IL136359A - Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same - Google Patents
Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL136359A IL136359A IL13635998A IL13635998A IL136359A IL 136359 A IL136359 A IL 136359A IL 13635998 A IL13635998 A IL 13635998A IL 13635998 A IL13635998 A IL 13635998A IL 136359 A IL136359 A IL 136359A
- Authority
- IL
- Israel
- Prior art keywords
- derivatives
- same
- pharmaceutical compositions
- compositions containing
- dihydrobenzofuran
- Prior art date
Links
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical group C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 2
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97122039 | 1997-12-15 | ||
| PCT/EP1998/008054 WO1999031090A1 (en) | 1997-12-15 | 1998-12-10 | Dihydrobenzofurans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL136359A0 IL136359A0 (en) | 2001-06-14 |
| IL136359A true IL136359A (en) | 2003-03-12 |
Family
ID=8227798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13635998A IL136359A (en) | 1997-12-15 | 1998-12-10 | Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6380196B1 (cs) |
| EP (1) | EP1042319B1 (cs) |
| JP (1) | JP2002508368A (cs) |
| AT (1) | ATE258930T1 (cs) |
| AU (1) | AU753576B2 (cs) |
| CA (1) | CA2314111A1 (cs) |
| CZ (1) | CZ299304B6 (cs) |
| DE (1) | DE69821530T2 (cs) |
| DK (1) | DK1042319T3 (cs) |
| EE (1) | EE04312B1 (cs) |
| ES (1) | ES2216349T3 (cs) |
| HU (1) | HU225114B1 (cs) |
| IL (1) | IL136359A (cs) |
| PL (1) | PL191236B1 (cs) |
| PT (1) | PT1042319E (cs) |
| SI (1) | SI1042319T1 (cs) |
| WO (1) | WO1999031090A1 (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| AU7654200A (en) * | 1999-09-14 | 2001-04-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| HUP0203487A2 (hu) | 1999-10-25 | 2003-02-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények |
| WO2001030766A1 (en) * | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pde 4 inhibitors |
| NZ522882A (en) | 2000-06-05 | 2004-07-30 | Altana Pharma Bv | Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors |
| CZ20032491A3 (cs) * | 2001-02-15 | 2004-01-14 | Altana Pharma Ag | Ftalazinonpiperidinové deriváty |
| EP1385848A2 (en) | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Phtalazinones derivatives useful as pde4/7 inhibitors |
| BR0209076A (pt) * | 2001-04-25 | 2004-08-10 | Altana Pharma Ag | Derivados de piperazino e seu uso como inibidor de pde4 |
| CN1646118A (zh) * | 2002-03-29 | 2005-07-27 | 中外制药株式会社 | 预防或治疗呼吸系统疾病的药物组合物 |
| US20060166995A1 (en) * | 2002-08-10 | 2006-07-27 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| BR0313330A (pt) * | 2002-08-10 | 2005-06-14 | Altana Pharma Ag | Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4 |
| EP1556369A1 (en) * | 2002-08-10 | 2005-07-27 | ALTANA Pharma AG | Pyridazinone-derivatives as pde4 inhibitors |
| WO2004018449A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| US20080227790A1 (en) * | 2004-02-04 | 2008-09-18 | Altana Pharma Ag | Pyridazinone Derivatives and their Use as Pde4 Inhibitors |
| DE602005005638T2 (de) * | 2004-02-04 | 2009-05-14 | Nycomed Gmbh | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-on-derivate als pde4-inhibitoren |
| WO2006095666A1 (ja) * | 2005-03-07 | 2006-09-14 | Kyorin Pharmaceutical Co., Ltd. | ピラゾロピリジン－４－イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤 |
| AR057986A1 (es) * | 2005-11-21 | 2008-01-09 | Japan Tobacco Inc | Compuesto heterociclico y su uso farmaceutico |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721784A (en) * | 1986-12-22 | 1988-01-26 | Ortho Pharmaceutical Corporation | 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones |
| DE59009351D1 (de) * | 1989-04-17 | 1995-08-03 | Byk Gulden Lomberg Chem Fab | Neue arylpyridazine, ihre herstellung, verwendung und sie enthaltende arzneimittel. |
| JP3120857B2 (ja) | 1990-02-19 | 2000-12-25 | 中外製薬株式会社 | 新規な縮合複素環化合物とこれを用いた抗喘息剤 |
| EP0553174B1 (de) * | 1990-10-16 | 1998-07-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Arylpyridazinone |
| WO1992019602A1 (de) * | 1991-04-26 | 1992-11-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue pyridazine |
| EP0593567B1 (de) * | 1991-07-05 | 1996-08-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Verwendung substituierter pyridazine gegen dermatosen |
| ZA927755B (en) * | 1991-10-09 | 1994-04-08 | Syntex Inc | Pyrido pyridazinone and pyridazinthione compounds |
| DE4230755A1 (de) * | 1992-09-14 | 1994-03-17 | Schering Ag | Verwendung von PDE-Inhibitoren bei der Behandlung von Nieren- und Ureter-Erkrankungen |
| NZ257955A (en) * | 1992-12-02 | 1996-05-28 | Pfizer | Catechol diethers pharmaceutical compositions |
| US5411935A (en) * | 1993-03-17 | 1995-05-02 | Sumitomo Chemical Co., Ltd. | Dihydrobenzofuran derivatives, their production and use |
| DK0772610T3 (da) * | 1994-07-22 | 2001-01-29 | Byk Gulden Lomberg Chem Fab | Dihydrobenzofuraner |
| DE69533057T2 (de) | 1994-08-09 | 2005-06-16 | Eisai Co., Ltd. | Kondensierte pyridazinverbindungen |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| US5821250A (en) * | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
-
1998
- 1998-12-10 WO PCT/EP1998/008054 patent/WO1999031090A1/en not_active Ceased
- 1998-12-10 PT PT98966288T patent/PT1042319E/pt unknown
- 1998-12-10 HU HU0004561A patent/HU225114B1/hu not_active IP Right Cessation
- 1998-12-10 DK DK98966288T patent/DK1042319T3/da active
- 1998-12-10 JP JP2000539014A patent/JP2002508368A/ja not_active Withdrawn
- 1998-12-10 CZ CZ20002218A patent/CZ299304B6/cs not_active IP Right Cessation
- 1998-12-10 IL IL13635998A patent/IL136359A/xx not_active IP Right Cessation
- 1998-12-10 ES ES98966288T patent/ES2216349T3/es not_active Expired - Lifetime
- 1998-12-10 DE DE69821530T patent/DE69821530T2/de not_active Expired - Fee Related
- 1998-12-10 CA CA002314111A patent/CA2314111A1/en not_active Abandoned
- 1998-12-10 AU AU22701/99A patent/AU753576B2/en not_active Ceased
- 1998-12-10 EP EP98966288A patent/EP1042319B1/en not_active Expired - Lifetime
- 1998-12-10 US US09/554,088 patent/US6380196B1/en not_active Expired - Fee Related
- 1998-12-10 AT AT98966288T patent/ATE258930T1/de not_active IP Right Cessation
- 1998-12-10 SI SI9830628T patent/SI1042319T1/xx unknown
- 1998-12-10 PL PL341239A patent/PL191236B1/pl unknown
- 1998-12-10 EE EEP200000335A patent/EE04312B1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SI1042319T1 (en) | 2004-08-31 |
| HU225114B1 (en) | 2006-06-28 |
| EE04312B1 (et) | 2004-06-15 |
| PL341239A1 (en) | 2001-03-26 |
| HUP0004561A2 (hu) | 2002-03-28 |
| PT1042319E (pt) | 2004-06-30 |
| EP1042319A1 (en) | 2000-10-11 |
| JP2002508368A (ja) | 2002-03-19 |
| US6380196B1 (en) | 2002-04-30 |
| DE69821530D1 (de) | 2004-03-11 |
| PL191236B1 (pl) | 2006-04-28 |
| HUP0004561A3 (en) | 2002-04-29 |
| DE69821530T2 (de) | 2004-12-23 |
| AU2270199A (en) | 1999-07-05 |
| AU753576B2 (en) | 2002-10-24 |
| CZ299304B6 (cs) | 2008-06-11 |
| DK1042319T3 (da) | 2004-06-01 |
| EE200000335A (et) | 2001-10-15 |
| IL136359A0 (en) | 2001-06-14 |
| EP1042319B1 (en) | 2004-02-04 |
| ES2216349T3 (es) | 2004-10-16 |
| ATE258930T1 (de) | 2004-02-15 |
| CA2314111A1 (en) | 1999-06-24 |
| CZ20002218A3 (cs) | 2000-11-15 |
| WO1999031090A1 (en) | 1999-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |