PL2168968T3 - Inhibitory kinazy białkowej stanowiące związki heterobicykliczne z podstawionym pierścieniem 6,6-bicyklicznym - Google Patents
Inhibitory kinazy białkowej stanowiące związki heterobicykliczne z podstawionym pierścieniem 6,6-bicyklicznymInfo
- Publication number
- PL2168968T3 PL2168968T3 PL09156987T PL09156987T PL2168968T3 PL 2168968 T3 PL2168968 T3 PL 2168968T3 PL 09156987 T PL09156987 T PL 09156987T PL 09156987 T PL09156987 T PL 09156987T PL 2168968 T3 PL2168968 T3 PL 2168968T3
- Authority
- PL
- Poland
- Prior art keywords
- protein kinase
- kinase inhibitors
- bicyclic ring
- ring substituted
- substituted heterobicyclic
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
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- Virology (AREA)
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- Endocrinology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
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- Molecular Biology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
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- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55925004P | 2004-04-02 | 2004-04-02 | |
| EP05742128A EP1740591B1 (en) | 2004-04-02 | 2005-03-31 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| EP09156987.1A EP2168968B1 (en) | 2004-04-02 | 2005-03-31 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2168968T3 true PL2168968T3 (pl) | 2018-02-28 |
Family
ID=34967819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05742128T PL1740591T3 (pl) | 2004-04-02 | 2005-03-31 | Heterobicykliczne inhibitory kinazy białkowej podstawione 6,6-bicyklicznym pierścieniem |
| PL09156987T PL2168968T3 (pl) | 2004-04-02 | 2005-03-31 | Inhibitory kinazy białkowej stanowiące związki heterobicykliczne z podstawionym pierścieniem 6,6-bicyklicznym |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05742128T PL1740591T3 (pl) | 2004-04-02 | 2005-03-31 | Heterobicykliczne inhibitory kinazy białkowej podstawione 6,6-bicyklicznym pierścieniem |
Country Status (30)
| Country | Link |
|---|---|
| US (6) | US7534797B2 (pl) |
| EP (4) | EP1740591B1 (pl) |
| JP (2) | JP4832426B2 (pl) |
| KR (1) | KR101079272B1 (pl) |
| CN (2) | CN102924458B (pl) |
| AP (1) | AP2139A (pl) |
| AR (1) | AR048518A1 (pl) |
| AT (1) | ATE433979T1 (pl) |
| AU (1) | AU2005230818B2 (pl) |
| BR (1) | BRPI0509576A (pl) |
| CA (1) | CA2561950C (pl) |
| CY (1) | CY1109372T1 (pl) |
| DE (1) | DE602005014964D1 (pl) |
| DK (1) | DK1740591T3 (pl) |
| EA (1) | EA012873B1 (pl) |
| ES (2) | ES2652440T3 (pl) |
| HK (1) | HK1100040A1 (pl) |
| HR (1) | HRP20090495T1 (pl) |
| IL (1) | IL178419A0 (pl) |
| MX (1) | MXPA06011423A (pl) |
| MY (1) | MY143225A (pl) |
| NO (1) | NO20064895L (pl) |
| PL (2) | PL1740591T3 (pl) |
| PT (2) | PT1740591E (pl) |
| RU (1) | RU2379308C2 (pl) |
| SG (1) | SG163576A1 (pl) |
| SI (1) | SI1740591T1 (pl) |
| TW (2) | TW201134828A (pl) |
| UA (1) | UA89493C2 (pl) |
| WO (1) | WO2005097800A1 (pl) |
Families Citing this family (157)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| AU2004282219C1 (en) * | 2003-10-15 | 2009-12-17 | Osi Pharmaceuticals, Inc. | Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors |
| RU2379308C2 (ru) | 2004-04-02 | 2010-01-20 | Оси Фармасьютикалз, Инк. | 6, 6-бициклические кольцевые замещенные гетеробициклические ингибиторы протеинкиназ |
| AR053090A1 (es) * | 2004-07-20 | 2007-04-25 | Osi Pharm Inc | Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos |
| WO2006068760A2 (en) * | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| JP5335432B2 (ja) | 2005-11-17 | 2013-11-06 | オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー | 縮合２環系ｍＴＯＲ阻害剤 |
| AR057960A1 (es) * | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
| TW200730529A (en) * | 2005-12-07 | 2007-08-16 | Osi Pharm Inc | Process to prepare substituted imidazopyrazine compounds |
| US8575164B2 (en) * | 2005-12-19 | 2013-11-05 | OSI Pharmaceuticals, LLC | Combination cancer therapy |
| US20080299113A1 (en) * | 2005-12-19 | 2008-12-04 | Arnold Lee D | Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents |
| WO2007079164A2 (en) * | 2005-12-29 | 2007-07-12 | Abbott Laboratories | Protein kinase inhibitors |
| CN101003537A (zh) * | 2006-01-17 | 2007-07-25 | 上海恒瑞医药有限公司 | 吡咯并哒嗪类衍生物及其制备方法和用途 |
| WO2007087395A2 (en) * | 2006-01-25 | 2007-08-02 | Osi Pharmaceuticals, Inc. | UNSATURATED mTOR INHIBITORS |
| PT2004654E (pt) * | 2006-04-04 | 2013-08-27 | Univ California | Derivados de pirazolopirimidina para utilização como antagonistas da quinase |
| DE102006016426A1 (de) * | 2006-04-07 | 2007-10-11 | Merck Patent Gmbh | Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren |
| EP2021338A1 (en) | 2006-05-09 | 2009-02-11 | Pfizer Products Inc. | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
| EP2057164A1 (en) | 2006-08-07 | 2009-05-13 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| DE102006043443A1 (de) * | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| HUE026659T2 (en) | 2006-11-22 | 2016-07-28 | Incyte Holdings Corp | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
| WO2008076143A1 (en) * | 2006-12-18 | 2008-06-26 | Osi Pharmaceuticals, Inc. | Combination of igfr inhibitor and anti-cancer agent |
| TW200900070A (en) * | 2007-02-27 | 2009-01-01 | Osi Pharm Inc | Combination cancer therapy |
| WO2008141140A1 (en) * | 2007-05-09 | 2008-11-20 | Abbott Laboratories | Condensed heterocyclic compounds as inhibitors of protein kinases |
| US8124759B2 (en) | 2007-05-09 | 2012-02-28 | Abbott Laboratories | Inhibitors of protein kinases |
| ATE527264T1 (de) * | 2007-05-09 | 2011-10-15 | Abbott Lab | Kondensierte heterozyklische verbindungen als hemmer von proteinkinasen |
| JP2010532758A (ja) * | 2007-07-06 | 2010-10-14 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | 組み合わせ抗癌療法 |
| WO2009008992A2 (en) * | 2007-07-06 | 2009-01-15 | Osi Pharmaceuticals Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mt0rc2 |
| JP2010540960A (ja) | 2007-10-03 | 2010-12-24 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | インスリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー |
| WO2009045389A2 (en) | 2007-10-03 | 2009-04-09 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
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