PL125030B1 - Method of manufacture of novel derivatives of 4-aminoquinoline-3-carboxylic acid - Google Patents

Method of manufacture of novel derivatives of 4-aminoquinoline-3-carboxylic acid Download PDF

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Publication number
PL125030B1
PL125030B1 PL1980222993A PL22299380A PL125030B1 PL 125030 B1 PL125030 B1 PL 125030B1 PL 1980222993 A PL1980222993 A PL 1980222993A PL 22299380 A PL22299380 A PL 22299380A PL 125030 B1 PL125030 B1 PL 125030B1
Authority
PL
Poland
Prior art keywords
preparation
carboxylic acid
ethyl ester
lower alkyl
acid ethyl
Prior art date
Application number
PL1980222993A
Other languages
English (en)
Polish (pl)
Other versions
PL222993A1 (OSRAM
Inventor
Harry R Munson
Reevis S Alphin
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of PL222993A1 publication Critical patent/PL222993A1/xx
Publication of PL125030B1 publication Critical patent/PL125030B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL1980222993A 1979-03-26 1980-03-25 Method of manufacture of novel derivatives of 4-aminoquinoline-3-carboxylic acid PL125030B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2398179A 1979-03-26 1979-03-26
US06/127,153 US4343804A (en) 1979-03-26 1980-03-04 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds

Publications (2)

Publication Number Publication Date
PL222993A1 PL222993A1 (OSRAM) 1981-01-30
PL125030B1 true PL125030B1 (en) 1983-03-31

Family

ID=26697875

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1980222993A PL125030B1 (en) 1979-03-26 1980-03-25 Method of manufacture of novel derivatives of 4-aminoquinoline-3-carboxylic acid

Country Status (31)

Country Link
US (1) US4343804A (OSRAM)
JP (1) JPH02117663A (OSRAM)
AR (1) AR230268A1 (OSRAM)
AT (1) AT372373B (OSRAM)
AU (1) AU528388B2 (OSRAM)
BR (1) BR8001779A (OSRAM)
CA (1) CA1147338A (OSRAM)
CH (1) CH644105A5 (OSRAM)
DE (1) DE3011490A1 (OSRAM)
DK (1) DK156056C (OSRAM)
EG (1) EG15009A (OSRAM)
ES (1) ES8103048A1 (OSRAM)
FI (1) FI77452C (OSRAM)
FR (1) FR2452485B1 (OSRAM)
GB (1) GB2047244B (OSRAM)
GR (1) GR68006B (OSRAM)
HK (1) HK67983A (OSRAM)
IE (1) IE49577B1 (OSRAM)
IL (1) IL59628A (OSRAM)
IN (1) IN151446B (OSRAM)
IT (1) IT1133079B (OSRAM)
MX (1) MX6264E (OSRAM)
NL (1) NL8001752A (OSRAM)
NO (1) NO153927C (OSRAM)
NZ (1) NZ193252A (OSRAM)
PH (1) PH16416A (OSRAM)
PL (1) PL125030B1 (OSRAM)
PT (1) PT71008B (OSRAM)
SE (1) SE435837B (OSRAM)
SG (1) SG33683G (OSRAM)
YU (1) YU41702B (OSRAM)

Families Citing this family (44)

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GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5432182A (en) * 1989-02-23 1995-07-11 Smithkline Beecham Intercredit B.V. Compounds substituted quinoline derivatives
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
DE3917233A1 (de) * 1989-05-26 1990-11-29 Basf Ag 8-substituierte 4-(heterocyclylmethylamino)-chinoline, ihre verwendung und daraus hergestellte arzneimittel
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
WO1995004720A2 (en) * 1993-08-10 1995-02-16 Black James Foundation Gastrin and cck receptor ligands
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
KR0169813B1 (ko) * 1995-07-12 1999-01-15 김종인 4-아미노-3-아실나프티리딘 유도체
US5760041A (en) * 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
US6875769B2 (en) * 1996-05-23 2005-04-05 Pfizer Inc. Substituted6,6-hetero-bicyclicderivatives
US5929080A (en) * 1997-05-06 1999-07-27 American Cyanamid Company Method of treating polycystic kidney disease
US6251912B1 (en) 1997-08-01 2001-06-26 American Cyanamid Company Substituted quinazoline derivatives
US6323209B1 (en) 1997-11-06 2001-11-27 American Cyanamid Company Method of treating or inhibiting colonic polyps
EP1117649A1 (en) 1998-09-29 2001-07-25 American Cyanamid Company Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
CN1217936C (zh) * 1999-12-28 2005-09-07 卫材株式会社 含有磺酰胺的杂环化合物
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
US6576644B2 (en) * 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
PL377847A1 (pl) 2003-01-14 2006-02-20 Arena Pharmaceuticals Inc. 1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia
PL1606261T3 (pl) 2003-03-10 2010-04-30 Astrazeneca Ab Nowy sposób przygotowania roflumilastu
KR20060056944A (ko) * 2003-07-14 2006-05-25 아레나 파마슈티칼스, 인크. 대사 조절제로서 융합된 아릴 및 헤테로아릴 유도체 및이에 관련된 장애의 예방 또는 치료
EP1861074B1 (en) * 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
WO2011022216A1 (en) * 2009-08-17 2011-02-24 High Point Pharmaceuticals, Llc Substituted pyridine derivatives, pharmaceutical compositions, and methods of use to treat oxidative stress
CN108558740B (zh) 2010-01-27 2021-10-19 艾尼纳制药公司 S1p1受体调节剂及其盐的制备方法
CA2812061A1 (en) 2010-09-22 2012-03-29 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US11007175B2 (en) 2015-01-06 2021-05-18 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
KR102883123B1 (ko) 2015-06-22 2025-11-10 아레나 파마슈티칼스, 인크. Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염
AU2017357503B2 (en) * 2016-11-11 2022-02-17 Elanco Animal Health Gmbh New anthelmintic quinoline-3-carboxamide derivatives
MA47504A (fr) 2017-02-16 2019-12-25 Arena Pharm Inc Composés et méthodes de traitement de l'angiocholite biliaire primitive
EP3700527A4 (en) * 2017-10-25 2021-03-10 Children's Medical Center Corporation PAPD5 INHIBITORS AND METHOD OF USING THEM
US11572357B2 (en) 2018-05-09 2023-02-07 Bayer Animal Health Gmbh Quinoline derivatives
WO2019236757A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
JP7617020B2 (ja) 2019-04-24 2025-01-17 チルドレンズ メディカル センター コーポレイション Ｐａｐｄ５阻害剤およびその使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
JPS4838712A (OSRAM) * 1971-09-18 1973-06-07

Also Published As

Publication number Publication date
PL222993A1 (OSRAM) 1981-01-30
AR230268A1 (es) 1984-03-01
MX6264E (es) 1985-02-19
NL8001752A (nl) 1980-09-30
FR2452485A1 (fr) 1980-10-24
NO153927B (no) 1986-03-10
BR8001779A (pt) 1980-11-18
ES489887A0 (es) 1981-02-16
IT1133079B (it) 1986-07-09
IL59628A (en) 1983-06-15
US4343804A (en) 1982-08-10
DE3011490C2 (OSRAM) 1988-12-22
IN151446B (OSRAM) 1983-04-23
NO800858L (no) 1980-09-29
JPH02117663A (ja) 1990-05-02
PT71008B (en) 1981-06-25
NO153927C (no) 1986-06-18
CH644105A5 (fr) 1984-07-13
SE435837B (sv) 1984-10-22
EG15009A (en) 1985-03-31
YU41702B (en) 1987-12-31
ES8103048A1 (es) 1981-02-16
NZ193252A (en) 1984-04-27
DE3011490A1 (de) 1981-03-12
PT71008A (en) 1980-04-01
YU84480A (en) 1983-10-31
SE8002292L (sv) 1980-09-27
ATA156480A (de) 1983-02-15
FI77452B (fi) 1988-11-30
CA1147338A (en) 1983-05-31
IE49577B1 (en) 1985-10-30
FI77452C (fi) 1989-03-10
DK128380A (da) 1980-09-27
GR68006B (OSRAM) 1981-10-26
IT8067465A0 (it) 1980-03-26
FR2452485B1 (fr) 1986-09-12
DK156056B (da) 1989-06-19
FI800910A7 (fi) 1980-09-27
HK67983A (en) 1983-12-23
IE800605L (en) 1980-09-26
IL59628A0 (en) 1980-06-30
AU5684880A (en) 1980-10-02
GB2047244A (en) 1980-11-26
GB2047244B (en) 1983-02-23
AT372373B (de) 1983-09-26
SG33683G (en) 1985-03-29
AU528388B2 (en) 1983-04-28
PH16416A (en) 1983-09-29
DK156056C (da) 1989-11-06

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