PL402948A1 - Kwasy tluszczowe o sredniej dlugosci lancucha, glicerydy i analogi jako czynniki zwiekszajace przezycie i aktywacje neutrofili - Google Patents
Kwasy tluszczowe o sredniej dlugosci lancucha, glicerydy i analogi jako czynniki zwiekszajace przezycie i aktywacje neutrofiliInfo
- Publication number
- PL402948A1 PL402948A1 PL402948A PL40294802A PL402948A1 PL 402948 A1 PL402948 A1 PL 402948A1 PL 402948 A PL402948 A PL 402948A PL 40294802 A PL40294802 A PL 40294802A PL 402948 A1 PL402948 A1 PL 402948A1
- Authority
- PL
- Poland
- Prior art keywords
- medium chain
- neutrophils
- survival
- activation
- fatty acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/02—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Wynalazek dotyczy kompozycji i sposobu zwiekszania przezycia i aktywacji neutrofili, np. w przypadku leczenia neutropenii bedacej niepozadanym skutkiem ubocznym chemioterapii i radioterapii. Kompozycje zawierajaca kwasy tluszczowe o sredniej dlugosci lancucha, takie jak kwas kaprynowy lub kwas kaprylowy, lub ich sole albo triglicerydy, albo ich mono- lub diglicerydy lub inne analogi, albo triglicerydy o sredniej dlugosci lancucha (MCT), podaje sie czlowiekowi lub zwierzeciu potrzebujacemu leczenia w ilosci wystarczajacej do zmniejszenia lub wyleczenia neutropenii. Kompozycje podaje sie w ilosci skutecznej do leczenia tego zaburzenia. Ujawnione sposoby sa takze uzyteczne w przeszczepianiu szpiku kostnego i w leczeniu róznych chorób zwiazanych z neutropenia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28445801P | 2001-04-18 | 2001-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
PL402948A1 true PL402948A1 (pl) | 2013-05-13 |
PL222876B1 PL222876B1 (pl) | 2016-09-30 |
Family
ID=23090294
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL366435A PL223348B1 (pl) | 2001-04-18 | 2002-04-18 | Zastosowanie karboksylanu |
PL402948A PL222876B1 (pl) | 2001-04-18 | 2002-04-18 | Zastosowanie pochodnych glicerolu |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL366435A PL223348B1 (pl) | 2001-04-18 | 2002-04-18 | Zastosowanie karboksylanu |
Country Status (30)
Country | Link |
---|---|
US (2) | US7745488B2 (pl) |
EP (2) | EP1385498B1 (pl) |
JP (3) | JP5026655B2 (pl) |
KR (1) | KR20030096323A (pl) |
CN (1) | CN1633286A (pl) |
AP (1) | AP1740A (pl) |
AU (2) | AU2002308456B2 (pl) |
BG (1) | BG66418B1 (pl) |
BR (1) | BR0208984A (pl) |
CA (2) | CA2444463C (pl) |
CY (1) | CY1107081T1 (pl) |
CZ (1) | CZ305273B6 (pl) |
DE (1) | DE60223670T2 (pl) |
DK (2) | DK1900364T3 (pl) |
EA (1) | EA007322B1 (pl) |
EE (1) | EE200300510A (pl) |
ES (2) | ES2439738T3 (pl) |
HU (1) | HUP0303817A3 (pl) |
IL (3) | IL158322A0 (pl) |
MX (1) | MXPA03009436A (pl) |
NO (1) | NO335105B1 (pl) |
NZ (2) | NZ528690A (pl) |
OA (1) | OA12506A (pl) |
PL (2) | PL223348B1 (pl) |
PT (2) | PT1900364E (pl) |
SI (1) | SI1385498T1 (pl) |
SK (1) | SK12772003A3 (pl) |
TN (1) | TNSN03089A1 (pl) |
WO (1) | WO2002083120A2 (pl) |
ZA (1) | ZA200307778B (pl) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5026655B2 (ja) | 2001-04-18 | 2012-09-12 | プロメティック、バイオサイエンシーズ、インコーポレーテッド | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
ES2255467T3 (es) * | 2003-02-07 | 2009-05-01 | Prometic Biosciences Inc. | Acidos grasos de cadena de longitud media, gliceridos y analogos como estimuladores de eritropoyesis. |
KR101120813B1 (ko) | 2003-07-25 | 2012-03-23 | 프로메틱 바이오사이언시즈 인코포레이티드 | 중-쇄 지방산 금속염의 제조 방법 |
US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
MXPA06011871A (es) * | 2004-04-15 | 2007-10-08 | Chiasma Inc | Composiciones capaces de facilitar la penetracion a traves de una barrera biologica. |
EA200700543A1 (ru) * | 2004-09-03 | 2007-10-26 | Прометик Байосайенсиз Инк. | Замещенные пуринилпроизводные с иммуномодулирующей и химиозащитной активностью и их применение как таковых или с жирными кислотами со средней длиной цепи или глицеридами |
JP4948414B2 (ja) * | 2004-10-01 | 2012-06-06 | プロメティック バイオサイエンシズ インコーポレーテッド | 造血刺激剤としての中間鎖長脂肪アルコール |
US8071580B2 (en) | 2004-10-01 | 2011-12-06 | Prometic Biosciences Inc. | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
WO2006090289A2 (en) * | 2005-02-28 | 2006-08-31 | Alphabeta Ab | Compounds for reducing aggregation of amyloid beta-peptide |
EP2079832A4 (en) * | 2006-05-17 | 2010-08-04 | Cognate Therapeutics Inc | ISOLATION AND PURIFICATION OF HEMATOPOIETIC STEM CELLS FROM LIPOSUCCION ASPIRATES |
DK2180787T3 (da) | 2007-08-01 | 2014-02-03 | Univ Pittsburgh | Nitrooliesyremodulering af type ii-diabetes |
EP2299998B1 (en) * | 2007-11-02 | 2018-01-03 | Prometic Pharma Smt Limited | Medium-chain length fatty acids and glycerides as nephroprotection agents |
NZ586249A (en) * | 2007-12-19 | 2012-05-25 | Prometic Biosciences Inc | A combination of medium-chain length fatty acids, salts or triglycerides, gemcitabine, and optionally erlotinib, for the treatment of pancreatic cancer |
ES2692291T3 (es) | 2008-05-01 | 2018-12-03 | Complexa Inc. | Ácidos grasos vinil sustituidos |
US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
WO2009155439A2 (en) * | 2008-06-19 | 2009-12-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
WO2010032140A2 (en) | 2008-09-17 | 2010-03-25 | Chiasma Inc. | Pharmaceutical compositions and related methods of delivery |
EP2165713B1 (en) * | 2008-09-19 | 2012-11-14 | Nestec S.A. | Whey and thymus function |
JP2013500966A (ja) | 2009-07-31 | 2013-01-10 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 抗炎症剤としての脂肪酸 |
EP2483233A4 (en) | 2009-10-02 | 2013-08-14 | Complexa Inc | HETEROATOMA CONTAINING SUBSTITUTED FATTY ACIDS |
EP2394636B1 (en) * | 2010-05-28 | 2014-03-19 | Novagali Pharma S.A. | Method for treating retinal conditions using an intraocular tamponade |
WO2013028501A1 (en) | 2011-08-19 | 2013-02-28 | The University Of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
TWI572352B (zh) * | 2012-03-01 | 2017-03-01 | 波麥堤克藥學Smt有限公司 | 用於製備具中鏈長度之脂肪酸的三酸甘油酯之方法 |
SG10201603059YA (en) * | 2012-05-09 | 2016-05-30 | Cantex Pharmaceuticals Inc | Treatment Of Myelosuppression |
KR101621856B1 (ko) | 2013-08-19 | 2016-05-17 | 한국생명공학연구원 | 모노아세틸디아실글리세롤 화합물을 유효성분으로 함유하는 류마티스 관절염의 예방 또는 치료용 조성물 |
KR20180015297A (ko) | 2014-05-15 | 2018-02-12 | 주식회사 엔지켐생명과학 | 백혈구 감소증 및 혈소판 감소증에 대한 치료 방법 |
MA41462A (fr) | 2015-02-03 | 2021-05-12 | Chiasma Inc | Méthode de traitement de maladies |
EP3258941A4 (en) | 2015-02-17 | 2018-09-26 | Cantex Pharmaceuticals, Inc. | Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction |
PL3865484T3 (pl) | 2015-07-07 | 2024-04-22 | H. Lundbeck A/S | Inhibitor PDE9 ze szkieletem imidazopirazynonowym do leczenia chorób obwodowych |
KR20180098222A (ko) | 2015-10-02 | 2018-09-03 | 컴플렉사, 인코포레이티드 | 활성화된 지방산의 치료학적 유효량을 이용한 질환의 예방, 치료 및 역행 |
US9808438B2 (en) | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
AU2017252575B2 (en) | 2016-04-22 | 2021-11-18 | Spoke Sciences, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
AU2017277005B2 (en) | 2016-06-08 | 2022-12-22 | Sunregen Healthcare Ag | Lipids with odd number of carbon atoms and their use as pharmaceutical composition or nutritional supplement |
EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
CN107382710B (zh) * | 2017-08-19 | 2020-11-06 | 中国铁道科学研究院集团有限公司铁道建筑研究所 | 一种接枝抗氧剂分子的多元醇 |
BR112020004023A2 (pt) * | 2017-09-12 | 2020-09-08 | Sunregen Healthcare Ag | uso de um composto e composição farmacêutica ou suplemento nutricional |
WO2019071211A1 (en) * | 2017-10-05 | 2019-04-11 | Receptor Life Sciences, Inc. | HERB COMPOSITIONS HAVING IMPROVED BIOAVAILABILITY |
CA3078549A1 (en) * | 2017-10-05 | 2019-04-11 | Receptor Holdings, Inc. | Rapid onset and extended action plant-based and synthetic cannabinoid formulations |
KR102054401B1 (ko) * | 2018-03-26 | 2019-12-10 | 주식회사 엔지켐생명과학 | 1,2-디아실글리세롤 화합물, 그 제조방법 및 이를 유효성분으로 함유하는 면역조절제 |
KR20210014662A (ko) | 2018-05-25 | 2021-02-09 | 이마라 인크. | 6-[(3S,4S)-4-메틸-1-(피리미딘-2-일메틸)피롤리딘-3-일]-3-테트라히드로피란-4-일-7H-이미다조[1,5-a]피라진-8-온의 일수화물 및 결정형 |
KR20220086574A (ko) * | 2019-10-31 | 2022-06-23 | 니폰 제온 가부시키가이샤 | 전기 화학 소자용 기능층 및 그 제조 방법, 전기 화학 소자용 기능층 형성 세퍼레이터 및 그 제조 방법, 그리고 전기 화학 소자 및 그 제조 방법 |
US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
KR20240089762A (ko) * | 2021-10-18 | 2024-06-20 | 주식회사 엔지켐생명과학 | 점막염 치료용 조성물 및 방법 |
WO2023205196A1 (en) * | 2022-04-21 | 2023-10-26 | Merck Sharp & Dohme Llc | Process for preparing agglomerated crystalline medium-chain fatty acid sodium salts |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
US4528197A (en) * | 1983-01-26 | 1985-07-09 | Kabivitrum Ab | Controlled triglyceride nutrition for hypercatabolic mammals |
US4703062A (en) * | 1984-01-16 | 1987-10-27 | Baxter Travenol Laboratories, Inc. | Parenteral nutrition with medium and long chain triglycerides |
US4871768A (en) * | 1984-07-12 | 1989-10-03 | New England Deaconess Hospital Corporation | Dietary supplement utilizing ω-3/medium chain trigylceride mixtures |
US4816440A (en) * | 1985-09-26 | 1989-03-28 | Cetus Corporation | Stable formulation of biologically active proteins for parenteral injection |
US6060459A (en) * | 1987-10-28 | 2000-05-09 | Pro-Neuron, Inc. | Enhancing blood cell count with oxypurine nucleosides |
US5011852A (en) * | 1988-07-25 | 1991-04-30 | Applied Analytical Industries, Inc. | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs |
JPH02134326A (ja) * | 1988-11-14 | 1990-05-23 | Snow Brand Milk Prod Co Ltd | 高度侵襲用経腸栄養剤 |
JP3249147B2 (ja) * | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
WO1992014480A1 (en) * | 1991-02-22 | 1992-09-03 | Amgen Inc. | Use of gm-csf and g-csf to promote accelerated wound healing |
JP3132085B2 (ja) * | 1991-09-06 | 2001-02-05 | ウェルファイド株式会社 | 脂肪乳剤 |
JPH05163160A (ja) * | 1991-12-13 | 1993-06-29 | Snow Brand Milk Prod Co Ltd | 免疫低下に伴う感染症の予防及び治療用栄養剤 |
US5214035A (en) * | 1992-04-16 | 1993-05-25 | Hoechst-Roussel Agri-Vet Company | Thixotropic formulations |
US5308832A (en) * | 1992-07-27 | 1994-05-03 | Abbott Laboratories | Nutritional product for persons having a neurological injury |
US5318781A (en) * | 1993-04-06 | 1994-06-07 | Hoffmann-La Roche Inc. | Absorption enhancement of antibiotics |
US20010003739A1 (en) | 1993-06-24 | 2001-06-14 | Astrazeneca Ab | Systemic administration of a therapeutic preparation |
US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
WO1995030413A1 (fr) | 1994-05-10 | 1995-11-16 | The Kitasato Institute | Accelerateur de proliferation de cellules souches hematopoietiques |
US5470861A (en) * | 1994-08-04 | 1995-11-28 | Hoffmann-La Roche Inc. | Method of promoting hair growth |
US5549905A (en) * | 1994-10-18 | 1996-08-27 | Clintec Nutrition Co. | Enternal composition for pediatric patients |
JPH08208510A (ja) | 1994-11-03 | 1996-08-13 | F Hoffmann La Roche Ag | インターフェロン組成物 |
GB9516268D0 (en) * | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
US5733884A (en) * | 1995-11-07 | 1998-03-31 | Nestec Ltd. | Enteral formulation designed for optimized wound healing |
PL186618B1 (pl) * | 1995-11-28 | 2004-02-27 | Braun Melsungen Ag | Izotoniczna emulsja lipidowa do podawania pozajelitowego i jej zastosowanie |
AUPN933396A0 (en) * | 1996-04-17 | 1996-05-09 | Pfizer Pty Limited | Non-aqueuos oral-drench compositions containing avermectin compounds |
US5851534A (en) * | 1996-05-03 | 1998-12-22 | Dynagen, Inc. | Methods for prevention and/or treatment of neutropenia |
JPH10265380A (ja) | 1997-03-17 | 1998-10-06 | Bristol Myers Squibb Co | 抗ガン剤 |
US6017531A (en) * | 1997-06-02 | 2000-01-25 | W. R. Grace & Co. | Hydrophilic composition containing protease produced by Vibrio |
JP2001514209A (ja) | 1997-09-04 | 2001-09-11 | バイオゾーン ラボラトリーズ,インコーポレイテッド | 経口リポソーム送達系 |
BR9814693B1 (pt) * | 1997-11-19 | 2011-04-19 | suspensões de polìmero fluidificado de polissacarìdeos catiÈnicos em emolientes e processo para preparação de uma composição para cuidado pessoal. | |
WO1999026640A1 (en) * | 1997-11-20 | 1999-06-03 | Bukwang Pharm. Ind. Co., Ltd. | Pharmaceutical composition containing extracts of cervus nippon antlers having growth-stimulating activities of hematopoietic stem cells and megakaryocytes |
DE69910183T2 (de) | 1998-03-11 | 2004-06-03 | Grelan Pharmaceutical Co., Ltd., Hamura | Darmlösliche sprudelnde zusammensetzungen |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
CA2385989A1 (en) * | 1999-09-27 | 2001-04-05 | Andrew Nienstedt | Compositions of tocol-soluble therapeutics |
US6835750B1 (en) * | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
DE60123603T2 (de) | 2000-06-14 | 2007-08-16 | William Leslie Diss Porter | Lipide zur änderung des abwehrsystems |
JP5259905B2 (ja) * | 2000-06-20 | 2013-08-07 | エヌ・ブイ・ニュートリション・サイエンシス | 抗菌剤として適用可能な中鎖脂肪酸 |
US6967028B2 (en) * | 2000-07-31 | 2005-11-22 | Mainelab | Prolonged release microspheres for injectable administration |
IL142535A0 (en) | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of inflammation |
JP5026655B2 (ja) | 2001-04-18 | 2012-09-12 | プロメティック、バイオサイエンシーズ、インコーポレーテッド | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
US20040052836A1 (en) | 2002-09-13 | 2004-03-18 | Li Luk Chiu | Pharmaceutical compositions containing at least one stable liposphere having an improved shelf life |
ES2255467T3 (es) | 2003-02-07 | 2009-05-01 | Prometic Biosciences Inc. | Acidos grasos de cadena de longitud media, gliceridos y analogos como estimuladores de eritropoyesis. |
