IL136359A - Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same - Google Patents

Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL136359A
IL136359A IL13635998A IL13635998A IL136359A IL 136359 A IL136359 A IL 136359A IL 13635998 A IL13635998 A IL 13635998A IL 13635998 A IL13635998 A IL 13635998A IL 136359 A IL136359 A IL 136359A
Authority
IL
Israel
Prior art keywords
derivatives
same
pharmaceutical compositions
compositions containing
dihydrobenzofuran
Prior art date
Application number
IL13635998A
Other languages
English (en)
Other versions
IL136359A0 (en
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of IL136359A0 publication Critical patent/IL136359A0/xx
Publication of IL136359A publication Critical patent/IL136359A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL13635998A 1997-12-15 1998-12-10 Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same IL136359A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122039 1997-12-15
PCT/EP1998/008054 WO1999031090A1 (en) 1997-12-15 1998-12-10 Dihydrobenzofurans

Publications (2)

Publication Number Publication Date
IL136359A0 IL136359A0 (en) 2001-06-14
IL136359A true IL136359A (en) 2003-03-12

Family

ID=8227798

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13635998A IL136359A (en) 1997-12-15 1998-12-10 Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same

Country Status (17)

Country Link
US (1) US6380196B1 (xx)
EP (1) EP1042319B1 (xx)
JP (1) JP2002508368A (xx)
AT (1) ATE258930T1 (xx)
AU (1) AU753576B2 (xx)
CA (1) CA2314111A1 (xx)
CZ (1) CZ299304B6 (xx)
DE (1) DE69821530T2 (xx)
DK (1) DK1042319T3 (xx)
EE (1) EE04312B1 (xx)
ES (1) ES2216349T3 (xx)
HU (1) HU225114B1 (xx)
IL (1) IL136359A (xx)
PL (1) PL191236B1 (xx)
PT (1) PT1042319E (xx)
SI (1) SI1042319T1 (xx)
WO (1) WO1999031090A1 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02001830A (es) 1999-08-21 2002-08-12 Byk Gulden Lomberg Chem Fab Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor.
WO2001019818A1 (en) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
CA2388121A1 (en) 1999-10-25 2001-05-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pde 4 inhibitors
PL354979A1 (en) * 1999-10-25 2004-03-22 Altana Pharma Ag Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors
AU6233201A (en) * 2000-06-05 2001-12-17 Byk Gulden Lomberg Chem Fab Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors
MXPA03007310A (es) * 2001-02-15 2003-12-04 Altana Pharma Ag Derivados de ftalazinona piperidino como inhibidores pde4.
MXPA03009583A (es) 2001-04-25 2004-02-12 Altana Pharma Ag Ftalazinonas novedosas.
KR20030089723A (ko) * 2001-04-25 2003-11-22 알타나 파마 아게 피페라지노-유도체 및 이것의 ｐｄｅ4 억제제로서의 용도
CN1646118A (zh) * 2002-03-29 2005-07-27 中外制药株式会社 预防或治疗呼吸系统疾病的药物组合物
CA2494643A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-n-oxide-derivatives
JP4555684B2 (ja) * 2002-08-10 2010-10-06 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４阻害剤としての、ピロリジンジオンにより置換されたピペリジン−フタラゾン
WO2004018451A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
AU2003255376A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
US7494990B2 (en) * 2004-02-04 2009-02-24 Nycomed Gmbh 2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
US7763617B2 (en) * 2005-03-07 2010-07-27 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine-4-yl pyridazinone derivatives and addition salts thereof, and PDE inhibitors comprising the same derivatives or salts as active ingredient
EP1953147A1 (en) * 2005-11-21 2008-08-06 Japan Tobacco, Inc. Heterocyclic compound and medicinal application thereof
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721784A (en) * 1986-12-22 1988-01-26 Ortho Pharmaceutical Corporation 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
AU640137B2 (en) * 1989-04-17 1993-08-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel arylpyridazines, their manufacture, use and medicaments containing them
JP3120857B2 (ja) 1990-02-19 2000-12-25 中外製薬株式会社 新規な縮合複素環化合物とこれを用いた抗喘息剤
JPH06501941A (ja) * 1990-10-16 1994-03-03 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング アリールピリダジノン
WO1992019602A1 (de) * 1991-04-26 1992-11-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue pyridazine
JPH06508842A (ja) * 1991-07-05 1994-10-06 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 置換ピリダジンの皮膚病に対する使用
WO1993007146A1 (en) 1991-10-09 1993-04-15 Syntex (U.S.A.) Inc. Benzo and pyrido pyridazinone and pyridazinthione compounds with pde iv inhibiting activity
DE4230755A1 (de) * 1992-09-14 1994-03-17 Schering Ag Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen
CA2150812C (en) * 1992-12-02 2002-12-24 Allen J. Duplantier Catechol diethers as selective pde iv inhibitors
US5476834A (en) * 1993-03-17 1995-12-19 Sumitomo Chemical Company, Limited Dihydrobenzofuran derivatives, their production and use
EP0772610B9 (de) * 1994-07-22 2001-07-25 Byk Gulden Lomberg Chemische Fabrik GmbH Dihydrobenzofurane
EP0722936B1 (en) * 1994-08-09 2004-05-19 Eisai Co., Ltd. Fused pyridazine compound
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5821250A (en) * 1996-02-01 1998-10-13 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
HU225114B1 (en) 2006-06-28
CA2314111A1 (en) 1999-06-24
CZ20002218A3 (cs) 2000-11-15
ATE258930T1 (de) 2004-02-15
ES2216349T3 (es) 2004-10-16
HUP0004561A2 (hu) 2002-03-28
PT1042319E (pt) 2004-06-30
AU2270199A (en) 1999-07-05
WO1999031090A1 (en) 1999-06-24
DE69821530T2 (de) 2004-12-23
IL136359A0 (en) 2001-06-14
EE200000335A (et) 2001-10-15
EE04312B1 (et) 2004-06-15
US6380196B1 (en) 2002-04-30
PL341239A1 (en) 2001-03-26
DK1042319T3 (da) 2004-06-01
EP1042319B1 (en) 2004-02-04
EP1042319A1 (en) 2000-10-11
DE69821530D1 (de) 2004-03-11
SI1042319T1 (en) 2004-08-31
CZ299304B6 (cs) 2008-06-11
JP2002508368A (ja) 2002-03-19
PL191236B1 (pl) 2006-04-28
AU753576B2 (en) 2002-10-24
HUP0004561A3 (en) 2002-04-29

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees