AR068111A1 - Compuesto de pirazina y piperidina piperazinil sustituida, composicion farmaceutica que lo comprende y su uso para preparar un medicamento - Google Patents
Compuesto de pirazina y piperidina piperazinil sustituida, composicion farmaceutica que lo comprende y su uso para preparar un medicamentoInfo
- Publication number
- AR068111A1 AR068111A1 ARP080103721A ARP080103721A AR068111A1 AR 068111 A1 AR068111 A1 AR 068111A1 AR P080103721 A ARP080103721 A AR P080103721A AR P080103721 A ARP080103721 A AR P080103721A AR 068111 A1 AR068111 A1 AR 068111A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluoro
- chloro
- methyl
- optionally substituted
- group
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- -1 piperazinyl compound Chemical class 0.000 abstract 8
- 125000001153 fluoro group Chemical group F* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 108091005436 5-HT7 receptors Proteins 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuesto de pirazina y piperidina piperazinil sustituida, antagonista selectivo del receptor 5-HT7, de la formula (1),donde: A es -C(H)= O -N=, R1 se selecciona del grupo que consiste de fenilo opcionalmente sustituido con metoxi o 1 a 3 sustituyentes independientemente seleccionados de fluoro o cloro, pirazol-4-ilo opcionalmente sustituido con 1 a 3 grupos metilo o etilo, imidazolilo opcionalmente sustituido con 1 o 2 metilo o etilo C1-3, piridilo opcionalmente sustituido con fluoro o cloro; y tienilo; R2 es hidrogeno o metilo; m es 0, 1 o 2; R3 se selecciona del grupo que consiste de hidrogeno, fluoro, cloro, hidroxi, metoxi, hidroximetilo, cianometilo, metoximetilo, acetilo, metilcarbonilamino, metilcarbonilaminometilo, pirazol-1-ilmetilo y triazolilmetilo, siempre que cuando R3 es hidrogeno, m no es 0; cada R4 es seleccionado independientemente del grupo que consiste de fluoro, cloro, metilo y metoxi, o alternativamente, dos grupos R4 junto con el fenilo al cual están unidos, forman un grupo indol-4-ilo o una sal del mismo farmacéuticamente aceptable. Composicion farmacéutica que lo comprende. Su uso para preparar un medicamento util para el tratamiento o profilaxis de la migrana.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96834407P | 2007-08-28 | 2007-08-28 | |
| US4875208P | 2008-04-29 | 2008-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068111A1 true AR068111A1 (es) | 2009-11-04 |
Family
ID=39873874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103721A AR068111A1 (es) | 2007-08-28 | 2008-08-27 | Compuesto de pirazina y piperidina piperazinil sustituida, composicion farmaceutica que lo comprende y su uso para preparar un medicamento |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8048884B2 (es) |
| EP (1) | EP2188268B1 (es) |
| JP (1) | JP5290293B2 (es) |
| KR (1) | KR101148616B1 (es) |
| CN (1) | CN101790522B (es) |
| AR (1) | AR068111A1 (es) |
| AT (1) | ATE520673T1 (es) |
| AU (1) | AU2008293715B2 (es) |
| BR (1) | BRPI0816468A2 (es) |
| CA (1) | CA2694911C (es) |
| CY (1) | CY1111848T1 (es) |
| DK (1) | DK2188268T3 (es) |
| EA (1) | EA017809B1 (es) |
| HR (1) | HRP20110624T1 (es) |
| MX (1) | MX2010002352A (es) |
| PE (1) | PE20090629A1 (es) |
| PL (1) | PL2188268T3 (es) |
| PT (1) | PT2188268E (es) |
| SI (1) | SI2188268T1 (es) |
| TW (1) | TW200914020A (es) |
| WO (1) | WO2009029439A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI118473B (fi) | 2006-02-17 | 2007-11-30 | Outotec Oyj | Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista |
| CA2699674C (en) * | 2007-10-12 | 2013-07-16 | Eli Lilly And Company | 5-ht7 receptor antagonists |
