CA2653769A1 - Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use - Google Patents

Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use Download PDF

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Publication number
CA2653769A1
CA2653769A1 CA002653769A CA2653769A CA2653769A1 CA 2653769 A1 CA2653769 A1 CA 2653769A1 CA 002653769 A CA002653769 A CA 002653769A CA 2653769 A CA2653769 A CA 2653769A CA 2653769 A1 CA2653769 A1 CA 2653769A1
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CA
Canada
Prior art keywords
diaza
bicyclo
alkyl
phenyl
oxadiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002653769A
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English (en)
French (fr)
Inventor
Dan Peters
Gunnar M. Olsen
Elsebet Oestergaard Nielsen
Daniel B. Timmermann
Steven Charles Loechel
Jens Damsgaard Mikkelsen
Henrik Bjoerk Hansen
John Paul Redrobe
Jeppe Kejser Christensen
Tino Dyhring
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NTG Nordic Transport Group AS
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Individual
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Filing date
Publication date
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Publication of CA2653769A1 publication Critical patent/CA2653769A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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CA002653769A 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use Abandoned CA2653769A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
DKPA200600731 2006-05-30
US60/809,024 2006-05-30
PCT/EP2007/055168 WO2007138037A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

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CA2653769A1 true CA2653769A1 (en) 2007-12-06

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CA002653769A Abandoned CA2653769A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
CA002653818A Abandoned CA2653818A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

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CA002653818A Abandoned CA2653818A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

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Country Link
US (4) US8158619B2 (enExample)
EP (3) EP2194056B1 (enExample)
JP (2) JP2009538866A (enExample)
KR (1) KR101458194B1 (enExample)
CN (2) CN101432286A (enExample)
AT (3) ATE463497T1 (enExample)
AU (2) AU2007267174B2 (enExample)
BR (1) BRPI0708843A2 (enExample)
CA (2) CA2653769A1 (enExample)
DE (2) DE602007005802D1 (enExample)
DK (2) DK2032574T3 (enExample)
ES (1) ES2342334T3 (enExample)
IL (1) IL193925A (enExample)
MX (2) MX2008014886A (enExample)
MY (1) MY147764A (enExample)
NO (1) NO20085398L (enExample)
NZ (1) NZ571288A (enExample)
PL (1) PL2032575T3 (enExample)
PT (1) PT2032575E (enExample)
RU (1) RU2427581C2 (enExample)
UA (1) UA95946C2 (enExample)
WO (2) WO2007138038A1 (enExample)
ZA (1) ZA200807756B (enExample)

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NZ571288A (en) 2006-05-30 2011-05-27 Neurosearch As Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
EP2079734A1 (en) * 2006-10-25 2009-07-22 NeuroSearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
WO2009024517A1 (en) 2007-08-17 2009-02-26 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
US8106042B2 (en) 2008-03-11 2012-01-31 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
US20110112078A1 (en) * 2008-06-10 2011-05-12 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110263577A1 (en) * 2008-10-13 2011-10-27 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110257161A1 (en) * 2008-12-04 2011-10-20 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
WO2010084185A1 (en) 2009-01-26 2010-07-29 Neurosearch A/S Novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120238553A1 (en) * 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
WO2011058002A1 (en) 2009-11-11 2011-05-19 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
WO2011073296A1 (en) 2009-12-18 2011-06-23 Neurosearch A/S Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
WO2012139925A1 (en) 2011-04-15 2012-10-18 Neurosearch A/S Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
MX2020001425A (es) 2017-08-04 2020-08-06 Skyhawk Therapeutics Inc Metodos y composiciones para modular el empalme.
MX2020010999A (es) 2018-04-18 2021-01-20 Constellation Pharmaceuticals Inc Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos.
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
WO2020163248A1 (en) 2019-02-04 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN113660936A (zh) * 2019-02-04 2021-11-16 斯基霍克疗法公司 用于调节剪接的方法和组合物
WO2020163541A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
KR102913697B1 (ko) 2019-02-05 2026-01-15 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
KR102925385B1 (ko) 2019-02-06 2026-02-11 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물
PE20220562A1 (es) 2019-07-24 2022-04-13 Constellation Pharmaceuticals Inc Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamida

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