IL136359A - Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same - Google Patents
Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL136359A IL136359A IL13635998A IL13635998A IL136359A IL 136359 A IL136359 A IL 136359A IL 13635998 A IL13635998 A IL 13635998A IL 13635998 A IL13635998 A IL 13635998A IL 136359 A IL136359 A IL 136359A
- Authority
- IL
- Israel
- Prior art keywords
- derivatives
- same
- pharmaceutical compositions
- compositions containing
- dihydrobenzofuran
- Prior art date
Links
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical group C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 2
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97122039 | 1997-12-15 | ||
| PCT/EP1998/008054 WO1999031090A1 (en) | 1997-12-15 | 1998-12-10 | Dihydrobenzofurans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL136359A0 IL136359A0 (en) | 2001-06-14 |
| IL136359A true IL136359A (en) | 2003-03-12 |
Family
ID=8227798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13635998A IL136359A (en) | 1997-12-15 | 1998-12-10 | Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6380196B1 (cs) |
| EP (1) | EP1042319B1 (cs) |
| JP (1) | JP2002508368A (cs) |
| AT (1) | ATE258930T1 (cs) |
| AU (1) | AU753576B2 (cs) |
| CA (1) | CA2314111A1 (cs) |
| CZ (1) | CZ299304B6 (cs) |
| DE (1) | DE69821530T2 (cs) |
| DK (1) | DK1042319T3 (cs) |
| EE (1) | EE04312B1 (cs) |
| ES (1) | ES2216349T3 (cs) |
| HU (1) | HU225114B1 (cs) |
| IL (1) | IL136359A (cs) |
| PL (1) | PL191236B1 (cs) |
| PT (1) | PT1042319E (cs) |
| SI (1) | SI1042319T1 (cs) |
| WO (1) | WO1999031090A1 (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL200923B1 (pl) | 1999-08-21 | 2009-02-27 | Nycomed Gmbh | Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu |
| WO2001019818A1 (en) * | 1999-09-14 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| ATE374189T1 (de) * | 1999-10-25 | 2007-10-15 | Nycomed Gmbh | Phthalazinon-derivate als pde 4 hemmer |
| AU781137B2 (en) | 1999-10-25 | 2005-05-05 | Altana Pharma Ag | Tetrahydrothiopy ranphthalazinone derivatives as PDE4 inhibitors |
| CN1471515A (zh) * | 2000-06-05 | 2004-01-28 | ��̹��ҽҩ��˾ | 作为β2-肾上腺素受体激动剂及PDE-4抑制剂的有效的化合物 |
| NZ527424A (en) * | 2001-02-15 | 2005-02-25 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
| BR0209076A (pt) * | 2001-04-25 | 2004-08-10 | Altana Pharma Ag | Derivados de piperazino e seu uso como inibidor de pde4 |
| EP1385848A2 (en) | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Phtalazinones derivatives useful as pde4/7 inhibitors |
| AU2003219559A1 (en) * | 2002-03-29 | 2003-10-13 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for preventing or treating respiratory disease |
| HRP20050198A2 (hr) * | 2002-08-10 | 2006-04-30 | Altana Pharma Ag | Piperidin-piridazoni i ftalazoni kao inhibitori pde4 |
| WO2004018449A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| US20060166995A1 (en) * | 2002-08-10 | 2006-07-27 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| US20060167001A1 (en) * | 2002-08-10 | 2006-07-27 | Sterk Jan G | Pyridazinone-derivatives as pde4 inhibitors |
| JP2006522151A (ja) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症におけるホスホジエステラーゼ阻害剤 |
| EP1716133B1 (en) | 2004-02-04 | 2008-03-26 | Nycomed GmbH | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
| US20080227790A1 (en) * | 2004-02-04 | 2008-09-18 | Altana Pharma Ag | Pyridazinone Derivatives and their Use as Pde4 Inhibitors |
| US7763617B2 (en) * | 2005-03-07 | 2010-07-27 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine-4-yl pyridazinone derivatives and addition salts thereof, and PDE inhibitors comprising the same derivatives or salts as active ingredient |
| AR057986A1 (es) * | 2005-11-21 | 2008-01-09 | Japan Tobacco Inc | Compuesto heterociclico y su uso farmaceutico |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721784A (en) * | 1986-12-22 | 1988-01-26 | Ortho Pharmaceutical Corporation | 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones |
| AU640137B2 (en) * | 1989-04-17 | 1993-08-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel arylpyridazines, their manufacture, use and medicaments containing them |
| JP3120857B2 (ja) | 1990-02-19 | 2000-12-25 | 中外製薬株式会社 | 新規な縮合複素環化合物とこれを用いた抗喘息剤 |
| WO1992006963A1 (de) * | 1990-10-16 | 1992-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Arylpyridazinone |
| US5449676A (en) * | 1991-04-26 | 1995-09-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyridazines |
| EP0523513A1 (de) * | 1991-07-05 | 1993-01-20 | Byk Gulden Lomberg Chemische Fabrik GmbH | Verwendung substituierter Pyridazine zur Behandlung von Dermatosen |
| JP3245165B2 (ja) * | 1991-10-09 | 2002-01-07 | シンテックス（ユー・エス・エイ）・インコーポレイテッド | ピリドピリダジノンおよびピリダジンチオン化合物 |
| DE4230755A1 (de) * | 1992-09-14 | 1994-03-17 | Schering Ag | Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen |
| DK0672031T3 (da) | 1992-12-02 | 2003-06-10 | Pfizer | Catecholdiethere som selektive PDE IV-inhibitorer |
| US5476834A (en) * | 1993-03-17 | 1995-12-19 | Sumitomo Chemical Company, Limited | Dihydrobenzofuran derivatives, their production and use |
| ES2152414T3 (es) * | 1994-07-22 | 2001-02-01 | Byk Gulden Lomberg Chem Fab | Dihidrobenzofuranos. |
| EP0722936B1 (en) | 1994-08-09 | 2004-05-19 | Eisai Co., Ltd. | Fused pyridazine compound |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| US5821250A (en) * | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
-
1998
- 1998-12-10 US US09/554,088 patent/US6380196B1/en not_active Expired - Fee Related
- 1998-12-10 IL IL13635998A patent/IL136359A/xx not_active IP Right Cessation
- 1998-12-10 AU AU22701/99A patent/AU753576B2/en not_active Ceased
- 1998-12-10 SI SI9830628T patent/SI1042319T1/xx unknown
- 1998-12-10 WO PCT/EP1998/008054 patent/WO1999031090A1/en not_active Ceased
- 1998-12-10 DE DE69821530T patent/DE69821530T2/de not_active Expired - Fee Related
- 1998-12-10 DK DK98966288T patent/DK1042319T3/da active
- 1998-12-10 JP JP2000539014A patent/JP2002508368A/ja not_active Withdrawn
- 1998-12-10 PT PT98966288T patent/PT1042319E/pt unknown
- 1998-12-10 EP EP98966288A patent/EP1042319B1/en not_active Expired - Lifetime
- 1998-12-10 ES ES98966288T patent/ES2216349T3/es not_active Expired - Lifetime
- 1998-12-10 HU HU0004561A patent/HU225114B1/hu not_active IP Right Cessation
- 1998-12-10 EE EEP200000335A patent/EE04312B1/xx not_active IP Right Cessation
- 1998-12-10 CZ CZ20002218A patent/CZ299304B6/cs not_active IP Right Cessation
- 1998-12-10 PL PL341239A patent/PL191236B1/pl unknown
- 1998-12-10 AT AT98966288T patent/ATE258930T1/de not_active IP Right Cessation
- 1998-12-10 CA CA002314111A patent/CA2314111A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL191236B1 (pl) | 2006-04-28 |
| US6380196B1 (en) | 2002-04-30 |
| ES2216349T3 (es) | 2004-10-16 |
| HU225114B1 (en) | 2006-06-28 |
| WO1999031090A1 (en) | 1999-06-24 |
| DE69821530D1 (de) | 2004-03-11 |
| EP1042319A1 (en) | 2000-10-11 |
| EE04312B1 (et) | 2004-06-15 |
| AU2270199A (en) | 1999-07-05 |
| EE200000335A (et) | 2001-10-15 |
| AU753576B2 (en) | 2002-10-24 |
| ATE258930T1 (de) | 2004-02-15 |
| CZ299304B6 (cs) | 2008-06-11 |
| DE69821530T2 (de) | 2004-12-23 |
| SI1042319T1 (en) | 2004-08-31 |
| IL136359A0 (en) | 2001-06-14 |
| CA2314111A1 (en) | 1999-06-24 |
| CZ20002218A3 (cs) | 2000-11-15 |
| HUP0004561A3 (en) | 2002-04-29 |
| HUP0004561A2 (hu) | 2002-03-28 |
| JP2002508368A (ja) | 2002-03-19 |
| EP1042319B1 (en) | 2004-02-04 |
| DK1042319T3 (da) | 2004-06-01 |
| PT1042319E (pt) | 2004-06-30 |
| PL341239A1 (en) | 2001-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |