PL2032575T3 - Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie - Google Patents
Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanieInfo
- Publication number
- PL2032575T3 PL2032575T3 PL07729591T PL07729591T PL2032575T3 PL 2032575 T3 PL2032575 T3 PL 2032575T3 PL 07729591 T PL07729591 T PL 07729591T PL 07729591 T PL07729591 T PL 07729591T PL 2032575 T3 PL2032575 T3 PL 2032575T3
- Authority
- PL
- Poland
- Prior art keywords
- diseases
- disorders
- diaza
- bicyclo
- novel
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
- 201000010099 disease Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 230000001713 cholinergic effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 2
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 208000017701 Endocrine disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 230000016160 smooth muscle contraction Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80902406P | 2006-05-30 | 2006-05-30 | |
| DKPA200600731 | 2006-05-30 | ||
| EP07729591A EP2032575B1 (en) | 2006-05-30 | 2007-05-29 | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivative and its medical use |
| PCT/EP2007/055169 WO2007138038A1 (en) | 2006-05-30 | 2007-05-29 | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2032575T3 true PL2032575T3 (pl) | 2010-09-30 |
Family
ID=40616686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07729591T PL2032575T3 (pl) | 2006-05-30 | 2007-05-29 | Nowa pochodna oksadiazolylu, 1,4-diaza-bicyklo[3.2.2]nonylu i jej medyczne zastosowanie |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US8158619B2 (enExample) |
| EP (3) | EP2194056B1 (enExample) |
| JP (2) | JP2009538866A (enExample) |
| KR (1) | KR101458194B1 (enExample) |
| CN (2) | CN101432286A (enExample) |
| AT (3) | ATE467634T1 (enExample) |
| AU (2) | AU2007267174B2 (enExample) |
| BR (1) | BRPI0708843A2 (enExample) |
| CA (2) | CA2653818A1 (enExample) |
| DE (2) | DE602007005802D1 (enExample) |
| DK (2) | DK2032575T3 (enExample) |
| ES (1) | ES2342334T3 (enExample) |
| IL (1) | IL193925A (enExample) |
| MX (2) | MX2008014887A (enExample) |
| MY (1) | MY147764A (enExample) |
| NO (1) | NO20085398L (enExample) |
| NZ (1) | NZ571288A (enExample) |
| PL (1) | PL2032575T3 (enExample) |
| PT (1) | PT2032575E (enExample) |
| RU (1) | RU2427581C2 (enExample) |
| UA (1) | UA95946C2 (enExample) |
| WO (2) | WO2007138038A1 (enExample) |
| ZA (1) | ZA200807756B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101432286A (zh) | 2006-05-30 | 2009-05-13 | 神经研究公司 | 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 |
| MX2009003892A (es) * | 2006-10-25 | 2009-04-23 | Neurosearch As | Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico. |
| US7935695B2 (en) | 2007-08-17 | 2011-05-03 | Neurosearch A/S | 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands |
| JP2011513459A (ja) | 2008-03-11 | 2011-04-28 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体のモジュレーターとして有用な、新規な１，４−ジアザ−ビシクロ［３．２．２］ノニルオキサジアゾリル誘導体 |
| US20110112078A1 (en) * | 2008-06-10 | 2011-05-12 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
| WO2010043539A1 (en) * | 2008-10-13 | 2010-04-22 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
| WO2010063784A1 (en) * | 2008-12-04 | 2010-06-10 | Neurosearch A/S | Novel diaza-bicyclononyl-phenyl derivatives and their medical use |
| CA2750450A1 (en) | 2009-01-26 | 2010-07-29 | Neurosearch A/S | Novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use |
| US20110319397A1 (en) | 2009-01-27 | 2011-12-29 | Neurosearch A/S | Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
| US20120028968A1 (en) | 2009-01-27 | 2012-02-02 | Neurosearch A/S | Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
| US20120238553A1 (en) * | 2009-01-27 | 2012-09-20 | Neurosearch A/S | Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
| WO2010130768A1 (en) * | 2009-05-14 | 2010-11-18 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| WO2011058002A1 (en) | 2009-11-11 | 2011-05-19 | Neurosearch A/S | Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods |
| EP2513097A1 (en) | 2009-12-18 | 2012-10-24 | NeuroSearch AS | Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
| WO2012139925A1 (en) | 2011-04-15 | 2012-10-18 | Neurosearch A/S | Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
| CN111499615B (zh) | 2017-08-04 | 2024-02-02 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| AU2019255310B2 (en) | 2018-04-18 | 2022-11-24 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| CN120097995A (zh) | 2018-05-21 | 2025-06-06 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| WO2020163323A1 (en) * | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| EP3920915A4 (en) | 2019-02-05 | 2022-10-05 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICE |
| JP7603595B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665745A (en) * | 1994-10-24 | 1997-09-09 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
| FR2809732B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
| FR2809731B1 (fr) | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
| FR2832713B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| FR2832712B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
| BR0314183A (pt) * | 2002-09-30 | 2005-08-09 | Neurosearch As | Derivados de 1,4-diazabicicloalcano, quaisquer de seus enanciÈmeros ou qualquer mistura de seus enaciÈmeros, ou um seu sal de adição farmaceuticamente aceitável ou um seu n-óxido, composição farmacêutica, uso do dito composto, de qualquer um de seus enanciÈmeros ou de qualquer mistura de seus enanciÈmeros, ou de um seu sal de adição farmaceuticamente aceitável, e, método de tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou condição de um corpo animal vivo |
| PL375025A1 (en) | 2002-09-30 | 2005-11-14 | Neurosearch A/S | Novel 1,4-diazabicycloalkane derivatives, their preparation and use |
| DK1562945T3 (da) * | 2002-11-11 | 2007-03-05 | Neurosearch As | Hidtil ukendte diazebicykliske biarylderivater |
| US6996399B2 (en) * | 2003-01-13 | 2006-02-07 | Micrel, Inc. | Wireless device and method using frequency hopping and sweep modes |
| EP1713487B1 (en) * | 2004-02-04 | 2009-12-02 | Neurosearch A/S | Diazabicyclic aryl derivatives as cholinergic receptor modulators |
| JP2008530172A (ja) | 2005-02-16 | 2008-08-07 | ノイロサーチ アクティーゼルスカブ | ジアザ二環系アリール誘導体及びそれらのニコチン様アセチルコリン受容体におけるコリン作動性リガンドとしての使用 |
| CN101432286A (zh) * | 2006-05-30 | 2009-05-13 | 神经研究公司 | 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 |
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2007
- 2007-05-29 CN CNA200780015245XA patent/CN101432286A/zh active Pending
- 2007-05-29 AT AT07729590T patent/ATE467634T1/de active
- 2007-05-29 AT AT07729591T patent/ATE463497T1/de active
- 2007-05-29 US US12/297,333 patent/US8158619B2/en not_active Expired - Fee Related
- 2007-05-29 PL PL07729591T patent/PL2032575T3/pl unknown
- 2007-05-29 MX MX2008014887A patent/MX2008014887A/es active IP Right Grant
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- 2007-05-29 BR BRPI0708843-4A patent/BRPI0708843A2/pt not_active IP Right Cessation
- 2007-05-29 EP EP10154049A patent/EP2194056B1/en not_active Not-in-force
- 2007-05-29 WO PCT/EP2007/055169 patent/WO2007138038A1/en not_active Ceased
- 2007-05-29 NZ NZ571288A patent/NZ571288A/en not_active IP Right Cessation
- 2007-05-29 MY MYPI20084717A patent/MY147764A/en unknown
- 2007-05-29 JP JP2009512568A patent/JP2009538866A/ja active Pending
- 2007-05-29 WO PCT/EP2007/055168 patent/WO2007138037A1/en not_active Ceased
- 2007-05-29 CN CN200780014526.3A patent/CN101426790B/zh not_active Expired - Fee Related
- 2007-05-29 US US12/300,060 patent/US7807667B2/en not_active Expired - Fee Related
- 2007-05-29 DE DE602007005802T patent/DE602007005802D1/de active Active
- 2007-05-29 DE DE602007006486T patent/DE602007006486D1/de active Active
- 2007-05-29 DK DK07729591.3T patent/DK2032575T3/da active
- 2007-05-29 CA CA002653818A patent/CA2653818A1/en not_active Abandoned
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- 2007-05-29 JP JP2009512569A patent/JP5290964B2/ja not_active Expired - Fee Related
- 2007-05-29 ES ES07729591T patent/ES2342334T3/es active Active
- 2007-05-29 KR KR1020087031858A patent/KR101458194B1/ko not_active Expired - Fee Related
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- 2007-05-29 ZA ZA200807756A patent/ZA200807756B/xx unknown
- 2007-05-29 CA CA002653769A patent/CA2653769A1/en not_active Abandoned
- 2007-05-29 UA UAA200811110A patent/UA95946C2/ru unknown
- 2007-05-29 DK DK07729590.5T patent/DK2032574T3/da active
- 2007-05-29 EP EP07729591A patent/EP2032575B1/en not_active Not-in-force
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2008
- 2008-09-04 IL IL193925A patent/IL193925A/en not_active IP Right Cessation
- 2008-12-29 NO NO20085398A patent/NO20085398L/no not_active Application Discontinuation
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2010
- 2010-08-23 US US12/861,420 patent/US8101598B2/en not_active Expired - Fee Related
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2012
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