| EP2558458B1 (de) | 2010-04-16 | 2017-09-06 | Bayer Intellectual Property GmbH | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| EA025288B1 (ru) | 2011-10-11 | 2016-12-30 | Юсб Фарма, С.А. | Производные 2-оксопиперидинила |
| FR2995605B1 (fr) | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
| AU2014368368C1 (en) | 2013-12-20 | 2019-06-27 | Esteve Pharmaceuticals, S.A. | Piperazine derivatives having multimodal activity against pain |
| EP3589626B1 (en) | 2017-03-03 | 2024-06-12 | National Taiwan University | 8-phenyl-isoquinolines and pharmaceutical composition thereof used in the treatment of irritable bowel syndrome |
| KR102014335B1 (ko) * | 2017-12-01 | 2019-08-26 | 한국과학기술연구원 | 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60036924T2 (de) * | 1999-02-10 | 2008-08-14 | Eli Lilly And Co., Indianapolis | 5-ht1f agonisten |
| US20030008880A1 (en) * | 2001-05-02 | 2003-01-09 | Pfizer Inc. | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| BRPI0406704A (pt) * | 2003-01-31 | 2005-12-20 | Pfizer Prod Inc | Antagonistas de 5ht~7~ e agonistas inversos |
-
2008
- 2008-08-01 TW TW097129418A patent/TW200914020A/zh unknown
- 2008-08-19 WO PCT/US2008/073543 patent/WO2009029439A1/en active Application Filing
- 2008-08-19 CN CN2008801048354A patent/CN101790522B/zh not_active Expired - Fee Related
- 2008-08-19 SI SI200830392T patent/SI2188268T1/sl unknown
- 2008-08-19 DK DK08798144.5T patent/DK2188268T3/da active
- 2008-08-19 CA CA2694911A patent/CA2694911C/en not_active Expired - Fee Related
- 2008-08-19 PL PL08798144T patent/PL2188268T3/pl unknown
- 2008-08-19 BR BRPI0816468 patent/BRPI0816468A2/pt not_active Application Discontinuation
- 2008-08-19 AU AU2008293715A patent/AU2008293715B2/en not_active Ceased
- 2008-08-19 AT AT08798144T patent/ATE520673T1/de active
- 2008-08-19 EA EA201070321A patent/EA017809B1/ru not_active IP Right Cessation
- 2008-08-19 US US12/447,546 patent/US8048884B2/en not_active Expired - Fee Related
- 2008-08-19 MX MX2010002352A patent/MX2010002352A/es active IP Right Grant
- 2008-08-19 JP JP2010523034A patent/JP5290293B2/ja not_active Expired - Fee Related
- 2008-08-19 EP EP08798144A patent/EP2188268B1/en not_active Not-in-force
- 2008-08-19 PT PT08798144T patent/PT2188268E/pt unknown
- 2008-08-19 KR KR1020107004378A patent/KR101148616B1/ko not_active IP Right Cessation
- 2008-08-27 AR ARP080103721A patent/AR068111A1/es unknown
- 2008-08-27 PE PE2008001449A patent/PE20090629A1/es not_active Application Discontinuation
-
2011
- 2011-08-30 HR HR20110624T patent/HRP20110624T1/hr unknown
- 2011-09-20 CY CY20111100910T patent/CY1111848T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201070321A1 (ru) | 2010-08-30 |
| BRPI0816468A2 (pt) | 2015-03-24 |
| CA2694911C (en) | 2013-05-07 |
| ATE520673T1 (de) | 2011-09-15 |
| US20100075976A1 (en) | 2010-03-25 |
| PT2188268E (pt) | 2011-10-03 |
| PE20090629A1 (es) | 2009-05-16 |
| AU2008293715B2 (en) | 2013-09-19 |
| CN101790522A (zh) | 2010-07-28 |
| CY1111848T1 (el) | 2015-10-07 |
| JP2010537994A (ja) | 2010-12-09 |
| HRP20110624T1 (hr) | 2011-09-30 |
| SI2188268T1 (sl) | 2011-11-30 |
| TW200914020A (en) | 2009-04-01 |
| JP5290293B2 (ja) | 2013-09-18 |
| WO2009029439A1 (en) | 2009-03-05 |
| EP2188268A1 (en) | 2010-05-26 |
| CN101790522B (zh) | 2012-06-27 |
| AU2008293715A1 (en) | 2009-03-05 |
| US8048884B2 (en) | 2011-11-01 |
| EP2188268B1 (en) | 2011-08-17 |
| CA2694911A1 (en) | 2009-03-05 |
| PL2188268T3 (pl) | 2011-12-30 |
| KR101148616B1 (ko) | 2012-05-21 |
| KR20100038117A (ko) | 2010-04-12 |
| EA017809B1 (ru) | 2013-03-29 |
| MX2010002352A (es) | 2010-08-04 |
| DK2188268T3 (da) | 2011-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |