WO2003041687A3 - Procede de production de solutions stables de substances phenoliques et les solutions en resultant - Google Patents

Procede de production de solutions stables de substances phenoliques et les solutions en resultant Download PDF

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Publication number
WO2003041687A3
WO2003041687A3 PCT/FR2002/003922 FR0203922W WO03041687A3 WO 2003041687 A3 WO2003041687 A3 WO 2003041687A3 FR 0203922 W FR0203922 W FR 0203922W WO 03041687 A3 WO03041687 A3 WO 03041687A3
Authority
WO
WIPO (PCT)
Prior art keywords
solutions
phenolic substances
deoxygenation
gas
invention concerns
Prior art date
Application number
PCT/FR2002/003922
Other languages
English (en)
Other versions
WO2003041687A2 (fr
Inventor
Bernard Dinnequin
Original Assignee
Aguettant Lab
Bernard Dinnequin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aguettant Lab, Bernard Dinnequin filed Critical Aguettant Lab
Priority to US10/495,841 priority Critical patent/US7199269B2/en
Priority to EP02803055A priority patent/EP1443902A2/fr
Publication of WO2003041687A2 publication Critical patent/WO2003041687A2/fr
Publication of WO2003041687A3 publication Critical patent/WO2003041687A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention se rapporte au domaine de la chimie thérapeutique et plus particulièrement au domaine de la pharmacotechnie. Elle a plus particulièrement pour objet un nouveau procédé de production de solutions à base de substances phénoliques stabilisés n'incluant pas d'agent anti-oxydant dans lequel on procède à la désoxygénation des solutions par un gaz inerte d'une part, et à la désoxygénation des volumes morts des cuves, des canalisations de fabrication ainsi qu'à un inertage des ampoules ou flacons contenant le soluté par un gaz inerte rare dense tel que l'argon, en opérant à basse température et à pH ajusté au-dessus de 3,0 et en dessous de 5,0 pour obtenir des solutions stables de substances phénoliques contenant moins de ou au plus 0,02 ppm d'oxygène dans la solution, que l'on filtre par double filtration stérilisante. Utilisation en thérapeutique humaine ou animale.
PCT/FR2002/003922 2001-11-15 2002-11-15 Procede de production de solutions stables de substances phenoliques et les solutions en resultant WO2003041687A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/495,841 US7199269B2 (en) 2001-11-15 2002-11-15 Method for producing stable solutions of phenolic substances and resulting solutions
EP02803055A EP1443902A2 (fr) 2001-11-15 2002-11-15 Procede de production de solutions stables de substances phenoliques et les solutions en resultant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0114796A FR2832063B1 (fr) 2001-11-15 2001-11-15 Procede de production de solutions stables de substances phenoliques et les solutions en resultant
FR01/14796 2001-11-15

Publications (2)

Publication Number Publication Date
WO2003041687A2 WO2003041687A2 (fr) 2003-05-22
WO2003041687A3 true WO2003041687A3 (fr) 2004-03-04

Family

ID=8869440

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/003922 WO2003041687A2 (fr) 2001-11-15 2002-11-15 Procede de production de solutions stables de substances phenoliques et les solutions en resultant

Country Status (4)

Country Link
US (1) US7199269B2 (fr)
EP (1) EP1443902A2 (fr)
FR (1) FR2832063B1 (fr)
WO (1) WO2003041687A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2880807B1 (fr) * 2005-01-19 2007-04-13 Aguettant Sa Lab Composition pharmaceutique injectable
US20120245230A1 (en) 2009-12-10 2012-09-27 Tecnimede-Sociedade Tecnico- Medicinal, S.A. Method and composition for preparing stable liquid formulations of paracetamol
US20110207824A1 (en) * 2010-02-25 2011-08-25 Moly Pharma Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution
LT2680832T (lt) 2011-03-04 2019-10-25 Gruenenthal Gmbh Tapentadolio vandeninė farmacinė kompozicija, skirta vartoti geriant
CN103371969A (zh) * 2012-04-17 2013-10-30 上海禾丰制药有限公司 重酒石酸间羟胺注射液及其制剂工艺
UY35988A (es) * 2014-02-27 2015-09-30 Sint Sa Proceso para la producción de una solución inyectable de noradrenalina de baja concentración
DK3142651T3 (en) * 2014-05-13 2019-03-25 Centre Hospitalier Regional Et Univ De Lille PHARMACEUTICAL SOLUTION CONTAINING DOPAMINE FOR USE TO TREAT PARKINSON'S DISEASE
ES2770731T3 (es) 2014-08-28 2020-07-02 Sun Pharmaceutical Ind Ltd Forma de dosificación parenteral de norepinefrina
CN104523582A (zh) * 2014-12-16 2015-04-22 成都新恒创药业有限公司 一种稳定的硫酸特步他林注射液及制备工艺
PT3479823T (pt) 2015-03-27 2020-09-29 Gruenenthal Gmbh Formulação estável para administração parentérica de tapentadol
EP3120837A1 (fr) 2015-07-22 2017-01-25 Stada Arzneimittel Ag Solution de bortezomib prêts à l'emploi
KR20190057349A (ko) 2016-09-23 2019-05-28 그뤼넨탈 게엠베하 타펜타돌의 비경구 투여용 안정한 제제
CA3051467C (fr) 2017-01-30 2022-11-29 Nevakar, Inc Compositions de norepinephrine et procedes associes
WO2019150381A1 (fr) * 2018-02-01 2019-08-08 Joshi Mahendra R Composition pharmaceutique stable et procédé de production d'une injection de chlorhydrate d'isoprotérénol
FR3095122B1 (fr) * 2019-04-18 2021-04-09 Crossject Solution pharmaceutique d’adrénaline pour dispositif d’injection
AU2021366122A1 (en) 2020-10-21 2023-05-25 Sintetica S.A. Stable, injectable noradrenaline solutions free of antioxidants
EP4231996A1 (fr) 2020-10-21 2023-08-30 Sintetica S.A. Poches de perfusion prêtes à l'emploi, à faible nombre de particules subvisibles
CN114601791B (zh) * 2020-12-08 2023-09-19 成都倍特药业股份有限公司 一种盐酸米托蒽醌液体制剂及其制备方法
CN112826793A (zh) * 2021-01-25 2021-05-25 石家庄四药有限公司 一种硫酸特布他林注射液及其制备方法
WO2024056749A1 (fr) 2022-09-14 2024-03-21 Inbrain Pharma Solution pharmaceutique injectable comprenant de la dopamine
CN116983259A (zh) * 2023-09-27 2023-11-03 成都瑞尔医药科技有限公司 一种依托泊苷注射液的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809619A1 (fr) * 2000-06-06 2001-12-07 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809619A1 (fr) * 2000-06-06 2001-12-07 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention

Also Published As

Publication number Publication date
FR2832063A1 (fr) 2003-05-16
US7199269B2 (en) 2007-04-03
WO2003041687A2 (fr) 2003-05-22
EP1443902A2 (fr) 2004-08-11
US20050070613A1 (en) 2005-03-31
FR2832063B1 (fr) 2004-08-27

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