EA202190798A1 - Ротамерные изомеры 4-алкил-5-гетероарил-3h-1,2-дитиол-3-тионов - Google Patents
Ротамерные изомеры 4-алкил-5-гетероарил-3h-1,2-дитиол-3-тионовInfo
- Publication number
- EA202190798A1 EA202190798A1 EA202190798A EA202190798A EA202190798A1 EA 202190798 A1 EA202190798 A1 EA 202190798A1 EA 202190798 A EA202190798 A EA 202190798A EA 202190798 A EA202190798 A EA 202190798A EA 202190798 A1 EA202190798 A1 EA 202190798A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rotameric
- complexes
- isomers
- thiones
- dithiol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение предусматривает, помимо прочего, ротамерные изомеры 4-алкил-5-гетероарил-3H-1,2-дитиол-3-тионов, комплексы таких изомеров, в которых отдельная ротамерная форма получена стабилизацией, и композиции, содержащие избыток отдельного ротамера (ротамерный избыток) в виде стабилизированного комплекса. Изобретение также относится к способам изготовления и применения таких ротамеров и комплексов, включая способы лечения пациента-человека или пациента-животного с помощью таких ротамеров или их комплексов, например, для предотвращения, лечения или уменьшения симптомов различных заболеваний, таких как воспаление слизистой оболочки, и/или обеспечения защиты от окислительного повреждения в различных органах и тканях в медицинских целях.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862732867P | 2018-09-18 | 2018-09-18 | |
PCT/IB2019/001138 WO2020058767A1 (en) | 2018-09-18 | 2019-09-17 | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2- dithiole-3-thiones |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202190798A1 true EA202190798A1 (ru) | 2021-09-10 |
Family
ID=69024428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202190798A EA202190798A1 (ru) | 2018-09-18 | 2019-09-17 | Ротамерные изомеры 4-алкил-5-гетероарил-3h-1,2-дитиол-3-тионов |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210206751A1 (ru) |
EP (1) | EP3853223A1 (ru) |
JP (1) | JP7514841B2 (ru) |
KR (1) | KR20210061390A (ru) |
CN (2) | CN113694068A (ru) |
AU (1) | AU2019341666A1 (ru) |
BR (1) | BR112021005010A2 (ru) |
CA (1) | CA3113169A1 (ru) |
EA (1) | EA202190798A1 (ru) |
IL (1) | IL281598A (ru) |
MX (1) | MX2021003123A (ru) |
SG (1) | SG11202102653WA (ru) |
WO (1) | WO2020058767A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021186244A1 (en) * | 2020-03-16 | 2021-09-23 | St Ip Holding Ag | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2-dithiole-3-thiones |
DE202023001038U1 (de) | 2023-05-10 | 2023-06-16 | Rainer Teutenberg | Ballistisch und akustisch wirksame Bekleidung für Schießanlagen |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3156369A (en) | 1962-09-19 | 1964-11-10 | Ethicon Inc | Bicameral container |
IT1292677B1 (it) | 1997-02-28 | 1999-02-11 | Bormioli Metalplast Spa | Confezione per mantenere separati dei prodotti prima dell'uso. |
TW200640898A (en) * | 2005-02-24 | 2006-12-01 | Solvay Pharm Bv | Anethole dithiolethione and other dithiolethiones for the treatment of conditions associated with dysfunction of monoamine neurotransmission |
CA2608978A1 (en) | 2005-07-15 | 2007-01-25 | Bormioli Rocco & Figlio S.P.A. | A reservoir with a cutter for substances to be mixed with liquids at moment of use, in particular for single-dose containers |
WO2007121356A2 (en) * | 2006-04-13 | 2007-10-25 | Accu-Break Technologies | Method of treatment with predictably breakable pharmaceutical tablets |
GB0704718D0 (en) * | 2007-03-12 | 2007-04-18 | Prendergast Patrick T | Compounds and methods for preventing and treating mucositis |
ES2527604T3 (es) | 2010-02-16 | 2015-01-27 | Teva Branded Pharmaceutical Products R & D, Inc. | Una composición farmacéutica inhalable |
SG10201703243QA (en) | 2012-02-28 | 2017-06-29 | Iceutica Holdings Inc | Inhalable pharmaceutical compositions |
BR112015027017A2 (pt) | 2013-04-29 | 2017-07-25 | Sanofi Sa | composições farmacêuticas inaláveis e dispositivos inaladores que contêm as mesmas |
WO2016207914A2 (en) | 2015-06-25 | 2016-12-29 | St Ip Holding Ag | Methods for preparing oltipraz |
CN105327337A (zh) * | 2015-10-30 | 2016-02-17 | 中国人民解放军96617部队 | 抗辐射防龋消炎口腔制剂 |
WO2018047013A1 (en) * | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same |
WO2018047002A1 (en) * | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
-
2019
- 2019-09-17 SG SG11202102653WA patent/SG11202102653WA/en unknown
- 2019-09-17 CN CN202111092175.6A patent/CN113694068A/zh active Pending
- 2019-09-17 MX MX2021003123A patent/MX2021003123A/es unknown
- 2019-09-17 EP EP19828305.3A patent/EP3853223A1/en active Pending
- 2019-09-17 EA EA202190798A patent/EA202190798A1/ru unknown
- 2019-09-17 WO PCT/IB2019/001138 patent/WO2020058767A1/en unknown
- 2019-09-17 KR KR1020217011340A patent/KR20210061390A/ko unknown
- 2019-09-17 AU AU2019341666A patent/AU2019341666A1/en not_active Abandoned
- 2019-09-17 JP JP2021538939A patent/JP7514841B2/ja active Active
- 2019-09-17 CA CA3113169A patent/CA3113169A1/en active Pending
- 2019-09-17 CN CN201980076028.4A patent/CN113166127A/zh active Pending
- 2019-09-17 BR BR112021005010-8A patent/BR112021005010A2/pt not_active Application Discontinuation
-
2021
- 2021-03-17 IL IL281598A patent/IL281598A/en unknown
- 2021-03-18 US US17/205,841 patent/US20210206751A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
SG11202102653WA (en) | 2021-04-29 |
AU2019341666A1 (en) | 2021-05-13 |
BR112021005010A2 (pt) | 2021-06-08 |
IL281598A (en) | 2021-05-31 |
CN113694068A (zh) | 2021-11-26 |
WO2020058767A4 (en) | 2020-06-04 |
KR20210061390A (ko) | 2021-05-27 |
MX2021003123A (es) | 2021-08-11 |
JP7514841B2 (ja) | 2024-07-11 |
US20210206751A1 (en) | 2021-07-08 |
WO2020058767A1 (en) | 2020-03-26 |
CA3113169A1 (en) | 2020-03-26 |
CN113166127A (zh) | 2021-07-23 |
EP3853223A1 (en) | 2021-07-28 |
JP2022501424A (ja) | 2022-01-06 |
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