IL136359A - Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same - Google Patents

Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL136359A
IL136359A IL13635998A IL13635998A IL136359A IL 136359 A IL136359 A IL 136359A IL 13635998 A IL13635998 A IL 13635998A IL 13635998 A IL13635998 A IL 13635998A IL 136359 A IL136359 A IL 136359A
Authority
IL
Israel
Prior art keywords
derivatives
same
pharmaceutical compositions
compositions containing
dihydrobenzofuran
Prior art date
Application number
IL13635998A
Other languages
English (en)
Other versions
IL136359A0 (en
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of IL136359A0 publication Critical patent/IL136359A0/xx
Publication of IL136359A publication Critical patent/IL136359A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IL13635998A 1997-12-15 1998-12-10 Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same IL136359A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122039 1997-12-15
PCT/EP1998/008054 WO1999031090A1 (en) 1997-12-15 1998-12-10 Dihydrobenzofurans

Publications (2)

Publication Number Publication Date
IL136359A0 IL136359A0 (en) 2001-06-14
IL136359A true IL136359A (en) 2003-03-12

Family

ID=8227798

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13635998A IL136359A (en) 1997-12-15 1998-12-10 Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same

Country Status (17)

Country Link
US (1) US6380196B1 (cs)
EP (1) EP1042319B1 (cs)
JP (1) JP2002508368A (cs)
AT (1) ATE258930T1 (cs)
AU (1) AU753576B2 (cs)
CA (1) CA2314111A1 (cs)
CZ (1) CZ299304B6 (cs)
DE (1) DE69821530T2 (cs)
DK (1) DK1042319T3 (cs)
EE (1) EE04312B1 (cs)
ES (1) ES2216349T3 (cs)
HU (1) HU225114B1 (cs)
IL (1) IL136359A (cs)
PL (1) PL191236B1 (cs)
PT (1) PT1042319E (cs)
SI (1) SI1042319T1 (cs)
WO (1) WO1999031090A1 (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2715683A1 (en) 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
WO2001019818A1 (en) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
HUP0203487A2 (hu) 1999-10-25 2003-02-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények
EP1228046B1 (en) 1999-10-25 2007-09-26 Nycomed GmbH Phthalazinone derivatives as pde 4 inhibitors
CZ20023997A3 (cs) 2000-06-05 2003-05-14 Altana Pharma Ag Pyridazinonové deriváty
HRP20030636B1 (en) * 2001-02-15 2012-05-31 Nycomed Gmbh Phthalayinone-piperidino-derivatives as pde4 inhibitors
EE200300514A (et) 2001-04-25 2004-02-16 Altana Pharma Ag Ftalasinoonid, nende kasutamine hingamisteede haigusnähte leevendavate ravimite valmistamiseks ningneid sisaldavad ravimid
JP4021329B2 (ja) * 2001-04-25 2007-12-12 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペラジノ誘導体およびｐｄｅ４阻害剤としてのその使用
CA2480054A1 (en) * 2002-03-29 2003-10-09 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for preventing or treating respiratory disease
JP2005538140A (ja) * 2002-08-10 2005-12-15 アルタナ　ファルマ　アクチエンゲゼルシャフト Ｐｄｅ４インヒビターとしてのピペリジン−ピリダゾン及びフタラゾン
WO2004018449A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
HRP20050197A2 (en) * 2002-08-10 2006-06-30 Altana Pharma Ag Piperidine-n-oxide-derivatives
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
AU2005210042B2 (en) * 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
JP4890439B2 (ja) * 2005-03-07 2012-03-07 杏林製薬株式会社 ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤
EP1953147A1 (en) * 2005-11-21 2008-08-06 Japan Tobacco, Inc. Heterocyclic compound and medicinal application thereof
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721784A (en) * 1986-12-22 1988-01-26 Ortho Pharmaceutical Corporation 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
ES2075202T3 (es) * 1989-04-17 1995-10-01 Byk Gulden Lomberg Chem Fab Nuevas arilpiridazinas, su preparacion, su utilizacion, y medicamentos que las contienen.
JP3120857B2 (ja) 1990-02-19 2000-12-25 中外製薬株式会社 新規な縮合複素環化合物とこれを用いた抗喘息剤
EP0553174B1 (de) * 1990-10-16 1998-07-08 Byk Gulden Lomberg Chemische Fabrik Gmbh Arylpyridazinone
EP0510562A1 (de) * 1991-04-26 1992-10-28 Byk Gulden Lomberg Chemische Fabrik GmbH Neue Pyridazine
ATE141791T1 (de) * 1991-07-05 1996-09-15 Byk Gulden Lomberg Chem Fab Verwendung substituierter pyridazine gegen dermatosen
JP3245165B2 (ja) * 1991-10-09 2002-01-07 シンテックス（ユー・エス・エイ）・インコーポレイテッド ピリドピリダジノンおよびピリダジンチオン化合物
DE4230755A1 (de) * 1992-09-14 1994-03-17 Schering Ag Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen
BR9307570A (pt) * 1992-12-02 1999-05-25 Pfizer Diéteres de catecol como inibidores seletivos de pdeiv
US5476834A (en) * 1993-03-17 1995-12-19 Sumitomo Chemical Company, Limited Dihydrobenzofuran derivatives, their production and use
NZ290420A (en) * 1994-07-22 1999-01-28 Byk Gulden Lomberg Chem Fab Phenyl or pyridyl-amide substituted dihydro benzofurans; medicaments
CA2173493C (en) * 1994-08-09 2008-03-25 Nobuhisa Watanabe Fused pyridazine compounds
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US5821250A (en) * 1996-02-01 1998-10-13 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
CZ299304B6 (cs) 2008-06-11
PT1042319E (pt) 2004-06-30
EE04312B1 (et) 2004-06-15
PL341239A1 (en) 2001-03-26
US6380196B1 (en) 2002-04-30
DE69821530T2 (de) 2004-12-23
WO1999031090A1 (en) 1999-06-24
HUP0004561A3 (en) 2002-04-29
CA2314111A1 (en) 1999-06-24
ATE258930T1 (de) 2004-02-15
JP2002508368A (ja) 2002-03-19
EP1042319B1 (en) 2004-02-04
HUP0004561A2 (hu) 2002-03-28
AU753576B2 (en) 2002-10-24
EE200000335A (et) 2001-10-15
CZ20002218A3 (cs) 2000-11-15
AU2270199A (en) 1999-07-05
HU225114B1 (en) 2006-06-28
IL136359A0 (en) 2001-06-14
PL191236B1 (pl) 2006-04-28
ES2216349T3 (es) 2004-10-16
DE69821530D1 (de) 2004-03-11
DK1042319T3 (da) 2004-06-01
SI1042319T1 (en) 2004-08-31
EP1042319A1 (en) 2000-10-11

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees