DE69724618T2 - Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungen - Google Patents
Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungen Download PDFInfo
- Publication number
- DE69724618T2 DE69724618T2 DE69724618T DE69724618T DE69724618T2 DE 69724618 T2 DE69724618 T2 DE 69724618T2 DE 69724618 T DE69724618 T DE 69724618T DE 69724618 T DE69724618 T DE 69724618T DE 69724618 T2 DE69724618 T2 DE 69724618T2
- Authority
- DE
- Germany
- Prior art keywords
- mesembrine
- pharmaceutical compositions
- related compounds
- compounds
- compounds containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- DAHIQPJTGIHDGO-UHFFFAOYSA-N mesembrine Natural products C1=C(OC)C(OC)=CC=C1C1(CCC(=O)C2)C2N(C)CC1 DAHIQPJTGIHDGO-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- DAHIQPJTGIHDGO-IAGOWNOFSA-N mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@]1(CCC(=O)C2)[C@@H]2N(C)CC1 DAHIQPJTGIHDGO-IAGOWNOFSA-N 0.000 title 1
- DAHIQPJTGIHDGO-IRXDYDNUSA-N Mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@@]1(CCC(=O)C2)[C@H]2N(C)CC1 DAHIQPJTGIHDGO-IRXDYDNUSA-N 0.000 abstract 3
- KPMLOZVRLWHOBN-UHFFFAOYSA-N 3a-(3,4-dimethoxyphenyl)-1-methyl-3,4,5,6,7,7a-hexahydro-2h-indol-6-ol Chemical compound C1=C(OC)C(OC)=CC=C1C1(CCC(O)C2)C2N(C)CC1 KPMLOZVRLWHOBN-UHFFFAOYSA-N 0.000 abstract 2
- 208000020016 psychiatric disease Diseases 0.000 abstract 2
- 241000219479 Aizoaceae Species 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241001601435 Mesembryanthemum sect. Planifolia Species 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA964595 | 1996-06-04 | ||
| PCT/GB1997/001493 WO1997046234A1 (en) | 1996-06-04 | 1997-06-03 | Pharmaceutical compositions containing mesembrine and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69724618D1 DE69724618D1 (de) | 2003-10-09 |
| DE69724618T2 true DE69724618T2 (de) | 2005-04-21 |
Family
ID=25585724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69724618T Expired - Lifetime DE69724618T2 (de) | 1996-06-04 | 1997-06-03 | Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6288104B1 (de) |
| EP (1) | EP0910372B1 (de) |
| JP (2) | JP4315469B2 (de) |
| CN (1) | CN1227487A (de) |
| AT (1) | ATE248593T1 (de) |
| AU (1) | AU716611B2 (de) |
| DE (1) | DE69724618T2 (de) |
| WO (1) | WO1997046234A1 (de) |
| ZA (1) | ZA974576B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7643874B2 (en) | 2001-10-24 | 2010-01-05 | Power Paper Ltd. | Dermal patch |
| AU2002347567B2 (en) | 2001-10-24 | 2008-07-17 | Power Paper Ltd. | Dermal patch |
| CA2464949A1 (en) | 2001-10-24 | 2003-05-01 | Daniela Mavor | Device and method for controlled delivery of active substance into the skin |
| US7785324B2 (en) | 2005-02-25 | 2010-08-31 | Endoscopic Technologies, Inc. (Estech) | Clamp based lesion formation apparatus and methods configured to protect non-target tissue |
| WO2005051381A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) |
| WO2005051380A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octahydroindols as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
| TW200640529A (en) | 2005-02-28 | 2006-12-01 | Thomas Christian Lines | Composition for treating mental health disorders |
| WO2006114402A1 (en) * | 2005-04-25 | 2006-11-02 | Biovitrum Ab (Publ) | Substituted octahydroisoindoles as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
| US8980338B2 (en) * | 2009-03-20 | 2015-03-17 | H.L. Hall & Sons Limited | Sceletium extract and uses thereof |
| AU2010224485B2 (en) * | 2009-03-20 | 2014-04-17 | Hg&H Pharmaceuticals (Pty) Ltd | Use of pharmaceutical compositions containing mesembrenone |
| US9085559B2 (en) | 2010-01-29 | 2015-07-21 | Council Of Scientific & Industrial Research | Triazine-aryl-bis-indoles and process for preparation thereof |
| US9752932B2 (en) | 2010-03-10 | 2017-09-05 | Drexel University | Tunable electro-optic filter stack |
| US9576694B2 (en) | 2010-09-17 | 2017-02-21 | Drexel University | Applications for alliform carbon |
| US20160038551A1 (en) | 2013-03-28 | 2016-02-11 | Botanical Resource Holdings Proprietary Limited | Stabilized mesembrine compositions |
| CA2941099A1 (en) | 2014-02-28 | 2015-09-03 | Matthew L. Tripp | Phosphodiesterase inhibiting phytochemical compositions |
| US11173142B2 (en) * | 2015-03-27 | 2021-11-16 | Botanical Resource Holdings (Proprietary) Limited | Cancer treatment composition |
| CN106866496B (zh) * | 2017-04-21 | 2019-10-15 | 中国科学院上海有机化学研究所 | 六氢苯并喹啉-6-酮和六氢苯并吲哚-5-酮化合物、合成方法及用途 |
| US20200215033A1 (en) * | 2017-07-26 | 2020-07-09 | Hg&H Pharmaceuticals (Pty) Ltd | Mesembrenol and/or mesembranol for prophylaxis and treatment of patients suffering from epilepsy and associated diseases |
| AU2021409812A1 (en) | 2020-12-21 | 2023-07-27 | Kanna Health Ltd. | Methods for delay of ejaculation in human males |
| CN113072576B (zh) * | 2021-04-07 | 2022-04-26 | 四川大学 | 一类手性硅代松叶菊碱、合成方法及用途 |
| WO2023004428A1 (en) * | 2021-07-22 | 2023-01-26 | Kanna Health Ltd. | Novel compounds and uses thereof |
| CA3233930A1 (en) * | 2021-10-19 | 2023-04-27 | Justin KIRKLAND | Mesembrine derivatives |
| WO2023076533A1 (en) * | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| GB2616343A (en) * | 2022-03-02 | 2023-09-06 | Kanna Health Ltd | Compounds for the use in the treatment of mood disorders |
| WO2023166304A1 (en) * | 2022-03-02 | 2023-09-07 | Kanna Health Ltd | Compounds for the use in the treatment of mood disorders |
| WO2023225773A1 (en) * | 2022-05-23 | 2023-11-30 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| GB2623122A (en) * | 2022-10-07 | 2024-04-10 | Kanna Health Ltd | Preparation of mesembrine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3604112A1 (de) | 1986-02-10 | 1987-08-13 | Bernhard Dr Janiak | Pflanzenextrakte von mesembryanthemaceen sowie solche enthaltende schaedlingsbekaempfungsmittel und arzneimittel |
-
1997
- 1997-05-26 ZA ZA9704576A patent/ZA974576B/xx unknown
- 1997-06-03 WO PCT/GB1997/001493 patent/WO1997046234A1/en active IP Right Grant
- 1997-06-03 US US09/194,836 patent/US6288104B1/en not_active Expired - Lifetime
- 1997-06-03 DE DE69724618T patent/DE69724618T2/de not_active Expired - Lifetime
- 1997-06-03 JP JP50031498A patent/JP4315469B2/ja not_active Expired - Fee Related
- 1997-06-03 AT AT97924158T patent/ATE248593T1/de not_active IP Right Cessation
- 1997-06-03 CN CN97197056A patent/CN1227487A/zh active Pending
- 1997-06-03 EP EP97924158A patent/EP0910372B1/de not_active Expired - Lifetime
- 1997-06-03 AU AU29722/97A patent/AU716611B2/en not_active Expired
-
2008
- 2008-10-22 JP JP2008272215A patent/JP2009062387A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US6288104B1 (en) | 2001-09-11 |
| JP2000511896A (ja) | 2000-09-12 |
| AU2972297A (en) | 1998-01-05 |
| JP4315469B2 (ja) | 2009-08-19 |
| ATE248593T1 (de) | 2003-09-15 |
| AU716611B2 (en) | 2000-03-02 |
| CN1227487A (zh) | 1999-09-01 |
| EP0910372A1 (de) | 1999-04-28 |
| JP2009062387A (ja) | 2009-03-26 |
| ZA974576B (en) | 1998-02-04 |
| EP0910372B1 (de) | 2003-09-03 |
| DE69724618D1 (de) | 2003-10-09 |
| WO1997046234A1 (en) | 1997-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: H.L. HALL & SONS LTD., SANDTON, ZA |