US6725510B1 (en) * | 2003-04-25 | 2004-04-27 | Almetta Clyburn | Inclining coffin |
KR101120813B1 (ko) | 2003-07-25 | 2012-03-23 | 프로메틱 바이오사이언시즈 인코포레이티드 | 중-쇄 지방산 금속염의 제조 방법 |
EA200700543A1 (ru) * | 2004-09-03 | 2007-10-26 | Прометик Байосайенсиз Инк. | Замещенные пуринилпроизводные с иммуномодулирующей и химиозащитной активностью и их применение как таковых или с жирными кислотами со средней длиной цепи или глицеридами |
US8071580B2 (en) | 2004-10-01 | 2011-12-06 | Prometic Biosciences Inc. | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
-
2002
- 2002-04-18 JP JP2002580924A patent/JP5026655B2/ja not_active Expired - Lifetime
- 2002-04-18 EP EP02761857A patent/EP1385498B1/en not_active Expired - Lifetime
- 2002-04-18 CN CNA028094263A patent/CN1633286A/zh active Pending
- 2002-04-18 ES ES07116425.5T patent/ES2439738T3/es not_active Expired - Lifetime
- 2002-04-18 DK DK07116425.5T patent/DK1900364T3/da active
- 2002-04-18 WO PCT/CA2002/000535 patent/WO2002083120A2/en active Application Filing
- 2002-04-18 PT PT71164255T patent/PT1900364E/pt unknown
- 2002-04-18 NZ NZ528690A patent/NZ528690A/en not_active IP Right Cessation
- 2002-04-18 PT PT02761857T patent/PT1385498E/pt unknown
- 2002-04-18 PL PL366435A patent/PL223348B1/pl unknown
- 2002-04-18 SI SI200230655T patent/SI1385498T1/sl unknown
- 2002-04-18 MX MXPA03009436A patent/MXPA03009436A/es active IP Right Grant
- 2002-04-18 DE DE60223670T patent/DE60223670T2/de not_active Expired - Lifetime
- 2002-04-18 HU HU0303817A patent/HUP0303817A3/hu unknown
- 2002-04-18 EA EA200301131A patent/EA007322B1/ru not_active IP Right Cessation
- 2002-04-18 NZ NZ541140A patent/NZ541140A/en not_active IP Right Cessation
- 2002-04-18 EP EP07116425.5A patent/EP1900364B1/en not_active Expired - Lifetime
- 2002-04-18 EE EEP200300510A patent/EE200300510A/xx unknown
- 2002-04-18 US US10/475,266 patent/US7745488B2/en active Active
- 2002-04-18 CZ CZ2003-2685A patent/CZ305273B6/cs not_active IP Right Cessation
- 2002-04-18 AP APAP/P/2003/002888A patent/AP1740A/en active
- 2002-04-18 SK SK1277-2003A patent/SK12772003A3/sk unknown
- 2002-04-18 CA CA2444463A patent/CA2444463C/en not_active Expired - Lifetime
- 2002-04-18 DK DK02761857T patent/DK1385498T3/da active
- 2002-04-18 KR KR10-2003-7013555A patent/KR20030096323A/ko active Search and Examination
- 2002-04-18 AU AU2002308456A patent/AU2002308456B2/en not_active Expired
- 2002-04-18 IL IL15832202A patent/IL158322A0/xx active IP Right Grant
- 2002-04-18 PL PL402948A patent/PL222876B1/pl unknown
- 2002-04-18 OA OA1200300273A patent/OA12506A/en unknown
- 2002-04-18 CA CA2763637A patent/CA2763637C/en not_active Expired - Lifetime
- 2002-04-18 ES ES02761857T patent/ES2295397T3/es not_active Expired - Lifetime
- 2002-04-18 BR BR0208984-0A patent/BR0208984A/pt not_active Application Discontinuation
-
2003
- 2003-07-08 TN TNPCT/CA2002/000535A patent/TNSN03089A1/en unknown
- 2003-10-06 ZA ZA200307778A patent/ZA200307778B/en unknown
- 2003-10-09 IL IL158322A patent/IL158322A/en unknown
- 2003-10-17 BG BG108280A patent/BG66418B1/bg unknown
- 2003-10-17 NO NO20034644A patent/NO335105B1/no not_active IP Right Cessation
-
2006
- 2006-03-21 AU AU2006201163A patent/AU2006201163B2/en not_active Expired
-
2007
- 2007-12-12 CY CY20071101574T patent/CY1107081T1/el unknown
-
2008
- 2008-11-10 IL IL195200A patent/IL195200A/en active IP Right Grant
-
2009
- 2009-11-30 JP JP2009272679A patent/JP5657879B2/ja not_active Expired - Lifetime
-
2010
- 2010-06-11 US US12/814,028 patent/US8487001B2/en not_active Expired - Lifetime
-
2014
- 2014-08-15 JP JP2014165557A patent/JP6420089B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL402948A1 (pl) | Kwasy tluszczowe o sredniej dlugosci lancucha, glicerydy i analogi jako czynniki zwiekszajace przezycie i aktywacje neutrofili | |
ES2179319T3 (es) | Acido linoleico conjugado para mantener o aumentar el contenido de minerales de los huesos. | |
SE9803710D0 (sv) | Use of certain drugs for treating nerve root injury | |
ATE345130T1 (de) | Arylharnstoff-verbindungen in kombination mit anderen zytostatisch oder zytotoxisch wirksamen stoffen zur behandlungen menschlicher krebserkrankungen | |
EA200200990A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы дельта человека | |
NZ591810A (en) | Pharmaceutical compositions and related methods of delivery the composition comprises a medium chain fatty acid | |
EP2127687A4 (en) | COMPOSITION FOR THE TREATMENT OF CARTILAGE DISEASE | |
BR0308854A (pt) | Benzazolas substituìdas e seus usos como inibidoras de quinase raf | |
ATE401088T1 (de) | Zusammensetzung mit einem survivin-antisense- oligonucleotid und gemcitabin zur behandlung von krebs | |
EA200500893A1 (ru) | Трициклические соединения, представляющие собой ингибиторы протеинкиназ, для увеличения эффективности противоопухолевых агентов и лучевой терапии | |
MX2009002054A (es) | Metodos para inhibir angiogenesis y tratamiento contra enfermedades asociadas con angiogenesis. | |
BRPI0409796A (pt) | uso de dipiridamol ou mopidamol para tratamento e prevenção de doenças tromboembolìticas e distúrbios provocados pela formação excessiva de trombina e/ou pela expressão elevada de receptores de trombina | |
US9364512B1 (en) | Aloe vera based vaping compositions | |
AU2002357191A1 (en) | Derivatives of isoindigo, indigo and indirubin and use in treating cancer | |
AR016233A1 (es) | Tienopirimidinas, un procedimiento para su preparacion, el empleo de las mismas para preparar un medicamento, las composiciones farmaceuticas que lascontienen, y un procedimiento para obtener estas composiciones farmaceuticas. | |
ES2094702B1 (es) | Composiciones farmaceuticas para la prevencion y el tratamiento de enfermedades cancerosas y procedimiento para su preparacion. | |
RU2008151713A (ru) | Способы и композиции с применением иммуномодулирующих соединений при комбинированном лечении | |
Langell et al. | Pharmacological agents for the prevention and treatment of toxic radiation exposure in spaceflight | |
ATE435643T1 (de) | Verbesserte lipidzusammensetzungen und darin enthaltene derivate des 3- methoxybenzylthioharnstoffs | |
EA200700543A1 (ru) | Замещенные пуринилпроизводные с иммуномодулирующей и химиозащитной активностью и их применение как таковых или с жирными кислотами со средней длиной цепи или глицеридами | |
BR0206954A (pt) | Processo de terapia para câncer | |
EA202190798A1 (ru) | Ротамерные изомеры 4-алкил-5-гетероарил-3h-1,2-дитиол-3-тионов | |
MX9304925A (es) | Composiciones terapeuticas contra el cancer para profilaxis o para el tratamiento de cancer. | |
UA94074C2 (ru) | Производные диоксолана для лечения рака | |
HUT62474A (en) | Process for producing veterinary composition with antiparasitic effect |