 (ru)
EA (1) EA017809B1 (ru)
HR (1) HRP20110624T1 (ru)
MX (1) MX2010002352A (ru)
PE (1) PE20090629A1 (ru)
PL (1) PL2188268T3 (ru)
PT (1) PT2188268E (ru)
SI (1) SI2188268T1 (ru)
TW (1) TW200914020A (ru)
WO (1) WO2009029439A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2709482C1 (ru) * 2013-12-20 2019-12-18 Эстеве Фармасьютикалз, С.А. Производные пиперазина, характеризующиеся мультимодальной активностью в отношении боли

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI118473B (fi) 2006-02-17 2007-11-30 Outotec Oyj Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista
MX2010003986A (es) * 2007-10-12 2010-04-27 Lilly Co Eli Antagonistas del receptor 5-ht7.
CN103119034B (zh) 2010-04-16 2016-08-03 拜耳知识产权有限责任公司 作为害虫防治剂的杂环化合物
US9067930B2 (en) 2011-10-11 2015-06-30 Ucb Pharma, S.A. 2-oxo-piperidinyl derivatives
FR2995605B1 (fr) 2012-09-18 2014-09-19 Sanofi Sa Derives de macrolides, leur preparation et leur application therapeutique.
KR102296368B1 (ko) 2017-03-03 2021-09-01 내셔널 타이완 유니버시티 과민성 대장 증후군의 치료에서 사용되는 8-페닐-이소퀴놀린 및 이의 약제 조성물
KR102014335B1 (ko) * 2017-12-01 2019-08-26 한국과학기술연구원 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1149195C (zh) * 1999-02-10 2004-05-12 伊莱利利公司 5－ht1f激动剂
US20030008880A1 (en) * 2001-05-02 2003-01-09 Pfizer Inc. 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
BRPI0406704A (pt) * 2003-01-31 2005-12-20 Pfizer Prod Inc Antagonistas de 5ht~7~ e agonistas inversos

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2709482C1 (ru) * 2013-12-20 2019-12-18 Эстеве Фармасьютикалз, С.А. Производные пиперазина, характеризующиеся мультимодальной активностью в отношении боли

Also Published As

Publication number Publication date
CY1111848T1 (el) 2015-10-07
CN101790522B (zh) 2012-06-27
PE20090629A1 (es) 2009-05-16
ATE520673T1 (de) 2011-09-15
AR068111A1 (es) 2009-11-04
DK2188268T3 (da) 2011-10-03
EP2188268B1 (en) 2011-08-17
SI2188268T1 (sl) 2011-11-30
KR101148616B1 (ko) 2012-05-21
PT2188268E (pt) 2011-10-03
EP2188268A1 (en) 2010-05-26
US20100075976A1 (en) 2010-03-25
US8048884B2 (en) 2011-11-01
CA2694911C (en) 2013-05-07
AU2008293715B2 (en) 2013-09-19
CA2694911A1 (en) 2009-03-05
AU2008293715A1 (en) 2009-03-05
TW200914020A (en) 2009-04-01
MX2010002352A (es) 2010-08-04
BRPI0816468A2 (pt) 2015-03-24
KR20100038117A (ko) 2010-04-12
JP2010537994A (ja) 2010-12-09
PL2188268T3 (pl) 2011-12-30
EA017809B1 (ru) 2013-03-29
JP5290293B2 (ja) 2013-09-18
WO2009029439A1 (en) 2009-03-05
HRP20110624T1 (hr) 2011-09-30
CN101790522A (zh) 2010-07-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM BY KZ KG MD TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ TJ

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU