PT1042319E - Di-hidro-benzofuranos - Google Patents

Di-hidro-benzofuranos

Info

Publication number
PT1042319E
PT1042319E PT98966288T PT98966288T PT1042319E PT 1042319 E PT1042319 E PT 1042319E PT 98966288 T PT98966288 T PT 98966288T PT 98966288 T PT98966288 T PT 98966288T PT 1042319 E PT1042319 E PT 1042319E
Authority
PT
Portugal
Prior art keywords
benzofuranes
hydro
meaningand
heterocycle
meanings
Prior art date
Application number
PT98966288T
Other languages
English (en)
Portuguese (pt)
Inventor
Dietrich Hafner
Hans-Peter Kley
Hildegard Boss
Armin Hatzelmann
Ulrich Thibaut
Wolf-Rudiger Ulrich
Margaretha Van Der Mey
Ivonne Johanna Van Der Laan
Hendrik Timmerman
Geert Jan Sterk
Rolf Beume
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of PT1042319E publication Critical patent/PT1042319E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
PT98966288T 1997-12-15 1998-12-10 Di-hidro-benzofuranos PT1042319E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97122039 1997-12-15

Publications (1)

Publication Number Publication Date
PT1042319E true PT1042319E (pt) 2004-06-30

Family

ID=8227798

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98966288T PT1042319E (pt) 1997-12-15 1998-12-10 Di-hidro-benzofuranos

Country Status (17)

Country Link
US (1) US6380196B1 (cs)
EP (1) EP1042319B1 (cs)
JP (1) JP2002508368A (cs)
AT (1) ATE258930T1 (cs)
AU (1) AU753576B2 (cs)
CA (1) CA2314111A1 (cs)
CZ (1) CZ299304B6 (cs)
DE (1) DE69821530T2 (cs)
DK (1) DK1042319T3 (cs)
EE (1) EE04312B1 (cs)
ES (1) ES2216349T3 (cs)
HU (1) HU225114B1 (cs)
IL (1) IL136359A (cs)
PL (1) PL191236B1 (cs)
PT (1) PT1042319E (cs)
SI (1) SI1042319T1 (cs)
WO (1) WO1999031090A1 (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60026855T2 (de) 1999-08-21 2006-12-07 Altana Pharma Ag Synergistische kombination von roflumilast und salmeterol
AU7654200A (en) * 1999-09-14 2001-04-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
WO2001030766A1 (en) * 1999-10-25 2001-05-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pde 4 inhibitors
JP2003512466A (ja) * 1999-10-25 2003-04-02 アルタナ ファルマ アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのテトラヒドロチオピランフタラジノン誘導体
JP2003535850A (ja) 2000-06-05 2003-12-02 アルタナ ファルマ アクチエンゲゼルシャフト β−２−アドレナリン受容体として効果的な化合物並びにＰＤＥ４−インヒビター
CZ20032491A3 (cs) * 2001-02-15 2004-01-14 Altana Pharma Ag Ftalazinonpiperidinové deriváty
BR0209076A (pt) * 2001-04-25 2004-08-10 Altana Pharma Ag Derivados de piperazino e seu uso como inibidor de pde4
EP1385848A2 (en) 2001-04-25 2004-02-04 ALTANA Pharma AG Phtalazinones derivatives useful as pde4/7 inhibitors
CN1646118A (zh) * 2002-03-29 2005-07-27 中外制药株式会社 预防或治疗呼吸系统疾病的药物组合物
WO2004018449A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
WO2004018451A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
MXPA05001354A (es) * 2002-08-10 2005-04-28 Altana Pharma Ag Piperidina-ftalazonas sustituidas por pirrolidinodiona como inhibidores pde4.
US20060166995A1 (en) * 2002-08-10 2006-07-27 Altana Pharma Ag Piperidine-n-oxide-derivatives
JP4778449B2 (ja) 2004-02-04 2011-09-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体
WO2005075437A1 (en) * 2004-02-04 2005-08-18 Altana Pharma Ag Pyridazinone derivatives and their use as pde4 inhibitors
JP4890439B2 (ja) * 2005-03-07 2012-03-07 杏林製薬株式会社 ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤
AR057986A1 (es) * 2005-11-21 2008-01-09 Japan Tobacco Inc Compuesto heterociclico y su uso farmaceutico
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721784A (en) * 1986-12-22 1988-01-26 Ortho Pharmaceutical Corporation 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
CA2065364A1 (en) * 1989-04-17 1990-10-18 Hermann Amschler Arylpyridazines, their manufacture, use and medicaments containing them
AU7238191A (en) 1990-02-19 1991-09-03 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
CA2094127A1 (en) * 1990-10-16 1992-04-17 Hermann Amschler Arylpyridazinones
EP0510562A1 (de) * 1991-04-26 1992-10-28 Byk Gulden Lomberg Chemische Fabrik GmbH Neue Pyridazine
ATE141791T1 (de) * 1991-07-05 1996-09-15 Byk Gulden Lomberg Chem Fab Verwendung substituierter pyridazine gegen dermatosen
MX9205794A (es) * 1991-10-09 1993-04-01 Syntex Inc Compuesto de benzo- y pirido- piridazinona y piridazinotiona
DE4230755A1 (de) * 1992-09-14 1994-03-17 Schering Ag Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen
DE69332762T2 (de) 1992-12-02 2003-08-14 Pfizer Inc., New York Cathecoldiether als selektive pde iv hemmungsmittel
US5411935A (en) * 1993-03-17 1995-05-02 Sumitomo Chemical Co., Ltd. Dihydrobenzofuran derivatives, their production and use
MX9700557A (es) 1994-07-22 1997-12-31 Byk Gulden Lomberg Chem Fab Dihidrobenzofuranos.
NZ290952A (en) 1994-08-09 1998-05-27 Eisai Co Ltd Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5821250A (en) * 1996-02-01 1998-10-13 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
CZ299304B6 (cs) 2008-06-11
AU753576B2 (en) 2002-10-24
AU2270199A (en) 1999-07-05
HU225114B1 (en) 2006-06-28
EE200000335A (et) 2001-10-15
EP1042319B1 (en) 2004-02-04
EP1042319A1 (en) 2000-10-11
HUP0004561A2 (hu) 2002-03-28
JP2002508368A (ja) 2002-03-19
US6380196B1 (en) 2002-04-30
IL136359A0 (en) 2001-06-14
ES2216349T3 (es) 2004-10-16
PL341239A1 (en) 2001-03-26
DK1042319T3 (da) 2004-06-01
DE69821530T2 (de) 2004-12-23
WO1999031090A1 (en) 1999-06-24
SI1042319T1 (en) 2004-08-31
CA2314111A1 (en) 1999-06-24
IL136359A (en) 2003-03-12
CZ20002218A3 (cs) 2000-11-15
HUP0004561A3 (en) 2002-04-29
EE04312B1 (et) 2004-06-15
DE69821530D1 (de) 2004-03-11
ATE258930T1 (de) 2004-02-15
PL191236B1 (pl) 2006-04-28

Similar Documents

Publication Publication Date Title
DK1070056T3 (da) Phthalazinon-PDE III/IV-inhibitorer
ATE258930T1 (de) Dihydrobenzifurane
DE59711733D1 (de) 3-thiocarbamoylpyrazol-derivate als pestiziden
DE69910831D1 (de) Epothilonderivate und ihre verwendung als antitumormittel
DK1147089T3 (da) Phenylphenanthridiner med PDE-IV-inhiberende virkning
TR199901653T2 (xx) Fitalazinonlar.
EE200000033A (et) Uudsed tetrasoolderivaadid
YU19499A (sh) Benzonaftiridini kao bronhijalni terapeutici
DE59909760D1 (de) Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität
PT1086096E (pt) Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
NO20022976D0 (no) 2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
ATE294793T1 (de) Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
DE60202669D1 (de) 6-phenylbenzonaphthyidine
ATE320422T1 (de) Metalloproteinase inhibitoren
DE60017374D1 (de) Antibakterielle mittel
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
BR0110328A (pt) Compostos heterocìclicos com atividade antiinflamatória
DE59711147D1 (de) Neue Imidazo- und Oxazolopyridine als Phosphodiesterase Inhibitoren.
AU758194C (en) Novel benzimidazoles and benzoxazoles