PL362801A1 - Sposób krystalizacji (R)-lub (S)-lansoprazolu - Google Patents
Sposób krystalizacji (R)-lub (S)-lansoprazoluInfo
- Publication number
- PL362801A1 PL362801A1 PL01362801A PL36280101A PL362801A1 PL 362801 A1 PL362801 A1 PL 362801A1 PL 01362801 A PL01362801 A PL 01362801A PL 36280101 A PL36280101 A PL 36280101A PL 362801 A1 PL362801 A1 PL 362801A1
- Authority
- PL
- Poland
- Prior art keywords
- lansoprazole
- crystallization
- crystal
- production method
- present
- Prior art date
Links
- MJIHNNLFOKEZEW-VWLOTQADSA-N 2-[(s)-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1h-benzimidazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1C[S@](=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-VWLOTQADSA-N 0.000 title abstract 4
- MJIHNNLFOKEZEW-RUZDIDTESA-N dexlansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1C[S@@](=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-RUZDIDTESA-N 0.000 title abstract 4
- 238000002425 crystallisation Methods 0.000 title abstract 2
- 230000008025 crystallization Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 229960003568 dexlansoprazole Drugs 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- -1 C1-4 alkyl acetate Chemical compound 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000367757 | 2000-12-01 | ||
| PCT/JP2001/010462 WO2002044167A1 (en) | 2000-12-01 | 2001-11-30 | Process for the crystallization of (r)- or (s)-lansoprazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL362801A1 true PL362801A1 (pl) | 2004-11-02 |
| PL214684B1 PL214684B1 (pl) | 2013-09-30 |
Family
ID=18838123
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL399787A PL399787A1 (pl) | 2000-12-01 | 2001-11-30 | Krysztaly (R)- lub (S)-2-[[[3-metylo-4-(2,2,2-trifluoroetoksy)-2-pirydynylo]metylo]sulfinylo]-1H-benzimidazolu, kompozycja farmaceutyczna zawierajaca te krysztaly i ich zastosowanie |
| PL362801A PL214684B1 (pl) | 2000-12-01 | 2001-11-30 | Sposób wytwarzania krysztalów (R) lub (S)-2-[[[3-metylo-4-(2,2,2-trifluoroetoksy)-2-pirydynylo]metylo]sulfinylo]-1H-benzimidazolu |
| PL409463A PL409463A1 (pl) | 2000-12-01 | 2001-11-30 | Kryształy (R) lub (S)-2-[[[3-metylo-4(2,2,2-trifluoroetoksy)-2-pirydynylo] metylo] sulfinylo]-1H-benzimidazolu, kompozycja farmaceutyczna zawierająca te kryształy i ich zastosowanie oraz sposób ich stabilizacji |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL399787A PL399787A1 (pl) | 2000-12-01 | 2001-11-30 | Krysztaly (R)- lub (S)-2-[[[3-metylo-4-(2,2,2-trifluoroetoksy)-2-pirydynylo]metylo]sulfinylo]-1H-benzimidazolu, kompozycja farmaceutyczna zawierajaca te krysztaly i ich zastosowanie |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL409463A PL409463A1 (pl) | 2000-12-01 | 2001-11-30 | Kryształy (R) lub (S)-2-[[[3-metylo-4(2,2,2-trifluoroetoksy)-2-pirydynylo] metylo] sulfinylo]-1H-benzimidazolu, kompozycja farmaceutyczna zawierająca te kryształy i ich zastosowanie oraz sposób ich stabilizacji |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7285668B2 (pl) |
| EP (2) | EP2345650A1 (pl) |
| KR (3) | KR20100002278A (pl) |
| CN (1) | CN1254473C (pl) |
| AT (1) | ATE511508T1 (pl) |
| AU (1) | AU2002218506A1 (pl) |
| CA (1) | CA2436825C (pl) |
| CY (1) | CY1112347T1 (pl) |
| DK (1) | DK1337525T3 (pl) |
| ES (1) | ES2367419T3 (pl) |
| HK (1) | HK1054380B (pl) |
| HU (1) | HU229356B1 (pl) |
| NO (1) | NO326019B1 (pl) |
| PL (3) | PL399787A1 (pl) |
| PT (1) | PT1337525E (pl) |
| TW (1) | TWI290922B (pl) |
| WO (1) | WO2002044167A1 (pl) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020027315A1 (en) * | 2000-03-10 | 2002-03-07 | Parker Gerard E. | Low-firing temperature method for producing Al2O3 bodies having enhanced chemical resistance |
| DE60131649T2 (de) | 2000-05-15 | 2008-10-30 | Takeda Pharmaceutical Co. Ltd. | Verfahren zur herstellung eines kristalls |
| EP1476442A2 (en) * | 2002-03-27 | 2004-11-17 | Teva Pharmaceutical Industries Ltd. | Lansoprazole polymorphs and processes for preparation thereof |
| EP1552833B1 (en) * | 2002-10-16 | 2016-12-28 | Takeda Pharmaceutical Company Limited | Process for producing an amorphous optically active isomer of lansoprazole |
| WO2004067526A1 (ja) * | 2003-01-31 | 2004-08-12 | Teijin Pharma Limited | (23S)-1αーヒドロキシー27-ノルー25-メチレンビタミンD3-26,23-ラクトンの結晶およびその製造方法 |
| US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| AR045061A1 (es) * | 2003-07-18 | 2005-10-12 | Santarus Inc | Formulacion farmaceutica y metodo para tratar trastornos gastrointestinales causados por acido |
| TWI398273B (zh) * | 2003-07-18 | 2013-06-11 | Santarus Inc | 用於抑制酸分泌之醫藥調配物及其製備及使用之方法 |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| CA2554271A1 (en) * | 2004-02-10 | 2005-08-25 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent |
| CA2561700A1 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
| US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2570916C (en) | 2004-06-16 | 2013-06-11 | Tap Pharmaceutical Products, Inc. | Pulsed release dosage form of a ppi |
| EP1681056A1 (en) * | 2005-01-14 | 2006-07-19 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for preparing lansoprazole |
| AU2006299424A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric H+, K+-ATPase with enhanced therapeutic properties |
| ZA200805646B (en) | 2005-12-28 | 2009-12-30 | Takeda Pharmaceutical | Controlled release solid preparation |
| KR100758600B1 (ko) | 2006-01-05 | 2007-09-13 | 주식회사 대웅제약 | 란소프라졸 결정형 a의 제조방법 |
| US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| EP2098250B1 (en) | 2006-12-28 | 2016-09-28 | Takeda Pharmaceutical Company Limited | Orally disintegrating solid preparation |
| WO2008087665A2 (en) * | 2007-01-18 | 2008-07-24 | Matrix Laboratories Ltd | Process for preparation of lansoprazole |
| KR101303813B1 (ko) | 2007-04-16 | 2013-09-04 | 에스케이케미칼주식회사 | 라세믹 오메프라졸로부터 에스오메프라졸의 개선된제조방법 |
| CA2702356C (en) * | 2007-10-12 | 2014-02-11 | Takeda Pharmaceuticals North America, Inc. | Pharmaceutical formulation comprising a proton pump inhibitor for the treatment of gastrointestinal conditions independent of food intake |
| EP2222663A1 (en) * | 2007-12-18 | 2010-09-01 | Watson Pharma Private Limited | A process for preparation of stable amorphous r-lansoprazole |
| BRPI0909651A2 (pt) | 2008-03-10 | 2015-09-22 | Takeda Pharmaceutical | cristal, agente farmacêutico, método para tratar ou evitar doença, uso do cristal, e, método para a produção de um cristal |
| EP2303868A2 (en) | 2008-05-14 | 2011-04-06 | Watson Pharma Private Limited | Stable r(+)-lansoprazole amine salt and a process for preparing the same |
| US20100113527A1 (en) * | 2008-09-30 | 2010-05-06 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of dexlansoprazole |
| KR101321055B1 (ko) * | 2008-11-14 | 2013-10-23 | 한미사이언스 주식회사 | 덱스란소프라졸의 신규 결정형 및 이를 포함하는 약학 조성물 |
| IT1391776B1 (it) * | 2008-11-18 | 2012-01-27 | Dipharma Francis Srl | Procedimento per la preparazione di dexlansoprazolo |
| WO2010095144A2 (en) * | 2009-02-04 | 2010-08-26 | Msn Laboratories Limited | Process for the preparation of proton pump inhibitors |
| IT1392813B1 (it) | 2009-02-06 | 2012-03-23 | Dipharma Francis Srl | Forme cristalline di dexlansoprazolo |
| US20110009637A1 (en) * | 2009-02-10 | 2011-01-13 | Dario Braga | Crystals of Dexlansoprazole |
| WO2011004387A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | Process for the preparation of dexlansoprazole polymorphic forms |
| IT1395118B1 (it) * | 2009-07-29 | 2012-09-05 | Dipharma Francis Srl | Procedimento per la preparazione di dexlansoprazolo cristallino |
| US20130197232A1 (en) | 2010-01-29 | 2013-08-01 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline forms of dexlansoprazole |
| CA2795056C (en) | 2010-03-31 | 2015-03-24 | Ranbaxy Laboratories Limited | Salts of dexlansoprazole and their preparation |
| AU2011234003B2 (en) * | 2010-03-31 | 2013-09-19 | Sun Pharmaceutical Industries Limited | Process for the preparation of dexlansoprazole |
| US20130216617A1 (en) | 2010-06-29 | 2013-08-22 | Cadila Healthcare Limited | Pharmaceutical compositions of (r)-lansoprazole |
| AU2011337549A1 (en) | 2010-12-03 | 2013-07-04 | Takeda Pharmaceutical Company Limited | Orally disintegrating tablet |
| UY33841A (es) | 2010-12-27 | 2012-07-31 | Takeda Pharmaceutical | Comprimido de desintegracion oral |
| WO2012104805A1 (en) | 2011-02-01 | 2012-08-09 | Ranbaxy Laboratories Limited | Process for the preparation of dexlansoprazole |
| EP2723728A1 (en) | 2011-06-21 | 2014-04-30 | Ranbaxy Laboratories Limited | Process for the preparation of dexlansoprazole |
| CN102234265B (zh) * | 2011-08-08 | 2013-11-20 | 天津市汉康医药生物技术有限公司 | 兰索拉唑化合物 |
| TWI630002B (zh) | 2011-11-30 | 2018-07-21 | 武田藥品工業股份有限公司 | 乾塗覆錠 |
| KR101604420B1 (ko) | 2011-12-29 | 2016-03-21 | 인텔 코포레이션 | 가변 깊이 압축 |
| WO2013140120A1 (en) | 2012-03-22 | 2013-09-26 | Cipla Limited | Glycerol solvate forms of (r) - 2 - [ [ [3 -methyl -4 (2,2, 2 - trifluoroethoxy) pyridin- 2 - yl] methyl] sulphinyl] - 1h - ben zimidazole |
| WO2013179194A1 (en) | 2012-05-31 | 2013-12-05 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline dexlansoprazole |
| HK1221899A1 (en) | 2013-05-21 | 2017-06-16 | Takeda Pharmaceutical Company Limited | Oral disintegrating tablets |
| CN103254174B (zh) * | 2013-06-05 | 2014-06-11 | 湖北济生医药有限公司 | 一种兰索拉唑化合物及其药物组合物 |
| US9920196B2 (en) | 2013-06-20 | 2018-03-20 | Japan Polypropylene Corporation | Propylene-based block copolymer |
| CN104958276A (zh) * | 2015-07-30 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗胃溃疡的药物兰索拉唑组合物胶囊 |
| CN104997739A (zh) * | 2015-08-31 | 2015-10-28 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗消化系统疾病的药物兰索拉唑组合物冻干粉针剂 |
| CN105399728B (zh) * | 2015-12-20 | 2017-11-28 | 寿光富康制药有限公司 | 一种适用于工业化生产的右兰索拉唑的处理方法 |
| CN106279107A (zh) * | 2016-08-10 | 2017-01-04 | 成都尚药科技有限公司 | 一种右旋兰索拉唑晶型的制备方法 |
| CN106749182A (zh) * | 2016-11-08 | 2017-05-31 | 山东裕欣药业有限公司 | 一种右旋兰索拉唑晶型化合物及其制备方法 |
| IT201700050223A1 (it) | 2017-05-09 | 2018-11-09 | Dipharma Francis Srl | Procedimento per la preparazione di dexlansoprazolo cristallino |
| EP4598528A1 (en) | 2022-10-04 | 2025-08-13 | Arsenil Zabirnyk | Inhibition of aortic valve calcification |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| DK171989B1 (da) | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| SE504459C2 (sv) | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
| HRP960232A2 (en) | 1995-07-03 | 1998-02-28 | Astra Ab | A process for the optical purification of compounds |
| JPH1085502A (ja) * | 1996-09-19 | 1998-04-07 | Konica Corp | 晶析方法 |
| TW385306B (en) | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| JP3828648B2 (ja) | 1996-11-14 | 2006-10-04 | 武田薬品工業株式会社 | 2−(2−ピリジルメチルスルフィニル)ベンズイミダゾール系化合物の結晶およびその製造法 |
| CN1238694A (zh) * | 1996-11-22 | 1999-12-15 | 普罗克特和甘保尔公司 | 治疗肠胃病用的含铋和nsaid的组合物 |
| AU2481899A (en) * | 1998-01-30 | 1999-08-16 | Sepracor, Inc. | S-lansoprazole compositions and methods |
| JP3283252B2 (ja) * | 1999-06-17 | 2002-05-20 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の結晶 |
| TWI289557B (en) * | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| JP4536905B2 (ja) * | 1999-06-17 | 2010-09-01 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の結晶 |
| EP1191025B1 (en) * | 1999-06-30 | 2005-06-22 | Takeda Pharmaceutical Company Limited | Crystals of lansoprazole |
| JP2001039975A (ja) * | 1999-07-26 | 2001-02-13 | Eisai Co Ltd | スルホキシド誘導体の結晶およびその製造法 |
| AU6727700A (en) | 1999-08-25 | 2001-03-19 | Takeda Chemical Industries Ltd. | Process for the preparation of optically active sulfoxide derivatives |
| ES2273829T3 (es) | 2000-04-28 | 2007-05-16 | Takeda Pharmaceutical Company Limited | Procedimiento para producir derivado de sulfoxido opticamente activo. |
| DE60131649T2 (de) | 2000-05-15 | 2008-10-30 | Takeda Pharmaceutical Co. Ltd. | Verfahren zur herstellung eines kristalls |
| CN1117747C (zh) * | 2000-06-19 | 2003-08-13 | 中国科学院成都有机化学研究所 | 光学纯兰索拉唑的制备方法 |
-
2001
- 2001-11-30 TW TW090129629A patent/TWI290922B/zh not_active IP Right Cessation
- 2001-11-30 PL PL399787A patent/PL399787A1/pl unknown
- 2001-11-30 EP EP10177469A patent/EP2345650A1/en not_active Ceased
- 2001-11-30 AU AU2002218506A patent/AU2002218506A1/en not_active Abandoned
- 2001-11-30 HK HK03106568.6A patent/HK1054380B/en not_active IP Right Cessation
- 2001-11-30 DK DK01998545.6T patent/DK1337525T3/da active
- 2001-11-30 PT PT01998545T patent/PT1337525E/pt unknown
- 2001-11-30 CN CNB018198163A patent/CN1254473C/zh not_active Expired - Lifetime
- 2001-11-30 WO PCT/JP2001/010462 patent/WO2002044167A1/en not_active Ceased
- 2001-11-30 CA CA2436825A patent/CA2436825C/en not_active Expired - Lifetime
- 2001-11-30 KR KR1020097023619A patent/KR20100002278A/ko not_active Ceased
- 2001-11-30 HU HU0400781A patent/HU229356B1/hu unknown
- 2001-11-30 ES ES01998545T patent/ES2367419T3/es not_active Expired - Lifetime
- 2001-11-30 US US10/432,798 patent/US7285668B2/en not_active Expired - Lifetime
- 2001-11-30 AT AT01998545T patent/ATE511508T1/de active
- 2001-11-30 EP EP01998545A patent/EP1337525B8/en not_active Expired - Lifetime
- 2001-11-30 PL PL362801A patent/PL214684B1/pl unknown
- 2001-11-30 KR KR1020087028441A patent/KR100939948B1/ko not_active Expired - Lifetime
- 2001-11-30 KR KR1020037007334A patent/KR100887912B1/ko not_active Expired - Lifetime
- 2001-11-30 PL PL409463A patent/PL409463A1/pl unknown
-
2003
- 2003-05-28 NO NO20032437A patent/NO326019B1/no not_active IP Right Cessation
-
2007
- 2007-09-07 US US11/899,918 patent/US20080306118A1/en not_active Abandoned
-
2011
- 2011-08-24 CY CY20111100809T patent/CY1112347T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1337525E (pt) | Processo para a cristalização de (r)- ou (s)-lansoprazole | |
| DK0573848T3 (da) | Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler | |
| DE3886297D1 (de) | Verfahren zur Herstellung von hochreinem Sauerstoffgas aus Luft. | |
| DK479389D0 (da) | Fremgangsmaade til produktion af en hydroponisk afgroede samt saaledes behandlet underlag og system | |
| ATE96167T1 (de) | Verfahren zur kristallisation von enzymen. | |
| DK0527537T3 (da) | Metalfjernelse fra vandige peroxysyrer eller peroxysalte | |
| WO2003041687A3 (fr) | Procede de production de solutions stables de substances phenoliques et les solutions en resultant | |
| PL315141A1 (en) | Derivatives of aryloacetic acid, method of obtaining them and fungicides containing such derivatives | |
| ATE85044T1 (de) | Verminderung von nitrosamin-bildung. | |
| DK546489A (da) | Thienopyridin-mevalonolactoner, fremgangsmaade til fremstilling heraf og farmaceutisk praeparat omfattende samme | |
| DE60104687D1 (de) | Mikrofiltration unter verwendung von aktivkohle | |
| PT85901A (en) | Method of desinfecting soft contact lenses with a stabilized hidrogen peroxide solution and process for preparing said solution | |
| DE3176791D1 (en) | Extraction process for the selective removal of cobalt (ii) from aqueous solutions | |
| ATE115547T1 (de) | Verfahren zur reinigung von tetraacetylethylendiamin (taed). | |
| DK0810989T3 (da) | DTPA-derivater, substitueret på hidtil ukendt måde, deres metalkomplekser, farmaceutiske midler indeholdende disse kompleks | |
| DE59713058D1 (de) | Verfahren zur herstellung von natriumpercarbonat | |
| ATE273263T1 (de) | Verfahren zur kontinuierlichen herstellung von glutaraldehyd | |
| DK0782996T3 (da) | Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af | |
| IT1243828B (it) | Processo per la rimozione del ferro da concentrati di caolino, quarzo e altri materiali di interesse industriale. | |
| DE60019723D1 (de) | Eine methode zur herstellung von verbindungen der formel 1 und derivaten | |
| JPS57100908A (en) | Stabilization of hydroxylamine or solution containing it by addition of 8 hydroxyquinoline | |
| SG118290A1 (en) | Processes for purifying phosphoric acid and for preparing phosphoric acid | |
| ATE191508T1 (de) | Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen | |
| DE60023232D1 (de) | Kristallisierung von Alpha-L-Aspartyl-L-Phenylalaninmethylester aus übersättigten Lösungen | |
| ATE275574T1 (de) | Verfahren zur reinigung von 5'-geschützten thymidinen |